AR028736A1 - Derivados de indol - Google Patents
Derivados de indolInfo
- Publication number
- AR028736A1 AR028736A1 ARP010102901A ARP010102901A AR028736A1 AR 028736 A1 AR028736 A1 AR 028736A1 AR P010102901 A ARP010102901 A AR P010102901A AR P010102901 A ARP010102901 A AR P010102901A AR 028736 A1 AR028736 A1 AR 028736A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- proviso
- chr8
- cycloalkyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un derivado de indol que tiene la formula 1 en donde a) Y1 es N, que está unido a Z, Z e Y2 están seleccionados a partir de CH2, CO, CS, SO y SO2; con la condicion de que al menos uno de Z e Y2 sea CH2; Y3 es O, S o CHR7 e Y4 es O, S o CHR8, con la condicion de que solo uno de Y3 e Y4 sea O o S;b) Y2 es N, que está unido a Z, Z e Y1 están seleccionados a partir de CH2, CO, CS, SO y SO2; con la condicion de que al menos uno de Z e Y1 sea CH2; Y3 es CHR7 e Y4 es O, S o CHR8;c) Y2 es N, que está unido a Z, Z e Y3 están seleccionados a partir de CH2, CO, CS, SO y SO2 con la condicion de que al menos uno de Z e Y3 sea CH2;Y1 es CHR6 e Y4 es O, S, o CHR8; W es un enlace, O, S, CO, CS, SO o SO2; n es 0-5, m es 0-5 y n + m es 1-6; con la condicion de que cuando W es O o S, entonces n l 2 y m l 1; cuando W es CO, CS, SO o SO2, entonces n l 2 y m l 1;X es C, CH o N, con la condicion de que cuando X es C, la línea punteada indique un enlace, y cuando X es N o CH, la línea punteada no indique enlace alguno; uno de R1, R2, R3 y R4 forma un enlace con X y los otros de R1, R2, R3, R4 y R5 y R9-R12 están independientemente seleccionados a partir de hidrogeno, halogeno, ciano, nitro, amino, hidroxi, C1-6-alquil-amino, di-(C1-6-alquil)-amino, C1-6-alquilo, C2-6-alquenilo, C2-6-alquinilo, C1-6 alcoxi, C1-6-alquiltio, C1-6-alquilo sustituido con hidroxi o tiol, C3-8-cicloalquilo, C3-8-cicloalquil-C1-6-alquilo, acilo, tioacilo, trifluormetilo, trifluormetilsulfonilo o C1-6-alquilsulfonilo; R es hidrogeno, C1-6-alquilo, C2-6-alquenilo, C2-6-alquinilo, C1-6-alquilo sustituido con hidroxi o tiol, C3-8-cicloalaquilo, C3-8-cicloalquil-C1-6-alquilo, acilo, tioacilo, trifluormetilsulfonilo y C1-6 alquilsulfonilo; o sales farmacéuticamente aceptables del mismo. Los compuestos de la invencion son potentes ligandos D4 de dopamina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001018 | 2000-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR028736A1 true AR028736A1 (es) | 2003-05-21 |
Family
ID=8159589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010102901A AR028736A1 (es) | 2000-06-29 | 2001-06-19 | Derivados de indol |
Country Status (23)
Country | Link |
---|---|
US (1) | US20030232822A1 (es) |
EP (1) | EP1299380B1 (es) |
JP (1) | JP2004501912A (es) |
KR (1) | KR20030011365A (es) |
CN (1) | CN1439004A (es) |
AR (1) | AR028736A1 (es) |
AT (1) | ATE268765T1 (es) |
AU (1) | AU2001273882A1 (es) |
BG (1) | BG107471A (es) |
BR (1) | BR0112286A (es) |
CA (1) | CA2414115A1 (es) |
CZ (1) | CZ20024192A3 (es) |
DE (1) | DE60103761D1 (es) |
EA (1) | EA200300084A1 (es) |
HU (1) | HUP0300786A2 (es) |
IL (1) | IL153254A0 (es) |
IS (1) | IS6642A (es) |
MX (1) | MXPA02012506A (es) |
NO (1) | NO20026029L (es) |
PL (1) | PL358966A1 (es) |
SK (1) | SK1092003A3 (es) |
WO (1) | WO2002000645A1 (es) |
ZA (1) | ZA200209886B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
AU2003257407A1 (en) * | 2002-08-29 | 2004-03-19 | H. Lundbeck A/S | S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof |
DE102004027358A1 (de) | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyrimidinverbindungen und ihre Verwendung |
EP2049120A4 (en) | 2006-07-31 | 2011-09-07 | Janssen Pharmaceutica Nv | UROTENSIN II RECEPTOR ANTAGONISTS |
SE531698C2 (sv) | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL310443A1 (en) * | 1993-03-01 | 1995-12-11 | Merck Sharp & Dohme | Derivatives of pyrolo-pyridine |
ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
-
2001
- 2001-06-13 KR KR1020027017614A patent/KR20030011365A/ko not_active Application Discontinuation
- 2001-06-13 DE DE60103761T patent/DE60103761D1/de not_active Expired - Fee Related
- 2001-06-13 PL PL01358966A patent/PL358966A1/xx not_active Application Discontinuation
- 2001-06-13 HU HU0300786A patent/HUP0300786A2/hu unknown
- 2001-06-13 CN CN01811847A patent/CN1439004A/zh active Pending
- 2001-06-13 AT AT01940241T patent/ATE268765T1/de not_active IP Right Cessation
- 2001-06-13 EP EP01940241A patent/EP1299380B1/en not_active Expired - Lifetime
- 2001-06-13 MX MXPA02012506A patent/MXPA02012506A/es unknown
- 2001-06-13 WO PCT/DK2001/000407 patent/WO2002000645A1/en not_active Application Discontinuation
- 2001-06-13 JP JP2002505393A patent/JP2004501912A/ja not_active Withdrawn
- 2001-06-13 AU AU2001273882A patent/AU2001273882A1/en not_active Abandoned
- 2001-06-13 CA CA002414115A patent/CA2414115A1/en not_active Abandoned
- 2001-06-13 BR BR0112286-0A patent/BR0112286A/pt not_active Application Discontinuation
- 2001-06-13 SK SK109-2003A patent/SK1092003A3/sk unknown
- 2001-06-13 CZ CZ20024192A patent/CZ20024192A3/cs unknown
- 2001-06-13 IL IL15325401A patent/IL153254A0/xx unknown
- 2001-06-13 EA EA200300084A patent/EA200300084A1/ru unknown
- 2001-06-19 AR ARP010102901A patent/AR028736A1/es unknown
-
2002
- 2002-11-29 IS IS6642A patent/IS6642A/is unknown
- 2002-12-05 ZA ZA200209886A patent/ZA200209886B/en unknown
- 2002-12-16 NO NO20026029A patent/NO20026029L/no not_active Application Discontinuation
- 2002-12-17 US US10/327,670 patent/US20030232822A1/en not_active Abandoned
-
2003
- 2003-01-17 BG BG107471A patent/BG107471A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1299380B1 (en) | 2004-06-09 |
ATE268765T1 (de) | 2004-06-15 |
CN1439004A (zh) | 2003-08-27 |
HUP0300786A2 (hu) | 2003-07-28 |
BG107471A (en) | 2003-10-31 |
SK1092003A3 (en) | 2003-05-02 |
PL358966A1 (en) | 2004-08-23 |
JP2004501912A (ja) | 2004-01-22 |
ZA200209886B (en) | 2003-12-05 |
NO20026029D0 (no) | 2002-12-16 |
KR20030011365A (ko) | 2003-02-07 |
MXPA02012506A (es) | 2003-04-25 |
IL153254A0 (en) | 2003-07-06 |
AU2001273882A1 (en) | 2002-01-08 |
BR0112286A (pt) | 2003-05-13 |
EP1299380A1 (en) | 2003-04-09 |
WO2002000645A1 (en) | 2002-01-03 |
EA200300084A1 (ru) | 2003-06-26 |
DE60103761D1 (de) | 2004-07-15 |
US20030232822A1 (en) | 2003-12-18 |
IS6642A (is) | 2002-11-29 |
CA2414115A1 (en) | 2002-01-03 |
CZ20024192A3 (cs) | 2003-04-16 |
NO20026029L (no) | 2002-12-16 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |