MX2018013342A - Polipeptido de fusion multicircular "contorsbody" - ligante de diana de cadena sencilla. - Google Patents

Polipeptido de fusion multicircular "contorsbody" - ligante de diana de cadena sencilla.

Info

Publication number
MX2018013342A
MX2018013342A MX2018013342A MX2018013342A MX2018013342A MX 2018013342 A MX2018013342 A MX 2018013342A MX 2018013342 A MX2018013342 A MX 2018013342A MX 2018013342 A MX2018013342 A MX 2018013342A MX 2018013342 A MX2018013342 A MX 2018013342A
Authority
MX
Mexico
Prior art keywords
domain
binding domain
contorsbody
single chain
polypeptide
Prior art date
Application number
MX2018013342A
Other languages
English (en)
Inventor
Georges Guy
Platzer Josef
Hesse Friederike
Dengl Stefan
Imhof-Jung Sabine
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2018013342A publication Critical patent/MX2018013342A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

En la presente descripción se informa de un polipéptido de fusión circular que comprende una primera parte de un dominio de unión, una segunda parte de un dominio de unión y un dominio espaciador, en el que el dominio espaciador es un polipéptido y comprende por lo menos 25 residuos aminoácidos, la primera parte del dominio de unión es un polipéptido y se fusiona mediante un primer conector con el extremo N-terminal del dominio espaciador, la segunda parte del dominio de unión es un polipéptido y se fusiona mediante un segundo conector con el extremo C-terminal del dominio espaciador, la primera parte del dominio de unión y la segunda parte del dominio de unión se asocian entre sí y forman un sitio de unión que se une específicamente a una diana.
MX2018013342A 2016-05-02 2017-05-02 Polipeptido de fusion multicircular "contorsbody" - ligante de diana de cadena sencilla. MX2018013342A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16167920 2016-05-02
PCT/EP2017/060354 WO2017191101A1 (en) 2016-05-02 2017-05-02 The contorsbody - a single chain target binder

Publications (1)

Publication Number Publication Date
MX2018013342A true MX2018013342A (es) 2019-05-09

Family

ID=56008478

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018013342A MX2018013342A (es) 2016-05-02 2017-05-02 Polipeptido de fusion multicircular "contorsbody" - ligante de diana de cadena sencilla.

Country Status (18)

Country Link
US (2) US20190389971A1 (es)
EP (2) EP3889175A1 (es)
JP (2) JP6675017B2 (es)
KR (1) KR102523682B1 (es)
CN (1) CN109071635B (es)
AU (1) AU2017259869A1 (es)
BR (1) BR112018069890A2 (es)
CA (1) CA3019524A1 (es)
CL (1) CL2018003007A1 (es)
CR (1) CR20180509A (es)
IL (1) IL262523A (es)
MA (1) MA56474A (es)
MX (1) MX2018013342A (es)
PE (1) PE20181890A1 (es)
RU (1) RU2018141360A (es)
SG (1) SG11201809620UA (es)
UA (1) UA123323C2 (es)
WO (1) WO2017191101A1 (es)

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CN111278856A (zh) * 2017-11-01 2020-06-12 豪夫迈·罗氏有限公司 三Fab-康特斯体
WO2019086500A2 (en) * 2017-11-01 2019-05-09 F. Hoffmann-La Roche Ag Bispecific 2+1 contorsbodies
US20210061922A1 (en) * 2018-01-05 2021-03-04 City Of Hope Multi-specific ligand binders
US20220195045A1 (en) 2018-08-03 2022-06-23 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing two antigen-binding domains that are linked to each other
CN115175930A (zh) 2020-02-05 2022-10-11 中外制药株式会社 用于产生和/或富集重组抗原结合分子的方法
TW202325741A (zh) 2020-03-31 2023-07-01 日商中外製藥股份有限公司 Dll3靶向之多特異性抗原結合分子及其用途
KR20220104423A (ko) 2021-01-18 2022-07-26 성기봉 페달엔진자전거(실용모델)
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JP2020103314A (ja) 2020-07-09
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CN109071635A (zh) 2018-12-21
IL262523A (en) 2018-12-31
CA3019524A1 (en) 2017-11-09
KR102523682B1 (ko) 2023-04-19
CN109071635B (zh) 2023-09-01
EP3452502A1 (en) 2019-03-13
WO2017191101A1 (en) 2017-11-09
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AU2017259869A1 (en) 2018-09-27
UA123323C2 (uk) 2021-03-17
EP3889175A1 (en) 2021-10-06
MA56474A (fr) 2022-05-11
US20190389971A1 (en) 2019-12-26
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US20210347916A1 (en) 2021-11-11
RU2018141360A (ru) 2020-06-03

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