ME02148B - Notch-vezivni agensi i antagonisti i postupci za njihovo korišćenje - Google Patents

Notch-vezivni agensi i antagonisti i postupci za njihovo korišćenje

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Publication number
ME02148B
ME02148B MEP-2015-63A MEP6315A ME02148B ME 02148 B ME02148 B ME 02148B ME P6315 A MEP6315 A ME P6315A ME 02148 B ME02148 B ME 02148B
Authority
ME
Montenegro
Prior art keywords
antibody
seq
cancer
agent
heavy chain
Prior art date
Application number
MEP-2015-63A
Other languages
English (en)
Inventor
Austin Gurney
Timothy Charles Hoey
Maureen Fitch Bruhns
Van Der Horst Edward Thein Htun
Aaron Ken Sato
Yuan Ching Liu
John A Lewicki
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Publication of ME02148B publication Critical patent/ME02148B/me

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Claims (19)

1.Izolovano antitelo koje specifično vezuje humani Notch2 i Notch3 sadrži:a)teški lanac CDR1 koji sadrži SSSGMS (SEQ ID NO:5), teški lanac CDR2 koji sadrži VIASSGSNTYYADSVKG (SEQ ID NO:6), i teški lanac CDR3 koji sadrži SIFYTT (SEQ ID NO:51) ili SEQ ID NO:30; ib)laki lanac CDR1 koji sadrži RASQSVRSNYLA (SEQ ID NO:8), laki lanac CDR2 koji sadrži GASSRAT(SEQ ID NO:9), i laki lanac CDR3 koji sadrži QQYSNFPI (SEQ ID NO:10).
2.Antitelo prema patentnom zahtevu 1 gde teški lanac CDR3 sadrži SIFYTT (SEQ ID NO:51).
3.Antitelo prema patentnom zahtevu 2 koje sadrži varijabilnu regiju teškog lanca SEQ ID NO:50 i varijabilnu regiju lakog lanca SEQ ID NO:13.
4.Antitelo prema patentnom zahtevu 1, gde teški lanac CDR3 sadrži SIFYPT (SEQ ID NO:22), SSFFAS (SEQ ID NO:23), SSFYAS (SEQ ID NO:24), SSFFAT (SEQ ID NO:25), SIFYPS (SEQ ID NO:26), SSFFAN (SEQ ID NO:27) ili GIFFAI (SEQ ID NO:7).
5.Antitelo prema patentnom zahtevu 1, patentnom zahtevu 2 ili patentnom zahtevu 4, koje sadrži: a)varijabilnu regiju teškog lanca koja ima bar 90% identičnosti sekvence sa SEQ ID NO:50, SEQ ID NO:14, ili SEQ ID NO:20; i b)varijabilnu regiju lakog lanca koja ima bar 90% identičnosti sekvence sa SEQ ID NO:13 ili SEQ ID NO:19.
6.Antitelo prema bilo kom od patentnih zahteva 1 do 5 gde je antitelo rekombinantno antitelo, monoklonsko antitelo, himerno antitelo, humanizovano antitelo, humano antitelo, fragment antitela, bispecifično antitelo, monospecifično antitelo, IgG1 antitelo ili IgG2 antitelo.
7.Antitelo kodirano od strane polinukleotida deponovanog kod ATCC pod PTA-10170 ili od strane polinukleotida deponovanog kod ATCC pod PTA-9547.
8.Ćelija koja sadrži ili proizvodi antitelo kako je definisano prema bilo kom od patentnih zahteva od 1 do 7.
9.Izolovani polinukleotid koji sadrži polinukleotid koji kodira antitelo prema bilo kom od patentnih zahteva 1 do 7.
10.Antitelo prema bilo kom od patentnih zahteva 1 do 7 za korišćenje u tretmanu kancera.
11.Antitelo prema bilo kom od patentnih zahteva 1 do 7 za korišćenje prema patentnom zahtevu 10, gde tretman tumora smanjuje kancerogenost tumora i/ili smanjuje učestalost matičnih ćelija kancera u tumoru.
12.Antitelo prema bilo kom od patentnih zahteva 1 do 7, za korišćenje prema patentnom zahtevu 10, gde je kancer kolorektalni kancer, kancer dojke, kancer pankreasa, kancer pluća ili melanom.
13.Antitelo prema bilo kom od patentnih zahteva 1 do 7, za korišćenje prema patentnom zahtevu 10, gde tretman obuhvata davanje delotvorne količine antitela pacijentu, i dalje sadrži davanje terapeutski delotvorne količine drugog agensa pacijentu, gde je drugi agens agens protiv kancera i/ili antiangiogeni agens.
14.Antitelo prema bilo kom od patentnih zahteva 1 do 7, za korišćenje prema patentnom zahtevu 13, gde je drugi agens hemoterapijski agens.
15.Antitelo prema bilo kom od patentnih zahteva 1 do 7, za korišćenje prema patentnom zahtevu 14, gde je hemoterapijski agens paclitaksel, gemcitabin ili irinotekan.
16.Antitelo prema bilo kom od patentnih zahteva 1 do 7, za korišćenje prema patentnom zahtevu 13, gde je drugi agens antagonist faktora rasta vaskularnog endotela (VEGF) ili VEGF receptor.
17.Antitelo prema bilo kom od patentnih zahteva 1 do 7, za korišćenje prema patentnom zahtevu 13, gde je drugi agens antiDLL4 antitelo.
18.Korišćenje antitela kako je definisano u bilo kom od patentnih zahteva 1 do 7 za proizvodnju lekova za tretman kancera.
19. Korišćenje prema patentnom zahtevu 18 gde je lečenje kancera ono lečenje kako je definisano u u bilo kom od patentnih zahteva 11 do 17.
MEP-2015-63A 2008-07-08 2009-07-08 Notch-vezivni agensi i antagonisti i postupci za njihovo korišćenje ME02148B (me)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11269908P 2008-11-07 2008-11-07
US11270108P 2008-11-07 2008-11-07
EP09794821.0A EP2307051B1 (en) 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of use thereof
PCT/US2009/003994 WO2010005566A2 (en) 2008-07-08 2009-07-08 Notch-binding agents and antagonists and methods of use thereof

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