NZ609493A - Diagnosis and treatments relating to th2 inhibition - Google Patents

Diagnosis and treatments relating to th2 inhibition

Info

Publication number
NZ609493A
NZ609493A NZ609493A NZ60949311A NZ609493A NZ 609493 A NZ609493 A NZ 609493A NZ 609493 A NZ609493 A NZ 609493A NZ 60949311 A NZ60949311 A NZ 60949311A NZ 609493 A NZ609493 A NZ 609493A
Authority
NZ
New Zealand
Prior art keywords
diagnosis
inhibition
periostin
responders
treatments relating
Prior art date
Application number
NZ609493A
Inventor
Joseph R Arron
Richard W Erickson
Michelle Freemer
Meredith Hazen
Guiquan Jia
John G Matthews
Wendy Putnam
Heleen Scheerens
Yanan Zheng
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to NZ713202A priority Critical patent/NZ713202A/en
Publication of NZ609493A publication Critical patent/NZ609493A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6884—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a kit for detecting Total Periostin in a biological sample obtained from an asthma patient for stratifying/classifying asthma patients into likely responders and non-responders for therapeutic treatment with a TH2 Pathway Inhibitor wherein the kit comprises an antibody that binds to Total Periostin, which includes at least isoforms 1, 2, 3, and 4 of periostin.
NZ609493A 2010-12-16 2011-12-16 Diagnosis and treatments relating to th2 inhibition NZ609493A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ713202A NZ713202A (en) 2010-12-16 2011-12-16 Diagnosis and treatments relating to th2 inhibition

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US45976010P 2010-12-16 2010-12-16
US201161465425P 2011-03-18 2011-03-18
US201161484650P 2011-05-10 2011-05-10
US201161574485P 2011-08-02 2011-08-02
US201161557295P 2011-11-08 2011-11-08
PCT/US2011/065410 WO2012083132A2 (en) 2010-12-16 2011-12-16 Diagnosis and treatments relating to th2 inhibition

Publications (1)

Publication Number Publication Date
NZ609493A true NZ609493A (en) 2015-11-27

Family

ID=46234723

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ713202A NZ713202A (en) 2010-12-16 2011-12-16 Diagnosis and treatments relating to th2 inhibition
NZ609493A NZ609493A (en) 2010-12-16 2011-12-16 Diagnosis and treatments relating to th2 inhibition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NZ713202A NZ713202A (en) 2010-12-16 2011-12-16 Diagnosis and treatments relating to th2 inhibition

Country Status (19)

Country Link
US (4) US20120156194A1 (en)
EP (2) EP3447491A3 (en)
JP (4) JP6005657B2 (en)
KR (4) KR101923282B1 (en)
CN (4) CN103688171B (en)
AR (1) AR084342A1 (en)
AU (1) AU2011343570B2 (en)
BR (2) BR112013013460A8 (en)
CA (2) CA3040095C (en)
HK (2) HK1215711A1 (en)
IL (2) IL226821B (en)
MX (2) MX371228B (en)
MY (1) MY188365A (en)
NZ (2) NZ713202A (en)
RU (2) RU2737245C2 (en)
SG (3) SG10201401763SA (en)
TW (4) TWI666447B (en)
WO (1) WO2012083132A2 (en)
ZA (1) ZA201302979B (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3718564B1 (en) 2003-12-23 2023-10-11 Genentech, Inc. Novel anti-il 13 antibodies and uses thereof
MX348362B (en) * 2008-03-31 2017-06-07 Genentech Inc * Compositions and methods for treating and diagnosing asthma.
WO2012083132A2 (en) 2010-12-16 2012-06-21 Genentech, Inc. Diagnosis and treatments relating to th2 inhibition
SG11201405830VA (en) * 2012-03-27 2014-10-30 Genentech Inc Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis
AR091069A1 (en) 2012-05-18 2014-12-30 Amgen Inc PROTEINS OF UNION TO ANTIGEN DIRECTED AGAINST THE ST2 RECEIVER
BR112015021521A2 (en) 2013-03-15 2017-10-10 Genentech Inc anti-crth2 antibodies and methods for their use
WO2014151648A1 (en) * 2013-03-15 2014-09-25 Coronado Biosciences, Inc. Treatment of autoimmune disease using helminthic parasites
AU2014306960B2 (en) * 2013-08-12 2020-01-16 Astrazeneca Ab Methods for improving asthma symptoms using benralizumab
HUE043497T2 (en) * 2013-08-12 2019-08-28 Astrazeneca Ab Methods for increasing forced expiratory volume in asthmatics using benralizumab
CN105451760A (en) * 2013-08-12 2016-03-30 米迪缪尼有限公司 Methods for reducing exacerbation rates of asthma using benralizumab
BR112016004437A2 (en) 2013-09-13 2017-10-17 Genentech Inc immunotest and cell line selection methods, antibodies and kit
AR097651A1 (en) 2013-09-13 2016-04-06 Genentech Inc METHODS AND COMPOSITIONS THAT INCLUDE PURIFIED RECOMBINATING POLIPEPTIDES
JP6250351B2 (en) * 2013-09-30 2017-12-20 シスメックス株式会社 Method for obtaining information on eosinophilic airway inflammation and marker for obtaining such information
SG10201807318RA (en) * 2013-10-15 2018-09-27 Astrazeneca Ab Methods for treating chronic obstructive pulmonary disease using benralizumab
MX2016005159A (en) * 2013-10-23 2016-07-05 Genentech Inc Methods of diagnosing and treating eosinophilic disorders.
RU2019118984A (en) 2014-01-10 2019-08-06 Анаптисбайо, Инк. ANTIBODIES AIMED AGAINST INTERLEUKIN-33 (IL-33)
CA2937387A1 (en) 2014-01-27 2015-07-30 Medimmune, Llc Dipeptidyl peptidase-4 (dpp4/cd26) as a peripheral biomarker of il-13 activation in asthmatic lung
WO2015120171A1 (en) * 2014-02-07 2015-08-13 Medimmune, Llc Novel assay to detect human periostin
WO2015126750A1 (en) * 2014-02-19 2015-08-27 Array Biopharma Inc. BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR
WO2015127405A2 (en) * 2014-02-21 2015-08-27 Genentech, Inc. Anti-il-13/il-17 bispecific antibodies and uses thereof
WO2015155710A1 (en) 2014-04-11 2015-10-15 Novartis Ag Methods of selectively treating asthma using il-13 antagonists
MA40164A (en) * 2014-06-27 2017-05-03 Sanofi Sa Anti-il4-il 13 bispecific antibodies
TW201628647A (en) 2014-06-27 2016-08-16 賽諾菲公司 Anti-IL4-IL13 bispecific antibodies
PL3191513T3 (en) * 2014-09-08 2021-02-08 Cephalon, Inc. Use of reslizumab to treat moderate to severe eosinophilic asthma
WO2016044707A1 (en) * 2014-09-18 2016-03-24 Cedars-Sinai Medical Center Compositions and methods for treating fibrosis
SG11201703767XA (en) 2014-11-10 2017-06-29 Genentech Inc Anti-interleukin-33 antibodies and uses thereof
WO2016077366A1 (en) 2014-11-10 2016-05-19 Genentec, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
EP3237639A2 (en) 2014-12-23 2017-11-01 Genentech, Inc. Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
MX2017008748A (en) 2015-01-09 2017-11-17 Medimmune Llc Assay to detect human dpp-4.
CA2977285A1 (en) * 2015-03-16 2016-09-22 F. Hoffmann-La Roche Ag Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases
CA3002761A1 (en) 2015-11-04 2017-05-11 Astrazeneca Ab Dipeptidyl peptidase-4 and periostin as predictors of clinical response to eosinophil-targeted therapeutic agents in eosinophilic diseases
WO2017143152A1 (en) * 2016-02-17 2017-08-24 Icahn School Of Medicine At Mount Sinai Nasal biomarkers of asthma
JP2019516362A (en) 2016-04-27 2019-06-20 ファイザー・インク Anti-IL-33 antibodies, compositions, methods and uses thereof
KR20240052871A (en) * 2016-04-27 2024-04-23 애브비 인코포레이티드 Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies
EP3528838B1 (en) 2016-09-23 2023-07-19 F. Hoffmann-La Roche AG Uses of il-13 antagonists for treating atopic dermatitis
TWI778018B (en) 2017-02-10 2022-09-21 美商建南德克公司 Anti-tryptase antibodies, compositions thereof, and uses thereof
KR102417088B1 (en) 2018-02-09 2022-07-07 제넨테크, 인크. Methods of treatment and diagnosis for mast cell-mediated inflammatory diseases
CA3093422A1 (en) * 2018-03-19 2019-09-26 Bioventures, Llc Periostin antibodies and methods of using the same
CN108977511A (en) * 2018-07-03 2018-12-11 张罗 Detect the method and application of CST1 gene expression amount in nasal cavity cast-off cells
CN111415728A (en) * 2019-11-25 2020-07-14 刘雷 CT image data automatic classification method and device based on CNN and GAN
KR20220152262A (en) 2020-03-13 2022-11-15 제넨테크, 인크. Anti-interleukin-33 antibodies and uses thereof
CN113501878B (en) * 2021-02-03 2022-12-02 北京智仁美博生物科技有限公司 Antibodies against human TSLP and uses thereof

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578349A (en) 1982-04-08 1986-03-25 Abbott Laboratories Immunoassay for carcinoembryonic antigen (CEA)
US4818709A (en) 1983-01-21 1989-04-04 Primus Frederick J CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5122599A (en) 1986-08-13 1992-06-16 Molecular Diagnostics, Inc. CDNAS coding for members of the carcinoembryonic antigen family
DE3787864T2 (en) 1986-08-13 1994-02-10 Miles Inc Carcinoembryonic antigen-encoding cDNA.
US5274087A (en) 1986-08-13 1993-12-28 Molecular Diagnostics, Inc. cDNA coding for carcinoembryonic antigen (CEA)
US5231009A (en) 1986-08-13 1993-07-27 Molecular Diagnostics, Inc. Cdnas coding for members of the carcinoembryonic antigen family
US6013772A (en) 1986-08-13 2000-01-11 Bayer Corporation Antibody preparations specifically binding to unique determinants of CEA antigens or fragments thereof and use of the antibody preparations in immunoassays
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
US5770701A (en) 1987-10-30 1998-06-23 American Cyanamid Company Process for preparing targeted forms of methyltrithio antitumor agents
US5606040A (en) 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
GB8800078D0 (en) 1988-01-05 1988-02-10 Ciba Geigy Ag Novel antibodies
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
CA2026147C (en) 1989-10-25 2006-02-07 Ravi J. Chari Cytotoxic agents comprising maytansinoids and their therapeutic use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69129154T2 (en) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. METHOD FOR ENRICHING PROTEIN VARIANTS WITH CHANGED BINDING PROPERTIES
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
EP0604580A1 (en) 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
EP1514934B1 (en) 1992-02-06 2008-12-31 Novartis Vaccines and Diagnostics, Inc. Biosynthetic binding protein for cancer marker
JPH05268982A (en) 1992-03-27 1993-10-19 Hoechst Japan Ltd Novel protein having osteogenic action and its production
JPH07508179A (en) 1992-08-21 1995-09-14 シェリング・コーポレーション human interleukin-13
US5596072A (en) 1992-08-21 1997-01-21 Schering Corporation Method of refolding human IL-13
DK0669836T3 (en) 1992-11-13 1996-10-14 Idec Pharma Corp Therapeutic use of chimeric and radiolabeled antibodies and human B lymphocyte restricted differentiation antigen for the treatment of B cell lymphoma
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5889159A (en) 1993-10-29 1999-03-30 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies to tumor marker TC1 and methods for use of same
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
WO1996010911A1 (en) 1994-10-05 1996-04-18 Immunex Corporation Cytokine designated lerk-6
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US6518061B1 (en) 1995-03-15 2003-02-11 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US6911530B1 (en) 1995-10-23 2005-06-28 Amrad Operations, Pty., Ltd. Haemopoietin receptor and genetic sequences encoding same
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
DE19614062A1 (en) 1996-04-09 1997-10-16 Bayer Ag Process for the continuous production of diaryl carbonates
US20060073133A1 (en) * 1997-04-02 2006-04-06 Kikly Kristine K Sialoadhesin factor-3 antibodies
AU744087B2 (en) 1997-05-29 2002-02-14 Board Of Regents, The University Of Texas System OSF2/CBFA1 compositions and methods of use
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
JP2002506353A (en) 1997-06-24 2002-02-26 ジェネンテック・インコーポレーテッド Methods and compositions for galactosylated glycoproteins
CA2295474A1 (en) 1997-07-08 1999-01-21 Human Genome Sciences, Inc. 123 human secreted proteins
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
CA2307166A1 (en) 1997-10-31 1999-05-14 Genentech, Inc. Methods and compositions comprising glycoprotein glycoforms
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
ATE531812T1 (en) 1997-12-05 2011-11-15 Scripps Research Inst HUMANIZATION OF RODENT ANTIBODIES
ES2292236T3 (en) 1998-04-02 2008-03-01 Genentech, Inc. VARIATIONS OF ANTIBODIES AND THEIR FRAGMENTS.
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
ES2434961T5 (en) 1998-04-20 2018-01-18 Roche Glycart Ag Antibody glycosylation engineering to improve antibody-dependent cell cytotoxicity
US6482403B1 (en) 1998-05-29 2002-11-19 Heska Corporation Caniney IL-13 immunoregulatory proteins and uses thereof
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP2386574A3 (en) 1999-01-15 2012-06-27 Genentech, Inc. Polypeptide variants with altered effector function
AU2750800A (en) 1999-02-01 2000-08-18 Amgen Canada Inc. Materials and methods to inhibit hodgkin and reed sternberg cell growth
DK1914244T3 (en) 1999-04-09 2013-07-22 Kyowa Hakko Kirin Co Ltd Method for modulating the activity of functional immune molecules.
CA2385347C (en) 1999-10-04 2009-12-15 Medicago Inc. Method for regulating transcription of foreign genes
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
EP1229125A4 (en) 1999-10-19 2005-06-01 Kyowa Hakko Kogyo Kk Process for producing polypeptide
EP1240319A1 (en) 1999-12-15 2002-09-18 Genentech, Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes
PT1242438E (en) 1999-12-29 2007-02-28 Immunogen Inc Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
KR100890873B1 (en) 2000-03-03 2009-03-31 교와 핫꼬 기린 가부시키가이샤 Gene recombinant antibody and its fragment
US7439064B2 (en) 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
AU2001247616B2 (en) 2000-04-11 2007-06-14 Genentech, Inc. Multivalent antibodies and uses therefor
AU8448301A (en) 2000-09-08 2002-03-22 Suntory Ltd Remedies for heart failure
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
DK2314686T4 (en) 2000-10-06 2023-08-21 Kyowa Kirin Co Ltd Cells that form antibody complexes
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
ATE405282T1 (en) 2000-10-20 2008-09-15 Genetics Inst USE OF IL-13 INHIBITORS TO TREAT TUMORS
WO2002033073A1 (en) 2000-10-20 2002-04-25 Chugai Seiyaku Kabushiki Kaisha Degraded agonist antibody
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
TWI313299B (en) 2000-11-30 2009-08-11 Medarex Inc Transgenic transchromosomal rodents for making human antibodies
WO2002052006A1 (en) * 2000-12-26 2002-07-04 Genox Research, Inc. Method of examining allergic disease
US6596240B2 (en) 2001-01-12 2003-07-22 Porex Corporation Pipette tip for easy mounting and ejecting from a pipette
ATE522623T1 (en) 2001-06-20 2011-09-15 Genentech Inc COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF LUNG TUMORS
US7803915B2 (en) 2001-06-20 2010-09-28 Genentech, Inc. Antibody compositions for the diagnosis and treatment of tumor
US20050107595A1 (en) 2001-06-20 2005-05-19 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1423510A4 (en) 2001-08-03 2005-06-01 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
JP2005500059A (en) 2001-08-13 2005-01-06 ダナ−ファーバー キャンサー インスティテュート インク． Periostin-based diagnostic assay
AU2002338015B8 (en) 2001-08-31 2008-03-20 Kyowa Kirin Co., Ltd. Human CDR-grafted antibodies and antibody fragments thereof
US7384736B2 (en) 2001-09-06 2008-06-10 Decode Genetics Ehf. Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
GB0123951D0 (en) * 2001-10-05 2001-11-28 Glaxo Group Ltd Therapies for treating respiratory diseases
WO2003035835A2 (en) 2001-10-25 2003-05-01 Genentech, Inc. Glycoprotein compositions
EP1578912A4 (en) 2001-10-26 2007-12-26 Centocor Inc Il-13 mutein proteins, antibodies, compositions, methods and uses
WO2003038055A2 (en) 2001-10-31 2003-05-08 Mds Proteomics, Inc. Proteins involved in regulation of adipocytes and uses related thereto
US20050202421A1 (en) 2001-10-31 2005-09-15 Raphael Hirsch Method for diagnosis and treatment of rheumatoid arthritis
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
AU2003223497A1 (en) 2002-04-05 2003-10-27 Centocor, Inc. Asthma-related anti-il-13 immunoglobulin derived proteins, compositions, methods and uses
US7691568B2 (en) 2002-04-09 2010-04-06 Kyowa Hakko Kirin Co., Ltd Antibody composition-containing medicament
US7749753B2 (en) 2002-04-09 2010-07-06 Kyowa Hakko Kirin Co., Ltd Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lost
DE20205500U1 (en) 2002-04-09 2002-07-11 Hurth, Ursula, 66450 Bexbach tampon
CA2481837A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Production process for antibody composition
WO2003085107A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Cells with modified genome
EP1498491A4 (en) 2002-04-09 2006-12-13 Kyowa Hakko Kogyo Kk METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO Fc GAMMA RECEPTOR IIIa
AU2003236019A1 (en) 2002-04-09 2003-10-20 Kyowa Hakko Kirin Co., Ltd. Drug containing antibody composition appropriate for patient suffering from Fc Gamma RIIIa polymorphism
JP2005535572A (en) 2002-04-12 2005-11-24 メディミューン，インコーポレーテッド Recombinant anti-interleukin-9 antibody
AU2003239966B9 (en) 2002-06-03 2010-08-26 Genentech, Inc. Synthetic antibody phage libraries
SE522615C2 (en) 2002-07-09 2004-02-24 Martin Tiberg Med Tiberg Techn A method and system for biometric identification or verification.
JP2004121218A (en) 2002-08-06 2004-04-22 Jenokkusu Soyaku Kenkyusho:Kk Method for testing bronchial asthma or chronic obstructive pulmonary disease
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
MXPA05006511A (en) 2002-12-16 2006-02-17 Genentech Inc Immunoglobulin variants and uses thereof.
EP1585767A2 (en) 2003-01-16 2005-10-19 Genentech, Inc. Synthetic antibody phage libraries
DE10304350B3 (en) 2003-02-03 2004-06-09 Sabeu Kunststoffwerk Northeim Gmbh Container closure for liquid or solid material container with pressure equalization device having vent opening protected by angled membrane
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
AU2004229501B2 (en) 2003-04-11 2011-08-18 Medimmune, Llc Recombinant IL-9 antibodies and uses thereof
US8394379B2 (en) * 2003-05-15 2013-03-12 Iogenetics, Llc Targeted cryptosporidium biocides
KR20060015296A (en) 2003-05-23 2006-02-16 제넨테크, 인크. Compositions and methods for the diagnosis and treatment of tumors of glial origin
CA2527571A1 (en) 2003-05-29 2004-12-09 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
EP2327796A1 (en) 2003-06-10 2011-06-01 The Trustees Of Boston University Detection methods for disorders of the lung
GB0407315D0 (en) 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
WO2005019471A2 (en) 2003-08-13 2005-03-03 Temple University Of The Commonwealth System Of Higher Education Periostin-like factor: compositions and methods for making and using the same
US20050053549A1 (en) 2003-09-10 2005-03-10 Aperon Biosystems Corp. Method for treating airway disorders
CA2542046A1 (en) 2003-10-08 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. Fused protein composition
EP1705251A4 (en) 2003-10-09 2009-10-28 Kyowa Hakko Kirin Co Ltd PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY USING RNA INHIBITING THE FUNCTION OF a1,6-FUCOSYLTRANSFERASE
ME03330B (en) 2003-11-05 2019-10-20 Roche Glycart Ag Cd20 antibodies with increased fc receptor binding affinity and effector function
ES2579836T3 (en) 2003-11-06 2016-08-17 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation with ligands
JPWO2005053742A1 (en) 2003-12-04 2007-06-28 協和醗酵工業株式会社 Medicament containing antibody composition
EP3718564B1 (en) 2003-12-23 2023-10-11 Genentech, Inc. Novel anti-il 13 antibodies and uses thereof
BRPI0508761A (en) 2004-03-31 2007-08-14 Genentech Inc humanized antibody, composition comprising a humanized antibody, isolated nucleic acid, vector, host cell, humanized antibody production process, tgf-beta dysfunction treatment method, tgf-beta detection method, manufactured article and method of treating cancer
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
EP2357201B1 (en) 2004-04-13 2017-08-30 F. Hoffmann-La Roche AG Anti-P-selectin antibodies
US20070048785A1 (en) 2004-06-09 2007-03-01 Lin Laura L Anti-IL-13 antibodies and complexes
AR049390A1 (en) 2004-06-09 2006-07-26 Wyeth Corp ANTIBODIES AGAINST HUMAN INTERLEUQUINE-13 AND USES OF THE SAME
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
TWI380996B (en) 2004-09-17 2013-01-01 Hoffmann La Roche Anti-ox40l antibodies
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
KR100635540B1 (en) 2004-10-12 2006-10-18 경북대학교 산학협력단 Novel pharmaceutical composition for preventing or treating diseases or disorders associated with inflammation
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
ATE492563T1 (en) * 2004-11-17 2011-01-15 Amgen Inc COMPLETE HUMAN MONOCLONAL ANTIBODIES AGAINST IL-13
SI1942939T2 (en) 2005-09-30 2021-11-30 Medimmune Limited Interleukin-13 antibody composition
AR058104A1 (en) 2005-10-21 2008-01-23 Novartis Ag ORGANIC COMPOUNDS
WO2007056441A2 (en) 2005-11-07 2007-05-18 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
EP1973951A2 (en) 2005-12-02 2008-10-01 Genentech, Inc. Binding polypeptides with restricted diversity sequences
US8017119B2 (en) * 2005-12-28 2011-09-13 Daiichi Sankyo Company, Ltd. Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
CA2635849C (en) 2005-12-28 2017-05-09 Asubio Pharma Co., Ltd. An antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
AU2007204879A1 (en) 2006-01-11 2007-07-19 Aerovance, Inc. Methods and compositions for treating asthma in human and non human primates
GB0600488D0 (en) 2006-01-11 2006-02-22 Glaxo Group Ltd Immunoglobulins
JP2009528820A (en) * 2006-02-22 2009-08-13 フィロジェン・エッセペア Vascular tumor marker
JP2009536527A (en) 2006-05-09 2009-10-15 ジェネンテック・インコーポレーテッド Binding polypeptide with optimized scaffold
US20070275925A1 (en) 2006-05-17 2007-11-29 Regents Of The University Of California Asthma diagnosis and therapy
EP2052088A2 (en) 2006-08-02 2009-04-29 Genizon Biosciences Genemap of the human genes associated with psoriasis
EP2471816A1 (en) 2006-08-30 2012-07-04 Genentech, Inc. Multispecific antibodies
CA2914170C (en) 2006-09-08 2018-10-30 Abbvie Bahamas Ltd. Interleukin-13 binding proteins
US20100111965A1 (en) * 2006-10-11 2010-05-06 Fusion Antibodies Limited Combination therapy
JP4369468B2 (en) 2006-12-15 2009-11-18 日本分光株式会社 Irreversible reaction measurement method
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
JP5419709B2 (en) 2007-01-09 2014-02-19 ワイス・エルエルシー Anti-IL-13 antibody preparation and use thereof
PL2132230T3 (en) 2007-03-22 2014-09-30 Genentech Inc Apoptotic anti-ige antibodies binding the membrane-bound ige
CA2685123A1 (en) * 2007-04-23 2008-10-30 Wyeth Methods and compositions for treating and monitoring treatment of il-13-associated disorders
PL2152290T3 (en) 2007-04-30 2014-11-28 Glaxosmithkline Llc Methods for administering anti-il-5 antibodies
WO2008140455A1 (en) 2007-05-15 2008-11-20 Tanox, Inc. Treatment of radiation and chemo-therapy induced fibrosis using novel anti-il 13 monoclonal antibodies
CN100592373C (en) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 Liquid crystal panel drive device and its drive method
KR101560843B1 (en) 2007-06-27 2015-10-15 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 -17 cancer remedy containing antibody against peptide encoded by exon-17 of periostin
CN101784280A (en) 2007-07-11 2010-07-21 艾罗文斯公司 Pharmaceutical polypeptide dry powder aerosol formulation and preparation method
US8592562B2 (en) 2008-01-07 2013-11-26 Amgen Inc. Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
MX348362B (en) * 2008-03-31 2017-06-07 Genentech Inc * Compositions and methods for treating and diagnosing asthma.
JP5717178B2 (en) * 2008-06-05 2015-05-13 国立大学法人佐賀大学 Method for detecting idiopathic interstitial pneumonia
JPWO2010007701A1 (en) 2008-07-18 2012-01-05 国立大学法人東京工業大学 Therapeutic and testing agents for diseases with myocardial necrosis
EP2329025A4 (en) * 2008-09-08 2012-04-25 Ottawa Hospital Res Inst Periostin-induced pancreatic regeneration
JP5522717B2 (en) * 2008-09-19 2014-06-18 国立大学法人佐賀大学 Atopic dermatitis detection method and prophylactic / therapeutic agent screening method
US20100082438A1 (en) * 2008-10-01 2010-04-01 Ronnie Jack Garmon Methods and systems for customer performance scoring
FR2944448B1 (en) 2008-12-23 2012-01-13 Adocia STABLE PHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE MONODONAL ANTIBODY AND AT LEAST ONE AMPHIPHILIC POLYSACHARIDE COMPRISING SUBSTITUENTS DERIVED FROM HYDROFOB ALCOHOLS OR HYDROPHOBIC AMINES.
FR2946349B1 (en) * 2009-06-03 2013-10-04 Synarc Sas SEQUENCES, ANTIBODIES, METHODS AND NECESSARY FOR DETECTION AND IN VITRO ASSAYING OF PERIOSTIN FOR THE DIAGNOSIS OF MONITORING OR PROGNOSIS OF PATHOLOGIES OR BIOLOGICAL PHENOMENA INVOLVING PERIOSTIN
WO2012083132A2 (en) 2010-12-16 2012-06-21 Genentech, Inc. Diagnosis and treatments relating to th2 inhibition
JP6183809B2 (en) * 2011-09-06 2017-08-23 株式会社シノテスト Antibody binding to specific region of periostin and method for measuring periostin using the same

Also Published As

Publication number Publication date
NZ713202A (en) 2017-12-22
US20120156194A1 (en) 2012-06-21
SG10201401763SA (en) 2014-09-26
AU2011343570A1 (en) 2013-05-02
KR20160052758A (en) 2016-05-12
TWI732259B (en) 2021-07-01
CN103688171A (en) 2014-03-26
RU2015139698A3 (en) 2019-05-07
JP6502069B2 (en) 2019-04-17
RU2013132733A (en) 2015-01-27
CN105169390A (en) 2015-12-23
JP6005657B2 (en) 2016-10-12
JP6297526B2 (en) 2018-03-20
US20140044702A1 (en) 2014-02-13
CA2817380C (en) 2019-06-04
CA3040095A1 (en) 2012-06-21
KR20150008919A (en) 2015-01-23
KR101923282B1 (en) 2018-11-28
US11226341B2 (en) 2022-01-18
KR20150014985A (en) 2015-02-09
RU2737245C2 (en) 2020-11-26
AU2011343570B2 (en) 2016-11-03
KR20130082508A (en) 2013-07-19
SG190885A1 (en) 2013-07-31
WO2012083132A3 (en) 2012-08-30
US9684000B2 (en) 2017-06-20
EP2652498A2 (en) 2013-10-23
EP2652498B1 (en) 2018-04-18
CN105175542B (en) 2018-12-18
US20140044645A1 (en) 2014-02-13
CN105175542A (en) 2015-12-23
TWI708944B (en) 2020-11-01
RU2015139698A (en) 2018-12-26
IL262278B (en) 2020-11-30
JP2014506321A (en) 2014-03-13
KR101615474B1 (en) 2016-04-25
BR112013013460A2 (en) 2017-09-05
CA3040095C (en) 2021-09-07
TW201732294A (en) 2017-09-16
MY188365A (en) 2021-12-06
TW201250244A (en) 2012-12-16
TW201937166A (en) 2019-09-16
EP2652498A4 (en) 2014-05-21
KR101616260B1 (en) 2016-04-29
US9995755B2 (en) 2018-06-12
MX2013006712A (en) 2014-02-03
AR084342A1 (en) 2013-05-08
JP2016041689A (en) 2016-03-31
CN112168962A (en) 2021-01-05
JP2018009998A (en) 2018-01-18
BR112013013460A8 (en) 2019-02-12
MX352789B (en) 2017-12-08
SG10201401746TA (en) 2014-10-30
EP3447491A2 (en) 2019-02-27
JP2015091812A (en) 2015-05-14
MX371228B (en) 2020-01-10
WO2012083132A2 (en) 2012-06-21
CN103688171B (en) 2017-10-24
HK1215857A1 (en) 2016-09-23
EP3447491A3 (en) 2019-06-05
IL226821B (en) 2020-09-30
IL262278A (en) 2018-11-29
TWI666447B (en) 2019-07-21
US20190120854A1 (en) 2019-04-25
KR101615420B1 (en) 2016-04-26
BR122020012255B1 (en) 2022-08-09
CA2817380A1 (en) 2012-06-21
RU2578468C2 (en) 2016-03-27
ZA201302979B (en) 2019-09-25
TW201945734A (en) 2019-12-01
HK1215711A1 (en) 2016-09-09

Similar Documents

Publication Publication Date Title
NZ609493A (en) Diagnosis and treatments relating to th2 inhibition
PH12021550758A1 (en) The use of inhibitors of bruton`s tyrosine kinase (btk)
BRPI1007321A2 (en) methods for measuring and / or quantifying the presence and / or amount of her-3 or her-3 in a complex in a patient sample, and to determine if an individual with cancer is likely to respond to treatment with a targeted therapy. and antibody.
WO2010091049A3 (en) Diagnosis and treatment of cancer
BR112014024219A8 (en) METHODS FOR DETERMINING, OPTIMIZING THERAPEUTIC EFFECTIVENESS, MONITORING, THERAPY SELECTION AND DISORDER DIAGNOSIS AND KIT
MX2012001716A (en) Biological markers for monitoring patient response to vegf antagonists.
BR112012012610A2 (en) combination therapy for cancer treatment and diagnostic assays for use in it
WO2011133668A3 (en) Methods and compositions for the treatment of cancer
MX2013000674A (en) Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy.
GB2467467C (en) TAZ/WWTR1 for diagnosis and treatment of cancer
NZ584787A (en) Inhibition of angiogenesis with a Bv8 antagonist
MX2009005941A (en) Companion diagnostic assays for cancer therapy.
IN2012DN06309A (en)
MX347871B (en) Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate.
MX339340B (en) Methods for predicting and improving the survival of gastric cancer patients.
WO2012044696A3 (en) Prediction of clinical outcome in hematological malignancies using a self-renewal expression signature
EP2589665A4 (en) Method for predicting therapeutic effect of immunotherapy on cancer patient, and gene set and kit to be used in the method
WO2009122444A3 (en) Method for the diagnosis of higher- and lower-grade astrocytoma using biomarkers and diagnostic kit thereof
WO2012138691A3 (en) Diagnosis and treatment of taxane-resistant cancers
WO2014169011A3 (en) Methods for treating immune diseases
MX2011010920A (en) Biomarker for monitoring patients.
UA95956C2 (en) Set of instruments for determination of mage-a3
MX2011010061A (en) Biomarker for monitoring patients.
WO2012047637A3 (en) Assays and methods for determining risk of a macrophage-mediated disease development in a subject infected with hiv
WO2010088650A3 (en) Biomarker signature to predict cancer treatment response

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 16 DEC 2018 BY AJ PARK

Effective date: 20160527

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2019 BY THOMSON REUTERS

Effective date: 20181116

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2020 BY THOMSON REUTERS

Effective date: 20191116

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2021 BY THOMSON REUTERS

Effective date: 20200926

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2022 BY THOMSON REUTERS

Effective date: 20211102

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2023 BY THOMSON REUTERS

Effective date: 20221102

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 16 DEC 2024 BY ANAQUA SERVICES

Effective date: 20231122