ES2109682T3 - Derivados antipsicoticos de imidazoles. - Google Patents

Derivados antipsicoticos de imidazoles.

Info

Publication number
ES2109682T3
ES2109682T3 ES94910462T ES94910462T ES2109682T3 ES 2109682 T3 ES2109682 T3 ES 2109682T3 ES 94910462 T ES94910462 T ES 94910462T ES 94910462 T ES94910462 T ES 94910462T ES 2109682 T3 ES2109682 T3 ES 2109682T3
Authority
ES
Spain
Prior art keywords
pct
sec
dopamine
substituted
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94910462T
Other languages
English (en)
Inventor
Janusz Jozef Kulagowski
Paul David Leeson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2109682T3 publication Critical patent/ES2109682T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

UNA CLASE DE DERIVADOS DE BENZIMIDAZOLES, SUSTITUIDOS EN LA POSICION 2 POR UNA UNIDAD DE PIPERAZINILMETILO O PIPERAZINILETILO SUSTITUIDA, QUE SON ANTAGONISTAS DE LOS SUBTIPOS DE RECEPTORES DE DOPAMINA QUE SE ENCUENTRAN DENTRO DEL CEREBRO, Y TIENEN UNA AFINIDAD SELECTIVA AL SUBTIPO DEL RECEPTOR DE DOPAMINA D{SUB,4} RESPECTO A OTROS SUBTIPOS DE RECEPTORES DE DOPAMINA, Y EN CONSECUENCIA SON UTILES PARA EL TRATAMIENTO Y/O PREVENCION DE TRASTORNOS PSICOTICOS TALES COMO LA ESQUIZOFRENIA AL TIEMPO QUE MANIFIESTAN MENOS EFECTOS SECUNDARIOS QUE LOS ASOCIADOS A LOS FARMACOS CLASICOS NEUROLEPTICOS.
ES94910462T 1993-03-30 1994-03-23 Derivados antipsicoticos de imidazoles. Expired - Lifetime ES2109682T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939306578A GB9306578D0 (en) 1993-03-30 1993-03-30 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2109682T3 true ES2109682T3 (es) 1998-01-16

Family

ID=10732977

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94910462T Expired - Lifetime ES2109682T3 (es) 1993-03-30 1994-03-23 Derivados antipsicoticos de imidazoles.

Country Status (10)

Country Link
US (1) US5792768A (es)
EP (1) EP0691960B1 (es)
JP (1) JPH08508289A (es)
AT (1) ATE160774T1 (es)
AU (1) AU679049B2 (es)
CA (1) CA2159220A1 (es)
DE (1) DE69407176T2 (es)
ES (1) ES2109682T3 (es)
GB (1) GB9306578D0 (es)
WO (1) WO1994022839A1 (es)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
US5712392A (en) 1990-12-28 1998-01-27 Neurogen Corporation Certain 4-piperidine- and piperazinoalkyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
CA2205998C (en) * 1994-11-23 2002-07-16 Neurogen Corporation Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
US5912246A (en) * 1995-02-15 1999-06-15 Pharmacia & Upjohn Company Imidazo 1,2-a!pyridines for the treatment of CNS and cardiac diseases
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
US5948912A (en) * 1995-02-15 1999-09-07 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
EP0809641A1 (en) * 1995-02-15 1997-12-03 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
DK0944616T3 (da) 1996-11-15 2003-09-29 Darwin Discovery Ltd Bicykliske arylcarboxamider og deres terapeutiske anvendelse
US6359882B1 (en) 1997-04-01 2002-03-19 Yipes Communications, Inc. Method and apparatus for transmitting data
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
CA2345944A1 (en) * 1998-09-30 2000-04-06 Neurogen Corporation 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
DE60009154D1 (de) * 1999-12-30 2004-04-22 Lundbeck & Co As H Phenylpiperazinyl-derivate
AU8066701A (en) * 2000-07-20 2002-02-05 Neurogen Corp Capsaicin receptor ligands
JP4183506B2 (ja) * 2000-10-31 2008-11-19 イクシス、プリント、ゾルツィオーンズ、ドイチュラント、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング 超分岐ポリウレタン
US6960589B2 (en) * 2001-03-09 2005-11-01 Abbott Laboratories Benzimidazoles that are useful in treating sexual dysfunction
KR100863147B1 (ko) * 2001-03-09 2008-10-13 아보트 러보러터리즈 벤즈이미다졸 및 이를 포함하는 성 기능장애 치료용 약제학적 조성물
US20020169166A1 (en) * 2001-03-09 2002-11-14 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US7022728B2 (en) * 2001-03-09 2006-04-04 Abbott Laboratories Benzimidazoles that are useful in treating male sexual dysfunction
US7160879B2 (en) * 2002-01-10 2007-01-09 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues
EP2033951A3 (en) * 2002-02-01 2009-12-23 Euro-Celtique S.A. 2-Piperazine-pyridines useful for treating pain
WO2003101994A1 (en) * 2002-05-29 2003-12-11 Abbott Laboratories Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
US7057042B2 (en) 2002-05-29 2006-06-06 Abbott Laboratories Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction
DK1556354T3 (da) * 2002-06-28 2008-06-02 Euro Celtique Sa Terapeutiske piperazinderivater, der er egnede til behandling af smerter
US7262194B2 (en) * 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US20040127504A1 (en) * 2002-09-06 2004-07-01 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
NZ555491A (en) * 2005-01-03 2010-01-29 Univ Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
US7946206B2 (en) * 2007-11-21 2011-05-24 Rocksmart, Llc Quick-release system
US10913736B2 (en) * 2014-08-22 2021-02-09 University Of Washington Specific inhibitors of methionyl-tRNA synthetase
WO2017207340A1 (de) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Neue substituierte benzimidazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
NZ219380A (en) * 1986-02-27 1990-06-26 Duphar Int Res (n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions
CA2022451C (en) * 1989-08-03 2001-01-23 Albert Anthony Carr Anti-psychotic piperidynl benzimidazole compounds
JPH03102485U (es) * 1990-02-08 1991-10-24
CZ224195A3 (en) * 1993-03-01 1996-03-13 Merck Sharp & Dohme The use of pyrrolopyridine derivatives for preparing pharmaceutical preparations

Also Published As

Publication number Publication date
US5792768A (en) 1998-08-11
EP0691960B1 (en) 1997-12-03
WO1994022839A1 (en) 1994-10-13
EP0691960A1 (en) 1996-01-17
CA2159220A1 (en) 1994-10-13
AU679049B2 (en) 1997-06-19
GB9306578D0 (en) 1993-05-26
AU6286994A (en) 1994-10-24
DE69407176D1 (de) 1998-01-15
ATE160774T1 (de) 1997-12-15
DE69407176T2 (de) 1998-07-02
JPH08508289A (ja) 1996-09-03

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