DE69420394T2 - Pyrrolopyridinderivate als dopaminrezeptor liganden - Google Patents

Pyrrolopyridinderivate als dopaminrezeptor liganden

Info

Publication number
DE69420394T2
DE69420394T2 DE69420394T DE69420394T DE69420394T2 DE 69420394 T2 DE69420394 T2 DE 69420394T2 DE 69420394 T DE69420394 T DE 69420394T DE 69420394 T DE69420394 T DE 69420394T DE 69420394 T2 DE69420394 T2 DE 69420394T2
Authority
DE
Germany
Prior art keywords
pct
dopamine receptor
image
receptor ligands
pyrrolopyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69420394T
Other languages
English (en)
Other versions
DE69420394D1 (de
Inventor
Raymond Baker
Neil CURTIS
Janusz Kulagowski
Paul Leeson
Adrian Smith
Mark Ridgill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304110A external-priority patent/GB9304110D0/en
Priority claimed from GB939316260A external-priority patent/GB9316260D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Priority claimed from PCT/GB1994/000384 external-priority patent/WO1994020459A2/en
Publication of DE69420394D1 publication Critical patent/DE69420394D1/de
Application granted granted Critical
Publication of DE69420394T2 publication Critical patent/DE69420394T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DE69420394T 1993-03-01 1994-02-25 Pyrrolopyridinderivate als dopaminrezeptor liganden Expired - Fee Related DE69420394T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939304110A GB9304110D0 (en) 1993-03-01 1993-03-01 Therapeutic agents
GB939316260A GB9316260D0 (en) 1993-08-05 1993-08-05 Therapeutic agents
PCT/GB1994/000384 WO1994020459A2 (en) 1993-03-01 1994-02-25 Pyrrolo-pyridine derivatives as dopamine receptor ligands

Publications (2)

Publication Number Publication Date
DE69420394D1 DE69420394D1 (de) 1999-10-07
DE69420394T2 true DE69420394T2 (de) 2000-04-13

Family

ID=26302518

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69420394T Expired - Fee Related DE69420394T2 (de) 1993-03-01 1994-02-25 Pyrrolopyridinderivate als dopaminrezeptor liganden

Country Status (4)

Country Link
US (1) US5700809A (de)
AT (1) ATE184008T1 (de)
DE (1) DE69420394T2 (de)
ES (1) ES2134929T3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9605065D0 (en) * 1996-03-11 1996-05-08 Merck Sharp & Dohme Therapeutic agents
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
EP1696920B8 (de) * 2003-12-19 2015-05-06 Plexxikon Inc. Verbindungen und verfahren zur entwicklung von ret-modulatoren
US20060058339A1 (en) * 2004-06-17 2006-03-16 Ibrahim Prabha N Compounds modulating c-kit activity and uses therefor
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
DE102004060659A1 (de) * 2004-12-15 2006-07-06 Lanxess Deutschland Gmbh Neue substituierte 1H-Pyrrolo[2,3-b]pyridine und deren Herstellung
KR20080027775A (ko) * 2005-05-17 2008-03-28 플렉시콘, 인코퍼레이티드 피롤(２,３-ｂ)피리딘 유도체 단백질 키나제 억제제
MX2007015287A (es) * 2005-06-09 2008-02-22 Mallinckrodt Inc Metodo para separacion y purificacion de naltrexona por cromatografia de preparacion.
CN102603581B (zh) 2005-06-22 2015-06-24 普莱希科公司 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008080001A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CR20170089A (es) 2009-04-03 2017-07-17 Plexxikon Inc Composiciones del acido propano-1--sulfonico {3-[5-(4-cloro-fenil)-1h-pirrolo [2,3-b] piridina-3-carbonil] -2,4-difluoro-fenil}-amida y el uso de las mismas
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
NZ599866A (en) 2009-11-06 2014-09-26 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
MA34948B1 (fr) 2011-02-07 2014-03-01 Plexxikon Inc Composes et procedes de modulation de kinase, et leurs indications
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
JP2023507185A (ja) * 2019-12-18 2023-02-21 シーエイチディーアイ ファウンデーション，インコーポレーテッド ハンチンチンタンパク質をイメージングするための化合物及びプローブ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2044254B (en) * 1979-01-26 1983-01-26 Wyeth John & Brother Ltd Piperidine derivatives
US5124335A (en) * 1991-01-30 1992-06-23 Merck & Co., Inc. Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists
HUT71799A (en) * 1993-03-01 1996-02-28 Merck Sharp & Dohme Pyrrolo-pyridine derivatives, pharmaceutical compositions containing the same, process for producing them
US5622950A (en) * 1993-03-01 1997-04-22 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
US5576319A (en) * 1993-03-01 1996-11-19 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
DE69515177T2 (de) * 1994-08-10 2000-10-05 Merck Sharp & Dohme Tetrahydropyridinylmethylderivate von pyrrolo[2,3-b]pyridine
GB9416162D0 (en) * 1994-08-10 1994-09-28 Merck Sharp & Dohme Therapeutic agents
GB9416189D0 (en) * 1994-08-10 1994-09-28 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
DE69420394D1 (de) 1999-10-07
ATE184008T1 (de) 1999-09-15
US5700809A (en) 1997-12-23
ES2134929T3 (es) 1999-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee