ATE174591T1 - Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps - Google Patents

Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps

Info

Publication number
ATE174591T1
ATE174591T1 AT94925561T AT94925561T ATE174591T1 AT E174591 T1 ATE174591 T1 AT E174591T1 AT 94925561 T AT94925561 T AT 94925561T AT 94925561 T AT94925561 T AT 94925561T AT E174591 T1 ATE174591 T1 AT E174591T1
Authority
AT
Austria
Prior art keywords
ligands
pct
dopamine receptor
receptor subtype
tricyclic heteroaromatic
Prior art date
Application number
AT94925561T
Other languages
English (en)
Inventor
William Barnaby Davey
Paul David Leeson
Michael Rowley
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939319110A external-priority patent/GB9319110D0/en
Priority claimed from GB939319151A external-priority patent/GB9319151D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE174591T1 publication Critical patent/ATE174591T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT94925561T 1993-09-15 1994-09-06 Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps ATE174591T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939319110A GB9319110D0 (en) 1993-09-15 1993-09-15 Therapeutic agents
GB939319151A GB9319151D0 (en) 1993-09-16 1993-09-16 Therapeutic agents

Publications (1)

Publication Number Publication Date
ATE174591T1 true ATE174591T1 (de) 1999-01-15

Family

ID=26303522

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94925561T ATE174591T1 (de) 1993-09-15 1994-09-06 Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps

Country Status (9)

Country Link
US (1) US6080745A (de)
EP (1) EP0724572B1 (de)
JP (1) JPH09502449A (de)
AT (1) ATE174591T1 (de)
AU (1) AU681695B2 (de)
CA (1) CA2168739A1 (de)
DE (1) DE69415341T2 (de)
ES (1) ES2126773T3 (de)
WO (1) WO1995007893A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
EP1073435B1 (de) * 1998-04-30 2004-07-07 Abbott GmbH & Co. KG Substituierte trizyklische pyrazolderivate mit protein kinase aktivität
WO1999064425A1 (en) * 1998-06-09 1999-12-16 Neurogen Corporation Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands
CN100396670C (zh) 2002-05-15 2008-06-25 詹森药业有限公司 作为pdfg受体抑制剂的n-取代的3-氨基苯并环戊二烯并吡唑及药用组合物和用途
AR040967A1 (es) 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
CN100522972C (zh) * 2002-08-15 2009-08-05 詹森药业有限公司 稠合杂环异噁唑啉衍生物和它们作为抗抑郁剂的用途
WO2005042500A1 (en) * 2003-10-03 2005-05-12 Ortho-Mcneil Pharmaceutical, Inc. Arylindenopyridines and arylindenopyridines and their use as adenosine a2a receptor antagonist
ITMI20041033A1 (it) * 2004-05-24 2004-08-24 Neuroscienze S C A R L Composti farmaceutici
KR20090028819A (ko) * 2006-07-11 2009-03-19 얀센 파마슈티카 엔.브이. 히스타민 ｈ４ 수용체의 벤조푸로- 및 벤조티에노피리미딘 조절제
US8735411B2 (en) 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
US7985745B2 (en) 2006-10-02 2011-07-26 Abbott Laboratories Method for pain treatment
AU2010319879A1 (en) 2009-10-29 2012-06-14 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
JPWO2017131171A1 (ja) 2016-01-29 2018-11-22 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 新規化合物及びその薬理学的に許容される塩

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01250380A (ja) * 1987-12-26 1989-10-05 Tokyo Tanabe Co Ltd 光学活性ベンゾキノリジン誘導体、その製造方法およびそれを有効成分とする抗菌剤
NZ232091A (en) * 1989-01-16 1990-12-21 Bellon Labor Sa Roger 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof
US5041443A (en) * 1989-02-21 1991-08-20 Dainippon Pharmaceutical Co., Ltd. Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
ATE126512T1 (de) * 1989-05-19 1995-09-15 Hoechst Roussel Pharma N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
WO1994010162A1 (en) * 1992-10-23 1994-05-11 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands

Also Published As

Publication number Publication date
US6080745A (en) 2000-06-27
DE69415341T2 (de) 1999-07-15
AU681695B2 (en) 1997-09-04
WO1995007893A1 (en) 1995-03-23
DE69415341D1 (de) 1999-01-28
EP0724572B1 (de) 1998-12-16
JPH09502449A (ja) 1997-03-11
EP0724572A1 (de) 1996-08-07
CA2168739A1 (en) 1995-03-23
ES2126773T3 (es) 1999-04-01
AU7542694A (en) 1995-04-03

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Legal Events

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