MXPA04000358A - Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. - Google Patents

Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht.

Info

Publication number
MXPA04000358A
MXPA04000358A MXPA04000358A MXPA04000358A MXPA04000358A MX PA04000358 A MXPA04000358 A MX PA04000358A MX PA04000358 A MXPA04000358 A MX PA04000358A MX PA04000358 A MXPA04000358 A MX PA04000358A MX PA04000358 A MXPA04000358 A MX PA04000358A
Authority
MX
Mexico
Prior art keywords
hexahydroazepino
indolines
indoles
receptor ligands
compounds
Prior art date
Application number
MXPA04000358A
Other languages
English (en)
Inventor
Glenn Romero Arthur
Original Assignee
Pharmacia & Up John Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Up John Company filed Critical Pharmacia & Up John Company
Publication of MXPA04000358A publication Critical patent/MXPA04000358A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona compuestos de la Formula (I): (ver formula) en donde R1, R2, R3, R4, R5, R6 y --- tienen cualquiera de los valores definidos en la especificacion, asi como tambien, las composiciones farmaceuticas que comprenden los compuestos. La invencion tambien proporciona metodos terapeuticos, asi como tambien procesos e intermediarios utiles para prepararlos compuestos de la Formula (I). Los compuestos son utiles como ligandos 5-HT.
MXPA04000358A 2001-07-13 2002-07-10 Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. MXPA04000358A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30530501P 2001-07-13 2001-07-13
PCT/US2002/019804 WO2003006466A1 (en) 2001-07-13 2002-07-10 Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands

Publications (1)

Publication Number Publication Date
MXPA04000358A true MXPA04000358A (es) 2004-05-04

Family

ID=23180257

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000358A MXPA04000358A (es) 2001-07-13 2002-07-10 Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht.

Country Status (11)

Country Link
US (1) US7022694B2 (es)
EP (1) EP1406902B1 (es)
JP (1) JP2005522408A (es)
AT (1) ATE307133T1 (es)
BR (1) BR0211140A (es)
CA (1) CA2452610A1 (es)
DE (1) DE60206762T2 (es)
DK (1) DK1406902T3 (es)
ES (1) ES2250667T3 (es)
MX (1) MXPA04000358A (es)
WO (1) WO2003006466A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018432A1 (en) * 2002-08-20 2004-03-04 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
JP4555685B2 (ja) 2002-08-29 2010-10-06 シェーリング コーポレイション 肥満およびｃｎｓ障害の処置のための選択的ｄ１／ｄ５レセプターアンタゴニスト
EA011011B1 (ru) 2004-02-25 2008-12-30 Эли Лилли Энд Компани 6-ЗАМЕЩЁННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-БЕНЗО[d]АЗЕПИНЫ В КАЧЕСТВЕ АГОНИСТОВ РЕЦЕПТОРОВ 5-HT
EP2400300A1 (en) 2004-08-25 2011-12-28 Takeda Pharmaceutical Company Limited Method of screening preventives/remedies for stress urinary incontinence
BRPI0615048A2 (pt) 2005-09-01 2010-03-30 Lilly Co Eli composto, composição farmacêutica, e, uso de um composto
WO2007028132A2 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
SI1926712T1 (sl) 2005-09-01 2010-01-29 Lilly Co Eli 6-substituirani 2,3.4,5-tetrahidro-1h-benzo(d)azepini kot agonisti 5-ht2c receptorja
CA2619566C (en) 2005-09-01 2013-08-13 Eli Lilly And Company 6-substituted-2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
WO2015171514A1 (en) 2014-05-05 2015-11-12 Zhengbing Cao Antimicrobial surface coatings
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE
EP3753924A1 (en) * 2019-06-18 2020-12-23 AnaMar AB New tricyclic 5-ht2 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK26793D0 (da) 1993-03-10 1993-03-10 Novo Nordisk As Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling
US5917053A (en) 1994-09-14 1999-06-29 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
AU6290998A (en) 1997-03-07 1998-09-29 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno{3,2-c}pyridine derivatives, their preparation and use
DE69922936T2 (de) 1998-03-31 2005-12-08 Neurosearch A/S Verwendung von indol-2,3-dione-3-oximderivate als ampa-antagonisten
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi

Also Published As

Publication number Publication date
ATE307133T1 (de) 2005-11-15
EP1406902A1 (en) 2004-04-14
EP1406902B1 (en) 2005-10-19
US7022694B2 (en) 2006-04-04
WO2003006466A1 (en) 2003-01-23
DK1406902T3 (da) 2006-01-30
ES2250667T3 (es) 2006-04-16
DE60206762T2 (de) 2006-07-13
US20030060458A1 (en) 2003-03-27
BR0211140A (pt) 2005-10-25
JP2005522408A (ja) 2005-07-28
CA2452610A1 (en) 2003-01-23
DE60206762D1 (de) 2006-03-02

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