ATE126512T1 - N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. - Google Patents

N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Info

Publication number
ATE126512T1
ATE126512T1 AT90109208T AT90109208T ATE126512T1 AT E126512 T1 ATE126512 T1 AT E126512T1 AT 90109208 T AT90109208 T AT 90109208T AT 90109208 T AT90109208 T AT 90109208T AT E126512 T1 ATE126512 T1 AT E126512T1
Authority
AT
Austria
Prior art keywords
lower alkyl
alkyl
chem
alkoxy
hydrogen
Prior art date
Application number
AT90109208T
Other languages
English (en)
Inventor
Joseph T Strupczewski
Grover C Helsley
Yulin Chiang
Kenneth J Bordeau
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE126512T1 publication Critical patent/ATE126512T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
AT90109208T 1989-05-19 1990-05-16 N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. ATE126512T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35441189A 1989-05-19 1989-05-19
US45679089A 1989-12-29 1989-12-29

Publications (1)

Publication Number Publication Date
ATE126512T1 true ATE126512T1 (de) 1995-09-15

Family

ID=26998389

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90109208T ATE126512T1 (de) 1989-05-19 1990-05-16 N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.

Country Status (24)

Country Link
EP (1) EP0402644B1 (de)
JP (1) JPH0662580B2 (de)
KR (1) KR0157308B1 (de)
CN (2) CN1086387C (de)
AT (1) ATE126512T1 (de)
AU (1) AU640653B2 (de)
CA (1) CA2017193C (de)
CZ (1) CZ282385B6 (de)
DD (1) DD300433A5 (de)
DE (1) DE69021645T2 (de)
DK (1) DK0402644T3 (de)
ES (1) ES2076253T3 (de)
FI (2) FI104072B1 (de)
GR (1) GR3017447T3 (de)
HK (2) HK1006710A1 (de)
HU (2) HU218200B (de)
IE (1) IE68431B1 (de)
IL (1) IL94425A (de)
NO (1) NO177301C (de)
NZ (1) NZ233710A (de)
PL (1) PL163965B1 (de)
PT (1) PT94084B (de)
RU (3) RU2062776C1 (de)
SK (1) SK242590A3 (de)

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US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
TW241263B (de) * 1991-08-22 1995-02-21 Hoechst Roussel Pharma
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
AU672182B2 (en) * 1991-11-27 1996-09-26 Novo Nordisk A/S Piperidine derivatives and their use in treating psychosis
AU3170793A (en) * 1991-12-25 1993-07-28 Zeria Pharmaceutical Co., Ltd. Tricyclic compound and medicine containing the same
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
JPH08502508A (ja) * 1992-10-23 1996-03-19 メルク シヤープ エンド ドーム リミテツド ドーパミンレセプターサブタイプリガンド
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
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US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
NZ307958A (en) * 1995-06-06 1999-02-25 Hoechst Marion Roussel Inc Benzisoxazole and indazole derivatives as long acting antipsychotic agents and particularly in the treatment of schizophrenia
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
WO1997025317A1 (en) * 1996-01-05 1997-07-17 Hoechst Marion Roussel, Inc. 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
WO2001017993A1 (en) * 1999-09-09 2001-03-15 EGIS Gyógyszergyár Rt. Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
AU2006201188B2 (en) * 2001-02-05 2007-11-15 Novartis Ag New use of iloperidone
JP2005504783A (ja) * 2001-08-31 2005-02-17 ノバルティス アクチエンゲゼルシャフト イロペリドン代謝産物の光学異性体
JP5067998B2 (ja) 2001-10-30 2012-11-07 ノバルティス アーゲー イロペリドンおよび星形ポリマーのデポー製剤
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
WO2004026864A1 (en) * 2002-09-17 2004-04-01 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
CA2505397A1 (en) * 2002-11-08 2004-05-21 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
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JP2010519171A (ja) 2006-02-17 2010-06-03 メモリー・ファーマシューティカルズ・コーポレイション ５−ｈｔ６受容体親和性を有する化合物
EP2567696A1 (de) 2006-11-22 2013-03-13 Seaside Therapeutics, Inc. Zubereitungen zur Behandlung von Störungen des Autismusspektrums
US8198305B2 (en) 2007-04-13 2012-06-12 Concert Pharmaceuticals Inc. 1,2-benzisoxazol-3-yl compounds
CN101824030B (zh) * 2009-03-04 2014-06-18 北京德众万全药物技术开发有限公司 一种伊潘立酮的制备方法
DK2445502T4 (da) 2009-06-25 2022-11-28 Alkermes Pharma Ireland Ltd Heterocycliske forbindelser til behandling af neurologiske og psykologiske lidelser
CN102395582A (zh) * 2009-09-19 2012-03-28 浙江华海药业股份有限公司 伊潘立酮的一种制备方法及结晶方法
CN102030744B (zh) * 2009-09-30 2013-04-17 天津药物研究院 伊潘立酮晶体、其制备方法及药物组合物
US20120220776A1 (en) * 2009-11-19 2012-08-30 Symed Labs Limited Process for the preparation of iloperidone using a novel intermediate
WO2011154860A1 (en) * 2010-06-08 2011-12-15 Alembic Pharmaceuticals Limited An improved process for preparing iloperidone
CN102311430A (zh) * 2010-06-29 2012-01-11 大道隆达（北京）医药科技发展有限公司 伊潘立酮的新晶态及其制备方法
ITMI20101294A1 (it) * 2010-07-14 2012-01-15 Dipharma Francis Srl Procedimento per la preparazione di iloperidone
WO2012032532A1 (en) * 2010-09-07 2012-03-15 Symed Labs Limited "processes for the preparation of 4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone and intermediates thereof"
WO2012063269A2 (en) 2010-11-12 2012-05-18 Cadila Healthcare Limited Process for preparing iloperidone
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Also Published As

Publication number Publication date
NZ233710A (en) 1992-05-26
NO902214L (no) 1990-11-20
AU5577090A (en) 1990-11-22
HK1038316A1 (en) 2002-03-15
DD300433A5 (de) 1992-06-11
HUT58720A (en) 1992-03-30
HU903090D0 (en) 1990-09-28
SK279474B6 (sk) 1998-11-04
PT94084A (pt) 1991-01-08
GR3017447T3 (en) 1995-12-31
FI902449A0 (fi) 1990-05-17
HU218200B (hu) 2000-06-28
PL285247A1 (en) 1991-02-11
CN1048037A (zh) 1990-12-26
CZ242590A3 (en) 1997-03-12
NO902214D0 (no) 1990-05-18
CA2017193C (en) 2000-06-27
CN1223348C (zh) 2005-10-19
HU211853A9 (en) 1995-12-28
AU640653B2 (en) 1993-09-02
IE68431B1 (en) 1996-06-12
DK0402644T3 (da) 1996-01-02
CN1086387C (zh) 2002-06-19
RU2239434C2 (ru) 2004-11-10
FI19991869A (fi) 1999-09-02
RU2062776C1 (ru) 1996-06-27
EP0402644A1 (de) 1990-12-19
KR900018070A (ko) 1990-12-20
IE901809L (en) 1990-11-19
EP0402644B1 (de) 1995-08-16
IL94425A0 (en) 1991-03-10
DE69021645T2 (de) 1996-02-22
HK1006710A1 (en) 1999-03-12
JPH0662580B2 (ja) 1994-08-17
NO177301C (no) 1995-08-23
PT94084B (pt) 1996-12-31
KR0157308B1 (ko) 1998-11-16
RU2147583C1 (ru) 2000-04-20
JPH0363263A (ja) 1991-03-19
CN1305812A (zh) 2001-08-01
DE69021645D1 (de) 1995-09-21
IL94425A (en) 1994-02-27
FI104072B (fi) 1999-11-15
NO177301B (no) 1995-05-15
CZ282385B6 (cs) 1997-07-16
ES2076253T3 (es) 1995-11-01
SK242590A3 (en) 1998-11-04
FI104072B1 (fi) 1999-11-15
PL163965B1 (pl) 1994-05-31
CA2017193A1 (en) 1990-11-19

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Legal Events

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UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time