MY138268A - N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders - Google Patents

N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders

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Publication number
MY138268A
MY138268A MYPI20031800A MYPI20031800A MY138268A MY 138268 A MY138268 A MY 138268A MY PI20031800 A MYPI20031800 A MY PI20031800A MY PI20031800 A MYPI20031800 A MY PI20031800A MY 138268 A MY138268 A MY 138268A
Authority
MY
Malaysia
Prior art keywords
inhibitors
cell proliferative
proliferative disorders
aminopyrazoles
treatment
Prior art date
Application number
MYPI20031800A
Inventor
Chih Yung Ho
Eric D Strobel
Robert W Tuman
Hwa Kwo Yen
Bengt Anders Brunmark
Stuart Emanuel
Robert A Galemmo Jr
Dana L Johnson
Donald W Ludovici
Umar Maharoof
Jay M Mei
Jan L Sechler
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MY138268A publication Critical patent/MY138268A/en

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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D495/04—Ortho-condensed systems

Abstract

THE INVENION IS DIRECTED TO N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLE DERIVATIVES, WHICH ARE USEFUL AS INHIBITORS OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGF-R) KINASE, AND METHODS FOR THE PREPARATION OF SAID DERIVATIVES. THE PRESENT INVENTION IS FURTHER DIRECTED TO PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS OF THE PRESENT INVENTION AND TO METHODS FOR TREATING CONDITIONS SUCH AS TUMORS AND OTHER CELL PROLIFERATIVE DISORDERS.
MYPI20031800A 2002-05-15 2003-05-13 N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders MY138268A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38073502P 2002-05-15 2002-05-15

Publications (1)

Publication Number Publication Date
MY138268A true MY138268A (en) 2009-05-29

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MYPI20031800A MY138268A (en) 2002-05-15 2003-05-13 N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders

Country Status (29)

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US (2) US7196110B2 (en)
EP (1) EP1506175B1 (en)
JP (1) JP2006502097A (en)
KR (1) KR20040106554A (en)
CN (1) CN100396670C (en)
AR (1) AR040079A1 (en)
AT (1) ATE427301T1 (en)
AU (1) AU2003234567A1 (en)
BR (1) BRPI0311179A2 (en)
CA (1) CA2486097A1 (en)
CR (1) CR7574A (en)
DE (1) DE60326950D1 (en)
EA (1) EA008770B1 (en)
ES (1) ES2323952T3 (en)
HR (1) HRP20041188A2 (en)
IL (1) IL165197A0 (en)
MX (1) MXPA04011320A (en)
MY (1) MY138268A (en)
NO (1) NO20045451L (en)
NZ (1) NZ548796A (en)
PE (1) PE20040758A1 (en)
PL (1) PL374062A1 (en)
RS (1) RS98804A (en)
SA (1) SA03240431A (en)
TW (1) TW200407311A (en)
UA (1) UA80820C2 (en)
UY (1) UY27811A1 (en)
WO (1) WO2003097609A1 (en)
ZA (1) ZA200410108B (en)

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