PE20090689A1 - Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes - Google Patents
Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunesInfo
- Publication number
- PE20090689A1 PE20090689A1 PE2008000393A PE2008000393A PE20090689A1 PE 20090689 A1 PE20090689 A1 PE 20090689A1 PE 2008000393 A PE2008000393 A PE 2008000393A PE 2008000393 A PE2008000393 A PE 2008000393A PE 20090689 A1 PE20090689 A1 PE 20090689A1
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- amino acid
- acid sequence
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- antibody
- inflammatory
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
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Abstract
SE REFIERE A UN ANTICUERPO QUIMERICO, HUMANIZADO, MONOCLONAL O RECOMBINANTE QUE SE ENLAZA A UN EPITOPE OX40 HUMANO, QUE COMPRENDE: A) UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE i) UN VH CDR1 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 17, ii) UN VH CDR2 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 18, Y iii) UN VH CDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 19; B) UNA REGION VARIABLE DE CADENA LIGERA QUE COMPRENDE: i) UN VL CDR1 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 12, 15 O 61, ii) UN VL CDR2 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 13, Y iii) UN VL CDR3 QUE TIENE LA SECUENCIA DE AMINOACIDOS DE ID SEC NO. 14 O 16; Y C) UNA REGION CONSTANTE DE DOMINIO CH1, CH2 O CH3 QUE ES DE UN ANTICUERPO DE IgG1, IgG2, IgG3 O IgG4. SE REFIERE TAMBIEN A UNA MOLECULA DE ACIDO NUCLEICO QUE CODIFICA EL ANTICUERPO, UN VECTOR, UNA CELULA HUESPED, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y A UN METODO DE PRODUCCION. DICHO ANTICUERPO ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y AUTOINMUNES TALES COMO ESCLEROSIS MULTIPLE, ARTRITIS REUMATOIDE, ENFERMEDAD DE CROHN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90369307P | 2007-02-27 | 2007-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090689A1 true PE20090689A1 (es) | 2009-06-20 |
Family
ID=39620235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000393A PE20090689A1 (es) | 2007-02-27 | 2008-02-27 | Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100136030A1 (es) |
| EP (1) | EP2125891A2 (es) |
| JP (1) | JP2010518873A (es) |
| KR (1) | KR20100014588A (es) |
| CN (1) | CN101668776A (es) |
| AR (1) | AR065506A1 (es) |
| AU (1) | AU2008219666A1 (es) |
| BR (1) | BRPI0807269A2 (es) |
| CA (1) | CA2679399A1 (es) |
| CL (1) | CL2008000578A1 (es) |
| CO (1) | CO6231009A2 (es) |
| CR (1) | CR11042A (es) |
| EC (1) | ECSP099656A (es) |
| IL (1) | IL200572A0 (es) |
| MA (1) | MA31246B1 (es) |
| MX (1) | MX2009009194A (es) |
| PE (1) | PE20090689A1 (es) |
| RU (1) | RU2009135824A (es) |
| TW (1) | TW200846367A (es) |
| WO (1) | WO2008106116A2 (es) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291331B1 (en) | 2002-09-11 | 2007-11-06 | La Jolla Institute For Allergy And Immunology | Methods of treating OX40 medicated recall immune responses |
| RU2426744C2 (ru) | 2005-12-16 | 2011-08-20 | Дженентек, Инк. | Антитела к ox40l и способы их применения |
| CA2749539C (en) | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
| CA2751477C (en) | 2009-02-17 | 2019-08-27 | Ucb Pharma S.A. | Antibody molecules having specificity for human ox40 |
| BR112013004266A8 (pt) * | 2010-08-23 | 2018-01-02 | Univ Texas | anticorpos anti-ox40 e métodos de uso dos mesmos. |
| PT2731677T (pt) * | 2011-07-11 | 2018-07-27 | Glenmark Pharmaceuticals Sa | Anticorpos que se ligam com ox40 e suas utilizações |
| EP2748199B1 (en) * | 2011-08-23 | 2019-08-28 | Board of Regents, The University of Texas System | Anti-ox40 antibodies and methods of using the same |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| WO2014043708A1 (en) * | 2012-09-17 | 2014-03-20 | Traber Peter G | Method for enhancing specific immunotherapies in cancer treatment |
| CN105229032A (zh) | 2013-03-18 | 2016-01-06 | 比奥塞罗克斯产品公司 | 人源化抗cd134(ox40)抗体及其应用 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US10066267B2 (en) | 2014-04-11 | 2018-09-04 | Novartis Ag | Methods of selectively treating asthma using IL-13 antagonists |
| EP3498295A1 (en) | 2014-05-28 | 2019-06-19 | Agenus Inc. | Anti-gitr antibodies and methods of use thereof |
| WO2016029043A1 (en) | 2014-08-21 | 2016-02-25 | The General Hospital Corporation | Tumor necrosis factor superfamily and tnf-like ligand muteins and methods of preparing and using the same |
| TW201619200A (zh) * | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | 人類化抗－ｏｘ４０抗體及其用途 |
| MX2017008917A (es) | 2015-01-08 | 2018-02-09 | Biontech Ag | Agentes de ligacion agonistas del receptor tnf. |
| US9512229B2 (en) | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| EP3265123B1 (en) | 2015-03-03 | 2022-10-26 | Kymab Limited | Antibodies, uses & methods |
| KR20180002597A (ko) * | 2015-03-11 | 2018-01-08 | 프로비던스 헬스 앤드 서비시즈 - 오레곤 | 암 치료법의 효능을 증강시키기 위한 조성물 및 방법 |
| WO2016164920A1 (en) * | 2015-04-09 | 2016-10-13 | Cornell University | Gene therapy to prevent reactions to allergens |
| IL304950A (en) | 2015-04-10 | 2023-10-01 | Amgen Inc | Interleukin for the expansion of myotonic control T-2 cells |
| KR20180015650A (ko) | 2015-05-07 | 2018-02-13 | 아게누스 인코포레이티드 | 항-ox40 항체 및 이의 사용 방법 |
| HRP20230060T1 (hr) | 2015-05-29 | 2023-03-17 | Bristol-Myers Squibb Company | Antitijela protiv ox40 i njihova primjena |
| WO2017046746A1 (en) | 2015-09-15 | 2017-03-23 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist |
| AU2016328357B2 (en) | 2015-09-22 | 2023-03-02 | Ventana Medical Systems, Inc. | Anti-OX40 antibodies and diagnostic uses thereof |
| EP3363816A4 (en) * | 2015-10-15 | 2019-10-09 | Dingfu Biotarget Co., Ltd. | ANTI-OX40 ANTIBODIES AND USES THEREOF |
| KR20180083944A (ko) * | 2015-12-02 | 2018-07-23 | 아게누스 인코포레이티드 | 항체 및 이의 사용 방법 |
| WO2017134292A1 (en) * | 2016-02-04 | 2017-08-10 | Glenmark Pharmaceuticals S.A. | Anti-ox40 antagonistic antibodies for the treatment of atopic dermatitis |
| EP3471754A1 (en) | 2016-06-20 | 2019-04-24 | Kymab Limited | Anti-pd-l1 antibodies |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
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| CA3048601A1 (en) * | 2016-12-26 | 2018-07-05 | Kyowa Hakko Kirin Co., Ltd. | Antibody which binds to myelin oligodendrocyte glycoprotein |
| US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
| EP3562506A4 (en) | 2016-12-29 | 2021-01-06 | University of Miami | METHOD OF MODULATION OF INFLAMMATORY SOMACTIVITY AND INFLAMMATION OF THE LUNG |
| TW201837168A (zh) | 2017-01-06 | 2018-10-16 | 美商艾歐凡斯生物治療公司 | 以腫瘤壞死因子受體超家族（ｔｎｆｒｓｆ）促效劑使腫瘤浸潤淋巴球（ｔｉｌ）擴增及ｔｉｌ與ｔｎｆｒｓｆ促效劑的治療組合 |
| CN110198723B (zh) * | 2017-02-23 | 2024-03-05 | 志瑞亚新药工业株式会社 | 抗炎药 |
| CN108623686A (zh) * | 2017-03-25 | 2018-10-09 | 信达生物制药(苏州)有限公司 | 抗ox40抗体及其用途 |
| TW201919662A (zh) | 2017-06-05 | 2019-06-01 | 美商艾歐凡斯生物治療公司 | 對雙重難治性黑色素瘤使用腫瘤浸潤性淋巴細胞之方法 |
| AU2018368786A1 (en) | 2017-11-17 | 2020-06-18 | Iovance Biotherapeutics, Inc. | TIL expansion from fine needle aspirates and small biopsies |
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| US5821332A (en) * | 1993-11-03 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Receptor on the surface of activated CD4+ T-cells: ACT-4 |
| US5759546A (en) * | 1994-02-04 | 1998-06-02 | Weinberg; Andrew D. | Treatment of CD4 T-cell mediated conditions |
| US6057421A (en) * | 1994-11-30 | 2000-05-02 | Immpheron, Inc. | Variable heavy and light chain regions of murine monoclonal antibody 1F7 |
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| PL376536A1 (pl) * | 2002-08-28 | 2006-01-09 | Immunex Corporation | Kompozycje i sposoby leczenia chorób układu sercowo-naczyniowego |
| DE602005018325D1 (de) * | 2004-02-19 | 2010-01-28 | Genentech Inc | Antikörper mit korrigierten cdr |
| ES2707152T3 (es) * | 2005-04-15 | 2019-04-02 | Macrogenics Inc | Diacuerpos covalentes y usos de los mismos |
| TWI461436B (zh) * | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法 |
| RU2426744C2 (ru) * | 2005-12-16 | 2011-08-20 | Дженентек, Инк. | Антитела к ox40l и способы их применения |
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2008
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- 2008-02-26 MX MX2009009194A patent/MX2009009194A/es unknown
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- 2008-02-26 EP EP08726081A patent/EP2125891A2/en not_active Withdrawn
- 2008-02-26 JP JP2009551698A patent/JP2010518873A/ja not_active Withdrawn
- 2008-02-26 US US12/526,550 patent/US20100136030A1/en not_active Abandoned
- 2008-02-26 AU AU2008219666A patent/AU2008219666A1/en not_active Abandoned
- 2008-02-26 WO PCT/US2008/002498 patent/WO2008106116A2/en active Application Filing
- 2008-02-26 BR BRPI0807269-8A2A patent/BRPI0807269A2/pt not_active IP Right Cessation
- 2008-02-26 CL CL200800578A patent/CL2008000578A1/es unknown
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- 2008-02-26 RU RU2009135824/10A patent/RU2009135824A/ru not_active Application Discontinuation
- 2008-02-27 AR ARP080100818A patent/AR065506A1/es unknown
- 2008-02-27 TW TW097106870A patent/TW200846367A/zh unknown
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- 2009-09-23 CO CO09103883A patent/CO6231009A2/es not_active Application Discontinuation
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|---|---|
| RU2009135824A (ru) | 2011-04-10 |
| TW200846367A (en) | 2008-12-01 |
| MX2009009194A (es) | 2009-10-08 |
| US20100136030A1 (en) | 2010-06-03 |
| AR065506A1 (es) | 2009-06-10 |
| JP2010518873A (ja) | 2010-06-03 |
| CR11042A (es) | 2009-11-03 |
| CA2679399A1 (en) | 2008-09-04 |
| MA31246B1 (fr) | 2010-03-01 |
| IL200572A0 (en) | 2010-05-17 |
| ECSP099656A (es) | 2009-10-30 |
| EP2125891A2 (en) | 2009-12-02 |
| CL2008000578A1 (es) | 2008-10-10 |
| KR20100014588A (ko) | 2010-02-10 |
| WO2008106116A3 (en) | 2008-10-16 |
| CN101668776A (zh) | 2010-03-10 |
| CO6231009A2 (es) | 2010-12-20 |
| BRPI0807269A2 (pt) | 2014-04-29 |
| AU2008219666A1 (en) | 2008-09-04 |
| WO2008106116A2 (en) | 2008-09-04 |
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