DE69833451D1 - Behandlung der schizophrenie mit ampakinen und neuroleptika - Google Patents
Behandlung der schizophrenie mit ampakinen und neuroleptikaInfo
- Publication number
- DE69833451D1 DE69833451D1 DE69833451T DE69833451T DE69833451D1 DE 69833451 D1 DE69833451 D1 DE 69833451D1 DE 69833451 T DE69833451 T DE 69833451T DE 69833451 T DE69833451 T DE 69833451T DE 69833451 D1 DE69833451 D1 DE 69833451D1
- Authority
- DE
- Germany
- Prior art keywords
- schizophrenia
- treatment
- neuroleptika
- ampakins
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6362797P | 1997-10-27 | 1997-10-27 | |
US63627P | 1997-10-27 | ||
PCT/US1998/022707 WO1999021422A1 (en) | 1997-10-27 | 1998-10-26 | Treatment of schizophrenia with ampakines and neuroleptics |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69833451D1 true DE69833451D1 (de) | 2006-04-20 |
DE69833451T2 DE69833451T2 (de) | 2006-09-28 |
Family
ID=22050462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69833451T Expired - Lifetime DE69833451T2 (de) | 1997-10-27 | 1998-10-26 | Behandlung der schizophrenie mit ampakinen und neuroleptika |
Country Status (15)
Country | Link |
---|---|
US (1) | US6166008A (de) |
EP (1) | EP1026950B1 (de) |
JP (1) | JP2001520978A (de) |
CN (1) | CN1281335A (de) |
AT (1) | ATE317226T1 (de) |
AU (1) | AU745641B2 (de) |
BR (1) | BR9814106A (de) |
CA (1) | CA2306817A1 (de) |
CY (1) | CY1105557T1 (de) |
DE (1) | DE69833451T2 (de) |
DK (1) | DK1026950T3 (de) |
ES (1) | ES2258825T3 (de) |
HK (1) | HK1030338A1 (de) |
PT (1) | PT1026950E (de) |
WO (1) | WO1999021422A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE215079T1 (de) | 1992-07-24 | 2002-04-15 | Univ California | Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen |
US20040229898A1 (en) * | 2001-05-25 | 2004-11-18 | The Regents Of The University Of California | Cyclic bis-compounds clearing malformed proteins |
WO2002096431A1 (en) * | 2001-05-25 | 2002-12-05 | The Regents Of The University Of California | Optically active compounds clearing malformed proteins |
AU2002324666B2 (en) * | 2001-08-10 | 2007-10-11 | The Rockefeller University | Compostions and methods for modulation of DARPP-32 phosphorylation |
UA80317C2 (en) * | 2003-01-13 | 2007-09-10 | Cortex Pharma Inc | Method of treating cognitive decline due to sleep deprivation and stress |
WO2005013961A1 (en) * | 2003-07-17 | 2005-02-17 | Eli Lilly And Company | Combination therapy for treatment of cognitive disorders or psychoses |
NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
WO2005023182A2 (en) * | 2003-08-28 | 2005-03-17 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
GB0325175D0 (en) * | 2003-10-28 | 2003-12-03 | Novartis Ag | Organic compounds |
WO2005072345A2 (en) * | 2004-01-26 | 2005-08-11 | Cortex Pharmaceuticals Inc. | Enhancement of ampakine-induced facilitation of synaptic responses by cholinesterase inhibitors |
AU2005258161B2 (en) | 2004-06-21 | 2011-05-26 | The Board Of Trustees Of The Leland Stanford Junior University | Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder |
US20060063707A1 (en) * | 2004-09-17 | 2006-03-23 | Lifelike Biomatic, Inc. | Compositions for enhancing memory and methods therefor |
EP1809104A4 (de) * | 2004-09-23 | 2009-04-29 | Alexander Michalow | Verfahren zum regeln von neurotransmittersystemen durch gegenadaptationen |
AU2006216665A1 (en) * | 2005-02-24 | 2006-08-31 | Nicox S.A. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
KR101411167B1 (ko) | 2005-04-13 | 2014-06-23 | 아스텍스 테라퓨틱스 리미티드 | 하이드록시벤즈아미드 유도체 및 hsp90 억제제로서의이의 용도 |
KR20060119373A (ko) * | 2005-05-20 | 2006-11-24 | 엘지전자 주식회사 | 컴퓨터 시스템과 시스템 소프트웨어 설치방법 및 휴대용컴퓨터의 소프트웨어 설치방법 |
US20090233842A1 (en) | 2005-11-12 | 2009-09-17 | Prtzker Neuropsychiatric Research Fund Llc | Fgf2-related methods for diagnosing and treating depression |
US20090286797A1 (en) * | 2005-11-22 | 2009-11-19 | Dan Peters | Novel Quinoxaline Derivatives and Their Medical Use |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
WO2008036282A1 (en) * | 2006-09-18 | 2008-03-27 | The Regents Of The University Of Californina | Upregulating activity or expression of bdnf to mitigate cognitive impairment in asymptomatic huntington's subjects |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
JP5721949B2 (ja) | 2006-10-12 | 2015-05-20 | アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited | 複合薬剤 |
US8779132B2 (en) | 2006-10-12 | 2014-07-15 | Astex Therapeutics Limited | Pharmaceutical compounds |
WO2008128166A1 (en) * | 2007-04-13 | 2008-10-23 | Concert Pharmaceuticals Inc. | Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds |
US20090006902A1 (en) * | 2007-06-29 | 2009-01-01 | International Business Machines Corporation | Methods, systems, and computer program products for reporting fru failures in storage device enclosures |
WO2009023126A2 (en) | 2007-08-10 | 2009-02-19 | Cortex Pharmaceuticals, Inc. | Bicyclic amides for enhancing glutamatergic synaptic responses |
US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
US8071914B2 (en) * | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
WO2010087981A2 (en) * | 2009-02-02 | 2010-08-05 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
PT105083A (pt) | 2009-04-28 | 2011-07-25 | Univ De Coimbra | Processo para cultura de células estaminais neurais baseado nas ampacinas e/ou outros moduladores de receptores glutamatérgicos ionotrópicos, composições e seu uso em condições do sistema nervoso central |
US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
AU2012225784B2 (en) | 2011-03-04 | 2016-03-17 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
US8822464B2 (en) | 2011-11-28 | 2014-09-02 | Boehringer Ingelheim International Gmbh | N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
US8741892B2 (en) * | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
US8716277B2 (en) | 2011-12-14 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity |
US8883789B2 (en) | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
ES2673872T3 (es) | 2012-06-05 | 2018-06-26 | The Board Of Trustees Of The Leland Stanford Junior University | Mimético del péptido NCAM para su uso en el tratamiento de trastorno de depresión mayor |
MA52288A (fr) | 2018-04-18 | 2021-04-07 | Constellation Pharmaceuticals Inc | Modulateurs d'enzymes de modification de méthyle, compositions et utilisations de ceux-ci |
CN112262143A (zh) | 2018-05-21 | 2021-01-22 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8908085D0 (en) * | 1989-04-11 | 1989-05-24 | Lundbeck & Co As H | New therapeutic use |
US5312819A (en) * | 1990-08-20 | 1994-05-17 | Sandoz Ltd. | Pharmaceutical compositions comprising clozapine and a radical scavenger |
US5447948A (en) * | 1992-05-07 | 1995-09-05 | Yale University | Dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia |
GB9507230D0 (en) * | 1995-04-07 | 1995-05-31 | Inst Of Psychiatry | Novel method |
US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
US5773434A (en) * | 1995-08-30 | 1998-06-30 | Gary A. Rogers | Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia |
US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
-
1998
- 1998-10-26 AT AT98957382T patent/ATE317226T1/de active
- 1998-10-26 AU AU13658/99A patent/AU745641B2/en not_active Ceased
- 1998-10-26 US US09/179,341 patent/US6166008A/en not_active Expired - Lifetime
- 1998-10-26 WO PCT/US1998/022707 patent/WO1999021422A1/en active IP Right Grant
- 1998-10-26 CA CA002306817A patent/CA2306817A1/en not_active Abandoned
- 1998-10-26 JP JP2000517599A patent/JP2001520978A/ja active Pending
- 1998-10-26 PT PT98957382T patent/PT1026950E/pt unknown
- 1998-10-26 DK DK98957382T patent/DK1026950T3/da active
- 1998-10-26 ES ES98957382T patent/ES2258825T3/es not_active Expired - Lifetime
- 1998-10-26 DE DE69833451T patent/DE69833451T2/de not_active Expired - Lifetime
- 1998-10-26 BR BR9814106-6A patent/BR9814106A/pt not_active Application Discontinuation
- 1998-10-26 CN CN98812086A patent/CN1281335A/zh active Pending
- 1998-10-26 EP EP98957382A patent/EP1026950B1/de not_active Revoked
-
2001
- 2001-02-15 HK HK01101109A patent/HK1030338A1/xx not_active IP Right Cessation
-
2006
- 2006-05-04 CY CY20061100571T patent/CY1105557T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE317226T1 (de) | 2006-02-15 |
CN1281335A (zh) | 2001-01-24 |
CY1105557T1 (el) | 2010-07-28 |
ES2258825T3 (es) | 2006-09-01 |
EP1026950B1 (de) | 2006-02-08 |
PT1026950E (pt) | 2006-06-30 |
AU1365899A (en) | 1999-05-17 |
HK1030338A1 (en) | 2001-05-04 |
CA2306817A1 (en) | 1999-05-06 |
DE69833451T2 (de) | 2006-09-28 |
EP1026950A1 (de) | 2000-08-16 |
JP2001520978A (ja) | 2001-11-06 |
AU745641B2 (en) | 2002-03-28 |
DK1026950T3 (da) | 2006-06-26 |
US6166008A (en) | 2000-12-26 |
EP1026950A4 (de) | 2004-07-07 |
BR9814106A (pt) | 2000-10-03 |
WO1999021422A1 (en) | 1999-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |