NL1032452A1 - Menselijke monoklonale antilichamen tegen activine receptor-achtig kinase-1. - Google Patents
Menselijke monoklonale antilichamen tegen activine receptor-achtig kinase-1.Info
- Publication number
- NL1032452A1 NL1032452A1 NL1032452A NL1032452A NL1032452A1 NL 1032452 A1 NL1032452 A1 NL 1032452A1 NL 1032452 A NL1032452 A NL 1032452A NL 1032452 A NL1032452 A NL 1032452A NL 1032452 A1 NL1032452 A1 NL 1032452A1
- Authority
- NL
- Netherlands
- Prior art keywords
- kinase
- monoclonal antibodies
- antibodies against
- human monoclonal
- activin receptor
- Prior art date
Links
- 102100034136 Serine/threonine-protein kinase receptor R3 Human genes 0.000 title 1
- 101710082813 Serine/threonine-protein kinase receptor R3 Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71529205P | 2005-09-07 | 2005-09-07 | |
US71529205 | 2005-09-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
NL1032452A1 true NL1032452A1 (nl) | 2007-03-08 |
NL1032452C2 NL1032452C2 (nl) | 2008-01-18 |
Family
ID=37906640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL1032452A NL1032452C2 (nl) | 2005-09-07 | 2006-09-06 | Menselijke monoklonale antilichamen tegen activine receptor-achtig kinase-1. |
Country Status (41)
Country | Link |
---|---|
US (3) | US7537762B2 (nl) |
EP (4) | EP1933871B1 (nl) |
JP (3) | JP5161777B2 (nl) |
KR (3) | KR101390127B1 (nl) |
CN (2) | CN107056943B (nl) |
AP (2) | AP2723A (nl) |
AR (2) | AR055152A1 (nl) |
AU (1) | AU2006297571B2 (nl) |
BR (1) | BRPI0615766A2 (nl) |
CA (1) | CA2621371C (nl) |
CL (1) | CL2010000096A1 (nl) |
CR (3) | CR9819A (nl) |
CY (1) | CY1120794T1 (nl) |
DK (3) | DK2447283T3 (nl) |
DO (1) | DOP2006000195A (nl) |
EA (2) | EA018453B1 (nl) |
ES (3) | ES2546069T3 (nl) |
GE (1) | GEP20125398B (nl) |
GT (1) | GT200600406A (nl) |
HK (2) | HK1169999A1 (nl) |
HN (1) | HN2006031275A (nl) |
HU (2) | HUE038941T2 (nl) |
IL (2) | IL189642A (nl) |
LT (1) | LT2960253T (nl) |
MA (1) | MA29843B1 (nl) |
ME (1) | ME00501B (nl) |
MY (1) | MY164457A (nl) |
NL (1) | NL1032452C2 (nl) |
NO (1) | NO20081718L (nl) |
NZ (1) | NZ566774A (nl) |
PE (1) | PE20080035A1 (nl) |
PL (3) | PL2447283T3 (nl) |
PT (3) | PT2960253T (nl) |
RS (1) | RS54393B1 (nl) |
SI (3) | SI2447283T1 (nl) |
TN (1) | TNSN08080A1 (nl) |
TW (5) | TWI370137B (nl) |
UA (1) | UA94060C2 (nl) |
UY (1) | UY29783A1 (nl) |
WO (1) | WO2007040912A2 (nl) |
ZA (1) | ZA200802971B (nl) |
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AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
WO2006091930A2 (en) * | 2005-02-24 | 2006-08-31 | Massachusetts Eye & Ear Infirmary | Methods and compounds for promoting vessel regression |
KR101390127B1 (ko) * | 2005-09-07 | 2014-05-13 | 암젠 프레몬트 인코포레이티드 | 액티빈 수용체 유사 키나제-1에 대한 인간 모노클로날 항체 |
EP1986632B1 (en) * | 2006-02-10 | 2012-08-15 | Nerviano Medical Sciences S.R.L. | Combinations comprising a cdk inhibitor and a growth factor antibody or anti-mitotic |
CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
AU2012265564B2 (en) * | 2006-09-08 | 2016-05-26 | Amgen Inc | Anti-activin A antibodies and uses thereof |
JP2010508816A (ja) * | 2006-11-02 | 2010-03-25 | アクセルロン ファーマ, インコーポレイテッド | Alk1受容体およびリガンドアンタゴニストならびにその使用 |
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TW201718635A (zh) | 2007-03-06 | 2017-06-01 | 安美基公司 | 變異之活動素受體多肽及其用途 |
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BRPI0817063A2 (pt) * | 2007-11-09 | 2015-03-24 | Genentch Inc | "métodos de inibição, para o tratamento de uma condição patológica, para a inibição de linfagiogênese tumoral, de inibição ou prevenção,de desorganização, para inibição de crescimento de tumor, de tratamento, de acentuação da eficácia de um agente anti-angiogênese e antagonista de alk-1 |
RU2506276C2 (ru) * | 2007-11-12 | 2014-02-10 | УЗ ФАРМА ГмбХ | Axl-антитела |
US8507656B2 (en) * | 2008-01-28 | 2013-08-13 | Medimmune Limited | Stabilized angiopoietin-2 antibodies and uses thereof |
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US20110110944A1 (en) * | 2008-04-25 | 2011-05-12 | Morphosys Ag | Anti-alk1 antibodies and uses thereof |
KR20210113446A (ko) | 2008-05-02 | 2021-09-15 | 악셀레론 파마 인코포레이티드 | 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 alk1 길항제 기재의 방법 및 조성물 |
CA2724525A1 (en) * | 2008-05-15 | 2009-11-19 | Acceleron Pharma, Inc. | Antagonists of bmp9, bmp10, alk1 and other alk1 ligands, and uses thereof |
US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
NZ604818A (en) | 2008-11-26 | 2014-07-25 | Amgen Inc | Variants of activin iib receptor polypeptides and uses thereof |
WO2010126169A1 (ja) * | 2009-04-30 | 2010-11-04 | 協和発酵キリン株式会社 | Alk1阻害剤を有効成分とする血管障害を抑制するための医薬組成物 |
GB0915515D0 (en) * | 2009-09-04 | 2009-10-07 | Ucl Business Plc | Treatment of vasculoproliferative conditions |
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CA2783715A1 (en) * | 2009-12-29 | 2011-07-07 | F. Hoffmann-La Roche Ag | Novel antibody formulation |
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EP3712166A1 (en) | 2013-09-05 | 2020-09-23 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
US10156562B2 (en) | 2014-05-16 | 2018-12-18 | Amgen Inc. | Assay for detecting Th1 and Th2 cell populations |
WO2016054053A2 (en) * | 2014-09-29 | 2016-04-07 | Duke University | Hiv-1 antibodies and uses thereof (adcc and bispecific abs) |
GB201503438D0 (en) | 2015-02-27 | 2015-04-15 | Ucl Business Plc | Antibodies |
SG11201707815RA (en) | 2015-06-05 | 2017-12-28 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
KR101983013B1 (ko) * | 2015-09-25 | 2019-05-28 | 동우 화인켐 주식회사 | 필름 터치 센서 및 그 제조 방법 |
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US11236156B2 (en) | 2016-02-11 | 2022-02-01 | The Johns Hopkins University | Compositions and methods for targeting activin signaling to treat cancer |
RU2615908C1 (ru) * | 2016-05-16 | 2017-04-11 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ моделирования лимфогенного и гематогенного метастазирования мышиной меланомы В16 у белых нелинейных крыс |
EA201990222A1 (ru) * | 2016-08-05 | 2019-07-31 | МЕДИММЬЮН, ЭлЭлСи | Антитела к o2 и пути их применения |
KR20190064636A (ko) | 2016-10-19 | 2019-06-10 | 메디뮨 엘엘씨 | 항-o1 항체 및 이의 용도 |
MA47775A (fr) | 2017-03-14 | 2020-01-22 | Amgen Inc | Contrôle des glycoformes afucosylées totales d'anticorps produits en culture cellulaire |
IL313983A (en) | 2018-03-26 | 2024-08-01 | Amgen Inc | Fully fucose-free glycoforms of antibodies are produced in cell culture |
MX2022003461A (es) | 2019-09-26 | 2022-04-19 | Amgen Inc | Metodos de produccion de composiciones de anticuerpos. |
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CN111925442B (zh) * | 2020-08-19 | 2022-10-11 | 重庆医科大学 | 新冠病毒rbd特异性单克隆抗体和应用 |
KR20230087539A (ko) | 2020-10-15 | 2023-06-16 | 암젠 인크 | 항체 생산 방법에서의 상대적인 비결합 글리칸 |
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CN115746142A (zh) * | 2021-09-03 | 2023-03-07 | 开拓药业(广东)有限公司 | 抗alk-1/抗vegf双特异性抗体及其应用 |
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WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
WO2024153115A1 (zh) * | 2023-01-18 | 2024-07-25 | 开拓药业(广东)有限公司 | 抗alk-1抗体及其用途 |
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- 2008-02-21 IL IL189642A patent/IL189642A/en not_active IP Right Cessation
- 2008-02-21 TN TNP2008000080A patent/TNSN08080A1/en unknown
- 2008-03-14 CR CR9819A patent/CR9819A/es unknown
- 2008-04-01 MA MA30800A patent/MA29843B1/fr unknown
- 2008-04-07 NO NO20081718A patent/NO20081718L/no not_active Application Discontinuation
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2009
- 2009-03-12 US US12/402,854 patent/US8080646B2/en active Active
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2010
- 2010-02-04 CL CL2010000096A patent/CL2010000096A1/es unknown
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2011
- 2011-10-26 US US13/282,065 patent/US9221915B2/en active Active
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2012
- 2012-03-01 IL IL218429A patent/IL218429A0/en unknown
- 2012-07-02 JP JP2012148146A patent/JP5833978B2/ja not_active Expired - Fee Related
- 2012-10-26 HK HK12110733.7A patent/HK1169999A1/xx not_active IP Right Cessation
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2013
- 2013-07-19 CR CR20130351A patent/CR20130351A/es unknown
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2014
- 2014-05-22 CR CR20140239A patent/CR20140239A/es unknown
- 2014-08-13 JP JP2014164638A patent/JP5947840B2/ja active Active
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2016
- 2016-06-27 HK HK16107449.4A patent/HK1219488A1/zh not_active IP Right Cessation
- 2016-12-20 AR ARP160103944A patent/AR107003A2/es unknown
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2018
- 2018-08-09 CY CY181100829T patent/CY1120794T1/el unknown
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