ES2145289T3 - Derivados tetrahidropiridinilmetilo de pirrolo(2,3-b)piridina. - Google Patents

Derivados tetrahidropiridinilmetilo de pirrolo(2,3-b)piridina.

Info

Publication number
ES2145289T3
ES2145289T3 ES95927817T ES95927817T ES2145289T3 ES 2145289 T3 ES2145289 T3 ES 2145289T3 ES 95927817 T ES95927817 T ES 95927817T ES 95927817 T ES95927817 T ES 95927817T ES 2145289 T3 ES2145289 T3 ES 2145289T3
Authority
ES
Spain
Prior art keywords
pct
image
derivatives
tetrahidropiridinilmetilo
piridina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95927817T
Other languages
English (en)
Inventor
Neil Roy Curtis
Janusz Jozef Kulagowski
Paul David Leeson
Mark Peter Ridgill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9416161A external-priority patent/GB9416161D0/en
Priority claimed from GB9416160A external-priority patent/GB9416160D0/en
Priority claimed from GBGB9505888.9A external-priority patent/GB9505888D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2145289T3 publication Critical patent/ES2145289T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UNA CLASE DE DERIVADOS DE PIRROLO-[2,3-B]PIRIDINA DE FORMULA (I), DONDE Q REPRESENTA UNA FRACCION DE FORMULA Q{SUB,A} O Q{SUB,B}, QUE SON LIGANDOS DE SUBTIPOS DE RECEPTORES DE DOPAMINA DEL CUERPO HUMANO, ESPECIALMENTE DEL RECEPTOR D{SUB,4} DOPAMINERGICO, Y QUE SON UTILES POR TANTO EN EL TRATAMIENTO Y/O PREVENCION DE ALTERACIONES DEL SISTEMA DOPAMINICO, INCLUYENDO LA ESQUIZOFRENIA.
ES95927817T 1994-08-10 1995-08-01 Derivados tetrahidropiridinilmetilo de pirrolo(2,3-b)piridina. Expired - Lifetime ES2145289T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9416161A GB9416161D0 (en) 1994-08-10 1994-08-10 Therapeutic agents
GB9416160A GB9416160D0 (en) 1994-08-10 1994-08-10 Therapeutic agents
GBGB9505888.9A GB9505888D0 (en) 1995-03-23 1995-03-23 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2145289T3 true ES2145289T3 (es) 2000-07-01

Family

ID=27267327

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95927817T Expired - Lifetime ES2145289T3 (es) 1994-08-10 1995-08-01 Derivados tetrahidropiridinilmetilo de pirrolo(2,3-b)piridina.

Country Status (8)

Country Link
US (1) US5830901A (es)
EP (1) EP0775138B1 (es)
JP (1) JP3911012B2 (es)
AT (1) ATE189895T1 (es)
AU (1) AU699196B2 (es)
DE (1) DE69515177T2 (es)
ES (1) ES2145289T3 (es)
WO (1) WO1996005200A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700809A (en) * 1993-03-01 1997-12-23 Merck Sharp & Dohme, Ltd. Pyrrolo-pyridine derivatives
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
US20060263359A1 (en) * 2003-03-18 2006-11-23 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with dopamine receptor d4 (drd4)
PL1696920T3 (pl) 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508318D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2010114928A2 (en) 2009-04-03 2010-10-07 F.Hoffmann-La Roche Ag Compositions and uses thereof
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2044254B (en) * 1979-01-26 1983-01-26 Wyeth John & Brother Ltd Piperidine derivatives
CA2156410A1 (en) * 1993-03-01 1994-09-15 Raymond Baker Pyrrolo-pyridine derivatives
GB9416162D0 (en) * 1994-08-10 1994-09-28 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
AU699196B2 (en) 1998-11-26
ATE189895T1 (de) 2000-03-15
AU3182595A (en) 1996-03-07
JP3911012B2 (ja) 2007-05-09
DE69515177D1 (de) 2000-03-30
EP0775138B1 (en) 2000-02-23
EP0775138A1 (en) 1997-05-28
JPH10503774A (ja) 1998-04-07
US5830901A (en) 1998-11-03
WO1996005200A1 (en) 1996-02-22
DE69515177T2 (de) 2000-10-05

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