BRPI0517564A - métodos para modificar o destino de uma célula de adenoma e/ou adenocarcinoma, para induzir a formação de uma célula pós-mitótica a partir de um célula de adenoma e/ou adenocarcinoma e para, pelo menos em parte, diminuir um adenoma e/ou adenocarcinoma intestinal presente em um animal, uso de um inibidor do trajeto de notch, e, composição farmacêutica - Google Patents

métodos para modificar o destino de uma célula de adenoma e/ou adenocarcinoma, para induzir a formação de uma célula pós-mitótica a partir de um célula de adenoma e/ou adenocarcinoma e para, pelo menos em parte, diminuir um adenoma e/ou adenocarcinoma intestinal presente em um animal, uso de um inibidor do trajeto de notch, e, composição farmacêutica

Info

Publication number
BRPI0517564A
BRPI0517564A BRPI0517564-0A BRPI0517564A BRPI0517564A BR PI0517564 A BRPI0517564 A BR PI0517564A BR PI0517564 A BRPI0517564 A BR PI0517564A BR PI0517564 A BRPI0517564 A BR PI0517564A
Authority
BR
Brazil
Prior art keywords
adenoma
adenocarcinoma
cell
intestinal
methods
Prior art date
Application number
BRPI0517564-0A
Other languages
English (en)
Inventor
Johannes Carolus Clevers
Gijn Maria Elisabeth Van
Es Johannes Hendrikus Van
Original Assignee
Hubrecht Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hubrecht Lab filed Critical Hubrecht Lab
Publication of BRPI0517564A publication Critical patent/BRPI0517564A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

MéTODOS PARA MODIFICAR O DESTINO DE UMA CéLULA DE ADENOMA E/OU ADENOCARCINOMA, PARA INDUZIR A FORMAçãO DE UMA CéLULA PóS-MITóTICA A PARTIR DE UM CéLULA DE ADENOMA E/OU ADENOCARCINOMA E PARA, PELO MENOS EM PARTE, DIMINUIR UM ADENOMA E/OU ADENOCARCINOMA INTESTINAL PRESENTE EM UM ANIMAL, USO DE UM INIBIDOR DO TRAJETO DE NOTCH, E, COMPOSIçãO FARMACêUTICA. A invenção refere-se ao campo da bioquímica e medicina. Mais especificamente, a invenção refere-se a métodos e produtos farmacêuticos para o tratamento de um neoplasia intestinal. A invenção descreve a surpreendente descoberta de que inibidores de ativação de trajeto de Notch (por exemplo inibidores de g-secretase) são extremamente úteis no tratamento de adenoma e/ou adenocarcinoma intestinal.
BRPI0517564-0A 2004-11-10 2005-11-10 métodos para modificar o destino de uma célula de adenoma e/ou adenocarcinoma, para induzir a formação de uma célula pós-mitótica a partir de um célula de adenoma e/ou adenocarcinoma e para, pelo menos em parte, diminuir um adenoma e/ou adenocarcinoma intestinal presente em um animal, uso de um inibidor do trajeto de notch, e, composição farmacêutica BRPI0517564A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04078090 2004-11-10
EP05075806 2005-04-06
PCT/NL2005/000788 WO2006052128A1 (en) 2004-11-10 2005-11-10 Treatment of an intestinal adenoma and/or adenocarcinoma by inhibition of notch pathway activation

Publications (1)

Publication Number Publication Date
BRPI0517564A true BRPI0517564A (pt) 2008-10-14

Family

ID=36336759

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517564-0A BRPI0517564A (pt) 2004-11-10 2005-11-10 métodos para modificar o destino de uma célula de adenoma e/ou adenocarcinoma, para induzir a formação de uma célula pós-mitótica a partir de um célula de adenoma e/ou adenocarcinoma e para, pelo menos em parte, diminuir um adenoma e/ou adenocarcinoma intestinal presente em um animal, uso de um inibidor do trajeto de notch, e, composição farmacêutica

Country Status (11)

Country Link
US (2) US20070265246A1 (pt)
EP (1) EP1824503A1 (pt)
JP (1) JP2008519829A (pt)
AU (1) AU2005302846A1 (pt)
BR (1) BRPI0517564A (pt)
CA (1) CA2586781A1 (pt)
IL (1) IL183031A0 (pt)
NO (1) NO20072951L (pt)
NZ (1) NZ555216A (pt)
RU (1) RU2392961C2 (pt)
WO (1) WO2006052128A1 (pt)

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EP1795198A1 (en) * 2005-12-09 2007-06-13 Hubrecht Laboratorium Treatment of Barret's esophagus
US7919092B2 (en) * 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
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US8148147B2 (en) 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
WO2008100563A2 (en) * 2007-02-14 2008-08-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
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CN102266587B (zh) * 2011-07-20 2013-12-04 山东省眼科研究所 一种含杯状细胞的重组眼结膜上皮膜片的制备方法
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Also Published As

Publication number Publication date
EP1824503A1 (en) 2007-08-29
IL183031A0 (en) 2007-09-20
RU2007121737A (ru) 2008-12-20
US20100292165A1 (en) 2010-11-18
WO2006052128A1 (en) 2006-05-18
JP2008519829A (ja) 2008-06-12
RU2392961C2 (ru) 2010-06-27
NO20072951L (no) 2007-08-09
NZ555216A (en) 2010-05-28
CA2586781A1 (en) 2006-05-18
US20070265246A1 (en) 2007-11-15
AU2005302846A1 (en) 2006-05-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]