DK0402644T3 - N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter - Google Patents

N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter

Info

Publication number
DK0402644T3
DK0402644T3 DK90109208.0T DK90109208T DK0402644T3 DK 0402644 T3 DK0402644 T3 DK 0402644T3 DK 90109208 T DK90109208 T DK 90109208T DK 0402644 T3 DK0402644 T3 DK 0402644T3
Authority
DK
Denmark
Prior art keywords
lower alkyl
alkyl
heteroaryl
chem
alkoxy
Prior art date
Application number
DK90109208.0T
Other languages
Danish (da)
English (en)
Inventor
Joseph T Strupczewski
Grover C Helsley
Yulin Chiang
Kenneth J Bordeau
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of DK0402644T3 publication Critical patent/DK0402644T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK90109208.0T 1989-05-19 1990-05-16 N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter DK0402644T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35441189A 1989-05-19 1989-05-19
US45679089A 1989-12-29 1989-12-29

Publications (1)

Publication Number Publication Date
DK0402644T3 true DK0402644T3 (da) 1996-01-02

Family

ID=26998389

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90109208.0T DK0402644T3 (da) 1989-05-19 1990-05-16 N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter

Country Status (24)

Country Link
EP (1) EP0402644B1 (fi)
JP (1) JPH0662580B2 (fi)
KR (1) KR0157308B1 (fi)
CN (2) CN1086387C (fi)
AT (1) ATE126512T1 (fi)
AU (1) AU640653B2 (fi)
CA (1) CA2017193C (fi)
CZ (1) CZ282385B6 (fi)
DD (1) DD300433A5 (fi)
DE (1) DE69021645T2 (fi)
DK (1) DK0402644T3 (fi)
ES (1) ES2076253T3 (fi)
FI (2) FI104072B1 (fi)
GR (1) GR3017447T3 (fi)
HK (2) HK1006710A1 (fi)
HU (2) HU218200B (fi)
IE (1) IE68431B1 (fi)
IL (1) IL94425A (fi)
NO (1) NO177301C (fi)
NZ (1) NZ233710A (fi)
PL (1) PL163965B1 (fi)
PT (1) PT94084B (fi)
RU (3) RU2147583C1 (fi)
SK (1) SK242590A3 (fi)

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US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
TW241263B (fi) * 1991-08-22 1995-02-21 Hoechst Roussel Pharma
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
WO1993010742A2 (en) * 1991-11-27 1993-06-10 Novo Nordisk A/S Chemical compounds, their preparation and use
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
AU3170793A (en) * 1991-12-25 1993-07-28 Zeria Pharmaceutical Co., Ltd. Tricyclic compound and medicine containing the same
WO1994010162A1 (en) * 1992-10-23 1994-05-11 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
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DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
GB9318691D0 (en) * 1993-09-09 1993-10-27 Merck Sharp & Dohme Therapeutic agents
WO1995007893A1 (en) * 1993-09-15 1995-03-23 Merck Sharp & Dohme Limited Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2101646B1 (es) * 1995-04-12 1998-04-01 Ferrer Int Nuevo compuesto derivado del cromeno.
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
PT833820E (pt) * 1995-06-06 2001-07-31 Aventis Pharmaceuticals Inc Av Derivados de benzisoxazol e indazol uteis como agentes antipsicoticos
KR100308748B1 (ko) * 1996-01-05 2001-12-12 게리 디. 스트리트, 스티븐 엘. 네스비트 Cns활성을갖는4,5-디히드로나프트(1,2-c)이속사졸및그의유도체
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
WO2001017993A1 (en) * 1999-09-09 2001-03-15 EGIS Gyógyszergyár Rt. Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
AU2006201188B2 (en) * 2001-02-05 2007-11-15 Novartis Ag New use of iloperidone
DK1425272T3 (da) * 2001-08-31 2011-11-21 Novartis Ag Optiske isomerer af en iloperidon-metabolit
CN101912367A (zh) * 2001-10-30 2010-12-15 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
AU2003263413A1 (en) * 2002-09-17 2004-04-08 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
CA2505397A1 (en) * 2002-11-08 2004-05-21 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
GB0322994D0 (en) * 2003-10-01 2003-11-05 Novartis Ag Organic compounds
US7696229B2 (en) 2006-02-17 2010-04-13 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
HUE032743T2 (en) 2006-11-22 2017-10-30 Clinical Res Ass Llc A method for treating Down syndrome, fragilis X syndrome and autism
WO2008128166A1 (en) * 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds
CN101824030B (zh) * 2009-03-04 2014-06-18 北京德众万全药物技术开发有限公司 一种伊潘立酮的制备方法
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
US8802855B2 (en) 2009-09-19 2014-08-12 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for preparation of iloperidone and crystallization method thereof
CN102030744B (zh) * 2009-09-30 2013-04-17 天津药物研究院 伊潘立酮晶体、其制备方法及药物组合物
WO2011061750A2 (en) * 2009-11-19 2011-05-26 Symed Labs Limited Process for the preparation of iloperidone using a novel intermediate
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Also Published As

Publication number Publication date
KR0157308B1 (ko) 1998-11-16
IE901809L (en) 1990-11-19
IE68431B1 (en) 1996-06-12
NO902214L (no) 1990-11-20
HU211853A9 (en) 1995-12-28
FI902449A0 (fi) 1990-05-17
GR3017447T3 (en) 1995-12-31
HUT58720A (en) 1992-03-30
DE69021645T2 (de) 1996-02-22
PT94084B (pt) 1996-12-31
IL94425A (en) 1994-02-27
AU5577090A (en) 1990-11-22
FI19991869A (fi) 1999-09-02
ATE126512T1 (de) 1995-09-15
CN1305812A (zh) 2001-08-01
CA2017193A1 (en) 1990-11-19
AU640653B2 (en) 1993-09-02
NO177301B (no) 1995-05-15
DD300433A5 (de) 1992-06-11
KR900018070A (ko) 1990-12-20
DE69021645D1 (de) 1995-09-21
NO177301C (no) 1995-08-23
ES2076253T3 (es) 1995-11-01
HK1038316A1 (en) 2002-03-15
RU2147583C1 (ru) 2000-04-20
CZ282385B6 (cs) 1997-07-16
FI104072B (fi) 1999-11-15
CA2017193C (en) 2000-06-27
CN1048037A (zh) 1990-12-26
HU903090D0 (en) 1990-09-28
PL163965B1 (pl) 1994-05-31
EP0402644B1 (en) 1995-08-16
NO902214D0 (no) 1990-05-18
JPH0363263A (ja) 1991-03-19
JPH0662580B2 (ja) 1994-08-17
RU2062776C1 (ru) 1996-06-27
NZ233710A (en) 1992-05-26
CN1223348C (zh) 2005-10-19
CZ242590A3 (en) 1997-03-12
SK279474B6 (sk) 1998-11-04
PL285247A1 (en) 1991-02-11
FI104072B1 (fi) 1999-11-15
HU218200B (hu) 2000-06-28
HK1006710A1 (en) 1999-03-12
CN1086387C (zh) 2002-06-19
RU2239434C2 (ru) 2004-11-10
SK242590A3 (en) 1998-11-04
IL94425A0 (en) 1991-03-10
PT94084A (pt) 1991-01-08
EP0402644A1 (en) 1990-12-19

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