MXPA04003594A - Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. - Google Patents
Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2.Info
- Publication number
- MXPA04003594A MXPA04003594A MXPA04003594A MXPA04003594A MXPA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- azaindoles
- indolines
- tetracyclic
- serotonin
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 4
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 title 1
- 229940076279 serotonin Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 102100024959 5-hydroxytryptamine receptor 2C Human genes 0.000 abstract 1
- 101710138093 5-hydroxytryptamine receptor 2C Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invencion proporciona compuestos de la Formula (I):(ver formula I),en donde R1, R2, R3, R4, R5 y R6, tienen cualquiera de los valores definidos en la especificacion, asi como tambien las composiciones farmaceuticas que comprenden los compuestos. La invencion tambien proporciona los metodos terapeuticos, asi como tambien los procesos e intermediarios utiles para preparar los compuestos de la Formula (I). Los compuestos son ligandos 5-HT y son utiles para tratar enfermedades en donde se desea la modulacion de la actividad 5-HT2c.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33508101P | 2001-10-18 | 2001-10-18 | |
PCT/US2002/033176 WO2003033497A1 (en) | 2001-10-18 | 2002-10-15 | Tetracyclic azaindoles and -indolines having serotonin 5-ht2c activity |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04003594A true MXPA04003594A (es) | 2004-07-30 |
Family
ID=23310182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04003594A MXPA04003594A (es) | 2001-10-18 | 2002-10-15 | Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. |
Country Status (7)
Country | Link |
---|---|
US (1) | US6930105B2 (es) |
EP (1) | EP1436294A1 (es) |
JP (1) | JP2005508969A (es) |
BR (1) | BR0213417A (es) |
CA (1) | CA2464412A1 (es) |
MX (1) | MXPA04003594A (es) |
WO (1) | WO2003033497A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
US20050052815A1 (en) * | 2003-09-09 | 2005-03-10 | Smc Corporation | Static eliminating method and apparatus therefor |
WO2006022420A1 (ja) | 2004-08-25 | 2006-03-02 | Takeda Pharmaceutical Company Limited | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
WO2006117218A2 (en) * | 2005-05-04 | 2006-11-09 | Charite Universitätsmedizin - Berlin | Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache |
EP1728520A1 (de) * | 2005-05-04 | 2006-12-06 | Charité - Universitätsmedizin Berlin | Verwendung von spezifisch an das Serotonin-Transport-Protein (SERT) bindenden Radiopharmaka zur Herstellung eines Diagnostikums zur Untersuchung von Kopfschmerzerkrankungen |
AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
AU2007230997A1 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Treatment of pain |
AU2007231011A1 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | New therapeutic combinations for the treatment of depression |
CL2007000773A1 (es) * | 2006-03-24 | 2008-01-25 | Wyeth Corp | Uso de compuestos derivados de diazepina condensada para el tratamiento de un desorden cognitivo como add o adhd;o su uso para tratar spm o pmdd. |
EP2742936A1 (en) | 2006-05-16 | 2014-06-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
EP2384328B1 (en) * | 2008-11-27 | 2013-02-13 | Boehringer Ingelheim International GmbH | 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them |
WO2011071136A1 (ja) | 2009-12-11 | 2011-06-16 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20010052A1 (es) | 1999-04-23 | 2001-01-27 | Upjohn Co | Compuestos de azepinindol tetraciclico como agonistas o antagonistas del receptor de 5-ht |
EP1192165B1 (en) | 1999-06-15 | 2004-09-22 | Bristol-Myers Squibb Pharma Company | Substituted heterocycle fused gamma-carbolines |
-
2002
- 2002-10-15 MX MXPA04003594A patent/MXPA04003594A/es unknown
- 2002-10-15 JP JP2003536236A patent/JP2005508969A/ja not_active Withdrawn
- 2002-10-15 BR BR0213417-9A patent/BR0213417A/pt not_active IP Right Cessation
- 2002-10-15 EP EP02773791A patent/EP1436294A1/en not_active Withdrawn
- 2002-10-15 WO PCT/US2002/033176 patent/WO2003033497A1/en not_active Application Discontinuation
- 2002-10-15 CA CA002464412A patent/CA2464412A1/en not_active Abandoned
- 2002-10-15 US US10/271,349 patent/US6930105B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2464412A1 (en) | 2003-04-24 |
EP1436294A1 (en) | 2004-07-14 |
WO2003033497A1 (en) | 2003-04-24 |
US20030091505A1 (en) | 2003-05-15 |
JP2005508969A (ja) | 2005-04-07 |
US6930105B2 (en) | 2005-08-16 |
BR0213417A (pt) | 2004-11-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA04001203A (es) | 1-h-pirido[4,3-b] indoles terapeuticos. | |
MXPA04003594A (es) | Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. | |
AP1822A (en) | Substituted pyridinones as modulators of P38 MAP kinase. | |
TW200517109A (en) | Substituted pyridinones | |
WO2001017963A3 (en) | Aminoalkoxy carbazoles and their use as 5-ht ligands | |
DE60204452D1 (de) | Pyrazolo[1,5]pyridinderivate | |
MXPA02012425A (es) | Compuestos nuevos. | |
SE0104140D0 (sv) | Novel Compounds | |
MXPA05009359A (es) | Tetrahidroisoquinolinas 2,5- y 2,6 substituidas para uso como moduladores 5-ht6. | |
GB9813540D0 (en) | Chemical compounds | |
IL175819A0 (en) | Tricyclic indole hydroxyethylamine derivatives and their use in the treatment of alzheimer's disease | |
HK1069169A1 (en) | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors | |
MXPA04005886A (es) | Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6. | |
HUP0303254A2 (hu) | Új pirimidinvegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
WO2003024976A3 (en) | Tricyclic indole derivatives as 5-ht ligands | |
ZA200110540B (en) | Novel diphenyl-piperidine derivate. | |
MXPA06000701A (es) | Compuestos de sulfonildihidrobencimidazolona como ligandos de 5-hidroxitriptamina-6. | |
MY138466A (en) | Aminoalkoxyndoles as 5-ht6-receptor ligands for the treatment of cns-disorders | |
MXPA04000358A (es) | Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. | |
UA83821C2 (ru) | Производные бензолсульфонамидов, способ их получения и их применение для лечения воспалительных заболеваний и утоления боли | |
MXPA04000036A (es) | Benzofuranos sustituidos con (hetero) arilo como ligandos 5-ht. | |
SE9902551D0 (sv) | Novel compounds | |
MXPA02012426A (es) | Compuestos nuevos. | |
MXPA04001201A (es) | Derivados tetraciclicos de indol como ligandos del receptor de 5-ht. | |
MXPA04005151A (es) | Compuestos terapeuticos. |