BR0211140A - Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht - Google Patents

Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht

Info

Publication number
BR0211140A
BR0211140A BR0211140-3A BR0211140A BR0211140A BR 0211140 A BR0211140 A BR 0211140A BR 0211140 A BR0211140 A BR 0211140A BR 0211140 A BR0211140 A BR 0211140A
Authority
BR
Brazil
Prior art keywords
sup
compounds
hexahydroazepine
indolines
indoles
Prior art date
Application number
BR0211140-3A
Other languages
English (en)
Inventor
Jian-Min Fu
Jeanette Kay Morris
Arthur Glenn Romero
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR0211140A publication Critical patent/BR0211140A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS E COMPOSIçõES DE INDóIS DE HEXAIDROAZEPINA (4, 5-G) E INDOLINAS COMO LIGANTES DE RECEPTORES 5-HT". A presente invenção propicia compostos de Fórmula (I) : onde R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬ e têm qualquer dos valores definidos na especificação, assim como composições farmacêuticas que compreendem os compostos. A invenção também fornece métodos terapêuticos assim como processos e intermediários úteis para preparar compostos de Fórmula (I). Os compostos são úteis como ligantes de 5-HT.
BR0211140-3A 2001-07-13 2002-07-10 Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht BR0211140A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30530501P 2001-07-13 2001-07-13
PCT/US2002/019804 WO2003006466A1 (en) 2001-07-13 2002-07-10 Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands

Publications (1)

Publication Number Publication Date
BR0211140A true BR0211140A (pt) 2005-10-25

Family

ID=23180257

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211140-3A BR0211140A (pt) 2001-07-13 2002-07-10 Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht

Country Status (11)

Country Link
US (1) US7022694B2 (pt)
EP (1) EP1406902B1 (pt)
JP (1) JP2005522408A (pt)
AT (1) ATE307133T1 (pt)
BR (1) BR0211140A (pt)
CA (1) CA2452610A1 (pt)
DE (1) DE60206762T2 (pt)
DK (1) DK1406902T3 (pt)
ES (1) ES2250667T3 (pt)
MX (1) MXPA04000358A (pt)
WO (1) WO2003006466A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018432A1 (en) * 2002-08-20 2004-03-04 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
CN1688584A (zh) * 2002-08-29 2005-10-26 先灵公司 治疗肥胖和中枢神经系统疾病的选择性d1/d5受体拮抗剂
NZ549009A (en) 2004-02-25 2010-08-27 Lilly Co Eli 6-substituted 2,3,4,5-tetrahydro-1H-benzo[D]azepines as 5-HT2C receptor agonists
EP2248524A3 (en) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
CA2619450C (en) 2005-09-01 2013-10-22 Eli Lilly And Company 6-n-linked heterocycle-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2007028083A2 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
SI1926712T1 (sl) 2005-09-01 2010-01-29 Lilly Co Eli 6-substituirani 2,3.4,5-tetrahidro-1h-benzo(d)azepini kot agonisti 5-ht2c receptorja
DE602006008323D1 (de) 2005-09-01 2009-09-17 Lilly Co Eli 6-substituierte- 2,3,4,5-tetrahydro-1h-benzoädüazepine als 5-ht2c-rezeptoragonisten
JP5528699B2 (ja) 2006-05-16 2014-06-25 武田薬品工業株式会社 縮合複素環化合物およびその用途
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
EP2510949A4 (en) 2009-12-11 2013-11-13 Astellas Pharma Inc THERAPEUTICS FOR FIBROMYALGIA
CN106488702A (zh) 2014-05-05 2017-03-08 曹正兵 抗菌表面涂层
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬
EP3753924A1 (en) * 2019-06-18 2020-12-23 AnaMar AB New tricyclic 5-ht2 antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK26793D0 (da) 1993-03-10 1993-03-10 Novo Nordisk As Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling
US5917053A (en) 1994-09-14 1999-06-29 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
JP2001514631A (ja) 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
NZ507259A (en) 1998-03-31 2003-07-25 Neurosearch As Indole-2,3-dione-3-oxime derivatives for therapeutic use
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi

Also Published As

Publication number Publication date
DK1406902T3 (da) 2006-01-30
ATE307133T1 (de) 2005-11-15
EP1406902A1 (en) 2004-04-14
WO2003006466A1 (en) 2003-01-23
DE60206762D1 (de) 2006-03-02
CA2452610A1 (en) 2003-01-23
US20030060458A1 (en) 2003-03-27
EP1406902B1 (en) 2005-10-19
US7022694B2 (en) 2006-04-04
MXPA04000358A (es) 2004-05-04
DE60206762T2 (de) 2006-07-13
ES2250667T3 (es) 2006-04-16
JP2005522408A (ja) 2005-07-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009.

B15K Others concerning applications: alteration of classification

Ipc: C07D 487/04 (2006.01), A61P 25/00 (2006.01), A61P