DE69415341T2 - Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtyps - Google Patents
Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtypsInfo
- Publication number
- DE69415341T2 DE69415341T2 DE69415341T DE69415341T DE69415341T2 DE 69415341 T2 DE69415341 T2 DE 69415341T2 DE 69415341 T DE69415341 T DE 69415341T DE 69415341 T DE69415341 T DE 69415341T DE 69415341 T2 DE69415341 T2 DE 69415341T2
- Authority
- DE
- Germany
- Prior art keywords
- ligands
- pct
- dopamine receptor
- receptor subtype
- tricyclic heteroaromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000015554 Dopamine receptor Human genes 0.000 title abstract 2
- 108050004812 Dopamine receptor Proteins 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 150000002390 heteroarenes Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939319110A GB9319110D0 (en) | 1993-09-15 | 1993-09-15 | Therapeutic agents |
| GB939319151A GB9319151D0 (en) | 1993-09-16 | 1993-09-16 | Therapeutic agents |
| PCT/GB1994/001936 WO1995007893A1 (en) | 1993-09-15 | 1994-09-06 | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69415341D1 DE69415341D1 (de) | 1999-01-28 |
| DE69415341T2 true DE69415341T2 (de) | 1999-07-15 |
Family
ID=26303522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69415341T Expired - Fee Related DE69415341T2 (de) | 1993-09-15 | 1994-09-06 | Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtyps |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6080745A (de) |
| EP (1) | EP0724572B1 (de) |
| JP (1) | JPH09502449A (de) |
| AT (1) | ATE174591T1 (de) |
| AU (1) | AU681695B2 (de) |
| CA (1) | CA2168739A1 (de) |
| DE (1) | DE69415341T2 (de) |
| ES (1) | ES2126773T3 (de) |
| WO (1) | WO1995007893A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880121A (en) * | 1996-01-05 | 1999-03-09 | Hoechst Marion Roussel Inc. | 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| JP2002512962A (ja) * | 1998-04-30 | 2002-05-08 | ビーエーエスエフ アクチェンゲゼルシャフト | プロテインキナーゼ活性を有する置換三環式ピラゾール誘導体 |
| WO1999064425A1 (en) * | 1998-06-09 | 1999-12-16 | Neurogen Corporation | Substituted thienocycloalkylpyrazoles: dopamine receptor subtype specific ligands |
| MY138268A (en) | 2002-05-15 | 2009-05-29 | Janssen Pharmaceutica Nv | N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders |
| AR040967A1 (es) | 2002-08-12 | 2005-04-27 | Janssen Pharmaceutica Nv | Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos |
| ES2339444T3 (es) * | 2002-08-15 | 2010-05-20 | Janssen Pharmaceutica Nv | Derivados de isoxazolina heterociclicos condensados y su uso como antidepresivos. |
| JP4725963B2 (ja) * | 2003-10-03 | 2011-07-13 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | アリールインデノピリジンおよびアリールインデノピリミジンならびにアデノシンＡ２ａ受容体アンタゴニストとしてのそれらの使用 |
| ITMI20041033A1 (it) * | 2004-05-24 | 2004-08-24 | Neuroscienze S C A R L | Composti farmaceutici |
| MX2009000457A (es) * | 2006-07-11 | 2009-01-27 | Janssen Pharmaceutica Nv | Moduladores de benzofuro- y benzotienopirimidina del receptor h4 de histamina. |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| ES2759949T3 (es) | 2009-10-29 | 2020-05-12 | Bristol Myers Squibb Co | Compuestos heterocíclicos tricíclicos |
| US20190047966A1 (en) | 2016-01-29 | 2019-02-14 | Meiji Seika Pharma Co., Ltd. | Novel compound and pharmacologically acceptable salt thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01250380A (ja) * | 1987-12-26 | 1989-10-05 | Tokyo Tanabe Co Ltd | 光学活性ベンゾキノリジン誘導体、その製造方法およびそれを有効成分とする抗菌剤 |
| AU623474B2 (en) * | 1989-01-16 | 1992-05-14 | Laboratoire Roger Bellon | New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them |
| US5041443A (en) * | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
| ATE126512T1 (de) * | 1989-05-19 | 1995-09-15 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. |
| FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
| AU5341394A (en) * | 1992-10-23 | 1994-05-24 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
-
1994
- 1994-09-06 DE DE69415341T patent/DE69415341T2/de not_active Expired - Fee Related
- 1994-09-06 ES ES94925561T patent/ES2126773T3/es not_active Expired - Lifetime
- 1994-09-06 JP JP7509036A patent/JPH09502449A/ja active Pending
- 1994-09-06 US US08/617,895 patent/US6080745A/en not_active Expired - Fee Related
- 1994-09-06 EP EP94925561A patent/EP0724572B1/de not_active Expired - Lifetime
- 1994-09-06 CA CA002168739A patent/CA2168739A1/en not_active Abandoned
- 1994-09-06 AU AU75426/94A patent/AU681695B2/en not_active Ceased
- 1994-09-06 AT AT94925561T patent/ATE174591T1/de not_active IP Right Cessation
- 1994-09-06 WO PCT/GB1994/001936 patent/WO1995007893A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE69415341D1 (de) | 1999-01-28 |
| JPH09502449A (ja) | 1997-03-11 |
| AU681695B2 (en) | 1997-09-04 |
| ATE174591T1 (de) | 1999-01-15 |
| WO1995007893A1 (en) | 1995-03-23 |
| EP0724572A1 (de) | 1996-08-07 |
| ES2126773T3 (es) | 1999-04-01 |
| EP0724572B1 (de) | 1998-12-16 |
| AU7542694A (en) | 1995-04-03 |
| CA2168739A1 (en) | 1995-03-23 |
| US6080745A (en) | 2000-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |