DK2307459T3 - Notch1-receptorbindende midler og fremgangsmåder til anvendelse deraf - Google Patents

Notch1-receptorbindende midler og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK2307459T3
DK2307459T3 DK09794822.8T DK09794822T DK2307459T3 DK 2307459 T3 DK2307459 T3 DK 2307459T3 DK 09794822 T DK09794822 T DK 09794822T DK 2307459 T3 DK2307459 T3 DK 2307459T3
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Prior art keywords
procedures
receptor binding
binding agents
notch1 receptor
notch1
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DK09794822.8T
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English (en)
Inventor
Austin L Gurney
Timothy Charles Hoey
Maureen Fitch Bruhns
Fumiko Takada Axelrod
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Oncomed Pharm Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
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    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
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    • C12N5/0602—Vertebrate cells
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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DK09794822.8T 2008-07-08 2009-07-08 Notch1-receptorbindende midler og fremgangsmåder til anvendelse deraf DK2307459T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11270108P 2008-11-07 2008-11-07
US11269908P 2008-11-07 2008-11-07
PCT/US2009/003995 WO2010005567A2 (en) 2008-07-08 2009-07-08 Notch1 receptor binding agents and methods of use thereof

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DK2307459T3 true DK2307459T3 (da) 2015-02-09

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DK09794821.0T DK2307051T3 (da) 2008-07-08 2009-07-08 Notch-bindende stoffer og antagonister og fremgangsmåder til anvendelse deraf
DK09794822.8T DK2307459T3 (da) 2008-07-08 2009-07-08 Notch1-receptorbindende midler og fremgangsmåder til anvendelse deraf

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DK09794821.0T DK2307051T3 (da) 2008-07-08 2009-07-08 Notch-bindende stoffer og antagonister og fremgangsmåder til anvendelse deraf

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US (11) US8435513B2 (da)
EP (4) EP2899211A1 (da)
JP (2) JP5560270B2 (da)
KR (2) KR101640099B1 (da)
CN (3) CN102112490B (da)
AU (2) AU2009269095B2 (da)
BR (2) BRPI0914004A2 (da)
CA (2) CA2729306C (da)
CO (2) CO6390041A2 (da)
CR (1) CR20110069A (da)
CY (2) CY1116195T1 (da)
DK (2) DK2307051T3 (da)
DO (2) DOP2011000002A (da)
EA (2) EA026109B1 (da)
ES (2) ES2531541T3 (da)
HK (2) HK1151296A1 (da)
HR (2) HRP20150256T1 (da)
IL (2) IL210222A (da)
MA (2) MA32448B1 (da)
ME (2) ME02069B (da)
MX (2) MX2011000236A (da)
MY (2) MY159815A (da)
NZ (2) NZ590131A (da)
PL (2) PL2307459T3 (da)
PT (2) PT2307051E (da)
RS (2) RS53924B1 (da)
SG (2) SG192467A1 (da)
SI (2) SI2307459T1 (da)
SM (2) SMT201500047B (da)
UA (1) UA101672C2 (da)
WO (2) WO2010005566A2 (da)
ZA (2) ZA201009280B (da)

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US9540694B2 (en) * 2006-05-19 2017-01-10 The Johns Hopkins University HEYL as a therapeutic target and a diagnostic marker for neoplasia and uses therefor
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
AU2007333805B2 (en) 2006-12-18 2013-07-25 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
CA2676008A1 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
NZ590131A (en) 2008-07-08 2012-10-26 Oncomed Pharm Inc Notch-binding agents and antagonists and methods of use thereof
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
KR101712214B1 (ko) * 2008-10-01 2017-03-03 제넨테크, 인크. 항-노치2 항체 및 사용 방법
BRPI1011805A2 (pt) 2009-06-18 2016-10-11 Pfizer anticorpos anti incisura-1
EP2483311B1 (en) * 2009-09-30 2016-05-18 F.Hoffmann-La Roche Ag Anti-Notch3 antagonistic antibodies for treating of a gamma-secretase inhibitor positive T-cell leukemia that does not respond to an anti-Notch1 antagonistic antibody.
HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
WO2011088215A2 (en) 2010-01-13 2011-07-21 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
KR101821343B1 (ko) 2010-03-01 2018-01-23 타우 쎄라퓨틱스 엘엘씨 암 진단 및 영상화
KR20130079384A (ko) * 2010-05-03 2013-07-10 제넨테크, 인크. 종양의 진단 및 치료를 위한 조성물 및 방법
CN103547594B (zh) 2010-12-15 2016-05-11 惠氏有限责任公司 抗缺刻蛋白1抗体
US20130058947A1 (en) * 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
WO2013039859A1 (en) * 2011-09-12 2013-03-21 Gray Lloyd S Antagonists of products of the hs.459642 unigene cluster for the inhibition of proliferation, development or differentiation of stem cells including cancer stem cells
CN107722122B (zh) 2011-09-23 2022-05-27 昂考梅德药品有限公司 Vegf/dll4结合剂及其应用
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