FI971854A - Substituoituja tetrasyklisiä atsepiinijohdannaisia, joilla on 5-HT2-reseptoriaffiniteetti - Google Patents

Substituoituja tetrasyklisiä atsepiinijohdannaisia, joilla on 5-HT2-reseptoriaffiniteetti Download PDF

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Publication number
FI971854A
FI971854A FI971854A FI971854A FI971854A FI 971854 A FI971854 A FI 971854A FI 971854 A FI971854 A FI 971854A FI 971854 A FI971854 A FI 971854A FI 971854 A FI971854 A FI 971854A
Authority
FI
Finland
Prior art keywords
axepine
derivatives
receptor affinity
substituted tetracyclic
tetracyclic
Prior art date
Application number
FI971854A
Other languages
English (en)
Swedish (sv)
Other versions
FI113050B (fi
FI971854A0 (fi
Inventor
Victor Karel Sipido
Francisco Javi Fernandez-Gadea
Jose Ignacio Andres-Gil
Theo Frans Meert
Pilar Gil-Lopetegui
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI971854A publication Critical patent/FI971854A/fi
Publication of FI971854A0 publication Critical patent/FI971854A0/fi
Application granted granted Critical
Publication of FI113050B publication Critical patent/FI113050B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI971854A 1994-11-02 1997-04-30 2,3,3a, 8-tetrahydrodibents[c,f]isoksatsolo[2,3-a]-atsepiini-2-alkyyliamiinijohdannaisia, joilla on 5-HT2-reseptoriaffinitetti, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeenä FI113050B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP94203178 1994-11-02
EP94203178 1994-11-02
US08/457,968 US5552399A (en) 1994-11-02 1995-05-31 Substituted tetracyclic azepine derivatives
US45796895 1995-05-31
PCT/EP1995/004196 WO1996014320A1 (en) 1994-11-02 1995-10-25 Substituted tetracyclic azepine derivatives which have affinity for 5-ht2 receptors
EP9504196 1995-10-25

Publications (3)

Publication Number Publication Date
FI971854A true FI971854A (fi) 1997-04-30
FI971854A0 FI971854A0 (fi) 1997-04-30
FI113050B FI113050B (fi) 2004-02-27

Family

ID=8217337

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971854A FI113050B (fi) 1994-11-02 1997-04-30 2,3,3a, 8-tetrahydrodibents[c,f]isoksatsolo[2,3-a]-atsepiini-2-alkyyliamiinijohdannaisia, joilla on 5-HT2-reseptoriaffinitetti, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeenä

Country Status (30)

Country Link
US (1) US5552399A (fi)
EP (1) EP0789701B1 (fi)
JP (1) JP3818541B2 (fi)
KR (1) KR100392060B1 (fi)
CN (1) CN1085667C (fi)
AR (1) AR002238A1 (fi)
AT (1) ATE199087T1 (fi)
AU (1) AU704285B2 (fi)
BR (1) BR9509552A (fi)
CA (1) CA2203661A1 (fi)
CZ (1) CZ286945B6 (fi)
DE (1) DE69520070T2 (fi)
DK (1) DK0789701T3 (fi)
ES (1) ES2155898T3 (fi)
FI (1) FI113050B (fi)
GR (1) GR3035680T3 (fi)
HR (1) HRP950537A2 (fi)
HU (1) HUT77408A (fi)
IL (1) IL115819A (fi)
MY (1) MY113325A (fi)
NO (1) NO308035B1 (fi)
NZ (1) NZ295656A (fi)
PL (1) PL183686B1 (fi)
PT (1) PT789701E (fi)
RU (1) RU2163240C2 (fi)
SI (1) SI0789701T1 (fi)
TR (1) TR199501356A2 (fi)
TW (1) TW349950B (fi)
WO (1) WO1996014320A1 (fi)
ZA (1) ZA959215B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0892804B1 (en) * 1996-04-12 2002-08-28 Janssen Pharmaceutica N.V. Isoxazolidine derivatives
UA52778C2 (uk) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
CA3069699A1 (en) * 2017-07-13 2019-01-17 Tonix Pharmaceuticals Holding Corp. Analogs of cyclobenzaprine and amitryptilene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT338799B (de) * 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
NL7414038A (nl) * 1974-10-28 1976-05-03 Akzo Nv Nieuwe tetracyclische pyrrolidino derivaten.
DE2647114A1 (de) * 1975-10-21 1977-05-05 Hans Fickler Vorrichtung zur erzeugung einer laengsbewegung
JPS5572177A (en) * 1978-11-27 1980-05-30 Shionogi & Co Ltd 4,1-benzoxazepine or 4,1-benzothiazepine
CA2026925A1 (en) * 1989-10-05 1991-04-06 Hiroshi Fukumi Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
FI113050B (fi) 2004-02-27
GR3035680T3 (en) 2001-06-29
AU704285B2 (en) 1999-04-15
CN1085667C (zh) 2002-05-29
DE69520070D1 (de) 2001-03-15
AU3924995A (en) 1996-05-31
DE69520070T2 (de) 2001-09-13
ATE199087T1 (de) 2001-02-15
BR9509552A (pt) 1997-09-16
EP0789701A1 (en) 1997-08-20
DK0789701T3 (da) 2001-06-18
JP3818541B2 (ja) 2006-09-06
EP0789701B1 (en) 2001-02-07
MY113325A (en) 2002-01-31
ES2155898T3 (es) 2001-06-01
CZ132397A3 (cs) 1998-01-14
HRP950537A2 (en) 1997-08-31
CN1162313A (zh) 1997-10-15
PL319939A1 (en) 1997-09-01
NO972017L (no) 1997-04-30
FI971854A0 (fi) 1997-04-30
CA2203661A1 (en) 1996-05-17
WO1996014320A1 (en) 1996-05-17
NZ295656A (en) 1998-10-28
NO972017D0 (no) 1997-04-30
MX9703255A (es) 1997-07-31
TW349950B (en) 1999-01-11
KR100392060B1 (ko) 2003-11-28
ZA959215B (en) 1997-04-30
PL183686B1 (pl) 2002-06-28
TR199501356A2 (tr) 1996-06-21
JPH10508308A (ja) 1998-08-18
IL115819A (en) 1998-10-30
CZ286945B6 (en) 2000-08-16
US5552399A (en) 1996-09-03
RU2163240C2 (ru) 2001-02-20
PT789701E (pt) 2001-07-31
NO308035B1 (no) 2000-07-10
SI0789701T1 (en) 2001-08-31
IL115819A0 (en) 1996-01-19
HUT77408A (hu) 1998-04-28
AR002238A1 (es) 1998-03-11

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