|
WO2005062795A2
(en)
|
2003-12-19 |
2005-07-14 |
Plexxikon, Inc. |
Compounds and methods for development of ret modulators
|
|
EP1730146B1
(en)
|
2004-03-30 |
2011-05-04 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful as inhibitors of jak and other protein kinases
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
CA2579810C
(en)
|
2004-09-17 |
2012-01-24 |
Eisai R&D Management Co., Ltd. |
Stable pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide
|
|
WO2007013896A2
(en)
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
NZ565255A
(en)
|
2005-06-22 |
2010-04-30 |
Plexxikon Inc |
Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors
|
|
EP2251341A1
(en)
|
2005-07-14 |
2010-11-17 |
Astellas Pharma Inc. |
Heterocyclic Janus kinase 3 inhibitors
|
|
CA2615291A1
(en)
|
2005-07-14 |
2007-01-18 |
Astellas Pharma Inc. |
Heterocyclic janus kinase 3 inhibitors
|
|
JP4989476B2
(ja)
|
2005-08-02 |
2012-08-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
血管新生阻害物質の効果を検定する方法
|
|
WO2007026864A1
(ja)
*
|
2005-09-01 |
2007-03-08 |
Eisai R & D Management Co., Ltd. |
崩壊性の改善された医薬組成物の製造方法
|
|
SI1966202T1
(sl)
|
2005-12-13 |
2012-01-31 |
Incyte Corp |
S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze
|
|
AU2007207533B8
(en)
|
2006-01-17 |
2012-06-28 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful as inhibitors of Janus kinases
|
|
US20070208053A1
(en)
*
|
2006-01-19 |
2007-09-06 |
Arnold Lee D |
Fused heterobicyclic kinase inhibitors
|
|
JP5099005B2
(ja)
|
2006-04-03 |
2012-12-12 |
アステラス製薬株式会社 |
ヘテロ化合物
|
|
US20090209580A1
(en)
|
2006-05-18 |
2009-08-20 |
Eisai R & D Management Co., Ltd. |
Antitumor agent for thyroid cancer
|
|
EP2029593A1
(en)
*
|
2006-05-22 |
2009-03-04 |
AstraZeneca AB |
Indole derivatives
|
|
CA2656905A1
(en)
*
|
2006-07-06 |
2008-01-10 |
Solvay Pharmaceuticals B.V. |
Azaindole derivatives with a combination of partial nicotinic acetylcholine receptor agonism and dopamine reuptake inhibition
|
|
US7964728B2
(en)
|
2006-07-06 |
2011-06-21 |
Solvay Pharmaceuticals B.V. |
Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition
|
|
GB0617161D0
(en)
*
|
2006-08-31 |
2006-10-11 |
Vernalis R&D Ltd |
Enzyme inhibitors
|
|
PL2526933T3
(pl)
|
2006-09-22 |
2015-08-31 |
Pharmacyclics Llc |
Inhibitory kinazy tyrozynowej Brutona
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
PE20121126A1
(es)
*
|
2006-12-21 |
2012-08-24 |
Plexxikon Inc |
Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
|
|
CA2673736A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
EP2124951B1
(en)
|
2006-12-21 |
2014-05-21 |
Vertex Pharmaceuticals Inc. |
5-cyan0-4- (pyrrolo[2, 3b]pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
|
|
EP2139487B1
(en)
*
|
2007-03-28 |
2015-11-11 |
Pharmacyclics LLC |
Inhibitors of bruton's tyrosine kinase
|
|
US20120101114A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
CA2683559C
(en)
|
2007-04-13 |
2019-09-24 |
Dana Farber Cancer Institute, Inc. |
Methods for treating cancer resistant to erbb therapeutics
|
|
GB0710528D0
(en)
*
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
EP4606378A3
(en)
|
2007-06-13 |
2025-11-05 |
Incyte Holdings Corporation |
Salts of the janus kinase inhibitor (r)-3-( 4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3- cyclopentylprop anenitrile
|
|
US20100190777A1
(en)
|
2007-07-17 |
2010-07-29 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
MX2010001636A
(es)
*
|
2007-08-14 |
2010-03-15 |
Hoffmann La Roche |
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
|
|
EP2184988B1
(en)
*
|
2007-08-17 |
2014-12-17 |
University of Maryland, Baltimore |
Small molecule inhibitors of lck sh2 domain binding
|
|
CA2639416C
(en)
|
2007-09-11 |
2019-12-31 |
F. Hoffmann-La Roche Ag |
Diagnostic test for susceptibility to b-raf kinase inhibitors
|
|
DE102007045956A1
(de)
|
2007-09-26 |
2009-04-09 |
Bayer Cropscience Ag |
Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
|
|
DE102007045919B4
(de)
|
2007-09-26 |
2018-07-05 |
Bayer Intellectual Property Gmbh |
Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
|
|
JP2011500806A
(ja)
|
2007-10-25 |
2011-01-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
治療用化合物
|
|
US8426396B2
(en)
*
|
2008-01-08 |
2013-04-23 |
Shriners Hospitals For Children |
Treatment for achondroplasia
|
|
JP5608097B2
(ja)
|
2008-01-08 |
2014-10-15 |
アレイ バイオファーマ、インコーポレイテッド |
キナーゼ阻害薬としてのピロロピリジン
|
|
US8372842B2
(en)
|
2008-01-09 |
2013-02-12 |
Array Biopharma Inc. |
Pyrazolopyridines as kinase inhibitors
|
|
EP2231282A1
(en)
*
|
2008-01-22 |
2010-09-29 |
Merck Patent GmbH |
Protein kinase inhibitors and use thereof
|
|
ATE517107T1
(de)
*
|
2008-02-25 |
2011-08-15 |
Hoffmann La Roche |
Pyrrolopyrazinkinaseinhibitoren
|
|
KR20100122505A
(ko)
|
2008-02-29 |
2010-11-22 |
어레이 바이오파마 인크. |
Raf 저해물질 화합물 및 이들의 이용 방법
|
|
BRPI0908268A2
(pt)
|
2008-02-29 |
2018-10-30 |
Array Biopharma Inc |
compostos do inibidor de raf e seus métodos de uso
|
|
US20110003859A1
(en)
|
2008-02-29 |
2011-01-06 |
Array Biopharma Inc. |
N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
|
|
UA103319C2
(en)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Thiazole- and oxazole-benzene sulfonamide compounds
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
WO2009143018A2
(en)
|
2008-05-19 |
2009-11-26 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
JP2011520937A
(ja)
*
|
2008-05-21 |
2011-07-21 |
ビーエーエスエフ ソシエタス・ヨーロピア |
殺菌剤としての置換ピリジン−4−イルメチルスルホンアミド
|
|
JP2011521924A
(ja)
*
|
2008-05-28 |
2011-07-28 |
ビーエーエスエフ ソシエタス・ヨーロピア |
殺菌剤としての置換ピリジン−4−イル−メチルスルホンアミド
|
|
WO2009152087A1
(en)
|
2008-06-10 |
2009-12-17 |
Plexxikon, Inc. |
Bicyclic heteroaryl compounds and methods for kinase modulation, and indications therefor
|
|
JP5767965B2
(ja)
*
|
2008-06-10 |
2015-08-26 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼを調節する5h−ピロロ[2,3−b]ピラジン誘導体、およびその適応症
|
|
AR072008A1
(es)
*
|
2008-06-13 |
2010-07-28 |
Merck & Co Inc |
Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38
|
|
US9447049B2
(en)
|
2010-03-01 |
2016-09-20 |
University Of Tennessee Research Foundation |
Compounds for treatment of cancer
|
|
WO2009157196A1
(ja)
|
2008-06-25 |
2009-12-30 |
武田薬品工業株式会社 |
アミド化合物
|
|
ES2660418T3
(es)
|
2008-07-16 |
2018-03-22 |
Pharmacyclics Llc |
Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos
|
|
DE102008052943A1
(de)
|
2008-10-23 |
2010-04-29 |
Merck Patent Gmbh |
Azaindolderivate
|
|
WO2010059771A1
(en)
*
|
2008-11-20 |
2010-05-27 |
Osi Pharmaceuticals, Inc. |
Substituted pyrrolo[2,3-b]-pyridines and-pyrazines
|
|
AU2009324894B2
(en)
*
|
2008-11-25 |
2015-04-09 |
University Of Rochester |
MLK inhibitors and methods of use
|
|
US8318446B2
(en)
*
|
2008-12-05 |
2012-11-27 |
California Institute Of Technology |
DNA-damage-induced proteolysis
|
|
HUE025314T2
(en)
*
|
2009-02-10 |
2016-02-29 |
Monsanto Technology Llc |
Preparations and procedures for controlling nematodes
|
|
JP2012520311A
(ja)
*
|
2009-03-11 |
2012-09-06 |
プレキシコン インコーポレーテッド |
Rafキナーゼの阻害のためのピロロ[2,3−b]ピリジン誘導体
|
|
JP2012520307A
(ja)
*
|
2009-03-11 |
2012-09-06 |
プレキシコン インコーポレーテッド |
Rafキナーゼの阻害のためのピロロ[2,3−b]ピリジン誘導体
|
|
WO2010111527A1
(en)
*
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
PT2414356E
(pt)
*
|
2009-04-03 |
2015-11-23 |
Hoffmann La Roche |
Composições de {3-[5-(4-cloro-fenil)-1h-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida do ácido propano-1-sulfónico e utilizações das mesmas
|
|
TW201041888A
(en)
*
|
2009-05-06 |
2010-12-01 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
UA106078C2
(uk)
|
2009-05-22 |
2014-07-25 |
Інсайт Корпорейшн |
3-[4-(7H-ПІРОЛО[2,3-d]ПІРИМІДИН-4-ІЛ)-1H-ПІРАЗОЛ-1-ІЛ]ОКТАН- АБО ГЕПТАННІТРИЛ ЯК JAK-ІНГІБІТОРИ
|
|
AU2010249380B2
(en)
|
2009-05-22 |
2015-08-20 |
Incyte Holdings Corporation |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as Janus kinase inhibitors
|
|
CN102448959B
(zh)
*
|
2009-05-26 |
2015-06-17 |
艾伯维巴哈马有限公司 |
用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂
|
|
US8546399B2
(en)
|
2009-05-26 |
2013-10-01 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US20220315555A1
(en)
|
2009-05-26 |
2022-10-06 |
Abbvie Inc. |
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US9034875B2
(en)
|
2009-05-26 |
2015-05-19 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
CN104151312B
(zh)
*
|
2009-06-17 |
2016-06-15 |
沃泰克斯药物股份有限公司 |
流感病毒复制抑制剂
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
US8329724B2
(en)
*
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
US20120077842A1
(en)
|
2009-08-19 |
2012-03-29 |
Eisai R&D Management Co., Ltd. |
Quinoline derivative-containing pharmaceutical composition
|
|
MX2012002317A
(es)
|
2009-08-24 |
2012-06-25 |
Ascepion Pharmaceuticals Inc |
Compuestos de urea que contienen heteroarilo 5,6-biciclicos como inhibidores de cinasa.
|
|
WO2011025965A1
(en)
|
2009-08-28 |
2011-03-03 |
Genentech, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
CN102712635A
(zh)
|
2009-08-28 |
2012-10-03 |
阵列生物制药公司 |
用于抑制raf激酶的1h-吡唑并[3,4-b]吡啶化合物
|
|
US20120157453A1
(en)
|
2009-08-28 |
2012-06-21 |
Genentech, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
EP2470538A1
(en)
*
|
2009-08-28 |
2012-07-04 |
Array Biopharma, Inc. |
Raf inhibitor compounds and methods of use thereof
|
|
CN102482283A
(zh)
|
2009-08-28 |
2012-05-30 |
阵列生物制药公司 |
Raf抑制剂化合物及其使用方法
|
|
JP2013503187A
(ja)
|
2009-08-28 |
2013-01-31 |
アレイ バイオファーマ、インコーポレイテッド |
Raf阻害化合物およびその使用方法
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
MX2012004721A
(es)
|
2009-10-23 |
2012-06-25 |
Mannkind Corp |
Inmunoterapia de cancer y metodo de tratamiento.
|
|
CA2780190C
(en)
*
|
2009-11-06 |
2020-05-05 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
WO2011060216A1
(en)
|
2009-11-12 |
2011-05-19 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
KR20120097512A
(ko)
*
|
2009-11-18 |
2012-09-04 |
플렉시콘, 인코퍼레이티드 |
키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
|
|
DE102009058280A1
(de)
*
|
2009-12-14 |
2011-06-16 |
Merck Patent Gmbh |
Thiazolderivate
|
|
CN102753549A
(zh)
|
2009-12-23 |
2012-10-24 |
普莱希科公司 |
用于激酶调节的化合物和方法及其适应症
|
|
US9180127B2
(en)
|
2009-12-29 |
2015-11-10 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
|
US8658170B2
(en)
|
2010-01-06 |
2014-02-25 |
Joseph P. Errico |
Combination therapy with MDM2 and EFGR inhibitors
|
|
CA2786277A1
(en)
|
2010-01-06 |
2011-07-14 |
Joseph P. Errico |
Methods and compositions of targeted drug development
|
|
US9163015B2
(en)
|
2010-02-11 |
2015-10-20 |
Vanderbilt University |
Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
|
|
US11084811B2
(en)
|
2010-03-01 |
2021-08-10 |
Oncternal Therapeutics, Inc. |
Compounds for treatment of cancer
|
|
SI2545045T1
(sl)
|
2010-03-10 |
2016-05-31 |
Incyte Holdings Corporation |
Derivati piperidin-4-ila kot zaviralci JAK1
|
|
WO2011119842A1
(en)
|
2010-03-25 |
2011-09-29 |
The J. David Gladstone Institutes |
Compositions and methods for treating neurological disorders
|
|
NZ602777A
(en)
|
2010-04-16 |
2014-07-25 |
Ac Immune Sa |
Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
WO2011140164A1
(en)
*
|
2010-05-06 |
2011-11-10 |
Merck Sharp & Dohme Corp. |
Aza-indole derivatives useful as modulators of faah
|
|
AR081039A1
(es)
|
2010-05-14 |
2012-05-30 |
Osi Pharmaceuticals Llc |
Inhibidores biciclicos fusionados de quinasa
|
|
EP2569315A1
(en)
|
2010-05-14 |
2013-03-20 |
OSI Pharmaceuticals, LLC |
Fused bicyclic kinase inhibitors
|
|
SMT201700372T1
(it)
|
2010-05-20 |
2017-09-07 |
Array Biopharma Inc |
Composti macrociclici come inibitori di trk chinasi
|
|
MX338228B
(es)
|
2010-05-21 |
2016-04-08 |
Incyte Corp |
Formulacion topica para inhibidor de cinasas janus (jak).
|
|
WO2011147764A1
(en)
*
|
2010-05-28 |
2011-12-01 |
N.V. Organon |
Thieno (2, 3b) pyrazine compounds as b - raf inhibitors
|
|
NZ736048A
(en)
|
2010-06-03 |
2019-09-27 |
Pharmacyclics Llc |
The use of inhibitors of bruton’s tyrosine kinase (btk)
|
|
CA2801834A1
(en)
|
2010-06-09 |
2011-12-15 |
Kathleen D'halluin |
Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
|
|
US8779150B2
(en)
|
2010-07-21 |
2014-07-15 |
Hoffmann-La Roche Inc. |
Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
|
|
US9845489B2
(en)
|
2010-07-26 |
2017-12-19 |
Biomatrica, Inc. |
Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
|
|
WO2012018638A2
(en)
|
2010-07-26 |
2012-02-09 |
Biomatrica, Inc. |
Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
|
|
US20120045433A1
(en)
|
2010-08-17 |
2012-02-23 |
Kapil Dhingra |
Combination therapy
|
|
US8709419B2
(en)
|
2010-08-17 |
2014-04-29 |
Hoffmann-La Roche, Inc. |
Combination therapy
|
|
WO2012037060A1
(en)
|
2010-09-13 |
2012-03-22 |
Concert Pharmaceuticals Inc. |
Substituted azaindoles
|
|
UA113500C2
(xx)
|
2010-10-29 |
2017-02-10 |
|
Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
|
|
MX349533B
(es)
|
2010-10-29 |
2017-08-02 |
Abbvie Inc |
Dispersiones solidas que contienen un agente inductor de apoptosis.
|
|
KR101236731B1
(ko)
|
2010-11-02 |
2013-02-25 |
한국과학기술원 |
아자인돌 화합물, 이를 포함하는 pi3k 저해제용 약학 조성물 및 pi3k와 연관된 질환 치료용 약학 조성물
|
|
US8933085B2
(en)
|
2010-11-19 |
2015-01-13 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
US9034884B2
(en)
|
2010-11-19 |
2015-05-19 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
|
|
RU2628560C2
(ru)
|
2010-11-23 |
2017-08-18 |
Эббви Инк. |
Соли и кристаллические формы индуцирующего апоптоз агента
|
|
AR083946A1
(es)
|
2010-11-23 |
2013-04-10 |
Abbott Lab |
Metodos de tratamiento con inhibidores selectivos de bcl-2
|
|
US9296811B2
(en)
|
2010-12-02 |
2016-03-29 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Methods for treating a tumor using an antibody that specifically binds HMW-MAA
|
|
US9295669B2
(en)
*
|
2010-12-14 |
2016-03-29 |
Hoffman La-Roche Inc. |
Combination therapy for proliferative disorders
|
|
MX2013006836A
(es)
|
2010-12-16 |
2013-09-26 |
Vertex Pharma |
Inhibidores de la replicacion de los virus de la influenza.
|
|
CA2824028A1
(en)
|
2011-01-06 |
2012-07-12 |
Beta Pharma Canada Inc. |
Novel ureas for the treatment and prevention of cancer
|
|
PE20141360A1
(es)
*
|
2011-02-07 |
2014-10-13 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
|
|
US20140031383A1
(en)
|
2011-02-08 |
2014-01-30 |
Dana-Farber Cancer Institute, Inc. |
Methods for treatment of melanoma
|
|
PT2675451E
(pt)
|
2011-02-18 |
2015-10-16 |
Incyte Corp |
Terapia de combinação com inibidores mtor/jak
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
US20140199292A1
(en)
*
|
2011-03-15 |
2014-07-17 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Compositions and methods for inhibiting tumor development caused by chemotherapy induced senescence
|
|
JP6239497B2
(ja)
*
|
2011-04-01 |
2017-11-29 |
ジェネンテック, インコーポレイテッド |
Akt阻害剤化合物及びアビラテロンの組み合わせ、及び使用方法
|
|
WO2012138809A1
(en)
*
|
2011-04-05 |
2012-10-11 |
Dawei Zhang |
Heterocyclic compounds as kinase inhibitors
|
|
AU2012246490B2
(en)
|
2011-04-18 |
2016-08-04 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
|
WO2012154908A2
(en)
*
|
2011-05-10 |
2012-11-15 |
Brunangelo Falini |
Hairy cell leukemia biomarkers and methods of using same
|
|
JP2014513724A
(ja)
|
2011-05-16 |
2014-06-05 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
融合二環キナーゼ阻害剤
|
|
BR112013029163A2
(pt)
|
2011-05-17 |
2017-01-31 |
Plexxikon Inc |
modulação quinase e indicações dos mesmos
|
|
EP2714688B1
(en)
|
2011-05-26 |
2016-02-24 |
Daiichi Sankyo Company, Limited |
Heterocyclic compounds as protein kinase inhibitors
|
|
US9945862B2
(en)
|
2011-06-03 |
2018-04-17 |
Eisai R&D Management Co., Ltd. |
Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
|
|
EP2717694A4
(en)
|
2011-06-10 |
2014-11-12 |
Glaxosmithkline Intellectual Property Ltd |
NEW COMPOUNDS
|
|
WO2012177606A1
(en)
|
2011-06-20 |
2012-12-27 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
KR20140048968A
(ko)
|
2011-07-13 |
2014-04-24 |
파마시클릭스, 인코포레이티드 |
브루톤형 티로신 키나제의 억제제
|
|
UA118010C2
(uk)
*
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
JP6238459B2
(ja)
|
2011-08-01 |
2017-11-29 |
ジェネンテック, インコーポレイテッド |
Pd−1軸結合アンタゴニストとmek阻害剤を使用する癌の治療方法
|
|
US9358229B2
(en)
|
2011-08-10 |
2016-06-07 |
Novartis Pharma Ag |
JAK PI3K/mTOR combination therapy
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
|
WO2013029043A1
(en)
*
|
2011-08-25 |
2013-02-28 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
|
AU2012300317B2
(en)
|
2011-08-26 |
2016-12-01 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
US9518029B2
(en)
|
2011-09-14 |
2016-12-13 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
EP2570127A1
(en)
|
2011-09-16 |
2013-03-20 |
Sanofi |
Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors
|
|
WO2013043715A1
(en)
|
2011-09-19 |
2013-03-28 |
Genentech, Inc. |
Combination treatments comprising c-met antagonists and b-raf antagonists
|
|
EP2771011A4
(en)
*
|
2011-10-24 |
2015-04-15 |
Glaxosmithkline Ip No 2 Ltd |
CHEMICAL COMPOUNDS
|
|
US9382239B2
(en)
|
2011-11-17 |
2016-07-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-Jun-N-terminal kinase (JNK)
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
CA2856347C
(en)
|
2011-12-31 |
2017-05-30 |
Beigene, Ltd. |
Fused tricyclic compounds as raf kinase inhibitors
|
|
WO2013109142A1
(en)
|
2012-01-16 |
2013-07-25 |
Stichting Het Nederlands Kanker Instituut |
Combined pdk and mapk/erk pathway inhibition in neoplasia
|
|
CN102603734A
(zh)
*
|
2012-01-19 |
2012-07-25 |
盛世泰科生物医药技术(苏州)有限公司 |
一种蛋白激酶抑制剂及其应用
|
|
WO2013112950A2
(en)
|
2012-01-25 |
2013-08-01 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
US9216170B2
(en)
|
2012-03-19 |
2015-12-22 |
Hoffmann-La Roche Inc. |
Combination therapy for proliferative disorders
|
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
EP2830608B8
(en)
|
2012-03-28 |
2020-01-15 |
UCB Biopharma SRL |
Phenyl-urea and phenyl-carbamate derivatives as inhibitors of protein aggregation
|
|
BR112014026367A2
(pt)
*
|
2012-04-23 |
2017-06-27 |
Genentech Inc |
5-bromo-4-cloro-3-nitro-1h-pirrol[2,3-b]piridina e seu processo
|
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
WO2013176970A1
(en)
*
|
2012-05-22 |
2013-11-28 |
Merck Sharp & Dohme Corp. |
TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
|
|
US10077474B2
(en)
*
|
2012-05-29 |
2018-09-18 |
Abbott Molecular, Inc. |
Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
|
|
US9150570B2
(en)
*
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
CA2870407A1
(en)
|
2012-05-31 |
2013-12-05 |
F. Hoffmann-La Roche Ag |
Aminoquinazoline and pyridopyrimidine derivatives
|
|
EA201492082A1
(ru)
|
2012-06-04 |
2015-03-31 |
Фармасайкликс, Инк. |
Кристаллические формы ингибитора тирозинкиназы брутона
|
|
JP2015522037A
(ja)
|
2012-07-03 |
2015-08-03 |
ラシオファルム ゲーエムベーハー |
ベムラフェニブコリン塩の固体形態
|
|
KR20180088926A
(ko)
|
2012-07-24 |
2018-08-07 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
|
|
EP2882748A4
(en)
*
|
2012-08-07 |
2015-06-17 |
Aurigene Discovery Tech Ltd |
5- (1H-PYRAZOL-4-YL-) 1H-PYRROLO- [2,3-B-] PYRIDINE DERIVATIVES AS A KINASE INHIBITOR
|
|
EP2884979B1
(en)
|
2012-08-17 |
2019-06-26 |
F.Hoffmann-La Roche Ag |
Combination therapies for melanoma comprising administering cobimetinib and vemurafinib
|
|
TWI601725B
(zh)
*
|
2012-08-27 |
2017-10-11 |
加拓科學公司 |
取代的氮雜吲哚化合物及其鹽、組合物和用途
|
|
CN103626765B
(zh)
*
|
2012-08-27 |
2016-08-10 |
广东东阳光药业有限公司 |
取代的氮杂吲哚化合物及其盐、组合物和用途
|
|
MX2015002887A
(es)
|
2012-09-06 |
2015-07-06 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
|
|
EP2897618B1
(en)
|
2012-09-24 |
2021-11-17 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
CN105712992B
(zh)
*
|
2012-09-29 |
2018-10-26 |
上海科州药物研发有限公司 |
作为cMet抑制剂的化合物及其制备方法和用途
|
|
JP2015531395A
(ja)
|
2012-10-04 |
2015-11-02 |
ファイザー・リミテッドPfizer Limited |
ピロロ[3,2−c]ピリジントロポミオシン関連キナーゼ阻害剤
|
|
AU2013328824B2
(en)
*
|
2012-10-08 |
2018-04-05 |
Atriva Therapeutics Gmbh |
MEK inhibitors in the treatment of virus diseases
|
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
US9758522B2
(en)
|
2012-10-19 |
2017-09-12 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
|
WO2014075077A1
(en)
|
2012-11-12 |
2014-05-15 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
|
AU2013344656A1
(en)
|
2012-11-15 |
2015-06-04 |
Pharmacyclics Llc |
Pyrrolopyrimidine compounds as kinase inhibitors
|
|
IL297429A
(en)
|
2012-11-15 |
2022-12-01 |
Incyte Holdings Corp |
Sustained release dosage forms of roxolitinib
|
|
US9260426B2
(en)
*
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
EP2934572A4
(en)
|
2012-12-20 |
2016-11-23 |
Biomatrica Inc |
FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
|
|
EP2937337A4
(en)
|
2012-12-21 |
2016-06-22 |
Eisai R&D Man Co Ltd |
AMORPHIC FORM OF CHINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
|
|
JP6385954B2
(ja)
|
2012-12-21 |
2018-09-05 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼ調節のための化合物および方法、ならびにその適応
|
|
US9278950B2
(en)
|
2013-01-14 |
2016-03-08 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
AU2014207691B2
(en)
|
2013-01-15 |
2018-08-30 |
Incyte Holdings Corporation |
Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
|
|
WO2014130856A2
(en)
*
|
2013-02-21 |
2014-08-28 |
Wayne Rothbaum |
Treatment of skeletal-related disorders
|
|
WO2014128235A1
(en)
|
2013-02-22 |
2014-08-28 |
F. Hoffmann-La Roche Ag |
Methods of treating cancer and preventing drug resistance
|
|
CN109568312A
(zh)
*
|
2013-03-05 |
2019-04-05 |
田纳西大学研究基金会 |
用于治疗癌症的化合物
|
|
PT3489239T
(pt)
|
2013-03-06 |
2021-12-17 |
Incyte Holdings Corp |
Processos e intermediários para a preparação de um inibidor de jak
|
|
EP2970270A1
(en)
|
2013-03-14 |
2016-01-20 |
ratiopharm GmbH |
Solid state forms of vemurafenib hydrochloride
|
|
US20140275082A1
(en)
|
2013-03-14 |
2014-09-18 |
Abbvie Inc. |
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
|
|
US20160030438A1
(en)
|
2013-03-15 |
2016-02-04 |
Sanofi |
Anti-tumoral composition comprising a pi3kbeta inhibitor and a raf inhibitor, to overcome cancer cells resistance
|
|
BR112015021983B1
(pt)
|
2013-03-15 |
2022-03-03 |
Plexxikon, Inc |
Compostos heterocíclicos, composições farmacêuticas que os compreendem e usos dos mesmos
|
|
CA2905123A1
(en)
|
2013-03-15 |
2014-09-18 |
Genentech, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
US20140303121A1
(en)
|
2013-03-15 |
2014-10-09 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
US9206188B2
(en)
*
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
ES2687968T3
(es)
|
2013-05-14 |
2018-10-30 |
Eisai R&D Management Co., Ltd. |
Biomarcadores para pronosticar y evaluar la reactividad de sujetos con cáncer de endometrio a compuestos con lenvatinib
|
|
KR20160013028A
(ko)
|
2013-05-30 |
2016-02-03 |
플렉시콘, 인코퍼레이티드 |
키나제 조정을 위한 화합물 및 그에 대한 적응증
|
|
EP3632208A1
(en)
|
2013-06-13 |
2020-04-08 |
Biomatrica, INC. |
Cell stabilization
|
|
US9670231B2
(en)
|
2013-06-28 |
2017-06-06 |
Beigene, Ltd. |
Fused tricyclic amide compounds as multiple kinase inhibitors
|
|
CN117731786A
(zh)
|
2013-07-12 |
2024-03-22 |
皮拉马尔企业有限公司 |
用于治疗黑素瘤的药物组合
|
|
JP6800750B2
(ja)
|
2013-08-02 |
2020-12-16 |
ファーマサイクリックス エルエルシー |
固形腫瘍の処置方法
|
|
CN114010611B
(zh)
|
2013-08-07 |
2023-11-28 |
因赛特控股公司 |
Jak1抑制剂的持续释放剂型
|
|
ES2709509T3
(es)
|
2013-08-12 |
2019-04-16 |
Pharmacyclics Llc |
Procedimientos para el tratamiento de cáncer amplificado por HER2
|
|
WO2015027124A1
(en)
|
2013-08-23 |
2015-02-26 |
Incyte Corporation |
Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
US9629851B2
(en)
|
2013-09-20 |
2017-04-25 |
Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis |
ROCK in combination with MAPK pathway
|
|
WO2015048689A1
(en)
|
2013-09-30 |
2015-04-02 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
WO2015058140A1
(en)
|
2013-10-18 |
2015-04-23 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
|
|
CA2927917C
(en)
|
2013-10-18 |
2022-08-09 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of proliferative diseases
|
|
HUE044667T2
(hu)
|
2013-11-13 |
2019-11-28 |
Vertex Pharma |
Influenza vírus replikáció inhibitorok
|
|
RS57541B1
(sr)
|
2013-11-13 |
2018-10-31 |
Vertex Pharma |
Postupci za pripremu inhibitora replikacije virusa gripa
|
|
JP6744218B2
(ja)
|
2013-11-15 |
2020-08-19 |
ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー |
Ebna1阻害剤およびそれらの使用方法
|
|
WO2015075749A1
(en)
*
|
2013-11-22 |
2015-05-28 |
Laurus Labs Private Limited |
Novel processes for the preparation of vemurafenib
|
|
CZ2013943A3
(cs)
|
2013-11-27 |
2015-06-03 |
Zentiva, K.S. |
Krystalické formy vemurafenibu
|
|
CN104710417B
(zh)
*
|
2013-12-11 |
2020-09-08 |
上海科州药物研发有限公司 |
氮杂吲哚类衍生物及其合成方法
|
|
JP6678585B2
(ja)
*
|
2013-12-20 |
2020-04-22 |
バイオメッド バレー ディスカバリーズ,インコーポレイティド |
Erk阻害剤およびraf阻害剤の組み合わせを使用するがん処置
|
|
CN104739823A
(zh)
*
|
2013-12-28 |
2015-07-01 |
复旦大学附属华山医院 |
淫羊藿素在制备维罗非尼增敏剂中的用途
|
|
EP3094736A4
(en)
|
2014-01-14 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
WO2015134536A1
(en)
|
2014-03-04 |
2015-09-11 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
WO2015143400A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics, Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
|
WO2015156674A2
(en)
|
2014-04-10 |
2015-10-15 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
US10017477B2
(en)
|
2014-04-23 |
2018-07-10 |
Dana-Farber Cancer Institute, Inc. |
Janus kinase inhibitors and uses thereof
|
|
US9862688B2
(en)
|
2014-04-23 |
2018-01-09 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged janus kinase inhibitors and uses thereof
|
|
EP3139927A4
(en)
*
|
2014-05-06 |
2017-12-13 |
The Regents of The University of California |
Wound healing using braf inhibitors
|
|
WO2015178770A1
(en)
|
2014-05-19 |
2015-11-26 |
Stichting Het Nederlands Kanker Instituut |
Compositions for cancer treatment
|
|
WO2015181628A1
(en)
*
|
2014-05-27 |
2015-12-03 |
Eisai R&D Management Co., Ltd. |
Treatment of acute myeloid leukemia with an hck inhibitor
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
TW201613916A
(en)
|
2014-06-03 |
2016-04-16 |
Gilead Sciences Inc |
TANK-binding kinase inhibitor compounds
|
|
WO2015191632A1
(en)
|
2014-06-10 |
2015-12-17 |
Biomatrica, Inc. |
Stabilization of thrombocytes at ambient temperatures
|
|
JP2017517552A
(ja)
|
2014-06-13 |
2017-06-29 |
ジェネンテック, インコーポレイテッド |
抗癌剤耐性の治療及び防止方法
|
|
WO2015191996A1
(en)
*
|
2014-06-13 |
2015-12-17 |
Genentech, Inc. |
Methods of treating and preventing cancer drug resistance
|
|
WO2015196072A2
(en)
|
2014-06-19 |
2015-12-23 |
Whitehead Institute For Biomedical Research |
Uses of kinase inhibitors for inducing and maintaining pluripotency
|
|
CN105777756B
(zh)
*
|
2014-07-02 |
2019-03-01 |
广东东阳光药业有限公司 |
杂芳化合物及其在药物中的应用
|
|
US9580416B2
(en)
|
2014-07-02 |
2017-02-28 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
WO2016010897A1
(en)
|
2014-07-14 |
2016-01-21 |
Incyte Corporation |
Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
|
|
US9580418B2
(en)
|
2014-07-14 |
2017-02-28 |
Incyte Corporation |
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
|
|
ES2742500T3
(es)
|
2014-07-15 |
2020-02-14 |
Federal Express Corp |
Composiciones para tratamiento del cáncer usando antagonistas de unión al eje de pd-1 e inhibidores de MEK
|
|
EP3174539A4
(en)
|
2014-08-01 |
2017-12-13 |
Pharmacyclics, LLC |
Inhibitors of bruton's tyrosine kinase
|
|
BR112017002231A2
(pt)
|
2014-08-07 |
2018-07-17 |
Pharmacyclics Llc |
novas formulações de um inibidor de tirosina cinase de bruton
|
|
EP3187491A4
(en)
|
2014-08-28 |
2018-08-01 |
Eisai R&D Management Co., Ltd. |
High-purity quinoline derivative and method for manufacturing same
|
|
JP6832846B2
(ja)
|
2014-09-15 |
2021-02-24 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
ヘテロ環化合物およびその用途
|
|
ES2881195T3
(es)
|
2014-09-26 |
2021-11-29 |
Gilead Sciences Inc |
Derivados de aminotriazina útiles como compuestos inhibidores de quinasas que se unen a TANK
|
|
CA2963091A1
(en)
|
2014-10-06 |
2016-04-14 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
|
US10611765B2
(en)
|
2014-11-06 |
2020-04-07 |
Ohio State Innovation Foundation |
Pyrrolopyrimidine derivatives as Mps1/TTK kinase inhibitors
|
|
US10414764B2
(en)
|
2014-11-29 |
2019-09-17 |
Shilpa Medicare Limited |
Substantially pure vemurafenib and its salts
|
|
JP6815318B2
(ja)
*
|
2014-12-23 |
2021-01-20 |
ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド |
二官能性分子によって標的化タンパク質分解を誘導する方法
|
|
JP6854762B2
(ja)
|
2014-12-23 |
2021-04-07 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
サイクリン依存性キナーゼ7(cdk7)の阻害剤
|
|
US9694084B2
(en)
|
2014-12-23 |
2017-07-04 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
|
WO2016136745A1
(ja)
|
2015-02-25 |
2016-09-01 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
キノリン誘導体の苦味抑制方法
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
AU2015384801B2
(en)
|
2015-03-04 |
2022-01-06 |
Eisai R&D Management Co., Ltd. |
Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
|
|
AU2016243529B2
(en)
|
2015-03-27 |
2021-03-25 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
US10160755B2
(en)
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
CZ2015250A3
(cs)
|
2015-04-14 |
2016-10-26 |
Zentiva, K.S. |
Amorfní formy vemurafenibu
|
|
HUE050506T2
(hu)
|
2015-05-06 |
2020-12-28 |
Plexxikon Inc |
Kinázokat moduláló vegyület szilárd formái
|
|
TWI660956B
(zh)
|
2015-05-06 |
2019-06-01 |
美商普雷辛肯公司 |
調節蛋白質激酶之化合物的合成
|
|
EP3294717B1
(en)
|
2015-05-13 |
2020-07-29 |
Vertex Pharmaceuticals Inc. |
Methods of preparing inhibitors of influenza viruses replication
|
|
WO2016183120A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
BR112017024481B1
(pt)
|
2015-05-14 |
2020-11-17 |
The Wistar Institute Of Anatomy And Biology |
composto inibidor de ebna1, composição farmacêutica compreendendo dito composto e usos terapêuticos do mesmo
|
|
CN107801378A
(zh)
|
2015-05-22 |
2018-03-13 |
普莱希科公司 |
用于治疗braf‑v600相关的疾病的plx‑8394或plx‑7904
|
|
WO2016191295A1
(en)
|
2015-05-22 |
2016-12-01 |
Plexxikon Inc. |
Solid forms of a compound for modulating kinases
|
|
WO2016196244A1
(en)
|
2015-05-29 |
2016-12-08 |
Incyte Corporation |
Pyridineamine compounds useful as pim kinase inhibitors
|
|
SI3307734T1
(sl)
*
|
2015-06-09 |
2020-03-31 |
Abbvie Inc. |
Modulatorji jedrnega receptorja (ROR) za zdravljenje vnetnih in avtoimunih bolezni
|
|
AU2016276963C1
(en)
|
2015-06-12 |
2021-08-05 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
|
MX373231B
(es)
|
2015-06-16 |
2020-05-08 |
Eisai R&D Man Co Ltd |
Agente anticancerigeno.
|
|
HRP20210177T1
(hr)
|
2015-07-16 |
2021-03-19 |
Array Biopharma, Inc. |
Supstituirani spojevi pirazolo[1,5-a]piridina kao inhibitori ret kinaze
|
|
KR102665765B1
(ko)
|
2015-07-20 |
2024-05-10 |
젠자임 코포레이션 |
콜로니 자극 인자-1 수용체(csf-1r) 저해제
|
|
US10829484B2
(en)
|
2015-07-28 |
2020-11-10 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
AU2016298175B2
(en)
|
2015-07-28 |
2022-01-06 |
University Of Iowa Research Foundation |
Compositions and methods of treating cancer
|
|
EP3338779B1
(en)
|
2015-08-20 |
2021-06-30 |
Eisai R&D Management Co., Ltd. |
Lenvatinib in combination with etoposide and ifosfamide for use in treating a tumor
|
|
AU2016319125B2
(en)
|
2015-09-09 |
2021-04-08 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
|
AR105967A1
(es)
|
2015-09-09 |
2017-11-29 |
Incyte Corp |
Sales de un inhibidor de pim quinasa
|
|
ES2913048T3
(es)
|
2015-09-21 |
2022-05-31 |
Opna Immuno Oncology Sa |
Compuestos heterocíclicos y usos de estos
|
|
WO2017059251A1
(en)
|
2015-10-02 |
2017-04-06 |
Incyte Corporation |
Heterocyclic compounds useful as pim kinase inhibitors
|
|
WO2017066193A1
(en)
|
2015-10-15 |
2017-04-20 |
Princeton Drug Discovery, Llc |
Novel inhibitors of protein kinases
|
|
EP3368039A1
(en)
|
2015-10-26 |
2018-09-05 |
The Regents of The University of Colorado, A Body Corporate |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
MX377351B
(es)
|
2015-11-19 |
2025-03-07 |
Genentech Inc |
Metodos para el tratamiento de cancer utilizando inhibidores b-raf e inhibidores de punto de control inmunologico
|
|
SG11201804711RA
(en)
|
2015-12-07 |
2018-07-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
ES3037826T3
(en)
|
2015-12-08 |
2025-10-07 |
Biomatrica Inc |
Reduction of erythrocyte sedimentation rate
|
|
US10116776B2
(en)
|
2015-12-14 |
2018-10-30 |
Red.Com, Llc |
Modular digital camera and cellular phone
|
|
US10316049B2
(en)
|
2015-12-17 |
2019-06-11 |
Gilead Sciences, Inc. |
Tank-binding kinase inhibitor compounds
|
|
WO2017147316A1
(en)
*
|
2016-02-25 |
2017-08-31 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and intermediates
|
|
US10160747B2
(en)
|
2016-03-16 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
US10045991B2
(en)
|
2016-04-04 |
2018-08-14 |
Loxo Oncology, Inc. |
Methods of treating pediatric cancers
|
|
PT3439662T
(pt)
|
2016-04-04 |
2024-09-30 |
Loxo Oncology Inc |
Formulações líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
|
|
BR112018070017A2
(pt)
|
2016-04-04 |
2019-02-05 |
Loxo Oncology Inc |
métodos de tratamento de cânceres pediátricos
|
|
CN109072311A
(zh)
|
2016-04-15 |
2018-12-21 |
豪夫迈·罗氏有限公司 |
用于癌症的诊断和治疗方法
|
|
PT3458456T
(pt)
|
2016-05-18 |
2020-12-07 |
Array Biopharma Inc |
Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida
|
|
KR20240110902A
(ko)
*
|
2016-06-13 |
2024-07-16 |
케모센트릭스, 인크. |
췌장 암을 치료하는 방법
|
|
AU2017281940C1
(en)
|
2016-06-24 |
2024-11-07 |
University Of Iowa Research Foundation |
Compositions and methods of treating melanoma
|
|
US10407427B2
(en)
|
2016-07-01 |
2019-09-10 |
Fermion Oy |
Processes for the preparation of Vemurafenib
|
|
CN116478131A
(zh)
|
2016-07-12 |
2023-07-25 |
锐新医药公司 |
作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪
|
|
JP7117293B2
(ja)
|
2016-09-16 |
2022-08-12 |
ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト (ゲーエムベーハー) |
Traf6阻害剤
|
|
TW201815766A
(zh)
|
2016-09-22 |
2018-05-01 |
美商普雷辛肯公司 |
用於ido及tdo調節之化合物及方法以及其適應症
|
|
TWI704148B
(zh)
*
|
2016-10-10 |
2020-09-11 |
美商亞雷生物製藥股份有限公司 |
作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
|
|
JOP20190077A1
(ar)
|
2016-10-10 |
2019-04-09 |
Array Biopharma Inc |
مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
|
|
EP3308773A1
(en)
|
2016-10-11 |
2018-04-18 |
Recordati Industria Chimica E Farmaceutica SPA |
Formulations of cysteamine and cysteamine derivatives
|
|
EP3528798A4
(en)
|
2016-10-19 |
2020-10-21 |
United States Government as Represented by The Department of Veterans Affairs |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
|
|
JOP20190092A1
(ar)
|
2016-10-26 |
2019-04-25 |
Array Biopharma Inc |
عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
|
|
WO2018098353A1
(en)
|
2016-11-23 |
2018-05-31 |
Chemocentryx, Inc. |
Method of treating focal segmental glomerulosclerosis
|
|
US11758928B2
(en)
|
2016-12-15 |
2023-09-19 |
Société des Produits Nestlé S.A. |
Compositions and methods that modulate phosphorus or enzymes in a companion animal
|
|
AU2017382436C1
(en)
*
|
2016-12-23 |
2021-05-27 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of Rapidly Accelerated Fibrosarcoma polypeptides
|
|
US11173211B2
(en)
|
2016-12-23 |
2021-11-16 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
|
|
JP7193460B2
(ja)
|
2016-12-23 |
2022-12-20 |
プレキシコン インコーポレーテッド |
Cdk8調節およびその適応症のための化合物および方法
|
|
JP7300394B2
(ja)
*
|
2017-01-17 |
2023-06-29 |
ヘパリジェニックス ゲーエムベーハー |
肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
|
|
WO2018136663A1
(en)
|
2017-01-18 |
2018-07-26 |
Array Biopharma, Inc. |
Ret inhibitors
|
|
CN110267960B
(zh)
|
2017-01-18 |
2022-04-26 |
阿雷生物药品公司 |
作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
|
|
CN110431134A
(zh)
|
2017-01-23 |
2019-11-08 |
锐新医药公司 |
作为变构shp2抑制剂的吡啶化合物
|
|
AU2018210770B2
(en)
|
2017-01-23 |
2022-03-24 |
Revolution Medicines, Inc. |
Bicyclic compounds as allosteric SHP2 inhibitors
|
|
KR102747905B1
(ko)
|
2017-01-31 |
2024-12-31 |
아비나스 오퍼레이션스, 인코포레이티드 |
세레블론 리간드 및 이를 포함하는 이작용성 화합물
|
|
AU2018219637B2
(en)
|
2017-02-08 |
2023-07-13 |
Eisai R&D Management Co., Ltd. |
Tumor-treating pharmaceutical composition
|
|
EP3579872A1
(en)
|
2017-02-10 |
2019-12-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
|
|
JOP20190213A1
(ar)
|
2017-03-16 |
2019-09-16 |
Array Biopharma Inc |
مركبات حلقية ضخمة كمثبطات لكيناز ros1
|
|
EP3601326A4
(en)
*
|
2017-03-20 |
2020-12-16 |
The Broad Institute, Inc. |
COMPOUNDS AND METHODS OF REGULATING INSULIN SECRETION
|
|
US10577366B2
(en)
|
2017-03-20 |
2020-03-03 |
Plexxikon Inc. |
Crystalline forms of a compound that inhibits bromodomain
|
|
WO2018183762A1
(en)
*
|
2017-03-29 |
2018-10-04 |
United States Government As Represented By The Department Of Veterans Affairs |
Methods and compositions for treating cancer
|
|
WO2018183917A1
(en)
|
2017-03-30 |
2018-10-04 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and synthetic intermediates
|
|
TW201902517A
(zh)
*
|
2017-04-28 |
2019-01-16 |
美商石英醫療公司 |
Raf降解結合物化合物
|
|
WO2018210661A1
(en)
*
|
2017-05-15 |
2018-11-22 |
Basf Se |
Heteroaryl compounds as agrochemical fungicides
|
|
CN110831597A
(zh)
|
2017-05-16 |
2020-02-21 |
卫材R&D管理有限公司 |
肝细胞癌的治疗
|
|
PT3624796T
(pt)
|
2017-05-19 |
2025-06-02 |
Nflection Therapeutics Inc |
Compostos de pirrolopiridina-anilina para tratamento de distúrbios dérmicos
|
|
MX2019013562A
(es)
|
2017-05-19 |
2020-08-03 |
Nflection Therapeutics Inc |
Compuestos de anilina heteroaromatica o fusionados para el tratamiento de trastornos dermicos.
|
|
US10428067B2
(en)
|
2017-06-07 |
2019-10-01 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
|
US11312714B2
(en)
|
2017-06-30 |
2022-04-26 |
The Regents Of The University Of California |
Compositions and methods for modulating hair growth
|
|
CN110944670B
(zh)
|
2017-07-25 |
2023-03-10 |
普莱希科公司 |
调制激酶的化合物的制剂
|
|
CN109384785B
(zh)
*
|
2017-08-10 |
2021-09-28 |
浙江海正药业股份有限公司 |
吡咯并吡啶酮类衍生物、其制备方法及其在医药上的用途
|
|
CN111373055B
(zh)
|
2017-09-08 |
2024-07-23 |
豪夫迈·罗氏有限公司 |
用于癌症的诊断和治疗方法
|
|
TWI791053B
(zh)
|
2017-10-10 |
2023-02-01 |
美商亞雷生物製藥股份有限公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
|
|
TWI876442B
(zh)
|
2017-10-10 |
2025-03-11 |
美商絡速藥業公司 |
6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
|
|
CN111417389A
(zh)
|
2017-10-11 |
2020-07-14 |
坎莫森特里克斯公司 |
Ccr2拮抗剂对局灶性节段性肾小球硬化症的治疗
|
|
KR20200070295A
(ko)
|
2017-10-12 |
2020-06-17 |
레볼루션 메디슨즈, 인크. |
알로스테릭 shp2 억제제로서의 피리딘, 피라진 및 트리아진 화합물
|
|
US10717735B2
(en)
|
2017-10-13 |
2020-07-21 |
Plexxikon Inc. |
Solid forms of a compound for modulating kinases
|
|
MX2020004148A
(es)
|
2017-10-26 |
2022-09-09 |
Xynomic Pharmaceuticals Inc |
Sales cristalinas de un inhibidor de cinasa de fibrosarcoma acelerado rapidamente (b-raf).
|
|
US11103505B2
(en)
|
2017-10-27 |
2021-08-31 |
Plexxikon Inc. |
Formulations of a compound modulating kinases
|
|
US10596161B2
(en)
|
2017-12-08 |
2020-03-24 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
CN111433205B
(zh)
|
2017-12-15 |
2024-01-19 |
锐新医药公司 |
作为变构shp2抑制剂的多环化合物
|
|
US11725185B2
(en)
|
2017-12-28 |
2023-08-15 |
University Of Houston System |
Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
|
|
CN111630054B
(zh)
|
2018-01-18 |
2023-05-09 |
奥瑞生物药品公司 |
作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物
|
|
CN111971286B
(zh)
|
2018-01-18 |
2023-04-14 |
阿雷生物药品公司 |
作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物
|
|
CA3087972C
(en)
|
2018-01-18 |
2023-01-10 |
Array Biopharma Inc. |
Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
|
|
UA127488C2
(uk)
|
2018-01-30 |
2023-09-06 |
Інсайт Корпорейшн |
Способи одержання (1-(3-фтор-2-(трифторметил)ізонікотиноїл)піперидин-4-ону)
|
|
HRP20241555T1
(hr)
|
2018-01-31 |
2025-01-17 |
Heparegenix Gmbh |
Inhibitori protein kinaze mkk4 za poticanje regeneracije jetre ili smanjenje ili sprječavanje smrti hepatocita
|
|
US20210008047A1
(en)
|
2018-02-13 |
2021-01-14 |
Vib Vzw |
Targeting minimal residual disease in cancer with rxr antagonists
|
|
AU2019239952A1
(en)
|
2018-03-20 |
2020-10-08 |
Plexxikon Inc. |
Compounds and methods for IDO and TDO modulation, and indications therefor
|
|
PT3773593T
(pt)
|
2018-03-30 |
2024-06-25 |
Incyte Corp |
Tratamento da hidradenite supurativa com inibidores de jak
|
|
WO2019195682A1
(en)
*
|
2018-04-05 |
2019-10-10 |
Beth Israel Deaconess Medical Center, Inc. |
Aryl hydrocarbon receptor modulators and uses thereof
|
|
EP3560516A1
(en)
*
|
2018-04-27 |
2019-10-30 |
Bergen Teknologioverforing AS |
Combination therapy including beta-sitosterol in combination with at least one of a braf inhibitor, a mek inhibitor or an erk inhibitor and methods and use thereof
|
|
CN112543634A
(zh)
|
2018-05-17 |
2021-03-23 |
威斯达研究所 |
Ebna1抑制剂晶体形式及其制备和使用方法
|
|
GB201808321D0
(en)
*
|
2018-05-21 |
2018-07-11 |
Univ College Dublin Nat Univ Ireland Dublin |
Compositions and uses thereof
|
|
RU2687107C1
(ru)
*
|
2018-06-18 |
2019-05-07 |
федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" |
Ингибитор braf киназы n-(3-(5-(4-хлорофенил)-1h-пиразоло[3,4-b]пиридин-3-карбонил)-2,4-дифторофенил) пропан-1-сульфонамид
|
|
EP3810139A1
(en)
|
2018-06-21 |
2021-04-28 |
HepaRegeniX GmbH |
Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
US12187701B2
(en)
|
2018-06-25 |
2025-01-07 |
Dana-Farber Cancer Institute, Inc. |
Taire family kinase inhibitors and uses thereof
|
|
GB2612522B
(en)
*
|
2018-07-06 |
2023-08-02 |
The Regents Of The Univ Of Colorado A Body Corporate Existing Under The Laws Of The State Of Colorad |
Genetically encoded system for constructing and detecting biologically active agents
|
|
SG11202012732UA
(en)
*
|
2018-07-16 |
2021-02-25 |
Heparegenix Gmbh |
Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
|
|
CN112469718B
(zh)
*
|
2018-07-19 |
2022-08-30 |
深圳市瓴方生物医药科技有限公司 |
氮杂吲哚衍生物及其作为FGFR和C-Met抑制剂的应用
|
|
KR102612513B1
(ko)
|
2018-07-31 |
2023-12-12 |
록쏘 온콜로지, 인코포레이티드 |
(s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제
|
|
US11964988B2
(en)
|
2018-09-10 |
2024-04-23 |
Array Biopharma Inc. |
Fused heterocyclic compounds as RET kinase inhibitors
|
|
WO2020070390A1
(en)
|
2018-10-03 |
2020-04-09 |
Jyväskylän Yliopisto |
Vemurafenib and salts thereof for use in the treatment of enteroviral infections
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
EP3867409A1
(en)
|
2018-10-16 |
2021-08-25 |
Novartis AG |
Tumor mutation burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy
|
|
US12428416B2
(en)
|
2018-11-16 |
2025-09-30 |
California Institute Of Technology |
ERK inhibitors and uses thereof
|
|
MA54741A
(fr)
|
2018-11-20 |
2021-11-24 |
Nflection Therapeutics Inc |
Composés thiényl-aniline destinés au traitement d'affections de la peau
|
|
US12378240B2
(en)
|
2018-11-20 |
2025-08-05 |
Nflection Therapeutics, Inc. |
Naphthyridinone-aniline compounds for treatment of dermal disorders
|
|
MA55141A
(fr)
|
2018-11-20 |
2021-09-29 |
Nflection Therapeutics Inc |
Composés cyanoaryl-aniline pour le traitement d'affections de la peau
|
|
JP2022510368A
(ja)
*
|
2018-12-03 |
2022-01-26 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
タンキラーゼのインヒビターとしての4-ヘテロアリールカルボニル-n-(フェニルまたはヘテロアリール)ピペリジン-1-カルボキサミド
|
|
WO2020131674A1
(en)
|
2018-12-19 |
2020-06-25 |
Array Biopharma Inc. |
7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
|
|
JP2022515198A
(ja)
|
2018-12-19 |
2022-02-17 |
アレイ バイオファーマ インコーポレイテッド |
FGFRチロシンキナーゼの阻害剤としての置換ピラゾロ[1,5-a]ピリジン化合物
|
|
US12281126B2
(en)
|
2018-12-28 |
2025-04-22 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 and uses thereof
|
|
EP4520326A3
(en)
|
2019-02-11 |
2025-06-11 |
Merck Patent GmbH |
Indazolyl-isoxazole derivatives for the treatment of diseases such as cancer
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
US11472791B2
(en)
|
2019-03-05 |
2022-10-18 |
Incyte Corporation |
Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
JP7636646B2
(ja)
|
2019-04-09 |
2025-02-27 |
オプナ バイオ ソシエテ アノニム |
Ep300またはcbpの調節のための縮合アジンおよびその適応
|
|
WO2020223558A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
Tricyclic amine compounds as cdk2 inhibitors
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
WO2020243519A1
(en)
*
|
2019-05-29 |
2020-12-03 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
JP7535537B2
(ja)
*
|
2019-05-31 |
2024-08-16 |
フォチョン・バイオサイエンシーズ・リミテッド |
タンパク質キナーゼ阻害剤としての置換ピロロ[2,3-b]ピリジン及びピラゾロ[3,4-b]ピリジン誘導体
|
|
JP7629442B2
(ja)
|
2019-07-29 |
2025-02-13 |
ヘパリジェニックス ゲーエムベーハー |
肝臓再生を促進または肝細胞死を縮減もしくは防止するためのヘテロアリール置換ピラゾロ-ピリジンタンパク質キナーゼ阻害剤
|
|
EP4013750A1
(en)
|
2019-08-14 |
2022-06-22 |
Incyte Corporation |
Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
US20220347182A1
(en)
*
|
2019-10-02 |
2022-11-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for the treatment of osteoarthritis
|
|
GEAP202516803A
(en)
|
2019-10-11 |
2025-10-10 |
Incyte Corp |
Bicyclic amines as cdk2 inhibitors
|
|
CN111004210A
(zh)
*
|
2019-10-23 |
2020-04-14 |
中山大学 |
化合物单晶及其制备方法
|
|
US20230101747A1
(en)
|
2019-12-06 |
2023-03-30 |
Schrödinger, Inc. |
Cyclic compounds and methods of using same
|
|
WO2021113625A1
(en)
|
2019-12-06 |
2021-06-10 |
Plexxikon Inc. |
Compounds and methods for cd73 modulation and indications therefor
|
|
CN115175901B
(zh)
|
2019-12-19 |
2024-03-22 |
阿尔维纳斯运营股份有限公司 |
用于雄激素受体的靶向降解的化合物和方法
|
|
BR112022012684A2
(pt)
|
2019-12-27 |
2023-03-07 |
Schroedinger Inc |
Compostos cíclicos e métodos de uso dos mesmos
|
|
AU2021205893A1
(en)
|
2020-01-08 |
2022-06-23 |
Synthis Therapeutics, Inc. |
ALK5 inhibitor conjugates and uses thereof
|
|
AU2021207236A1
(en)
*
|
2020-01-15 |
2022-08-11 |
Heparegenix Gmbh |
3-benzoyl-1h-pyrrolo[2,3-b]pyridine derivatives as MKK4 inhibitors for treating liver diseases
|
|
CN114981241B
(zh)
*
|
2020-01-17 |
2024-11-19 |
大邱庆北尖端医疗产业振兴财团 |
新型化合物及其制备方法和用途
|
|
WO2021152005A1
(en)
|
2020-01-28 |
2021-08-05 |
Universite De Strasbourg |
Antisense oligonucleotide targeting linc00518 for treating melanoma
|
|
EP4135700A4
(en)
*
|
2020-04-15 |
2024-04-17 |
Pyramid Biosciences, Inc. |
PROCESSES FOR PREPARING RECEPTOR TYROSINE KINASE INHIBITORS
|
|
CA3177522A1
(en)
|
2020-04-23 |
2021-10-28 |
Opna Immuno-Oncology Sa |
Compounds and methods for cd73 modulation and indications therefor
|
|
CA3176237A1
(en)
|
2020-04-29 |
2021-11-04 |
Jack Lin |
Synthesis of heterocyclic compounds
|
|
KR102841083B1
(ko)
*
|
2020-05-04 |
2025-07-31 |
아주대학교산학협력단 |
톨-유사 수용체 7/9 억제 기능이 있는 길항성 소분자 화합물
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
US11529335B2
(en)
|
2020-07-31 |
2022-12-20 |
University Of Iowa Research Foundation |
Compositions and methods for treating cancer
|
|
CN116322690A
(zh)
|
2020-08-21 |
2023-06-23 |
奥普纳生物有限公司 |
组合的药物抗癌疗法
|
|
JP2023539663A
(ja)
|
2020-08-28 |
2023-09-15 |
アルビナス・オペレーションズ・インコーポレイテッド |
急速進行性線維肉腫タンパク質分解化合物及び関連する使用方法
|
|
US20230365584A1
(en)
|
2020-09-10 |
2023-11-16 |
Schrödinger, Inc. |
Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer
|
|
US20240360154A1
(en)
*
|
2020-09-23 |
2024-10-31 |
Genfleet Therapeutics (Shanghai) Inc. |
Aroyl substituted tricyclic compound, preparation method therefor and use thereof
|
|
CN114478528A
(zh)
*
|
2020-10-28 |
2022-05-13 |
劲方医药科技(上海)有限公司 |
芳甲酰取代的三环化合物及其制法和用途
|
|
MX2023005761A
(es)
*
|
2020-11-17 |
2023-05-29 |
Fochon Biosciences Ltd |
Pirrolo [2,3-b] piridina sustituida y derivados de pirazolo [3,4-b] piridina como inhibidores de proteinas quinasas.
|
|
WO2022121900A1
(zh)
*
|
2020-12-07 |
2022-06-16 |
南京明德新药研发有限公司 |
吡咯并吡啶类化合物及其应用
|
|
EP4255420A1
(en)
*
|
2020-12-07 |
2023-10-11 |
Lieber Institute, Inc. |
Compounds for inhibiting inositol hexakisphosphate kinase (ip6k) and methods of use thereof
|
|
JP2024500919A
(ja)
|
2020-12-23 |
2024-01-10 |
ジェンザイム・コーポレーション |
重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤
|
|
EP4284804A1
(en)
|
2021-01-26 |
2023-12-06 |
Schrödinger, Inc. |
Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
|
|
CN112574200B
(zh)
*
|
2021-02-26 |
2021-06-11 |
安润医药科技(苏州)有限公司 |
Btk和/或btk的突变体c481s的小分子抑制剂
|
|
CN115073469B
(zh)
*
|
2021-03-15 |
2023-12-22 |
药雅科技(上海)有限公司 |
吡咯并嘧啶类化合物作为激酶抑制剂的制备及其应用
|
|
CN117321418A
(zh)
|
2021-03-18 |
2023-12-29 |
诺华股份有限公司 |
癌症生物标志物及其使用方法
|
|
TW202300150A
(zh)
|
2021-03-18 |
2023-01-01 |
美商薛定諤公司 |
環狀化合物及其使用方法
|
|
TW202304890A
(zh)
*
|
2021-04-14 |
2023-02-01 |
美商百歐克斯製藥公司 |
Klk5雙環雜芳香族抑制劑
|
|
US12371667B2
(en)
|
2021-05-13 |
2025-07-29 |
Washington University |
Enhanced methods for inducing and maintaining naive human pluripotent stem cells
|
|
KR102635126B1
(ko)
|
2021-05-27 |
2024-02-13 |
한국과학기술연구원 |
엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
WO2023059786A1
(en)
*
|
2021-10-06 |
2023-04-13 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Inhibitors of ulk1 and methods of use
|
|
CN118591373A
(zh)
|
2021-11-23 |
2024-09-03 |
恩福莱克逊治疗有限公司 |
吡咯并吡啶-苯胺化合物的制剂
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
CN116768896A
(zh)
*
|
2022-03-15 |
2023-09-19 |
劲方医药科技(上海)有限公司 |
Btk抑制剂的晶型及其酸式盐和其酸式盐的晶型
|
|
US20250186439A1
(en)
*
|
2022-03-16 |
2025-06-12 |
The Children's Medical Center Corporation |
Pyk2 inhibition modulates immune cell function
|
|
WO2023191425A1
(ko)
*
|
2022-03-28 |
2023-10-05 |
주식회사 비엔에이치리서치 |
약물의 전기생리학적 스크리닝 방법
|
|
WO2024003350A1
(en)
|
2022-06-30 |
2024-01-04 |
Universite De Strasbourg |
Combination therapy for melanoma
|
|
CN115141197B
(zh)
*
|
2022-07-27 |
2024-03-26 |
安徽医科大学 |
一种3-芳杂环取代苯基衍生物及其制备方法与用途
|
|
WO2024033381A1
(en)
|
2022-08-10 |
2024-02-15 |
Vib Vzw |
Inhibition of tcf4/itf2 in the treatment of cancer
|
|
US11957759B1
(en)
|
2022-09-07 |
2024-04-16 |
Arvinas Operations, Inc. |
Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use
|
|
EP4624576A1
(en)
*
|
2022-11-25 |
2025-10-01 |
Xenolis Pte. Ltd. |
Nucleic acid aptamer
|
|
CN116768886B
(zh)
*
|
2022-12-26 |
2025-09-16 |
安徽医科大学 |
N-(4-(1H-吡咯并[2,3-b]吡啶-5-基)苯基)酰胺衍生物及制备与用途
|
|
CN115991705B
(zh)
*
|
2022-12-26 |
2025-04-08 |
安徽医科大学 |
3-(1H吡咯并[2,3-b]吡啶-5-基)苯甲酰基衍生物及其制备与应用
|
|
WO2024209717A1
(ja)
|
2023-04-06 |
2024-10-10 |
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|
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