ES2121193T3 - Derivados de bencimidazoles. - Google Patents

Derivados de bencimidazoles.

Info

Publication number
ES2121193T3
ES2121193T3 ES94909233T ES94909233T ES2121193T3 ES 2121193 T3 ES2121193 T3 ES 2121193T3 ES 94909233 T ES94909233 T ES 94909233T ES 94909233 T ES94909233 T ES 94909233T ES 2121193 T3 ES2121193 T3 ES 2121193T3
Authority
ES
Spain
Prior art keywords
pct
date sep
sec
bencimidazoles
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909233T
Other languages
English (en)
Inventor
Janusz Jozef Kulagowski
Paul David Leeson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939305628A external-priority patent/GB9305628D0/en
Priority claimed from GB939316258A external-priority patent/GB9316258D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2121193T3 publication Critical patent/ES2121193T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

SE PRESENTAN CLASES DE COMPUESTOS QUIMICOS QUE COMPRENDEN UNA MOLECULA DE BENCIMIDAZOLA Y UNA MOLECULA HETEROCICLICA SUSTITUIDA, UNIDA POR MEDIO DE LA POSICION 3 DE LA MOLECULA DE BENCIMIDAZOLA POR UN GRUPO DE METILENO, LOS COMPUESTOS SON LIGANTES PARA LOS SUBTIPOS DE RECEPTORES DE LA DOPAMINA DENTRO DEL CUERPO Y POR LO TANTO SON UTILES PARA EL TRATAMIENTO Y/O LA PREVENCION DE ENFERMEDADES DEL SISTEMA DE LA DOPAMINA, EN PARTICULAR LA ESQUIZOFRENIA.
ES94909233T 1993-03-18 1994-03-16 Derivados de bencimidazoles. Expired - Lifetime ES2121193T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939305628A GB9305628D0 (en) 1993-03-18 1993-03-18 Therapeutic agents
GB939316258A GB9316258D0 (en) 1993-08-05 1993-08-05 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2121193T3 true ES2121193T3 (es) 1998-11-16

Family

ID=26302612

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909233T Expired - Lifetime ES2121193T3 (es) 1993-03-18 1994-03-16 Derivados de bencimidazoles.

Country Status (9)

Country Link
US (1) US5714498A (es)
EP (1) EP0689535B1 (es)
JP (1) JPH08508030A (es)
AT (1) ATE171447T1 (es)
AU (1) AU679045B2 (es)
CA (1) CA2156836A1 (es)
DE (1) DE69413523T2 (es)
ES (1) ES2121193T3 (es)
WO (1) WO1994021615A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9604036D0 (en) * 1996-02-26 1996-04-24 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
GB9605065D0 (en) * 1996-03-11 1996-05-08 Merck Sharp & Dohme Therapeutic agents
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
DK1065205T3 (da) 1998-03-18 2003-06-23 Taisho Pharmaceutical Co Ltd Heteroaromatiske derivater
EP1070715A4 (en) 1998-03-19 2002-10-17 Nihon Nohyaku Co Ltd ARYLPIPERIDINE AND THEIR USE
US6867209B1 (en) 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US6448257B1 (en) 1998-05-22 2002-09-10 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6340685B1 (en) 1998-05-22 2002-01-22 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6589954B1 (en) * 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6130235A (en) * 1998-05-22 2000-10-10 Scios Inc. Compounds and methods to treat cardiac failure and other disorders
IL146309A (en) 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
JP2003512422A (ja) * 1999-10-29 2003-04-02 メルク シャープ エンド ドーム リミテッド ベンズイミダゾールｎｍｄａ／ｎｒ２ｂアンタゴニストを使用する疼痛の治療方法
US6291499B1 (en) * 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6432976B1 (en) * 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6476041B1 (en) * 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6316474B1 (en) * 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US7842068B2 (en) * 2000-12-07 2010-11-30 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US6806275B2 (en) 2000-09-13 2004-10-19 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
EP1379520B2 (en) 2001-02-23 2014-04-09 Merck Sharp & Dohme Corp. N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
US7022728B2 (en) * 2001-03-09 2006-04-04 Abbott Laboratories Benzimidazoles that are useful in treating male sexual dysfunction
US6960589B2 (en) * 2001-03-09 2005-11-01 Abbott Laboratories Benzimidazoles that are useful in treating sexual dysfunction
AU2002338334B8 (en) 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
US20040127504A1 (en) * 2002-09-06 2004-07-01 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US7592360B2 (en) 2003-06-04 2009-09-22 Merck & Co., Inc. 3-fluoro-piperidines as NMDA/NR2B antagonists
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508318D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508319D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
TWI707683B (zh) 2018-06-13 2020-10-21 美商輝瑞股份有限公司 Ｇｌｐ－１受體促效劑及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1417745A (en) * 1973-07-07 1975-12-17 Beecham Group Ltd Chromene compounds
EP0034249B1 (en) * 1980-02-08 1984-10-24 Gruppo Lepetit S.P.A. New naphthimidazole and naphthoxazole derivatives, their preparation, and their use in pharmaceuticals
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
JP2643168B2 (ja) * 1987-08-24 1997-08-20 エーザイ株式会社 不整脈治療・予防剤
CA2022451C (en) * 1989-08-03 2001-01-23 Albert Anthony Carr Anti-psychotic piperidynl benzimidazole compounds
US5169855A (en) * 1990-03-28 1992-12-08 Du Pont Merck Pharmaceutical Company Piperidine ether derivatives as psychotropic drugs or plant fungicides

Also Published As

Publication number Publication date
DE69413523D1 (de) 1998-10-29
US5714498A (en) 1998-02-03
AU679045B2 (en) 1997-06-19
ATE171447T1 (de) 1998-10-15
EP0689535B1 (en) 1998-09-23
JPH08508030A (ja) 1996-08-27
AU6215694A (en) 1994-10-11
EP0689535A1 (en) 1996-01-03
CA2156836A1 (en) 1994-09-29
DE69413523T2 (de) 1999-05-12
WO1994021615A1 (en) 1994-09-29

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