FI902449A0 - N-(aryloxialkyl) heteroarylpiperidiner och -heteroarylpiperaziner, foerfarande foer deras framstaellning cch deras anvaendning som laekemedel. - Google Patents

N-(aryloxialkyl) heteroarylpiperidiner och -heteroarylpiperaziner, foerfarande foer deras framstaellning cch deras anvaendning som laekemedel.

Info

Publication number
FI902449A0
FI902449A0 FI902449A FI902449A FI902449A0 FI 902449 A0 FI902449 A0 FI 902449A0 FI 902449 A FI902449 A FI 902449A FI 902449 A FI902449 A FI 902449A FI 902449 A0 FI902449 A0 FI 902449A0
Authority
FI
Finland
Prior art keywords
lower alkyl
deras
alkyl
chem
alkoxy
Prior art date
Application number
FI902449A
Other languages
English (en)
Other versions
FI104072B (fi
FI104072B1 (fi
Inventor
Joseph T Strupczewski
Grover C Helsley
Yulin Chiang
Kenneth J Bordeau
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI902449A0 publication Critical patent/FI902449A0/fi
Application granted granted Critical
Publication of FI104072B publication Critical patent/FI104072B/fi
Publication of FI104072B1 publication Critical patent/FI104072B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
FI902449A 1989-05-19 1990-05-17 Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryylipiperidiinien ja -heteroaryylipiperatsiinien valmistamiseksi FI104072B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35441189A 1989-05-19 1989-05-19
US35441189 1989-05-19
US45679089A 1989-12-29 1989-12-29
US45679089 1989-12-29

Publications (3)

Publication Number Publication Date
FI902449A0 true FI902449A0 (fi) 1990-05-17
FI104072B FI104072B (fi) 1999-11-15
FI104072B1 FI104072B1 (fi) 1999-11-15

Family

ID=26998389

Family Applications (2)

Application Number Title Priority Date Filing Date
FI902449A FI104072B1 (fi) 1989-05-19 1990-05-17 Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryylipiperidiinien ja -heteroaryylipiperatsiinien valmistamiseksi
FI991869A FI19991869A (fi) 1989-05-19 1999-09-02 N-(aryylioksialkyyli)heteroaryylipiperidiinejä ja -heteroaryylipiperatsiineja ja niiden käyttö lääkkeinä

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI991869A FI19991869A (fi) 1989-05-19 1999-09-02 N-(aryylioksialkyyli)heteroaryylipiperidiinejä ja -heteroaryylipiperatsiineja ja niiden käyttö lääkkeinä

Country Status (24)

Country Link
EP (1) EP0402644B1 (fi)
JP (1) JPH0662580B2 (fi)
KR (1) KR0157308B1 (fi)
CN (2) CN1086387C (fi)
AT (1) ATE126512T1 (fi)
AU (1) AU640653B2 (fi)
CA (1) CA2017193C (fi)
CZ (1) CZ282385B6 (fi)
DD (1) DD300433A5 (fi)
DE (1) DE69021645T2 (fi)
DK (1) DK0402644T3 (fi)
ES (1) ES2076253T3 (fi)
FI (2) FI104072B1 (fi)
GR (1) GR3017447T3 (fi)
HK (2) HK1006710A1 (fi)
HU (2) HU218200B (fi)
IE (1) IE68431B1 (fi)
IL (1) IL94425A (fi)
NO (1) NO177301C (fi)
NZ (1) NZ233710A (fi)
PL (1) PL163965B1 (fi)
PT (1) PT94084B (fi)
RU (3) RU2062776C1 (fi)
SK (1) SK242590A3 (fi)

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US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
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US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
TW241263B (fi) * 1991-08-22 1995-02-21 Hoechst Roussel Pharma
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
AU672182B2 (en) * 1991-11-27 1996-09-26 Novo Nordisk A/S Piperidine derivatives and their use in treating psychosis
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
AU3170793A (en) * 1991-12-25 1993-07-28 Zeria Pharmaceutical Co., Ltd. Tricyclic compound and medicine containing the same
US5631269A (en) * 1992-10-23 1997-05-20 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
US5670522A (en) * 1992-10-23 1997-09-23 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
GB9318691D0 (en) * 1993-09-09 1993-10-27 Merck Sharp & Dohme Therapeutic agents
CA2168739A1 (en) * 1993-09-15 1995-03-23 William Barnaby Davey Fused tricyclic heteroaromatic derivatives
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2101646B1 (es) * 1995-04-12 1998-04-01 Ferrer Int Nuevo compuesto derivado del cromeno.
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
ATE199147T1 (de) * 1995-06-06 2001-02-15 Aventis Pharma Inc Benzisoxazol- und indazol- derivate als antipsychotika
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
WO1997025317A1 (en) * 1996-01-05 1997-07-17 Hoechst Marion Roussel, Inc. 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
WO2001017993A1 (en) * 1999-09-09 2001-03-15 EGIS Gyógyszergyár Rt. Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
AU2006201188B2 (en) * 2001-02-05 2007-11-15 Novartis Ag New use of iloperidone
JP2005504783A (ja) * 2001-08-31 2005-02-17 ノバルティス アクチエンゲゼルシャフト イロペリドン代謝産物の光学異性体
EP1441727B1 (en) 2001-10-30 2010-12-29 Novartis AG Depot formulations of iloperidone and a star polymer
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
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JP2006503106A (ja) * 2002-09-17 2006-01-26 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 統合失調症を処置するためのヘテロ環式置換ピペラジン
BR0316108A (pt) * 2002-11-08 2005-09-27 Warner Lambert Co Derivados de fenilalquil e piridilalquil piperazina e composição farmacêutica compreendendo os mesmos
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
GB0322994D0 (en) * 2003-10-01 2003-11-05 Novartis Ag Organic compounds
US7696229B2 (en) 2006-02-17 2010-04-13 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
CA2670116C (en) 2006-11-22 2015-03-10 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism
WO2008128166A1 (en) * 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds
CN101824030B (zh) * 2009-03-04 2014-06-18 北京德众万全药物技术开发有限公司 一种伊潘立酮的制备方法
LT2445502T (lt) 2009-06-25 2017-09-25 Alkermes Pharma Ireland Limited Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
EP2479176B1 (en) * 2009-09-19 2014-09-17 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for preparation of iloperidone and crystallization method thereof
CN102030744B (zh) * 2009-09-30 2013-04-17 天津药物研究院 伊潘立酮晶体、其制备方法及药物组合物
US20120220776A1 (en) * 2009-11-19 2012-08-30 Symed Labs Limited Process for the preparation of iloperidone using a novel intermediate
WO2011154860A1 (en) * 2010-06-08 2011-12-15 Alembic Pharmaceuticals Limited An improved process for preparing iloperidone
CN102311430A (zh) * 2010-06-29 2012-01-11 大道隆达（北京）医药科技发展有限公司 伊潘立酮的新晶态及其制备方法
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WO2012032532A1 (en) * 2010-09-07 2012-03-15 Symed Labs Limited "processes for the preparation of 4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone and intermediates thereof"
WO2012063269A2 (en) 2010-11-12 2012-05-18 Cadila Healthcare Limited Process for preparing iloperidone
WO2012068161A1 (en) 2010-11-15 2012-05-24 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
WO2012123963A2 (en) 2011-02-24 2012-09-20 Megafine Pharma (P) Ltd. A process for preparation of iloperidone and amorphous co- precipitate of iloperidone with pharmaceutically acceptable excipient
WO2012153341A1 (en) 2011-05-12 2012-11-15 Arch Pharmalabs Limited A process for the preparation of iloperidone and pharmaceutically acceptable salts thereof
WO2012164516A1 (en) 2011-06-03 2012-12-06 Lupin Limited Process for the preparation of iloperidone
ITMI20120511A1 (it) * 2012-03-29 2013-09-30 Procos Spa Processo one-pot per la sintesi di iloperidone
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN108026107B (zh) 2015-06-19 2021-07-30 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
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Also Published As

Publication number Publication date
NO902214L (no) 1990-11-20
FI104072B (fi) 1999-11-15
KR900018070A (ko) 1990-12-20
HUT58720A (en) 1992-03-30
PT94084A (pt) 1991-01-08
SK279474B6 (sk) 1998-11-04
IE68431B1 (en) 1996-06-12
IL94425A (en) 1994-02-27
AU640653B2 (en) 1993-09-02
CN1305812A (zh) 2001-08-01
RU2147583C1 (ru) 2000-04-20
CN1086387C (zh) 2002-06-19
DE69021645D1 (de) 1995-09-21
HU218200B (hu) 2000-06-28
HK1006710A1 (en) 1999-03-12
CA2017193A1 (en) 1990-11-19
CZ242590A3 (en) 1997-03-12
PT94084B (pt) 1996-12-31
CZ282385B6 (cs) 1997-07-16
RU2239434C2 (ru) 2004-11-10
IE901809L (en) 1990-11-19
HU211853A9 (en) 1995-12-28
PL163965B1 (pl) 1994-05-31
JPH0363263A (ja) 1991-03-19
FI19991869A (fi) 1999-09-02
CN1048037A (zh) 1990-12-26
ATE126512T1 (de) 1995-09-15
EP0402644A1 (en) 1990-12-19
EP0402644B1 (en) 1995-08-16
HU903090D0 (en) 1990-09-28
NO177301C (no) 1995-08-23
CN1223348C (zh) 2005-10-19
DD300433A5 (de) 1992-06-11
NO177301B (no) 1995-05-15
ES2076253T3 (es) 1995-11-01
JPH0662580B2 (ja) 1994-08-17
DE69021645T2 (de) 1996-02-22
FI104072B1 (fi) 1999-11-15
CA2017193C (en) 2000-06-27
HK1038316A1 (en) 2002-03-15
SK242590A3 (en) 1998-11-04
GR3017447T3 (en) 1995-12-31
PL285247A1 (en) 1991-02-11
NZ233710A (en) 1992-05-26
IL94425A0 (en) 1991-03-10
RU2062776C1 (ru) 1996-06-27
KR0157308B1 (ko) 1998-11-16
AU5577090A (en) 1990-11-22
NO902214D0 (no) 1990-05-18
DK0402644T3 (da) 1996-01-02

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.

FG Patent granted

Owner name: HOECHST MARION ROUSSEL INC., INC.

PC Transfer of assignment of patent

Owner name: AVENTIS PHARMACEUTICALS INC.