MX2023006604A - Lipidos cationicos ionizables y nanoparticulas lipidicas, y metodos de sintesis y uso de los mismos. - Google Patents
Lipidos cationicos ionizables y nanoparticulas lipidicas, y metodos de sintesis y uso de los mismos.Info
- Publication number
- MX2023006604A MX2023006604A MX2023006604A MX2023006604A MX2023006604A MX 2023006604 A MX2023006604 A MX 2023006604A MX 2023006604 A MX2023006604 A MX 2023006604A MX 2023006604 A MX2023006604 A MX 2023006604A MX 2023006604 A MX2023006604 A MX 2023006604A
- Authority
- MX
- Mexico
- Prior art keywords
- lipid nanoparticles
- methods
- synthesis
- cationic lipids
- ionizable cationic
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title abstract 4
- 239000002105 nanoparticle Substances 0.000 title abstract 3
- 125000002091 cationic group Chemical group 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
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- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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Abstract
Se proporcionan lípidos catiónicos ionizables y nanopartículas lipídicas para la administración de ácidos nucleicos a células (p. ej., células inmunes), y métodos para preparar y usar dichos lípidos y nanopartículas lipídicas dirigidas.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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US202063121801P | 2020-12-04 | 2020-12-04 | |
US202163166205P | 2021-03-25 | 2021-03-25 | |
US202163169296P | 2021-04-01 | 2021-04-01 | |
US202163169395P | 2021-04-01 | 2021-04-01 | |
US202163172024P | 2021-04-07 | 2021-04-07 | |
PCT/US2021/072745 WO2022120388A2 (en) | 2020-12-04 | 2021-12-03 | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
Publications (1)
Publication Number | Publication Date |
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MX2023006604A true MX2023006604A (es) | 2023-06-19 |
Family
ID=79287892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MX2023006604A MX2023006604A (es) | 2020-12-04 | 2021-12-03 | Lipidos cationicos ionizables y nanoparticulas lipidicas, y metodos de sintesis y uso de los mismos. |
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US (1) | US20220218614A1 (es) |
EP (1) | EP4256067A2 (es) |
JP (1) | JP2023552195A (es) |
KR (1) | KR20230123480A (es) |
AU (1) | AU2021393593A1 (es) |
CA (1) | CA3201219A1 (es) |
CO (1) | CO2023007408A2 (es) |
IL (1) | IL303373A (es) |
MX (1) | MX2023006604A (es) |
TW (1) | TW202241458A (es) |
WO (1) | WO2022120388A2 (es) |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20240109965A1 (en) * | 2022-06-14 | 2024-04-04 | Ablynx N.V. | Immunoglobulin single variable domains targeting t cell receptor |
WO2024079046A1 (en) * | 2022-10-10 | 2024-04-18 | Zelarion Malta Limited | Anti-cd2 antibodies for type 1 diabetes |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US6887471B1 (en) | 1991-06-27 | 2005-05-03 | Bristol-Myers Squibb Company | Method to inhibit T cell interactions with soluble B7 |
EP0568332B1 (en) | 1992-04-28 | 1999-07-28 | Sumitomo Rubber Industries, Ltd. | Solid golf ball |
DE69334305D1 (de) | 1992-08-21 | 2010-01-28 | Univ Bruxelles | Immunoglobuline ohne leichte Ketten |
EP0702722B1 (en) | 1993-06-07 | 2005-08-03 | Vical Incorporated | Plasmids suitable for gene therapy |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
JPH11509088A (ja) | 1995-06-23 | 1999-08-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 血管内皮増殖因子受容体をコードする遺伝子の転写調節 |
US6210707B1 (en) | 1996-11-12 | 2001-04-03 | The Regents Of The University Of California | Methods of forming protein-linked lipidic microparticles, and compositions thereof |
AU6703198A (en) | 1997-03-21 | 1998-10-20 | Brigham And Women's Hospital | Immunotherapeutic ctla-4 binding peptides |
US6849258B1 (en) | 1997-07-18 | 2005-02-01 | Universite Catholique De Louvain | LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation |
US6670453B2 (en) | 1997-10-27 | 2003-12-30 | Unilever Patent Holdings B.V. | Multivalent antigen-binding proteins |
US7109003B2 (en) | 1998-12-23 | 2006-09-19 | Abgenix, Inc. | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 |
US6682736B1 (en) | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
ES2706547T3 (es) | 1998-12-23 | 2019-03-29 | Pfizer | Anticuerpos monoclonales humanos para CTLA-4 |
US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
US20050222064A1 (en) | 2002-02-20 | 2005-10-06 | Sirna Therapeutics, Inc. | Polycationic compositions for cellular delivery of polynucleotides |
ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
BRPI0413326A (pt) | 2003-08-04 | 2006-10-10 | Bristol Myers Squibb Co | métodos para tratar doença cardiovasculares empregando-se uma molécula ctla4 solúvel |
WO2005018629A1 (en) | 2003-08-12 | 2005-03-03 | Yarbrough William M | Treatment for acne vulgaris and method of use |
US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
RU2406760C3 (ru) | 2005-05-09 | 2017-11-28 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
CN101248089A (zh) | 2005-07-01 | 2008-08-20 | 米德列斯公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
WO2008020079A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
SI2170959T1 (sl) | 2007-06-18 | 2014-04-30 | Merck Sharp & Dohme B.V. | Protitelesa proti receptorjem pd-1 za humano programirano smrt |
WO2009086558A1 (en) | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
WO2009100140A1 (en) | 2008-02-04 | 2009-08-13 | Medarex, Inc. | Anti-clta-4 antibodies with reduced blocking of binding of ctla-4 to b7 and uses thereof |
AU2009290543B2 (en) | 2008-09-12 | 2015-09-03 | Oxford University Innovation Limited | PD-1 specific antibodies and uses thereof |
CA2736829C (en) | 2008-09-12 | 2018-02-27 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
EP3133086B1 (en) | 2008-09-26 | 2018-08-01 | Dana-Farber Cancer Institute, Inc. | Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses thereof |
EP2350043B9 (en) | 2008-10-09 | 2014-08-20 | TEKMIRA Pharmaceuticals Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
CN104479018B (zh) | 2008-12-09 | 2018-09-21 | 霍夫曼-拉罗奇有限公司 | 抗-pd-l1抗体及它们用于增强t细胞功能的用途 |
JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | Pd−1抗体およびpd−l1抗体ならびにその使用 |
CA2758191C (en) | 2009-04-10 | 2015-06-30 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
ES2613498T3 (es) * | 2009-07-01 | 2017-05-24 | Protiva Biotherapeutics Inc. | Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos |
US8569256B2 (en) * | 2009-07-01 | 2013-10-29 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
US20130017223A1 (en) | 2009-12-18 | 2013-01-17 | The University Of British Columbia | Methods and compositions for delivery of nucleic acids |
TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
RU2625034C2 (ru) | 2011-04-20 | 2017-07-11 | МЕДИММЬЮН, ЭлЭлСи | Антитела и другие молекулы, которые связывают в7-н1 и pd-1 |
CN108663504B (zh) | 2011-06-23 | 2021-06-22 | 埃博灵克斯股份有限公司 | 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术 |
EP3553086A1 (en) | 2012-05-31 | 2019-10-16 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind pd-l1 |
CA3080200A1 (en) | 2013-09-13 | 2015-03-19 | Beigene Switzerland Gmbh | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
IL302303A (en) | 2013-12-17 | 2023-06-01 | Genentech Inc | Anti-CD3 antibodies and methods of using them |
PL3143042T3 (pl) | 2014-05-16 | 2020-11-16 | Ablynx N.V. | Domeny zmienne immunoglobuliny |
WO2016118725A1 (en) | 2015-01-23 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
US20180303925A1 (en) * | 2015-04-27 | 2018-10-25 | The Trustees Of The University Of Pennsylvania | Nucleoside-Modified RNA For Inducing an Adaptive Immune Response |
US10920246B2 (en) | 2015-05-26 | 2021-02-16 | Ramot At Tel-Aviv University Ltd. | Targeted lipid particles for systemic delivery of nucleic acid molecules to leukocytes |
US10221127B2 (en) | 2015-06-29 | 2019-03-05 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
US20180271998A1 (en) | 2015-12-04 | 2018-09-27 | Merrimack Pharmaceuticals, Inc. | Disulfide-stabilized fabs |
CA3087147A1 (en) * | 2017-12-27 | 2019-07-04 | Takeda Pharmaceutical Company Limited | Nucleic acid-containing lipid nano-particle and use thereof |
CA3107126A1 (en) | 2018-07-19 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-bcma x anti-cd3 antibodies and uses thereof |
CA3107378A1 (en) | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Use of an anti-cd2 antibody drug conjugate (adc) in allogeneic cell therapy |
-
2021
- 2021-12-03 CA CA3201219A patent/CA3201219A1/en active Pending
- 2021-12-03 IL IL303373A patent/IL303373A/en unknown
- 2021-12-03 KR KR1020237022607A patent/KR20230123480A/ko unknown
- 2021-12-03 EP EP21840391.3A patent/EP4256067A2/en active Pending
- 2021-12-03 JP JP2023533878A patent/JP2023552195A/ja active Pending
- 2021-12-03 AU AU2021393593A patent/AU2021393593A1/en active Pending
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- 2021-12-03 US US17/542,348 patent/US20220218614A1/en active Pending
- 2021-12-03 MX MX2023006604A patent/MX2023006604A/es unknown
- 2021-12-06 TW TW110145547A patent/TW202241458A/zh unknown
-
2023
- 2023-06-05 CO CONC2023/0007408A patent/CO2023007408A2/es unknown
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WO2022120388A3 (en) | 2022-07-28 |
EP4256067A2 (en) | 2023-10-11 |
CO2023007408A2 (es) | 2023-08-28 |
IL303373A (en) | 2023-08-01 |
JP2023552195A (ja) | 2023-12-14 |
US20220218614A1 (en) | 2022-07-14 |
WO2022120388A2 (en) | 2022-06-09 |
KR20230123480A (ko) | 2023-08-23 |
TW202241458A (zh) | 2022-11-01 |
CA3201219A1 (en) | 2022-06-09 |
AU2021393593A1 (en) | 2023-07-20 |
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