ATE482275T1 - Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden - Google Patents
Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden bindenInfo
- Publication number
- ATE482275T1 ATE482275T1 AT00947904T AT00947904T ATE482275T1 AT E482275 T1 ATE482275 T1 AT E482275T1 AT 00947904 T AT00947904 T AT 00947904T AT 00947904 T AT00947904 T AT 00947904T AT E482275 T1 ATE482275 T1 AT E482275T1
- Authority
- AT
- Austria
- Prior art keywords
- poly
- binding partners
- ests
- genomic dna
- dna fragments
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 239000012634 fragment Substances 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 230000009870 specific binding Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 230000027455 binding Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 210000003000 inclusion body Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 241000724791 Filamentous phage Species 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99112815 | 1999-07-02 | ||
PCT/EP2000/006137 WO2001002588A2 (en) | 1999-07-02 | 2000-06-30 | Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE482275T1 true ATE482275T1 (de) | 2010-10-15 |
Family
ID=8238496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00947904T ATE482275T1 (de) | 1999-07-02 | 2000-06-30 | Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden |
Country Status (9)
Country | Link |
---|---|
US (2) | US6653068B2 (de) |
EP (1) | EP1133565B1 (de) |
JP (1) | JP4794789B2 (de) |
AT (1) | ATE482275T1 (de) |
CA (1) | CA2339889C (de) |
DE (1) | DE60044997D1 (de) |
DK (1) | DK1133565T3 (de) |
ES (1) | ES2353268T3 (de) |
WO (1) | WO2001002588A2 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
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US6696251B1 (en) * | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
US6764823B2 (en) | 2000-04-06 | 2004-07-20 | Pharmacia & Upjohn Company | Antimicrobial methods and materials |
EP1432814A2 (de) * | 2001-09-28 | 2004-06-30 | PHARMACIA & UPJOHN COMPANY | Antimikrobielle methoden und werkstoffen |
US20030235814A1 (en) * | 2002-06-19 | 2003-12-25 | Los Alamos National Laboratory | Compositions and methods for selecting open reading frames |
DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
US8524454B2 (en) * | 2006-04-07 | 2013-09-03 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
US9044461B2 (en) | 2006-04-07 | 2015-06-02 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
BRPI0807952A2 (pt) | 2007-02-20 | 2014-06-10 | Anaptysbio Inc | Sistemas de hipermutação somática |
US10485879B2 (en) | 2008-04-15 | 2019-11-26 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Plasma cell cytokine vehicle containing fusion proteins for targeted introduction of siRNA into cells and tissues |
AU2009236270B2 (en) | 2008-04-15 | 2014-06-26 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for delivering inhibitory oligonucleotides |
PL2307459T3 (pl) | 2008-07-08 | 2015-05-29 | Oncomed Pharm Inc | Czynniki wiążące receptor Notch1 i sposoby ich stosowania |
US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
US8832581B2 (en) * | 2009-03-05 | 2014-09-09 | Ming Zhang | Gene expression browser for web-based search and visualization of characteristics of gene expression |
AR076284A1 (es) | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
ES2561102T3 (es) | 2010-01-13 | 2016-02-24 | Oncomed Pharmaceuticals, Inc. | Agentes de unión a Notch1 y procedimientos de uso de los mismos |
CA2789446A1 (en) | 2010-02-12 | 2011-08-18 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
EP3178846B1 (de) | 2010-02-17 | 2018-08-22 | Cedars-Sinai Medical Center | Neuartige phosphorylierung von kardialem troponin i als ein monitor einer kardialen verletzung |
KR20220017432A (ko) | 2010-02-24 | 2022-02-11 | 이뮤노젠 아이엔씨 | 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도 |
LT2544719T (lt) | 2010-03-12 | 2019-10-25 | Debiopharm Int Sa | Cd37 surišančios molekulės, ir jų imunokonjugatai |
WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
WO2012019024A2 (en) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
WO2012162561A2 (en) | 2011-05-24 | 2012-11-29 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
CN106167526A (zh) | 2011-07-15 | 2016-11-30 | 昂考梅德药品有限公司 | Rspo结合剂和其应用 |
US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
ES2707580T3 (es) | 2011-09-23 | 2019-04-04 | Oncomed Pharm Inc | Agentes de unión a VEGF/DLL4 y usos de los mismos |
WO2013071233A1 (en) | 2011-11-10 | 2013-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for detecting infectious agents and a novel virus detected thereby |
RU2620068C2 (ru) | 2011-11-23 | 2017-05-22 | МЕДИММЬЮН, ЭлЭлСи | Связывающие молекулы, специфичные по отношению к her3, и их применения |
WO2013184912A2 (en) | 2012-06-06 | 2013-12-12 | Oncomed Pharmaceuticals, Inc. | Binding agents that modulate the hippo pathway and uses thereof |
PL2890717T3 (pl) | 2012-08-31 | 2020-08-10 | Immunogen, Inc. | Testy i zestawy diagnostyczne do wykrywania receptora folianu |
MX2015005722A (es) | 2012-11-05 | 2016-01-12 | Genzyme Corp | Composiciones y metodos para el tratamiento de proteinopatias. |
WO2014144600A2 (en) | 2013-03-15 | 2014-09-18 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
KR20210157418A (ko) | 2013-03-27 | 2021-12-28 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
EP4105236A1 (de) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antikörper zur behandlung von entzündlichen darmerkrankungen |
WO2015031815A2 (en) | 2013-08-30 | 2015-03-05 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
SG11201602361UA (en) | 2013-10-08 | 2016-04-28 | Immunogen Inc | Anti-folr1 immunoconjugate dosing regimens |
CA2948275C (en) | 2014-04-08 | 2023-10-17 | Boston Pharmaceuticals Inc. | Binding molecules specific for il-21 and uses thereof |
WO2015157592A1 (en) | 2014-04-11 | 2015-10-15 | Medimmune, Llc | Bispecific her2 antibodies |
RS62003B1 (sr) | 2014-11-10 | 2021-07-30 | Medimmune Ltd | Vezujući molekuli specifični za cd73 i njihove upotrebe |
EP3789403A1 (de) | 2014-11-11 | 2021-03-10 | MedImmune Limited | Therapeutische kombinationen mit anti-cd73-antikörpern und a2a-rezeptorinhibitoren sowie verwendungen davon |
BR112017020955A2 (pt) | 2015-03-31 | 2018-07-10 | Medimmune Limited | forma de il33, formas mutadas de il33, anticorpos, ensaios e métodos de uso dos mesmos |
WO2017004026A1 (en) | 2015-06-29 | 2017-01-05 | Immunogen, Inc. | Anti-cd 123 antibodies and conjugates and derivatives thereof |
WO2017049149A1 (en) | 2015-09-17 | 2017-03-23 | Immunogen, Inc. | Therapeutic combinations comprising anti-folr1 immunoconjugates |
HUE050312T2 (hu) | 2015-11-10 | 2020-11-30 | Medimmune Llc | ASCT2-RE specifikus kötõmolekulák és alkalmazásaik |
AU2017230091B2 (en) | 2016-03-10 | 2022-04-07 | Acceleron Pharma Inc. | Activin type 2 receptor binding proteins and uses thereof |
EP3426298A4 (de) | 2016-03-10 | 2019-11-27 | Viela Bio, Inc. | Ilt7-bindende moleküle und verfahren zur verwendung davon |
EP3430172A4 (de) | 2016-03-17 | 2019-08-21 | Cedars-Sinai Medical Center | Verfahren zur diagnose einer entzündlichen darmerkrankung durch rnaset2 |
AU2017274442B2 (en) | 2016-06-02 | 2021-08-19 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
AU2017306709A1 (en) | 2016-08-05 | 2019-03-14 | Humabs, BioMed SA | Anti-o2 antibodies and uses thereof |
JP7160484B2 (ja) | 2016-10-19 | 2022-10-25 | メディミューン,エルエルシー | 抗o1抗体およびその使用 |
SG11201903737PA (en) | 2016-10-26 | 2019-05-30 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
BR112019010349A2 (pt) | 2016-11-23 | 2019-10-08 | Bioverativ Therapeutics Inc | Anticorpos anti-fixa, anti-fxz e antifxa, molécula biespecífica, ácido nulceico, composiçãofarmacêutica e uso dos anteriores |
US11512127B2 (en) | 2018-02-14 | 2022-11-29 | Viela Bio, Inc. | Antibodies to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 receptor ligand (FLT3L) and uses thereof for treating autoimmune and inflammatory diseases |
AU2019261426A1 (en) | 2018-04-25 | 2020-12-03 | Cedars Sinai Medical Center | Optimized anti-TL1A antibodies |
WO2020106358A1 (en) | 2018-11-20 | 2020-05-28 | Takeda Vaccines, Inc. | Novel anti-zika virus antibodies and uses thereof |
JP2022516505A (ja) | 2018-12-28 | 2022-02-28 | スパークス・セラピューティクス・インコーポレイテッド | 癌および他の疾患の治療のための、クローディン18.2に特異的な結合分子、その組成物および方法 |
CN116063517A (zh) | 2019-10-24 | 2023-05-05 | 普罗米修斯生物科学公司 | Tnf样配体1a(tl1a)的人源化抗体及其用途 |
CA3193594A1 (en) | 2020-09-11 | 2022-03-17 | Medimmune Limited | Therapeutic b7-h4 binding molecules |
CA3194182A1 (en) | 2020-09-12 | 2022-03-17 | Medimmune Limited | A scoring method for an anti-b7h4 antibody-drug conjugate therapy |
MX2023010917A (es) | 2021-03-18 | 2023-09-27 | Medimmune Ltd | Molecula de union terapeutica que se une a ccr9. |
US11807685B2 (en) | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
US6069230A (en) * | 1994-11-10 | 2000-05-30 | Promega Corporation | High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications |
US5895651A (en) * | 1996-06-27 | 1999-04-20 | The United States Of America As Represented By The Secretary Of The Navy | Recombinant dengue virus envelope protein/maltose-binding protein antigens and subunit vaccine compositions containing said antigens |
EP0963435B1 (de) * | 1997-01-08 | 2008-05-28 | Invitrogen Corporation | Verfahren zur herstellung von proteinen |
-
2000
- 2000-06-30 ES ES00947904T patent/ES2353268T3/es not_active Expired - Lifetime
- 2000-06-30 WO PCT/EP2000/006137 patent/WO2001002588A2/en active Application Filing
- 2000-06-30 AT AT00947904T patent/ATE482275T1/de active
- 2000-06-30 DE DE60044997T patent/DE60044997D1/de not_active Expired - Lifetime
- 2000-06-30 EP EP00947904A patent/EP1133565B1/de not_active Expired - Lifetime
- 2000-06-30 CA CA2339889A patent/CA2339889C/en not_active Expired - Lifetime
- 2000-06-30 JP JP2001508360A patent/JP4794789B2/ja not_active Expired - Lifetime
- 2000-06-30 DK DK00947904.9T patent/DK1133565T3/da active
-
2001
- 2001-02-28 US US09/795,872 patent/US6653068B2/en not_active Expired - Lifetime
-
2003
- 2003-09-16 US US10/662,824 patent/US20040157291A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK1133565T3 (da) | 2011-01-24 |
US20030170622A1 (en) | 2003-09-11 |
ES2353268T3 (es) | 2011-02-28 |
JP4794789B2 (ja) | 2011-10-19 |
JP2003504031A (ja) | 2003-02-04 |
CA2339889A1 (en) | 2001-01-11 |
EP1133565A2 (de) | 2001-09-19 |
WO2001002588A3 (en) | 2001-07-12 |
DE60044997D1 (de) | 2010-11-04 |
WO2001002588A2 (en) | 2001-01-11 |
US6653068B2 (en) | 2003-11-25 |
US20040157291A1 (en) | 2004-08-12 |
CA2339889C (en) | 2012-01-31 |
EP1133565B1 (de) | 2010-09-22 |
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