ATE482275T1 - Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden - Google Patents
Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden bindenInfo
- Publication number
- ATE482275T1 ATE482275T1 AT00947904T AT00947904T ATE482275T1 AT E482275 T1 ATE482275 T1 AT E482275T1 AT 00947904 T AT00947904 T AT 00947904T AT 00947904 T AT00947904 T AT 00947904T AT E482275 T1 ATE482275 T1 AT E482275T1
- Authority
- AT
- Austria
- Prior art keywords
- poly
- binding partners
- ests
- genomic dna
- dna fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99112815 | 1999-07-02 | ||
| PCT/EP2000/006137 WO2001002588A2 (en) | 1999-07-02 | 2000-06-30 | Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482275T1 true ATE482275T1 (de) | 2010-10-15 |
Family
ID=8238496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00947904T ATE482275T1 (de) | 1999-07-02 | 2000-06-30 | Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6653068B2 (de) |
| EP (1) | EP1133565B1 (de) |
| JP (1) | JP4794789B2 (de) |
| AT (1) | ATE482275T1 (de) |
| CA (1) | CA2339889C (de) |
| DE (1) | DE60044997D1 (de) |
| DK (1) | DK1133565T3 (de) |
| ES (1) | ES2353268T3 (de) |
| WO (1) | WO2001002588A2 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696251B1 (en) | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| WO2001077365A2 (en) | 2000-04-06 | 2001-10-18 | Pharmacia & Upjohn Company | Antimicrobial methods and materials |
| WO2003029484A2 (en) * | 2001-09-28 | 2003-04-10 | Pharmacia & Upjohn Company | Antimicrobial methods and materials |
| US20030235814A1 (en) * | 2002-06-19 | 2003-12-25 | Los Alamos National Laboratory | Compositions and methods for selecting open reading frames |
| DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
| WO2007117657A2 (en) | 2006-04-07 | 2007-10-18 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
| US9044461B2 (en) | 2006-04-07 | 2015-06-02 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
| JP5675109B2 (ja) | 2007-02-20 | 2015-02-25 | アナプティスバイオ インコーポレイティッド | ライブラリーの生成方法及びその使用 |
| US10485879B2 (en) | 2008-04-15 | 2019-11-26 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues |
| AU2009236270B2 (en) | 2008-04-15 | 2014-06-26 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for delivering inhibitory oligonucleotides |
| CN102316897B (zh) | 2008-07-08 | 2014-11-05 | 昂考梅德药品有限公司 | Notch结合剂和拮抗剂及其应用方法 |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| US8832581B2 (en) * | 2009-03-05 | 2014-09-09 | Ming Zhang | Gene expression browser for web-based search and visualization of characteristics of gene expression |
| AR076284A1 (es) | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| AU2011205316B2 (en) | 2010-01-13 | 2015-05-28 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| AU2011215685B2 (en) | 2010-02-12 | 2015-08-20 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
| WO2011103330A2 (en) | 2010-02-17 | 2011-08-25 | The Johns Hopkins University | Novel phosphorylation of cardiac troponin i as a monitor for cardiac injury |
| KR20230044026A (ko) | 2010-02-24 | 2023-03-31 | 이뮤노젠 아이엔씨 | 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도 |
| CN106046159B (zh) | 2010-03-12 | 2020-06-16 | 德彪发姆国际有限公司 | Cd37结合分子及其免疫缀合物 |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| WO2012019024A2 (en) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| CN106167526A (zh) | 2011-07-15 | 2016-11-30 | 昂考梅德药品有限公司 | Rspo结合剂和其应用 |
| US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
| DK3485903T5 (da) | 2011-09-23 | 2024-09-02 | Mereo Biopharma 5 Inc | Vegf/dll4-bindende midler og anvendelser deraf |
| WO2013071233A1 (en) | 2011-11-10 | 2013-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for detecting infectious agents and a novel virus detected thereby |
| US9220775B2 (en) | 2011-11-23 | 2015-12-29 | Medimmune Llc | Binding molecules specific for HER3 and uses thereof |
| EP2858673A4 (de) | 2012-06-06 | 2016-06-22 | Oncomed Pharm Inc | Bindungsmittel zur modulation des hippo-pfads und verwendungen davon |
| JP6293147B2 (ja) | 2012-08-31 | 2018-03-14 | イミュノジェン, インコーポレイテッド | 葉酸受容体1の検出のための診断分析およびキット |
| CN104902923A (zh) | 2012-11-05 | 2015-09-09 | 建新公司 | 用于治疗蛋白质病的组合物和方法 |
| CA2907181C (en) | 2013-03-15 | 2023-10-17 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
| JP6671276B2 (ja) | 2013-03-27 | 2020-03-25 | セダーズ−シナイ メディカル センター | Tl1a機能および関連するシグナル経路の抑制による線維症および炎症の緩和および回復 |
| DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
| EP4105236A1 (de) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antikörper zur behandlung von entzündlichen darmerkrankungen |
| LT3038650T (lt) | 2013-08-30 | 2021-09-10 | Immunogen, Inc. | Antikūnai ir foliatų receptoriaus 1 nustatymo testai |
| WO2015054400A2 (en) | 2013-10-08 | 2015-04-16 | Immunogen, Inc. | Anti-folr1 immunoconjugate dosing regimens |
| SG10201913627TA (en) | 2014-04-08 | 2020-03-30 | Boston Pharmaceuticals Inc | Binding molecules specific for il-21 and uses thereof |
| HK1232127A1 (zh) | 2014-04-11 | 2018-01-05 | Medimmune, Llc | 双特异性her2抗体 |
| CN112778418B (zh) | 2014-11-10 | 2025-04-22 | 免疫医疗有限公司 | 对cd73具有特异性的结合分子及其用途 |
| HK1246304A1 (zh) | 2014-11-11 | 2018-09-07 | Medimmune Limited | 包含抗cd73抗体和a2a受体抑制剂的治疗组合及其用途 |
| HUE053097T2 (hu) | 2015-03-31 | 2021-06-28 | Medimmune Ltd | Új IL33 forma, IL33 mutáltatott formái, ellenanyagok, vizsgálati eljárások és eljárások azok alkalmazására |
| LT3313884T (lt) | 2015-06-29 | 2021-03-10 | Immunogen, Inc. | Anti-cd123 antikūnai, konjugatai ir jų dariniai |
| EP3349796A4 (de) | 2015-09-17 | 2019-05-29 | ImmunoGen, Inc. | Therapeutische kombinationen mit anti-folr1-immunkonjugaten |
| PT3374398T (pt) | 2015-11-10 | 2020-06-16 | Medimmune Llc | Moléculas de ligação específicas para asct2 e suas utilizações |
| MX2018010771A (es) | 2016-03-10 | 2019-05-15 | Viela Bio Inc | Moleculas de union al transcrito 7 similar a inmunoglobulina (ilt7) y metodos de uso de las mismas. |
| KR102866147B1 (ko) | 2016-03-10 | 2025-09-30 | 악셀레론 파마 인코포레이티드 | 액티빈 타입 2 수용체 결합 단백질 및 이의 용도 |
| US11186872B2 (en) | 2016-03-17 | 2021-11-30 | Cedars-Sinai Medical Center | Methods of diagnosing inflammatory bowel disease through RNASET2 |
| KR20220080015A (ko) | 2016-04-22 | 2022-06-14 | 악셀레론 파마 인코포레이티드 | Alk7 결합 단백질 및 이들의 용도 |
| MY194619A (en) | 2016-06-02 | 2022-12-07 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
| US11447542B2 (en) | 2016-08-05 | 2022-09-20 | Medimmune, Llc | Anti-O2 antibodies and uses thereof |
| KR20190064636A (ko) | 2016-10-19 | 2019-06-10 | 메디뮨 엘엘씨 | 항-o1 항체 및 이의 용도 |
| KR20190082815A (ko) | 2016-10-26 | 2019-07-10 | 세다르스-신나이 메디칼 센터 | 중화 항-tl1a 단일 클론 항체 |
| CN110662770A (zh) | 2016-11-23 | 2020-01-07 | 比奥维拉迪维治疗股份有限公司 | 结合凝血因子ix和凝血因子x的双特异性抗体 |
| US11512127B2 (en) | 2018-02-14 | 2022-11-29 | Viela Bio, Inc. | Antibodies to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 receptor ligand (FLT3L) and uses thereof for treating autoimmune and inflammatory diseases |
| CN112585165B8 (zh) | 2018-04-25 | 2025-02-14 | 普罗米修斯生物科学公司 | 优化的抗tl1a抗体 |
| EP3883961A1 (de) | 2018-11-20 | 2021-09-29 | Takeda Vaccines, Inc. | Neuartige zika-virus-antikörper und ihre verwendungen |
| JP7520848B2 (ja) | 2018-12-28 | 2024-07-23 | スパークス・セラピューティクス・インコーポレイテッド | 癌および他の疾患の治療のための、クローディン18.2に特異的な結合分子、その組成物および方法 |
| MX2022004942A (es) | 2019-10-24 | 2022-07-27 | Prometheus Biosciences Inc | Anticuerpos humanizados contra el ligando 1a de tipo tnf (tl1a) y usos de los mismos. |
| CR20230146A (es) | 2020-09-11 | 2023-06-07 | Medimmune Ltd | Moléculas de unión a b7-h4 terapéuticas |
| US20240302348A1 (en) | 2020-09-12 | 2024-09-12 | Medimmune Limited | A Scoring Method for an Anti-B7H4 Antibody-Drug Conjugate Therapy |
| US11452757B2 (en) * | 2021-02-25 | 2022-09-27 | Intron Biotechnology, Inc. | Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same |
| WO2022195028A2 (en) | 2021-03-18 | 2022-09-22 | Medimmune Limited | Therapeutic binding molecules |
| US11807685B2 (en) | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
| TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
| CN120659814A (zh) | 2023-02-13 | 2025-09-16 | 浙江大学绍兴研究院 | 双特异性抗体及其应用 |
| US20250051463A1 (en) | 2023-07-31 | 2025-02-13 | Astrazeneca Ab | Cd123 antibody-drug conjugates and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| US6069230A (en) * | 1994-11-10 | 2000-05-30 | Promega Corporation | High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications |
| US5895651A (en) * | 1996-06-27 | 1999-04-20 | The United States Of America As Represented By The Secretary Of The Navy | Recombinant dengue virus envelope protein/maltose-binding protein antigens and subunit vaccine compositions containing said antigens |
| DE69839553D1 (de) * | 1997-01-08 | 2008-07-10 | Invitrogen Corp | Verfahren zur herstellung von proteinen |
-
2000
- 2000-06-30 ES ES00947904T patent/ES2353268T3/es not_active Expired - Lifetime
- 2000-06-30 AT AT00947904T patent/ATE482275T1/de active
- 2000-06-30 CA CA2339889A patent/CA2339889C/en not_active Expired - Lifetime
- 2000-06-30 DK DK00947904.9T patent/DK1133565T3/da active
- 2000-06-30 DE DE60044997T patent/DE60044997D1/de not_active Expired - Lifetime
- 2000-06-30 EP EP00947904A patent/EP1133565B1/de not_active Expired - Lifetime
- 2000-06-30 JP JP2001508360A patent/JP4794789B2/ja not_active Expired - Lifetime
- 2000-06-30 WO PCT/EP2000/006137 patent/WO2001002588A2/en not_active Ceased
-
2001
- 2001-02-28 US US09/795,872 patent/US6653068B2/en not_active Expired - Lifetime
-
2003
- 2003-09-16 US US10/662,824 patent/US20040157291A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6653068B2 (en) | 2003-11-25 |
| WO2001002588A2 (en) | 2001-01-11 |
| DE60044997D1 (de) | 2010-11-04 |
| CA2339889C (en) | 2012-01-31 |
| JP2003504031A (ja) | 2003-02-04 |
| US20040157291A1 (en) | 2004-08-12 |
| US20030170622A1 (en) | 2003-09-11 |
| EP1133565B1 (de) | 2010-09-22 |
| EP1133565A2 (de) | 2001-09-19 |
| WO2001002588A3 (en) | 2001-07-12 |
| DK1133565T3 (da) | 2011-01-24 |
| ES2353268T3 (es) | 2011-02-28 |
| JP4794789B2 (ja) | 2011-10-19 |
| CA2339889A1 (en) | 2001-01-11 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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