HRP20191462T1 - Antitijela usmjerena protiv her-3 i njihove uporabe - Google Patents

Antitijela usmjerena protiv her-3 i njihove uporabe Download PDF

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Publication number
HRP20191462T1
HRP20191462T1 HRP20191462T HRP20191462T1 HR P20191462 T1 HRP20191462 T1 HR P20191462T1 HR P20191462 T HRP20191462 T HR P20191462T HR P20191462 T1 HRP20191462 T1 HR P20191462T1
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HR
Croatia
Prior art keywords
antibody
sequence
fragment
represented
isolated
Prior art date
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English (en)
Inventor
Mike Rothe
Martin Treder
Susanne Hartmann
Dan Freeman
Bob Radinsky
Eric Borges
Original Assignee
Daiichi Sankyo Europe Gmbh
Amgen Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38110697&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20191462(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Europe Gmbh, Amgen Inc filed Critical Daiichi Sankyo Europe Gmbh
Publication of HRP20191462T1 publication Critical patent/HRP20191462T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors

Claims (4)

1. Izolirano antitijelo koje se veže za HER-3 kombinirano s antineoplastičnim terapeutskim sredstvom za terapeutsku uporabu, naznačeno time što izolirano antitijelo koje se veže za HER3 sadrži CDR1 teškog lanca predstavljen sekvencom GGSFSGYYWS, CDR2 teškog lanca predstavljen sekvencom EINHSGSTNYNPSLKS i CDR3 teškog lanca predstavljen sekvencom DKWTWYFDL, i CDR1 lakog lanca predstavljen sekvencom RSSQSVLYSSSNRNYLA, CDR2 lakog lanca predstavljen sekvencom WASTRES i CDR3 lakog lanca predstavljen sekvencom QQYYSTPRT, i pri čemu, antineoplastično terapeutsko sredstvo je cetuksimab.
2. Izolirano antitijelo za uporabu prema patentnom zahtjevu 1, naznačeno time što sadrži aminokiselinsku sekvencu teškog lanca SEQ ID NO:70 i aminokiselinsku sekvencu lakog lanca SEQ ID NO:72.
3. Izolirano antitijelo za uporabu prema patentnom zahtjevu 1 ili 2, naznačeno time što predstavlja monoklonsko antitijelo, rekombinantno antitijelo, humano antitijelo, kimerno antitijelo, multispecifično antitijelo, ili njihov fragment antitijela, pri čemu je fragment antitijela poželjno Fab fragment, Fab’ fragment, F(ab’)2 fragment, Fv fragment, di-antitijelo, ili jednolančana molekula antitijela.
4. Izolirano antitijelo za uporabu prema bilo kojem od patentnih zahtjeva 1-3, naznačeno time što navedeno izolirano antitijelo je IgG1-, IgG2-, IgG3- ili IgG4-tip.
HRP20191462 2005-12-30 2019-08-13 Antitijela usmjerena protiv her-3 i njihove uporabe HRP20191462T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75510305P 2005-12-30 2005-12-30
EP15181115.5A EP2993187B1 (en) 2005-12-30 2006-12-29 Antibodies directed to her-3 and uses thereof

Publications (1)

Publication Number Publication Date
HRP20191462T1 true HRP20191462T1 (hr) 2019-11-15

Family

ID=38110697

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20170558TT HRP20170558T1 (hr) 2005-12-30 2017-04-06 Antitijela usmjerena protiv her-3 i njihove uporabe
HRP20191462 HRP20191462T1 (hr) 2005-12-30 2019-08-13 Antitijela usmjerena protiv her-3 i njihove uporabe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20170558TT HRP20170558T1 (hr) 2005-12-30 2017-04-06 Antitijela usmjerena protiv her-3 i njihove uporabe

Country Status (33)

Country Link
US (6) US7705130B2 (hr)
EP (4) EP3950715A1 (hr)
JP (3) JP5207979B2 (hr)
KR (1) KR101418606B1 (hr)
CN (3) CN102174105B (hr)
AR (1) AR056857A1 (hr)
AU (1) AU2006332065B2 (hr)
BR (1) BRPI0620803B8 (hr)
CA (1) CA2633222C (hr)
CL (1) CL2014001334A1 (hr)
CR (1) CR10082A (hr)
CY (2) CY1118979T1 (hr)
DK (2) DK2993187T3 (hr)
EA (1) EA015782B1 (hr)
ES (3) ES2743229T3 (hr)
HK (3) HK1133266A1 (hr)
HR (2) HRP20170558T1 (hr)
HU (2) HUE044756T2 (hr)
IL (2) IL225372A (hr)
LT (2) LT2993187T (hr)
MX (1) MX2008008248A (hr)
MY (2) MY153751A (hr)
NO (1) NO346160B1 (hr)
NZ (3) NZ569005A (hr)
PL (2) PL2993187T3 (hr)
PT (2) PT2993187T (hr)
RS (2) RS55979B1 (hr)
SG (2) SG10201500533QA (hr)
SI (1) SI2993187T1 (hr)
TW (2) TWI432452B (hr)
UA (1) UA97473C2 (hr)
WO (1) WO2007077028A2 (hr)
ZA (1) ZA200805474B (hr)

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