DE69407191D1 - Kondensierte tricyclische heteroaromatische verbindungen als dopamin-rezeptor-subtyp-liganden - Google Patents
Kondensierte tricyclische heteroaromatische verbindungen als dopamin-rezeptor-subtyp-ligandenInfo
- Publication number
- DE69407191D1 DE69407191D1 DE69407191T DE69407191T DE69407191D1 DE 69407191 D1 DE69407191 D1 DE 69407191D1 DE 69407191 T DE69407191 T DE 69407191T DE 69407191 T DE69407191 T DE 69407191T DE 69407191 D1 DE69407191 D1 DE 69407191D1
- Authority
- DE
- Germany
- Prior art keywords
- dopamine receptor
- heteroaromatic compounds
- pct
- receptor subtype
- tricyclic heteroaromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000015554 Dopamine receptor Human genes 0.000 title abstract 2
- 108050004812 Dopamine receptor Proteins 0.000 title abstract 2
- 150000002390 heteroarenes Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939318691A GB9318691D0 (en) | 1993-09-09 | 1993-09-09 | Therapeutic agents |
| PCT/GB1994/001935 WO1995007262A1 (en) | 1993-09-09 | 1994-09-06 | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69407191D1 true DE69407191D1 (de) | 1998-01-15 |
| DE69407191T2 DE69407191T2 (de) | 1998-07-02 |
Family
ID=10741750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69407191T Expired - Fee Related DE69407191T2 (de) | 1993-09-09 | 1994-09-06 | Kondensierte tricyclische heteroaromatische verbindungen als dopamin-rezeptor-subtyp-liganden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5686480A (de) |
| EP (1) | EP0717733B1 (de) |
| JP (1) | JPH09502199A (de) |
| AT (1) | ATE160773T1 (de) |
| AU (1) | AU684304B2 (de) |
| CA (1) | CA2168738A1 (de) |
| DE (1) | DE69407191T2 (de) |
| ES (1) | ES2110256T3 (de) |
| GB (1) | GB9318691D0 (de) |
| WO (1) | WO1995007262A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19519056A1 (de) * | 1995-05-24 | 1997-01-16 | Klinge Co Chem Pharm Fab | Verwendung von Antidepressiva zur Behandlung von Asthma und/oder Atemwegserkrankungen mittels inhalatorischer Applikation |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| WO2000012500A2 (en) * | 1998-09-02 | 2000-03-09 | Neurogen Corporation | 2-aryl-4-(1-[4-heteroaryl]piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands |
| US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
| US6462036B1 (en) * | 1998-11-06 | 2002-10-08 | Basf Aktiengesellschaft | Tricyclic pyrazole derivatives |
| US6956052B2 (en) * | 2001-09-19 | 2005-10-18 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
| AR040967A1 (es) * | 2002-08-12 | 2005-04-27 | Janssen Pharmaceutica Nv | Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos |
| ATE387455T1 (de) | 2002-08-21 | 2008-03-15 | Janssen Pharmaceutica Nv | C6- und c9-substituierte chromeno(4,3- c)isoxazoline und ihre verwendung als anti- depressiva |
| PL2089367T3 (pl) | 2006-10-31 | 2012-04-30 | Pfizer Prod Inc | Związki pirazolinowe jako antagoniści receptora mineralokortykoidowego |
| MX2009012117A (es) * | 2007-05-09 | 2009-11-23 | Pfizer | Composiciones y derivados heterociclicos sustituidos y su uso farmaceutico como antibacterianos. |
| WO2010049366A1 (en) * | 2008-10-27 | 2010-05-06 | Glaxo Group Limited | Tricyclic compounds as glutamate receptor modulators |
| DE102010055499A1 (de) * | 2010-12-22 | 2011-06-16 | W.C. Heraeus Gmbh | Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3553230A (en) * | 1967-09-26 | 1971-01-05 | Colgate Palmolive Co | 3-aminoalkyl and 3-amino derivatives of 4h(1)benzopyrano(3,4-d)isoxazoles |
| US3969527A (en) * | 1975-07-28 | 1976-07-13 | E. R. Squibb & Sons, Inc. | CNS active compounds |
| ATE126512T1 (de) * | 1989-05-19 | 1995-09-15 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. |
| WO1994010162A1 (en) * | 1992-10-23 | 1994-05-11 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
-
1993
- 1993-09-09 GB GB939318691A patent/GB9318691D0/en active Pending
-
1994
- 1994-09-06 AT AT94925560T patent/ATE160773T1/de not_active IP Right Cessation
- 1994-09-06 DE DE69407191T patent/DE69407191T2/de not_active Expired - Fee Related
- 1994-09-06 AU AU75425/94A patent/AU684304B2/en not_active Ceased
- 1994-09-06 ES ES94925560T patent/ES2110256T3/es not_active Expired - Lifetime
- 1994-09-06 WO PCT/GB1994/001935 patent/WO1995007262A1/en active IP Right Grant
- 1994-09-06 JP JP7508528A patent/JPH09502199A/ja active Pending
- 1994-09-06 EP EP94925560A patent/EP0717733B1/de not_active Expired - Lifetime
- 1994-09-06 CA CA002168738A patent/CA2168738A1/en not_active Abandoned
- 1994-09-06 US US08/605,096 patent/US5686480A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU684304B2 (en) | 1997-12-11 |
| ATE160773T1 (de) | 1997-12-15 |
| US5686480A (en) | 1997-11-11 |
| CA2168738A1 (en) | 1995-03-16 |
| DE69407191T2 (de) | 1998-07-02 |
| EP0717733B1 (de) | 1997-12-03 |
| ES2110256T3 (es) | 1998-02-01 |
| GB9318691D0 (en) | 1993-10-27 |
| EP0717733A1 (de) | 1996-06-26 |
| WO1995007262A1 (en) | 1995-03-16 |
| JPH09502199A (ja) | 1997-03-04 |
| AU7542594A (en) | 1995-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |