MX2009006315A - Compuesto heterociclico fusionado. - Google Patents
Compuesto heterociclico fusionado.Info
- Publication number
- MX2009006315A MX2009006315A MX2009006315A MX2009006315A MX2009006315A MX 2009006315 A MX2009006315 A MX 2009006315A MX 2009006315 A MX2009006315 A MX 2009006315A MX 2009006315 A MX2009006315 A MX 2009006315A MX 2009006315 A MX2009006315 A MX 2009006315A
- Authority
- MX
- Mexico
- Prior art keywords
- optionally substituted
- ring
- atom
- bonded
- heterocyclic compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se describe un compuesto heterocíclico fusionado que tiene actividad inhibidora de quinasa de tirosina. La fórmula (I) en la fórmula, R1 representa un átomo de hidrógeno, un átomo de halógeno, o un grupo opcionalmente sustituido el cual es unido a través de un átomo de carbono, un átomo de nitrógeno o un átomo de oxígeno, R2 representa un átomo de hidrógeno o un grupo opcionalmente sustituido el cual está unido a través de un átomo de carbono o un átomo de azufre, o como alternativa R1 y R2 o R2 y R3 son unidos respectivamente juntos para formar una estructura de anillo opcionalmente sustituido; R3 representa un átomo de hidrógeno o un grupo hidrocarburo alifático opcionalmente sustituido o alternativamente R2 está unido con un átomo de carbono del anillo A para formar una estructura de anillo opcionalmente sustituido; y el anillo A representa un anillo de benceno opcionalmente sustituido; y el anillo B representa (i) un anillo fusionado, o (u) un anillo de piridina que tiene un carbamoilo opcionalmente sustituido (en donde el anillo de piridina puede ser substituido en forma adicional).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006335158 | 2006-12-12 | ||
PCT/JP2007/073879 WO2008072634A1 (ja) | 2006-12-12 | 2007-12-11 | 縮合複素環化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009006315A true MX2009006315A (es) | 2009-10-13 |
Family
ID=39511655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009006315A MX2009006315A (es) | 2006-12-12 | 2007-12-11 | Compuesto heterociclico fusionado. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20100004238A1 (es) |
EP (1) | EP2103620A1 (es) |
JP (1) | JPWO2008072634A1 (es) |
KR (1) | KR20090090336A (es) |
CN (1) | CN101611041A (es) |
AR (1) | AR066962A1 (es) |
BR (1) | BRPI0720169A2 (es) |
CA (1) | CA2673097A1 (es) |
MX (1) | MX2009006315A (es) |
PE (1) | PE20091243A1 (es) |
RU (1) | RU2009126576A (es) |
TW (1) | TW200925160A (es) |
WO (1) | WO2008072634A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2009113560A1 (ja) * | 2008-03-12 | 2011-07-21 | 武田薬品工業株式会社 | 縮合複素環化合物 |
RU2712220C2 (ru) * | 2013-07-31 | 2020-01-27 | Мерк Патент Гмбх | Пиридины, пиримидины и пиразины в качестве ингибиторов тирозинкиназы брутона и их применение |
TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
ES2654931T3 (es) * | 2013-12-26 | 2018-02-15 | Ignyta, Inc. | Derivados de pirazolo[1,5-a]piridina y procedimientos de uso de los mismos |
CN104876941B (zh) * | 2014-02-28 | 2019-02-01 | 南京汇诚制药有限公司 | 稠合三环类化合物及其应用 |
CN105085489B (zh) | 2014-11-05 | 2019-03-01 | 益方生物科技(上海)有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
CN105924389A (zh) * | 2015-12-18 | 2016-09-07 | 重庆两江药物研发中心有限公司 | 瑞戈非尼中间体的制备方法 |
CN105837453A (zh) * | 2016-03-31 | 2016-08-10 | 常州大学 | 一种3,5-二氯-4’-硝基二苯醚的合成方法 |
WO2019214651A1 (zh) * | 2018-05-08 | 2019-11-14 | 南京明德新药研发有限公司 | 作为选择性HER2抑制剂的吡咯并[2,1-f][1,2,4]三嗪类衍生物及其应用 |
RS65413B1 (sr) * | 2018-09-18 | 2024-05-31 | Hoffmann La Roche | Derivati hinazolina kao antitumorski agensi |
WO2021088987A1 (zh) * | 2019-11-08 | 2021-05-14 | 南京明德新药研发有限公司 | 作为选择性her2抑制剂的盐型、晶型及其应用 |
KR20220110524A (ko) * | 2019-12-04 | 2022-08-08 | 아르커스 바이오사이언시즈 인코포레이티드 | Hif-2알파의 억제제 |
CN114671867B (zh) * | 2022-03-15 | 2023-09-19 | 上海法默生物科技有限公司 | 妥卡替尼中间体7-羟基-[1,2,4]三唑并[1,5-a]吡啶的制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
CA2223081C (en) | 1995-06-07 | 2001-03-06 | Pfizer Inc. | Heterocyclic ring-fused pyrimidine derivatives |
US6395733B1 (en) * | 1995-06-07 | 2002-05-28 | Pfizer Inc | Heterocyclic ring-fused pyrimidine derivatives |
AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
TR199900048T2 (xx) | 1996-07-13 | 1999-04-21 | Glaxo Group Limited | Protein tirozin kinaz inhibit�rleri olarak bisiklik heteroaromatik bile�ikler |
DE69730607T2 (de) | 1996-07-19 | 2005-01-27 | Takeda Chemical Industries, Ltd. | Fas ligand ähnliches protein, seine herstellung und verwendung |
CN1237177A (zh) | 1996-11-27 | 1999-12-01 | 辉瑞大药厂 | 稠合的二环嘧啶衍生物 |
UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
PE20011178A1 (es) | 2000-04-07 | 2001-11-19 | Takeda Chemical Industries Ltd | Compuestos heterociclicos y su produccion |
NZ522568A (en) | 2000-06-22 | 2004-12-24 | Pfizer Prod Inc | Substituted bicyclic derivatives for the treatment of abnormal cell growth |
CN1211382C (zh) | 2000-06-30 | 2005-07-20 | 葛兰素集团有限公司 | 喹唑啉二甲苯磺酸盐化合物 |
US6984653B2 (en) * | 2001-10-05 | 2006-01-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof |
JP4202926B2 (ja) | 2001-12-12 | 2008-12-24 | ファイザー・プロダクツ・インク | E−2−メトキシ−n−(3−(4−(3−メチル−ピリジン−3−イロキシ)−フェニルアミノ)−キナゾリン−6−イル)−アリル)−アセトアミドの塩形態、その製造および癌に対するその使用 |
AU2002339687A1 (en) | 2001-12-12 | 2003-06-23 | Pfizer Products Inc. | Quinazoline derivatives for the treatement of abnormal cell growth |
AU2002357193A1 (en) | 2001-12-19 | 2003-07-09 | Smithkline Beecham Corporation | Thienopyrimidine compounds as protein tyrosine kinase inhibitors |
ATE478872T1 (de) | 2002-03-28 | 2010-09-15 | Ustav Ex Botan Av Cr V V I I O | Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung |
MEP8409A (en) | 2004-06-02 | 2011-12-20 | Fused heterocyclic compound | |
TW200730527A (en) * | 2005-12-02 | 2007-08-16 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
-
2007
- 2007-12-11 JP JP2008549322A patent/JPWO2008072634A1/ja not_active Withdrawn
- 2007-12-11 MX MX2009006315A patent/MX2009006315A/es unknown
- 2007-12-11 EP EP07859772A patent/EP2103620A1/en not_active Withdrawn
- 2007-12-11 RU RU2009126576/04A patent/RU2009126576A/ru not_active Application Discontinuation
- 2007-12-11 KR KR1020097012130A patent/KR20090090336A/ko not_active Application Discontinuation
- 2007-12-11 US US12/518,596 patent/US20100004238A1/en not_active Abandoned
- 2007-12-11 CN CNA2007800512370A patent/CN101611041A/zh active Pending
- 2007-12-11 WO PCT/JP2007/073879 patent/WO2008072634A1/ja active Application Filing
- 2007-12-11 CA CA002673097A patent/CA2673097A1/en not_active Abandoned
- 2007-12-11 BR BRPI0720169-9A2A patent/BRPI0720169A2/pt not_active Application Discontinuation
-
2008
- 2008-06-11 PE PE2008000999A patent/PE20091243A1/es not_active Application Discontinuation
- 2008-06-11 TW TW097121661A patent/TW200925160A/zh unknown
- 2008-06-11 AR ARP080102486A patent/AR066962A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0720169A2 (pt) | 2013-12-24 |
TW200925160A (en) | 2009-06-16 |
US20100004238A1 (en) | 2010-01-07 |
CA2673097A1 (en) | 2008-06-19 |
PE20091243A1 (es) | 2009-09-07 |
AR066962A1 (es) | 2009-09-23 |
EP2103620A1 (en) | 2009-09-23 |
KR20090090336A (ko) | 2009-08-25 |
JPWO2008072634A1 (ja) | 2010-04-02 |
CN101611041A (zh) | 2009-12-23 |
RU2009126576A (ru) | 2011-01-20 |
WO2008072634A1 (ja) | 2008-06-19 |
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