HRP20180753T1 - Antagonistička protutijela specifična za peptid koji je u vezi s genom za kalcitonin za liječenje cluster glavobolje - Google Patents
Antagonistička protutijela specifična za peptid koji je u vezi s genom za kalcitonin za liječenje cluster glavobolje Download PDFInfo
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- HRP20180753T1 HRP20180753T1 HRP20180753TT HRP20180753T HRP20180753T1 HR P20180753 T1 HRP20180753 T1 HR P20180753T1 HR P20180753T T HRP20180753T T HR P20180753TT HR P20180753 T HRP20180753 T HR P20180753T HR P20180753 T1 HRP20180753 T1 HR P20180753T1
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- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 title claims 4
- 102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 title claims 2
- 239000005557 antagonist Substances 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 claims 9
- 229940127597 CGRP antagonist Drugs 0.000 claims 7
- 239000003735 calcitonin gene related peptide receptor antagonist Substances 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims 2
- 208000006561 Cluster Headache Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000018912 cluster headache syndrome Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 claims 1
- 210000004900 c-terminal fragment Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (16)
1. Anti-CGRP antagonističko protutijelo naznačeno time da je za uporabu u prevenciji ili liječenju cluster glavobolje.
2. Anti-CGRP antagonističko protutijelo za uporabu prema zahtjevu 1, naznačeno time da je protutijelo ljudsko protutijelo ili humanizirano protutijelo.
3. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da protutijelo ima afinitet vezanja (KD) za ljudski α-CGRP od 50 nM ili manji koji se mjeri rezonancijom površinskog plazmona kod 37°C.
4. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da se protutijelo veže na (a) C-terminalni fragment koji ima aminokiseline 25-37 od CGRP ili (b) C-terminalni epitop unutar aminokiselina 25-37 od CGRP.
5. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da protutijelo ima konstantnu regiju teškog lanca IgG.
6. Anti-CGRP antagonističko protutijelo prema zahtjevu 5, naznačeno time da protutijelo ima konstantnu regiju teškog lanca IgG1, IgG2, IgG3 ili IgG4.
7. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da je protutijelo: (a) protutijelo koje ima CDR H1 kao što se navodi u SEQ ID NO: 3; CDR H2 kao što se navodi u SEQ ID NO: 4; CDR H3 kao što se navodi u SEQ ID NO: 5; CDR L1 kao što se navodi u SEQ ID NO: 6; CDR L2 kao što se navodi u SEQ ID NO: 7; i CDR L3 kao što se navodi u SEQ ID NO: 8; ili (b) varijantu protutijela pod (a) kao što je prikazano u Tablici 6.
8. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da protutijelo sadrži VH domenu koja je najmanje 90% identična u sekvenci aminokiselina sa SEQ ID NO: 1 i VL domenu koja je najmanje 90% identična u sekvenci aminokiselina sa SEQ ID NO: 2; na primjer, pri čemu protutijelo sadrži VH domenu SEQ ID NO: 1 i VL domenu SEQ ID NO: 2.
9. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da protutijelo sadrži lagani lanac koji je proizveden od ekspresijskog vektora s ATCC pristupnim br. PTA-6866 i/ili teški lanac koji je proizveden od ekspresijskog vektora s ATCC pristupnim br. PTA-6867.
10. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da protutijelo blokira ili smanjuje aktivaciju receptora za CGRP (uključujući aktivaciju cAMP).
11. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da se protutijelo daje injekcijom; na primjer, intraperitonealno, intravenozno, subkutano, ili intramuskularno.
12. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da se protutijelo daje 1 do 4 puta tjedno.
13. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da se protutijelo daje u dnevnoj dozi od 3 µg/kg do 100 mg/kg.
14. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da se protutijelo daje oko 2 mg/kg.
15. Anti-CGRP antagonističko protutijelo za uporabu prema bilo kojem prethodnom zahtjevu, naznačeno time da se protutijelo daje čovjeku.
16. Uporaba anti-CGRP antagonističkog protutijela naznačena time da je za dobivanje lijeka za prevenciju ili liječenje cluster glavobolje.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73662305P | 2005-11-14 | 2005-11-14 | |
| EP16154418.4A EP3045182B1 (en) | 2005-11-14 | 2006-11-02 | Antagonist antibodies directed against calcitonin gene-related peptide for treating cluster headache |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180753T1 true HRP20180753T1 (hr) | 2018-08-24 |
Family
ID=37909474
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180753TT HRP20180753T1 (hr) | 2005-11-14 | 2018-05-14 | Antagonistička protutijela specifična za peptid koji je u vezi s genom za kalcitonin za liječenje cluster glavobolje |
| HRP20180752TT HRP20180752T1 (hr) | 2005-11-14 | 2018-05-14 | Antagonističko protutijelo specifično za peptid koji je u vezi s genom za kalcitonin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180752TT HRP20180752T1 (hr) | 2005-11-14 | 2018-05-14 | Antagonističko protutijelo specifično za peptid koji je u vezi s genom za kalcitonin |
Country Status (38)
| Country | Link |
|---|---|
| US (20) | US8007794B2 (hr) |
| EP (6) | EP3069731A1 (hr) |
| JP (1) | JP5123197B2 (hr) |
| KR (2) | KR101250049B1 (hr) |
| CN (2) | CN103421114B (hr) |
| AP (1) | AP2008004467A0 (hr) |
| AU (1) | AU2006313434B2 (hr) |
| BR (1) | BRPI0618705B8 (hr) |
| CA (1) | CA2626120C (hr) |
| CR (1) | CR9975A (hr) |
| CU (1) | CU23872B1 (hr) |
| CY (3) | CY1120249T1 (hr) |
| DK (3) | DK2380592T3 (hr) |
| EA (1) | EA015526B1 (hr) |
| EC (1) | ECSP088451A (hr) |
| ES (3) | ES2664854T3 (hr) |
| GE (1) | GEP20115333B (hr) |
| HK (2) | HK1125837A1 (hr) |
| HR (2) | HRP20180753T1 (hr) |
| HU (3) | HUE036940T2 (hr) |
| IL (3) | IL190876A (hr) |
| LT (3) | LT3045182T (hr) |
| LU (2) | LUC00119I2 (hr) |
| MA (1) | MA30136B1 (hr) |
| ME (1) | ME00419B (hr) |
| MY (1) | MY153249A (hr) |
| NL (1) | NL300997I2 (hr) |
| NO (3) | NO344099B1 (hr) |
| NZ (1) | NZ568237A (hr) |
| PL (3) | PL2380592T3 (hr) |
| PT (3) | PT3045182T (hr) |
| RS (3) | RS57192B1 (hr) |
| SI (3) | SI3045182T1 (hr) |
| SV (1) | SV2008002905A (hr) |
| TN (1) | TNSN08213A1 (hr) |
| UA (1) | UA94244C2 (hr) |
| WO (1) | WO2007054809A2 (hr) |
| ZA (1) | ZA200803484B (hr) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3069731A1 (en) | 2005-11-14 | 2016-09-21 | Labrys Biologics Inc. | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| RU2522493C2 (ru) | 2008-03-04 | 2014-07-20 | Пфайзер Лимитед | Способы лечения хронической боли |
| PL2265288T3 (pl) * | 2008-03-04 | 2017-01-31 | Labrys Biologics Inc | Sposoby leczenia bólu zapalnego |
| DK2278880T3 (da) * | 2008-04-09 | 2012-11-12 | Pherin Pharm Inc | Steroidbehandling af hedeture |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| WO2010107695A1 (en) | 2009-03-16 | 2010-09-23 | Colder Products Company | Aseptic coupling devices |
| US8623366B2 (en) * | 2009-08-28 | 2014-01-07 | Labrys Biologics, Inc. | Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide |
| JO3330B1 (ar) * | 2010-06-10 | 2019-03-13 | Lilly Co Eli | الأجسام المضادة cgrp |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| RU2609094C2 (ru) | 2011-02-10 | 2017-01-30 | Сони Корпорейшн | Устройство и способ обработки изображений |
| HUE054437T2 (hu) * | 2011-05-20 | 2021-09-28 | H Lundbeck As | Anti-CGRP készítmények és alkalmazásuk |
| SG194973A1 (en) | 2011-05-20 | 2013-12-30 | Alderbio Holdings Llc | Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
| US9855332B2 (en) | 2011-05-20 | 2018-01-02 | Alderbio Holdings Llc | Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels |
| DK2807187T3 (en) * | 2012-01-26 | 2017-09-11 | Christopher J Soares | PEPTIDE ANTAGONISTS OF THE CALCITONIN-CGRP FAMILY OF PEPTIDE HORMONES AND THEIR USE |
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