KR900018070A - N-(아릴옥시알킬)헤테로아릴피페리딘 및 -헤테로아릴피페라진, 이의 제조방법 및 약제로서의 이의 용도 - Google Patents

N-(아릴옥시알킬)헤테로아릴피페리딘 및 -헤테로아릴피페라진, 이의 제조방법 및 약제로서의 이의 용도 Download PDF

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KR900018070A
KR900018070A KR1019900007102A KR900007102A KR900018070A KR 900018070 A KR900018070 A KR 900018070A KR 1019900007102 A KR1019900007102 A KR 1019900007102A KR 900007102 A KR900007102 A KR 900007102A KR 900018070 A KR900018070 A KR 900018070A
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alkyl
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hydrogen
alkoxy
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토마스 스트루프쎄프스키 죠셉
클리블랜드 헤슬리 그로버
치앙 율린
제이. 보르도 케네스
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원본미기재
훼스트-러셀 파마슈티칼즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

내용 없음

Description

N-(아릴옥시알킬)헤테로아릴피페리딘 및 -헤테로아릴피페라진, 이의 제조방법 및 약제로서의 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (19)

  1. 일반식(Ⅰ)의 화합물 또는 약제학적으로 허용되는 이의 산 부가염.
  3. 상기식에서, X는 -O-, -S-, -NH- 또는이고, P는 1 또는 2이며, Y는 P가 1인 경우 수소, C1-C6-알킬, -OH, C1, F, Br, I, C1-C6-알콕시, -CF3, -NO2또는 -NH2이고, P가 2이고 X가 -O-인 경우, 저급 알콕시이며, R2는 저급 알킬, 아릴저급 알킬, 아릴, 사이클로알킬, 아로일, 알카노일 및 페닐설포닐 그룹으로 이루어진 그룹 중에서 선택되고, Z는또는이며, n은 2,3,4 또는 5이고, R은 수소, 알킬, C1-C6-알콕시, 하이드록실, 카복실, CI, F, Br, I, 아미노, C1-C6모노 또는 디알킬 아미노, -NO2, 저급알킬티오, -OCF3, 시아노, 아실아미노, -CF3, 트리플루오로아세틸, 아미노 카보닐,알킬,O-알킬,아릴,헤테로 아릴 또는알킬 [여기서, 알킬은 저급 알킬이고, 아릴은 페닐 또는 일반식의 그룹(여기서, R1은 수소, 저급 알킬, C1-C6-알콕시, 하이드록시, CI, F, Br, I, C1-C6알킬 아미노, -NO2, -CN, -CF3또는 -OCF3이다)이며, 헤테로아릴은 일반식의 그룹(여기서, Q는 -O-, -S-,또는 -CH=N 이다)이고, R3은 수소, 저급 알킬 또는 아실이다]이며, m은 1.2 또는 3이다.
  4. 제1항에 있어서, X는 -O-, -S- 또는 -NH인 화합물.
  5. 제2항에 있어서, n은 2,3 또느 ㄴ4이고 Y는 수소이거나 6위치에서 염소 또는 불소이며 p는 1인 화합물.
  6. 제3항에 있어서, R은 수소, 알킬, C1-C6-알콕시, C1-C6-알킬티오, 할로겐, C1-C6-알킬아미노,알킬,페닐 또는 -CH(OR3)-C1-C6-알킬이고 m은 2 또는 3인 화합물.
  7. 제3항에 있어서, n은 3 또는 4이고, m은 2이며 R은 -OCH3또는인 화합물.
  8. 제1항에 있어서, 1-[4-[3-[4-(1H-인다졸-3-일)-1-피페라지닐]프로폭시]-3-메톡시페닐]에탄온 또는 약제학적으로 허용되는 이의 산 부가염.
  9. 제1항에 있어서, 1-[4-[3-[4-(1,2-베느이속사졸-3-일)-1-피페라디닐]프로폭시]-3-메톡시페닐]에탄온 또는 약제학적으로 허용되는 이의 산 부가염.
  10. 제1항에 있어서, 1-[4-[3-[4-(6-플루오로-1,2-벤즈이속사졸-3-일)-1-피페라지닐]프로폭시]-3-메톡시페닐]에탈온 또는 약제학적으로 허용되는 이의 산 부가염.
  11. 제1항에있어서,1-[4-[4-[4-(1,2-벤즈이속사졸-3-일)-1-피페라지닐]부록시]-3-메톡시페닐]에탈온 또는 약제학적으로 허용되는 이의 산 부가염.
  12. 제1항에 있어서, 1-[4-[4-[4-(6-플루오로-1,2-벤즈이속사졸-3-일)-1-피페라지닐]부록시]-3-메톡시페닐]에탈온 또는 약제학적으로 허용되는 이의 산 부가염.
  13. 활성성분으로 제1항에서 청구한 화합물과 이에 적합한 담체를 포함하는 약제학적 조성물.
  14. 정신병 치료 활성 및/또는 진통 활성이 있는 약제를 제조하기 위한, 제1항에서 청구한 화합물의 용도.
  15. a)일반식(Ⅱ)의 화합물을 알킬화 조건하에 일반식(Ⅲ)의 화합물과 반응시키고, b)임의로 R이-C6-알킬인 일반식(Ⅰ)의 화합물을 환원시켜 R이 CH2(OH)-C1-C6-알킬인 일반식(Ⅰ)의 화합물을 수득하고, c)임의로 R이 -CH(OR3)-C1-C6-알킬이고, R3은 수소인 일반식(Ⅰ)의 화합물을 알카노산 무수물과 반응시켜 R이 C1-C6-알카노일인 일반식(Ⅰ)의 화합물을 수득하고, d)임의로 R이 하이드록시인 일반식(Ⅰ)의 화합물을 우선 강염기와 반응시키고, 이어서 일반식 Hal-C1-C6알킬의 화합물(여기서, Hal은 염소 또는 브롬이다)과 반응시켜 R이 C1-C6-알콕시인 일반식(Ⅰ)의 화합물을 수득하고, e)임의로 X가 N-R2이고, R2는 수소인 일반식(Ⅰ)의 화합물을 C1-C6-알카노일 또는 아로일 할라이드와 반응시켜 X가 NR2이고 R2는 C1-C6-알카노일 또는 아로일인 일반식(Ⅰ)의 화합물을 수득함을 특징으로 하여, 제1항에서 청구한 화합물을 제조하는 방법.
  17. 상기식에서, X,Y,X,R,m,n 및 p는 제1항에서 정의한 바와 같고, Hal은 염소 또는 브롬이다.
  18. 제13항에 있어서, 단계a)으 반응을 불활성 용매 중에서 50℃ 내지 용매의 환류온도에서 산 수용체의 존재하에 수행하는 방법.
  19. ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019900007102A 1989-05-19 1990-05-18 N-(아릴옥시알킬)헤테로아릴피페리딘 및 -헤테로아릴피페라진, 이의 제조방법 및 이를 함유하는 약제학적 조성물 KR0157308B1 (ko)

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US35441189A 1989-05-19 1989-05-19
US354411 1989-05-19
US354,411 1989-05-19
US45679089A 1989-12-29 1989-12-29
US456790 1989-12-29
US456,790 1989-12-29

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PL285247A1 (en) 1991-02-11
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IL94425A (en) 1994-02-27
NO177301C (no) 1995-08-23
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CN1305812A (zh) 2001-08-01
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HU218200B (hu) 2000-06-28
RU2239434C2 (ru) 2004-11-10
HK1006710A1 (en) 1999-03-12
CN1086387C (zh) 2002-06-19
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CZ282385B6 (cs) 1997-07-16
RU2062776C1 (ru) 1996-06-27
SK242590A3 (en) 1998-11-04
ES2076253T3 (es) 1995-11-01
IE901809L (en) 1990-11-19
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FI902449A0 (fi) 1990-05-17
HU211853A9 (en) 1995-12-28
DE69021645D1 (de) 1995-09-21
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CN1223348C (zh) 2005-10-19
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NZ233710A (en) 1992-05-26
IE68431B1 (en) 1996-06-12
PT94084B (pt) 1996-12-31
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FI104072B (fi) 1999-11-15
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HUT58720A (en) 1992-03-30
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