BR112014022562A8 - Formulação de rna para imunoterapia - Google Patents

Formulação de rna para imunoterapia

Info

Publication number
BR112014022562A8
BR112014022562A8 BR112014022562A BR112014022562A BR112014022562A8 BR 112014022562 A8 BR112014022562 A8 BR 112014022562A8 BR 112014022562 A BR112014022562 A BR 112014022562A BR 112014022562 A BR112014022562 A BR 112014022562A BR 112014022562 A8 BR112014022562 A8 BR 112014022562A8
Authority
BR
Brazil
Prior art keywords
immunotherapy
rna
systemic administration
present
rna formulation
Prior art date
Application number
BR112014022562A
Other languages
English (en)
Other versions
BR112014022562A2 (pt
Inventor
Sahin Ugur
Haas Heinrich
Kreiter Sebastian
Diken Mustafa
Fritz Daniel
meng Martin
Mareen Kranz Lena
Reuter Kerstin
Original Assignee
Tron Translationale Onkologie An Der Johannes Gutenbert Univ Mainz Gemeinnuetzige Gmbh
Univ Der Johannes Gutenbert Univ Mainz
Biontech Ag
Biontech Rna Pharmaceuticals Gmbh
Tron – Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh
BioNTech SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tron Translationale Onkologie An Der Johannes Gutenbert Univ Mainz Gemeinnuetzige Gmbh, Univ Der Johannes Gutenbert Univ Mainz, Biontech Ag, Biontech Rna Pharmaceuticals Gmbh, Tron – Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh, BioNTech SE filed Critical Tron Translationale Onkologie An Der Johannes Gutenbert Univ Mainz Gemeinnuetzige Gmbh
Publication of BR112014022562A2 publication Critical patent/BR112014022562A2/pt
Publication of BR112014022562A8 publication Critical patent/BR112014022562A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

FORMULAÇÃO DE RNA PARA IMUNOTERAPIA. A presente invenção está no campo da imunoterapia, em particular, a imunoterapia tumoral. A presente invenção proporciona formulações farmacêuticas para a distribuição de RNA para as células apresentadoras de antígenos, tais como células dendrítcas (DCs) no baço, após a administração sistêmica. Em particular, as formulações aqui descritas permitem induzir uma resposta imunológica após a administração sistêmica de RNA que codifica antígeno.
BR112014022562A 2012-03-26 2013-03-25 Formulação de rna para imunoterapia BR112014022562A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2012/001319 WO2013143555A1 (en) 2012-03-26 2012-03-26 Rna formulation for immunotherapy
PCT/EP2013/000902 WO2013143683A1 (en) 2012-03-26 2013-03-25 Rna formulation for immunotherapy

Publications (2)

Publication Number Publication Date
BR112014022562A2 BR112014022562A2 (pt) 2017-08-22
BR112014022562A8 true BR112014022562A8 (pt) 2022-10-11

Family

ID=48044720

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014022562A BR112014022562A8 (pt) 2012-03-26 2013-03-25 Formulação de rna para imunoterapia

Country Status (19)

Country Link
US (3) US10485884B2 (pt)
JP (4) JP6279545B2 (pt)
CN (2) CN109331176B (pt)
AU (3) AU2013242512B2 (pt)
BR (1) BR112014022562A8 (pt)
CA (2) CA2864253C (pt)
DK (1) DK2830593T3 (pt)
ES (2) ES2719480T3 (pt)
HK (1) HK1202060A1 (pt)
HR (1) HRP20201578T1 (pt)
HU (2) HUE052485T2 (pt)
LT (2) LT2830593T (pt)
MX (3) MX2014011466A (pt)
NZ (1) NZ628328A (pt)
PT (2) PT3427723T (pt)
RS (1) RS61002B1 (pt)
SI (1) SI3427723T1 (pt)
TR (1) TR201904758T4 (pt)
WO (2) WO2013143555A1 (pt)

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CA2864253A1 (en) 2013-10-03
JP7096282B2 (ja) 2022-07-05
CA3088428A1 (en) 2013-10-03
CN109331176A (zh) 2019-02-15
HUE052485T2 (hu) 2021-05-28
US11559587B2 (en) 2023-01-24
LT3427723T (lt) 2020-12-28
US20150086612A1 (en) 2015-03-26
WO2013143683A8 (en) 2013-12-12
PT3427723T (pt) 2020-10-12
JP2019031571A (ja) 2019-02-28
JP6832904B2 (ja) 2021-02-24
HK1202060A1 (en) 2015-09-18
HUE044594T2 (hu) 2019-11-28
AU2020202152A1 (en) 2020-04-16
NZ628328A (en) 2016-05-27
DK2830593T3 (en) 2019-04-23
AU2017279565B2 (en) 2020-01-30
US20230226217A1 (en) 2023-07-20
CN109331176B (zh) 2022-12-02
WO2013143683A1 (en) 2013-10-03
PT2830593T (pt) 2019-05-06
LT2830593T (lt) 2019-06-25
JP6279545B2 (ja) 2018-02-14

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