MXPA02012506A - Derivados de indol utiles para el tratamiento de enfermedades del sistema nervioso central. - Google Patents
Derivados de indol utiles para el tratamiento de enfermedades del sistema nervioso central.Info
- Publication number
- MXPA02012506A MXPA02012506A MXPA02012506A MXPA02012506A MXPA02012506A MX PA02012506 A MXPA02012506 A MX PA02012506A MX PA02012506 A MXPA02012506 A MX PA02012506A MX PA02012506 A MXPA02012506 A MX PA02012506A MX PA02012506 A MXPA02012506 A MX PA02012506A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- cns disorders
- indole derivatives
- derivatives useful
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
Un derivado de indol que tiene la formula (Ver formula) en donde a) Y1 es N, que esta unido a Z, Z e Y2 estan seleccionados a partir de CH2, CO, CS, SO y SO2; con la condicion de que al menos uno de Z e Y2 sea CH2; Y3 es O, S o CHR7 e Y4 es O, S o CHR8, con la condicion de que solo uno de Y3 e Y4 sea O o S; b) Y2 es N, que esta unido a Z, Z e Y1 estan seleccionados a partir de CH2, CO, CS, SO y SO2; con la condicion de que al menos uno de Z e Y1 sea CH2; Y3 es CHR7 e Y4 es O, S o CHR8; c) Y2 es N, que esta unido a Z, Z e Y3 estan seleccionados a partir de CH2, CO, CS, SO y SO2 con la condicion de que al menos uno de Z e Y3 sea CH2; Y1 es CHR6 e Y4 es O, S o CHR8; W es un enlace, O, S, CO, CS, SO o SO2; n es 0-5, m es 0-5 y n + m es 1-6; con la condicion de que cuando W es O o S, entonces n ( 2 y m ( 1; cuando W es CO, CS, SO o SO2, entonces n ( 1 y m ( 1; X es C, CH o N, con la condicion de que cuando X es C, la linea punteada indique un enlace, y cuando X es N o CH, la linea punteada no indique enlace alguno; uno de R1, R2, R3 y R4 forma un enlace con X y los otros de R1, R2, R3, R4 y R5 y R9-R12 estan independientemente seleccionados a partir de hidrogeno, halogeno, ciano, nitro, amino, hidroxi, C1-6-alquil-amino, di- ( C1-6-alquil ) -amino, C1-6-alquilo, C2-6-alquenilo, C2-6-alquinilo, C1-6 alcoxi, C1-6-alquiltio, C1-6-alquilo sustituido con hidroxi o tiol, C3-8-cicloalquilo, C3-8-cicloalquil C1-6-alquilo, acilo tioacilo, trifluormetilo, trifluormetilsulfonilo o C1-6 alquilsulfonilo; R es hidrogeno, C1-6-alquilo, C2-6-alquenilo, C2-6- alquinilo, C1-6-alquilo sustituido con hidroxi o tiol, C3-8 cicloalquilo, C3-8-cicloalquil-C1-6-alquilo, acilo, tioacilo, trifluormetilsulfonilo y C1-6 alquilsulfonilo; o sales farmaceuticamente aceptables del mismo. Los compuestos de la invencion son potentes ligandos D4 de dopamina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001018 | 2000-06-29 | ||
| PCT/DK2001/000407 WO2002000645A1 (en) | 2000-06-29 | 2001-06-13 | Indole derivatives useful for the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02012506A true MXPA02012506A (es) | 2003-04-25 |
Family
ID=8159589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02012506A MXPA02012506A (es) | 2000-06-29 | 2001-06-13 | Derivados de indol utiles para el tratamiento de enfermedades del sistema nervioso central. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20030232822A1 (es) |
| EP (1) | EP1299380B1 (es) |
| JP (1) | JP2004501912A (es) |
| KR (1) | KR20030011365A (es) |
| CN (1) | CN1439004A (es) |
| AR (1) | AR028736A1 (es) |
| AT (1) | ATE268765T1 (es) |
| AU (1) | AU2001273882A1 (es) |
| BG (1) | BG107471A (es) |
| BR (1) | BR0112286A (es) |
| CA (1) | CA2414115A1 (es) |
| CZ (1) | CZ20024192A3 (es) |
| DE (1) | DE60103761D1 (es) |
| EA (1) | EA200300084A1 (es) |
| HU (1) | HUP0300786A2 (es) |
| IL (1) | IL153254A0 (es) |
| IS (1) | IS6642A (es) |
| MX (1) | MXPA02012506A (es) |
| NO (1) | NO20026029L (es) |
| PL (1) | PL358966A1 (es) |
| SK (1) | SK1092003A3 (es) |
| WO (1) | WO2002000645A1 (es) |
| ZA (1) | ZA200209886B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| WO2004020437A1 (en) * | 2002-08-29 | 2004-03-11 | H. Lundbeck A/S | S-(+)-3-{1-[2-(2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof |
| DE102004027358A1 (de) * | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyrimidinverbindungen und ihre Verwendung |
| KR20090040352A (ko) | 2006-07-31 | 2009-04-23 | 얀센 파마슈티카 엔.브이. | 유로텐신 ⅱ 수용체 길항제 |
| SE531698C2 (sv) | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL310443A1 (en) * | 1993-03-01 | 1995-12-11 | Merck Sharp & Dohme | Derivatives of pyrolo-pyridine |
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
-
2001
- 2001-06-13 EP EP01940241A patent/EP1299380B1/en not_active Expired - Lifetime
- 2001-06-13 EA EA200300084A patent/EA200300084A1/ru unknown
- 2001-06-13 AU AU2001273882A patent/AU2001273882A1/en not_active Abandoned
- 2001-06-13 PL PL01358966A patent/PL358966A1/xx not_active Application Discontinuation
- 2001-06-13 CN CN01811847A patent/CN1439004A/zh active Pending
- 2001-06-13 WO PCT/DK2001/000407 patent/WO2002000645A1/en not_active Application Discontinuation
- 2001-06-13 KR KR1020027017614A patent/KR20030011365A/ko not_active Application Discontinuation
- 2001-06-13 MX MXPA02012506A patent/MXPA02012506A/es unknown
- 2001-06-13 IL IL15325401A patent/IL153254A0/xx unknown
- 2001-06-13 CZ CZ20024192A patent/CZ20024192A3/cs unknown
- 2001-06-13 BR BR0112286-0A patent/BR0112286A/pt not_active Application Discontinuation
- 2001-06-13 JP JP2002505393A patent/JP2004501912A/ja not_active Withdrawn
- 2001-06-13 DE DE60103761T patent/DE60103761D1/de not_active Expired - Fee Related
- 2001-06-13 CA CA002414115A patent/CA2414115A1/en not_active Abandoned
- 2001-06-13 AT AT01940241T patent/ATE268765T1/de not_active IP Right Cessation
- 2001-06-13 SK SK109-2003A patent/SK1092003A3/sk unknown
- 2001-06-13 HU HU0300786A patent/HUP0300786A2/hu unknown
- 2001-06-19 AR ARP010102901A patent/AR028736A1/es unknown
-
2002
- 2002-11-29 IS IS6642A patent/IS6642A/is unknown
- 2002-12-05 ZA ZA200209886A patent/ZA200209886B/en unknown
- 2002-12-16 NO NO20026029A patent/NO20026029L/no not_active Application Discontinuation
- 2002-12-17 US US10/327,670 patent/US20030232822A1/en not_active Abandoned
-
2003
- 2003-01-17 BG BG107471A patent/BG107471A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1299380B1 (en) | 2004-06-09 |
| SK1092003A3 (en) | 2003-05-02 |
| NO20026029D0 (no) | 2002-12-16 |
| BG107471A (en) | 2003-10-31 |
| CN1439004A (zh) | 2003-08-27 |
| EA200300084A1 (ru) | 2003-06-26 |
| IL153254A0 (en) | 2003-07-06 |
| HUP0300786A2 (hu) | 2003-07-28 |
| DE60103761D1 (de) | 2004-07-15 |
| ZA200209886B (en) | 2003-12-05 |
| BR0112286A (pt) | 2003-05-13 |
| IS6642A (is) | 2002-11-29 |
| AU2001273882A1 (en) | 2002-01-08 |
| PL358966A1 (en) | 2004-08-23 |
| CA2414115A1 (en) | 2002-01-03 |
| US20030232822A1 (en) | 2003-12-18 |
| WO2002000645A1 (en) | 2002-01-03 |
| KR20030011365A (ko) | 2003-02-07 |
| JP2004501912A (ja) | 2004-01-22 |
| AR028736A1 (es) | 2003-05-21 |
| CZ20024192A3 (cs) | 2003-04-16 |
| EP1299380A1 (en) | 2003-04-09 |
| ATE268765T1 (de) | 2004-06-15 |
| NO20026029L (no) | 2002-12-16 |
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