NO953406L - Pyrrolo-pyridinderivater - Google Patents

Pyrrolo-pyridinderivater

Info

Publication number
NO953406L
NO953406L NO953406A NO953406A NO953406L NO 953406 L NO953406 L NO 953406L NO 953406 A NO953406 A NO 953406A NO 953406 A NO953406 A NO 953406A NO 953406 L NO953406 L NO 953406L
Authority
NO
Norway
Prior art keywords
pyrrolo
pyridine derivatives
dopamine
receptor subtypes
substituted
Prior art date
Application number
NO953406A
Other languages
English (en)
Other versions
NO953406D0 (no
Inventor
Raymond Baker
Neil Roy Curtis
Janusz Jozef Kulagowski
Paul David Leeson
Mark Peter Ridgill
Adrian Leonard Smith
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939304111A external-priority patent/GB9304111D0/en
Priority claimed from GB939316275A external-priority patent/GB9316275D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NO953406D0 publication Critical patent/NO953406D0/no
Publication of NO953406L publication Critical patent/NO953406L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En klasse av pyrrolo[2,3-b]- pyridinderivater, substituert ved 3- stillingen ved en substituert piper- azinylmethylgruppe, er antagonister av dopaminreseptorsubtyper innen hjernen, en selektiv affinitet for dopamin D.-reseptorsubtypen over andre doparain-reseptorsubtyper, og er følgelig fordelaktige ved behandling og/eller forhindring av psykotiske sykdommer slik som schizofreni, mens de utviser færre bieffekter enn de som er assosiert med klassiske neuroleptiske legemidler.
NO953406A 1993-03-01 1995-08-30 Pyrrolo-pyridinderivater NO953406L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939304111A GB9304111D0 (en) 1993-03-01 1993-03-01 Therapeutic agents
GB939316275A GB9316275D0 (en) 1993-08-05 1993-08-05 Therapeutic agents
PCT/GB1994/000337 WO1994020497A1 (en) 1993-03-01 1994-02-21 Pyrrolo-pyridine derivatives

Publications (2)

Publication Number Publication Date
NO953406D0 NO953406D0 (no) 1995-08-30
NO953406L true NO953406L (no) 1995-10-31

Family

ID=26302519

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953406A NO953406L (no) 1993-03-01 1995-08-30 Pyrrolo-pyridinderivater

Country Status (20)

Country Link
US (1) US5432177A (no)
EP (1) EP0623618A3 (no)
JP (1) JP2710751B2 (no)
KR (1) KR960701052A (no)
CN (1) CN1118598A (no)
AU (1) AU674373B2 (no)
BG (1) BG99885A (no)
BR (1) BR9406128A (no)
CA (1) CA2116213A1 (no)
CZ (1) CZ224195A3 (no)
FI (1) FI954088A (no)
HU (1) HUT71799A (no)
IL (1) IL108729A0 (no)
NO (1) NO953406L (no)
NZ (1) NZ261593A (no)
PL (1) PL310443A1 (no)
SI (1) SI9400091A (no)
SK (1) SK106395A3 (no)
WO (1) WO1994020497A1 (no)
YU (1) YU9194A (no)

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DE69420394T2 (de) * 1993-03-01 2000-04-13 Merck Sharp & Dohme Ltd., Hoddesdon Pyrrolopyridinderivate als dopaminrezeptor liganden
US5622950A (en) * 1993-03-01 1997-04-22 Merck, Sharp & Dohme Ltd. Pyrrolo-pyridine derivatives
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9305641D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
AU6435594A (en) * 1993-04-15 1994-11-08 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
EP0717623A1 (en) 1993-09-10 1996-06-26 Cytomed, Inc. Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
US5807857A (en) * 1994-05-19 1998-09-15 Merck Sharp & Dohme Ltd. Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists
MX9702350A (es) * 1994-09-30 1997-06-28 Pfizer Derivados 2,7-sustituidos de octahidro-1h-pirido (1,2-a) pirazina.
GB9423460D0 (en) * 1994-11-21 1995-01-11 Merck Sharp & Dohme Therapeutic agents
EP0809642A1 (en) * 1995-02-15 1997-12-03 PHARMACIA & UPJOHN COMPANY Imidazo 1,2-a]pyridines for the treatment of cns and cardiac diseases
GB2298199A (en) * 1995-02-21 1996-08-28 Merck Sharp & Dohme Synthesis of azaindoles
GB9507291D0 (en) * 1995-04-07 1995-05-31 Merck Sharp & Dohme Therapeutic agents
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
US5725838A (en) * 1996-05-31 1998-03-10 Resolution Pharmaceuticals, Inc. Radiolabeled D4 receptor ligands
DE19637237A1 (de) 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
WO1999000386A1 (en) * 1997-06-27 1999-01-07 Resolution Pharmaceuticals Inc. Dopamine d4 receptor ligands
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
US6686374B1 (en) 1999-08-12 2004-02-03 Nps Allelix Corp. Azaindoles having serotonin receptor affinity
ES2222219T3 (es) * 1999-08-12 2005-02-01 Nps Allelix Corp. Azaindoles que tienen actividad con el receptor de serotonina.
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
MXPA02012506A (es) * 2000-06-29 2003-04-25 Lundbeck & Co As H Derivados de indol utiles para el tratamiento de enfermedades del sistema nervioso central.
WO2002010169A1 (en) * 2000-07-31 2002-02-07 F. Hoffmann-La Roche Ag Piperazine derivatives
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
WO2002100350A2 (en) * 2001-06-13 2002-12-19 The Regents Of University Of Michigan Dopamine receptor ligands and therapeutic methods based thereon
WO2003038060A2 (en) 2001-11-01 2003-05-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
CN100347171C (zh) * 2002-02-08 2007-11-07 中国科学院上海原子核研究所 一种吡啶类化合物及其制备方法和作为多巴胺d4受体拮抗剂的应用
CN1305873C (zh) * 2002-07-12 2007-03-21 中国科学院上海原子核研究所 [18f]氟标记的吡啶类化合物及其制备方法和作为多巴胺d4受体显像剂的应用
JP2004123562A (ja) * 2002-09-30 2004-04-22 Japan Science & Technology Corp 神経細胞死抑制作用を有する化合物を用いた医薬
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
US7504509B2 (en) * 2003-12-19 2009-03-17 Plexxikon, Inc. Compounds and methods for development of Ret modulators
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
JP2007530568A (ja) 2004-03-25 2007-11-01 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ゴシポール共結晶およびその使用
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
WO2006009755A2 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
DE102004054634A1 (de) * 2004-11-12 2006-05-18 Schwarz Pharma Ag Azaindolcarboxamide
EP1885723A2 (en) * 2005-05-17 2008-02-13 Plexxikon, Inc. Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
WO2007002433A1 (en) * 2005-06-22 2007-01-04 Plexxikon, Inc. Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
JP2010519171A (ja) 2006-02-17 2010-06-03 メモリー・ファーマシューティカルズ・コーポレイション ５−ｈｔ６受容体親和性を有する化合物
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
EP2094701A2 (en) 2006-12-21 2009-09-02 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
CN101808994B (zh) 2007-07-17 2013-05-15 普莱希科公司 用于激酶调节的化合物和方法以及其适应症
US9447089B2 (en) 2009-04-03 2016-09-20 Plexxikon Inc. Compositions and uses thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8546377B2 (en) * 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
UA105813C2 (uk) 2009-11-06 2014-06-25 Плексікон, Інк. Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти)
WO2012074769A1 (en) * 2010-12-02 2012-06-07 Eli Lilly And Company 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
SG11201502763VA (en) * 2012-11-08 2015-05-28 Pfizer Heteroaromatic compounds and their use as dopamine d1 ligands

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US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3511841A (en) * 1967-05-29 1970-05-12 Sterling Drug Inc 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines
US5422265A (en) * 1990-12-07 1995-06-06 State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The Oregon Health Sciences University DNA sequence for the human dopamine receptor D4 and expression thereof in mammalian cells

Also Published As

Publication number Publication date
EP0623618A2 (en) 1994-11-09
CN1118598A (zh) 1996-03-13
JPH06279442A (ja) 1994-10-04
NZ261593A (en) 1996-09-25
AU674373B2 (en) 1996-12-19
JP2710751B2 (ja) 1998-02-10
WO1994020497A1 (en) 1994-09-15
AU5647094A (en) 1994-09-08
FI954088A0 (fi) 1995-08-31
EP0623618A3 (en) 1997-04-02
HUT71799A (en) 1996-02-28
PL310443A1 (en) 1995-12-11
FI954088A (fi) 1995-08-31
BR9406128A (pt) 1996-02-27
CZ224195A3 (en) 1996-03-13
YU9194A (sh) 1997-08-22
KR960701052A (ko) 1996-02-24
SI9400091A (en) 1994-12-31
HU9501871D0 (en) 1995-08-28
BG99885A (en) 1996-02-29
IL108729A0 (en) 1994-05-30
SK106395A3 (en) 1995-12-06
NO953406D0 (no) 1995-08-30
CA2116213A1 (en) 1994-09-02
US5432177A (en) 1995-07-11

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