CA2195759A1 - Tetrahydropyridinylmethyl derivatives of pyrrolo[2,3-b]pyridine - Google Patents
Tetrahydropyridinylmethyl derivatives of pyrrolo[2,3-b]pyridineInfo
- Publication number
- CA2195759A1 CA2195759A1 CA002195759A CA2195759A CA2195759A1 CA 2195759 A1 CA2195759 A1 CA 2195759A1 CA 002195759 A CA002195759 A CA 002195759A CA 2195759 A CA2195759 A CA 2195759A CA 2195759 A1 CA2195759 A1 CA 2195759A1
- Authority
- CA
- Canada
- Prior art keywords
- pyrrolo
- pyridine
- derivatives
- tetrahydropyridinylmethyl
- dopamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Tetrahydropyridinylmethyl derivatives of pyrrolo[2,3-b]pyridine Chemical class 0.000 title 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical class C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 abstract 1
- 102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Abstract
A class of pyrrolo[2,3-b]pyridine derivatives of formula (I), wherein Q
represents a moiety of formula Qa or Qb, are ligands for dopamine receptor subtypes within the body, in particular the dopamine D4 receptor subtype and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, including schizophrenia.
represents a moiety of formula Qa or Qb, are ligands for dopamine receptor subtypes within the body, in particular the dopamine D4 receptor subtype and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, including schizophrenia.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9416160A GB9416160D0 (en) | 1994-08-10 | 1994-08-10 | Therapeutic agents |
GB9416161A GB9416161D0 (en) | 1994-08-10 | 1994-08-10 | Therapeutic agents |
GB9505888.9 | 1995-03-23 | ||
GBGB9505888.9A GB9505888D0 (en) | 1995-03-23 | 1995-03-23 | Therapeutic agents |
GB9416161.9 | 1995-03-23 | ||
GB9416160.1 | 1995-03-23 | ||
PCT/GB1995/001820 WO1996005200A1 (en) | 1994-08-10 | 1995-08-01 | TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO[2,3-b]PYRIDINE |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2195759A1 true CA2195759A1 (en) | 1996-02-22 |
CA2195759C CA2195759C (en) | 2006-04-11 |
Family
ID=36178102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002195759A Expired - Fee Related CA2195759C (en) | 1994-08-10 | 1995-08-01 | Tetrahydropyridinylmethyl derivatives of pyrrolo[2,3-b]pyridine |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2195759C (en) |
-
1995
- 1995-08-01 CA CA002195759A patent/CA2195759C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2195759C (en) | 2006-04-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1994020459A3 (en) | Pyrrolo-pyridine derivatives as dopamine receptor ligands | |
ZA200201511B (en) | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents. | |
MXPA02001497A (en) | 3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents. | |
PL347505A1 (en) | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | |
WO2000053610A3 (en) | 4-OXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS | |
CA2263561A1 (en) | Thienopyrimidines | |
CA2411008A1 (en) | Derivatives of 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione | |
AU7855191A (en) | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents | |
AU3182595A (en) | Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-b pyridine | |
AU5604594A (en) | Water soluble camptothecin derivatives | |
CA2384037A1 (en) | Pyrazolo[4,3-d]pyrimidines | |
IL104706A0 (en) | 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidine-4-ones and process for the preparation thereof | |
CA2014771A1 (en) | 5,11-dihydro-6h-dipyrido[3,2-b:2'3'-e][1,4]diazepin-6-ones and their use in the prevention or treatment of aids | |
AU2253297A (en) | Imidazo{1,2-a}pyridine c-nucleosides as antiviral agents | |
CA2168193A1 (en) | Aryalkyl-thiadiazinones | |
CA2412594A1 (en) | Pyrazino[1',2':1,6]pyrido[3-4-5] indole derivatives | |
AU5604094A (en) | Substituted-phenyl(n,n'-cycloalkyl/alkyl carboxamide)-1h/3h-imidazo{4,5-b}pyridine compounds as paf antagonists | |
HUT69738A (en) | Substituted pyridylsalicylaldehyde-and salicyklicacid derivatives, process for their preparation und their use as herbicide | |
EP0556671A3 (en) | Triazolopyridine derivatives, process for their preparation and their use as microbicides | |
CA2195759A1 (en) | Tetrahydropyridinylmethyl derivatives of pyrrolo[2,3-b]pyridine | |
GB9726130D0 (en) | 2,2'-BI-1H-pyrrole derivatives useful in the treatment of leukemia brought on by HTLV-I | |
AU3264393A (en) | 2-isocephem and oxacephem derivatives, processes for their preparation, intermediates thereof and use as antibacterial agents | |
WO1997013776A3 (en) | Novel amine derivatives of epipodophyllotoxin 2', 3'-dideoxyglycosides, preparation method therefor and use thereof as a drug and for treating cancer | |
FI914923A (en) | PROCEDURE FOR FRAMSTAELLNING AV 5,11-DIHYDRO-6H-DIPYRIDO- / 3,2-B: 2 ', 3'-E // 1,4 / DIAZEPINER. KNIPPE. | |
AU5464994A (en) | Antihypertensive 5-{(imidazo{4,5-b}pyridin-3-yl)methyl}benzofuran derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |