ES2126773T3 - Derivados triciclicos heteroaromaticos condensados como ligandos de subtipos de receptores de dopamina. - Google Patents

Derivados triciclicos heteroaromaticos condensados como ligandos de subtipos de receptores de dopamina.

Info

Publication number
ES2126773T3
ES2126773T3 ES94925561T ES94925561T ES2126773T3 ES 2126773 T3 ES2126773 T3 ES 2126773T3 ES 94925561 T ES94925561 T ES 94925561T ES 94925561 T ES94925561 T ES 94925561T ES 2126773 T3 ES2126773 T3 ES 2126773T3
Authority
ES
Spain
Prior art keywords
ligands
receptor subtypes
pct
dopamine receptor
tricyclic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925561T
Other languages
English (en)
Inventor
William Barnaby Terlings Davey
Paul David Terlings Par Leeson
Michael Terlings Park E Rowley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939319110A external-priority patent/GB9319110D0/en
Priority claimed from GB939319151A external-priority patent/GB9319151D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2126773T3 publication Critical patent/ES2126773T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

UNA CLASE DE COMPUESTOS HETEROAROMATICOS TRICICLICOS FUNDIDOS DE FORMULA (I), O UNA SAL DE LOS MISMOS O UN PROFARMACO DE LOS MISMOS, QUE CONTIENE PIRAZOL FUNDIDO, ANILLO DE OXAZOL O PIRIMIDINA SON LIGANDOS PARA SUBTIPOS RECEPTORES DE DOPAMINA EN EL CUERPO Y SON POR ELLO DE USO EN EL TRATAMIENTO Y/O PREVENCION DE ENFERMEDADES DEL SISTEMA DE DOPAMINA, COMO ESQUIZOFRENIA.
ES94925561T 1993-09-15 1994-09-06 Derivados triciclicos heteroaromaticos condensados como ligandos de subtipos de receptores de dopamina. Expired - Lifetime ES2126773T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939319110A GB9319110D0 (en) 1993-09-15 1993-09-15 Therapeutic agents
GB939319151A GB9319151D0 (en) 1993-09-16 1993-09-16 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2126773T3 true ES2126773T3 (es) 1999-04-01

Family

ID=26303522

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925561T Expired - Lifetime ES2126773T3 (es) 1993-09-15 1994-09-06 Derivados triciclicos heteroaromaticos condensados como ligandos de subtipos de receptores de dopamina.

Country Status (9)

Country Link
US (1) US6080745A (es)
EP (1) EP0724572B1 (es)
JP (1) JPH09502449A (es)
AT (1) ATE174591T1 (es)
AU (1) AU681695B2 (es)
CA (1) CA2168739A1 (es)
DE (1) DE69415341T2 (es)
ES (1) ES2126773T3 (es)
WO (1) WO1995007893A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
WO1999055335A1 (en) * 1998-04-30 1999-11-04 Basf Aktiengesellschaft Substituted tricyclic pyrazole derivatives with protein kinase activity
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
DE60326950D1 (de) 2002-05-15 2009-05-14 Janssen Pharmaceutica Nv N-substituierte tricyclische 3-aminopyrazole als pdgf rezeptorenhemmer
AR040967A1 (es) * 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
DE60331160D1 (de) 2002-08-15 2010-03-18 Janssen Pharmaceutica Nv Kondensierte heterocyclische isoxazolinderivate und deren verwendung als antidepressiva
AU2003275430A1 (en) * 2003-10-03 2005-05-19 Ortho-Mcneil Pharmaceutical, Inc. Arylindenopyridines and arylindenopyridines and their use as adenosine a2a receptor antagonist
ITMI20041033A1 (it) * 2004-05-24 2004-08-24 Neuroscienze S C A R L Composti farmaceutici
EP2040549B1 (en) * 2006-07-11 2013-10-23 Janssen Pharmaceutica NV Benzofuro-and benzothienopyryimidine modulators of the histamine h4 receptor
US7985745B2 (en) 2006-10-02 2011-07-26 Abbott Laboratories Method for pain treatment
US8735411B2 (en) 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
WO2011059784A1 (en) 2009-10-29 2011-05-19 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
JPWO2017131171A1 (ja) 2016-01-29 2018-11-22 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規化合物及びその薬理学的に許容される塩

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01250380A (ja) * 1987-12-26 1989-10-05 Tokyo Tanabe Co Ltd 光学活性ベンゾキノリジン誘導体、その製造方法およびそれを有効成分とする抗菌剤
AU623474B2 (en) * 1989-01-16 1992-05-14 Laboratoire Roger Bellon New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them
US5041443A (en) * 1989-02-21 1991-08-20 Dainippon Pharmaceutical Co., Ltd. Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
DK0402644T3 (da) * 1989-05-19 1996-01-02 Hoechst Roussel Pharma N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands

Also Published As

Publication number Publication date
AU7542694A (en) 1995-04-03
ATE174591T1 (de) 1999-01-15
CA2168739A1 (en) 1995-03-23
DE69415341T2 (de) 1999-07-15
JPH09502449A (ja) 1997-03-11
WO1995007893A1 (en) 1995-03-23
DE69415341D1 (de) 1999-01-28
EP0724572B1 (en) 1998-12-16
EP0724572A1 (en) 1996-08-07
US6080745A (en) 2000-06-27
AU681695B2 (en) 1997-09-04

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