EP1322761A4 - A humanized antibody to surface antigen s of hepatitis b virus and a preparing method thereof - Google Patents

A humanized antibody to surface antigen s of hepatitis b virus and a preparing method thereof

Info

Publication number
EP1322761A4
EP1322761A4 EP01974926A EP01974926A EP1322761A4 EP 1322761 A4 EP1322761 A4 EP 1322761A4 EP 01974926 A EP01974926 A EP 01974926A EP 01974926 A EP01974926 A EP 01974926A EP 1322761 A4 EP1322761 A4 EP 1322761A4
Authority
EP
European Patent Office
Prior art keywords
hepatitis
virus
humanized antibody
surface antigen
preparing method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01974926A
Other languages
German (de)
French (fr)
Other versions
EP1322761A1 (en
Inventor
Hyo-Jeong Hong
Keun-Soo Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Bioscience and Biotechnology KRIBB
Original Assignee
Korea Research Institute of Bioscience and Biotechnology KRIBB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR10-2001-0060966A external-priority patent/KR100484054B1/en
Application filed by Korea Research Institute of Bioscience and Biotechnology KRIBB filed Critical Korea Research Institute of Bioscience and Biotechnology KRIBB
Publication of EP1322761A1 publication Critical patent/EP1322761A1/en
Publication of EP1322761A4 publication Critical patent/EP1322761A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP01974926A 2000-10-02 2001-10-04 A humanized antibody to surface antigen s of hepatitis b virus and a preparing method thereof Withdrawn EP1322761A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20000057891 2000-10-02
KR2000057891 2000-10-02
KR10-2001-0060966A KR100484054B1 (en) 2000-10-02 2001-09-29 A humanized antibody to surface antigen S of hepatitis B virus and a preparing method thereof
KR2001060966 2001-09-29
PCT/KR2001/001657 WO2002059318A1 (en) 2000-10-02 2001-10-04 A humanized antibody to surface antigen s of hepatitis b virus and a preparing method thereof

Publications (2)

Publication Number Publication Date
EP1322761A1 EP1322761A1 (en) 2003-07-02
EP1322761A4 true EP1322761A4 (en) 2005-03-23

Family

ID=26638435

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01974926A Withdrawn EP1322761A4 (en) 2000-10-02 2001-10-04 A humanized antibody to surface antigen s of hepatitis b virus and a preparing method thereof

Country Status (4)

Country Link
EP (1) EP1322761A4 (en)
JP (1) JP2004517636A (en)
CN (1) CN1395617A (en)
WO (1) WO2002059318A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1324049C (en) * 2003-08-04 2007-07-04 中国疾病预防控制中心病毒病预防控制所 Human source anti SARS coronavirus gene engineering antibody
KR100789645B1 (en) * 2004-04-14 2007-12-27 주식회사유한양행 A humanized antibody against s-surface antigen of hepatitis b virus and a method for preparing thereof
EP2032166B1 (en) 2006-06-13 2013-04-10 OncoMed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
AU2008209482B2 (en) 2007-01-24 2014-05-01 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
JP5560270B2 (en) 2008-07-08 2014-07-23 オンコメッド ファーマシューティカルズ インコーポレイテッド NOTCH binding agents and antagonists and methods of use thereof
WO2015153997A2 (en) * 2014-04-04 2015-10-08 Oncomed Pharmaceuticals, Inc. Notch3 antibodies and uses thereof
EP3360896A4 (en) * 2015-10-09 2019-08-28 Xiamen University Antibody to hepatitis b surface antigen and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016192A1 (en) * 1992-02-11 1993-08-19 The Wellcome Foundation Limited Humanised antibody against hepatitis
WO1997047654A1 (en) * 1996-06-11 1997-12-18 Yeda Research And Development Co. Ltd. Human monoclonal antibodies to the hepatitis b surface antigen
WO2000031141A1 (en) * 1998-11-19 2000-06-02 Korea Institute Of Science And Technology Humanized antibody specific for surface antigen pre-s1 of hbv and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
KR960002358B1 (en) * 1993-05-26 1996-02-16 대우통신주식회사 Overload protection devices for an electronic switching system
KR100308758B1 (en) * 1999-02-12 2001-09-24 박호군 Humanized antibody specific for HBV surface antigen pre S2 and the process for preparation thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016192A1 (en) * 1992-02-11 1993-08-19 The Wellcome Foundation Limited Humanised antibody against hepatitis
WO1997047654A1 (en) * 1996-06-11 1997-12-18 Yeda Research And Development Co. Ltd. Human monoclonal antibodies to the hepatitis b surface antigen
WO2000031141A1 (en) * 1998-11-19 2000-06-02 Korea Institute Of Science And Technology Humanized antibody specific for surface antigen pre-s1 of hbv and preparation method thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHUN JEIH RYU ET AL: "A HUMANIZED ANTIBODY WITH SPECIFICITY FOR HEPATITIS B SURFACE ANTIGEN", HUMAN ANTIBODIES AND HYBRIDOMAS, XX, XX, vol. 7, no. 3, 1996, pages 113 - 122, XP001029078 *
EREN R ET AL: "Human monoclonal antibodies specific to hepatitis B virus generated in a human/mouse radiation chimera: the Trimera system", IMMUNOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, GB, vol. 93, no. 2, February 1998 (1998-02-01), pages 154 - 161, XP002200770, ISSN: 0019-2805 *
HEIJTINK R ET AL: "In vivo activity of a mixture of two human monoclonal antibodies (anti-HBs) in a chronic hepatitis B virus carrier chimpanzee", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 80, no. 6, June 1999 (1999-06-01), pages 1529 - 1535, XP002200771, ISSN: 0022-1317 *
See also references of WO02059318A1 *
TAMURA M ET AL: "STRUCTURAL CORRELATES OF AN ANTICARCINOMA ANTIBODY: IDENTIFICATION OF SPECIFICITY-DETERMINING RESIDUES (SDRS) AND DEVELOPMENT OF A MINIMALLY IMMUNOGENIC ANTIBODY VARIANT BY RETENTION OF SDRS ONLY", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 164, no. 3, 1 February 2000 (2000-02-01), pages 1432 - 1441, XP000901556, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
EP1322761A1 (en) 2003-07-02
CN1395617A (en) 2003-02-05
JP2004517636A (en) 2004-06-17
WO2002059318A1 (en) 2002-08-01

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020613

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 07K 16/08 B

Ipc: 7C 12N 15/13 A

A4 Supplementary search report drawn up and despatched

Effective date: 20050202

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060223