UA94060C2 - Моноклональное антитело, которое специфически связывает alk-1 - Google Patents

Моноклональное антитело, которое специфически связывает alk-1

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Publication number
UA94060C2
UA94060C2 UAA200804286A UAA200804286A UA94060C2 UA 94060 C2 UA94060 C2 UA 94060C2 UA A200804286 A UAA200804286 A UA A200804286A UA A200804286 A UAA200804286 A UA A200804286A UA 94060 C2 UA94060 C2 UA 94060C2
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UA
Ukraine
Prior art keywords
antibody
monoclonal antibodies
specifically binds
binds alk
alk
Prior art date
Application number
UAA200804286A
Other languages
English (en)
Ukrainian (uk)
Inventor
Майкл Айдан Норт
Карин Кристина Амундсон
Вахе Бедиан
Шелли Симс Белуски
Дана Дан Ху-Леуе
Синь Цзян
Шеннон Мари Карличек
Зирид-Аймее Келлерманн
Джеймс Артур Томсон
Цзяньин Ван
Грант Реймонд Уикман
Цзинчуань Чжан
Original Assignee
Эмджен Фримонт Инк.
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37906640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA94060(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эмджен Фримонт Инк., Пфайзер Инк. filed Critical Эмджен Фримонт Инк.
Publication of UA94060C2 publication Critical patent/UA94060C2/ru

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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Ophthalmology & Optometry (AREA)
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Abstract

Изобретение относится к моноклональному антителу или его антигенсвязующему участку, которое связывает ALK-1 (поверхностный клеточный рецептор типа 1 трансформирующего фактора роста бета – TGF-β1), выделенной молекулы нуклеиновой кислоты, которая его кодирует, гибридомы, депонированной под номером РТА-6808 в АТСС, фармацевтической композиции и применение заявленного антитела для приготовления лекарственного средства для ингибирования ангиогенеза у нуждающихся в этом животных.
UAA200804286A 2005-09-07 2006-09-06 Моноклональное антитело, которое специфически связывает alk-1 UA94060C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71529205P 2005-09-07 2005-09-07

Publications (1)

Publication Number Publication Date
UA94060C2 true UA94060C2 (ru) 2011-04-11

Family

ID=37906640

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UAA200804286A UA94060C2 (ru) 2005-09-07 2006-09-06 Моноклональное антитело, которое специфически связывает alk-1

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US (3) US7537762B2 (ru)
EP (4) EP2960253B1 (ru)
JP (3) JP5161777B2 (ru)
KR (3) KR101536506B1 (ru)
CN (2) CN107056943B (ru)
AP (2) AP2723A (ru)
AR (2) AR055152A1 (ru)
AU (1) AU2006297571B2 (ru)
BR (1) BRPI0615766A2 (ru)
CA (1) CA2621371C (ru)
CL (1) CL2010000096A1 (ru)
CR (3) CR9819A (ru)
CY (1) CY1120794T1 (ru)
DK (3) DK2447283T3 (ru)
DO (1) DOP2006000195A (ru)
EA (2) EA018453B1 (ru)
ES (3) ES2546069T3 (ru)
GE (1) GEP20125398B (ru)
GT (1) GT200600406A (ru)
HK (2) HK1169999A1 (ru)
HN (1) HN2006031275A (ru)
HU (2) HUE038941T2 (ru)
IL (2) IL189642A (ru)
LT (1) LT2960253T (ru)
MA (1) MA29843B1 (ru)
ME (1) ME00501B (ru)
MY (1) MY164457A (ru)
NL (1) NL1032452C2 (ru)
NO (1) NO20081718L (ru)
NZ (1) NZ566774A (ru)
PE (1) PE20080035A1 (ru)
PL (3) PL1933871T3 (ru)
PT (3) PT1933871E (ru)
RS (1) RS54393B1 (ru)
SI (3) SI2447283T1 (ru)
TN (1) TNSN08080A1 (ru)
TW (5) TWI569807B (ru)
UA (1) UA94060C2 (ru)
UY (1) UY29783A1 (ru)
WO (1) WO2007040912A2 (ru)
ZA (1) ZA200802971B (ru)

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