BR9814106A - Processo para tratar da esquizofrenia em um indivìduo, e, conjunto - Google Patents
Processo para tratar da esquizofrenia em um indivìduo, e, conjuntoInfo
- Publication number
- BR9814106A BR9814106A BR9814106-6A BR9814106A BR9814106A BR 9814106 A BR9814106 A BR 9814106A BR 9814106 A BR9814106 A BR 9814106A BR 9814106 A BR9814106 A BR 9814106A
- Authority
- BR
- Brazil
- Prior art keywords
- schizophrenia
- individual
- treatment
- relates
- treat schizophrenia
- Prior art date
Links
- 201000000980 schizophrenia Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 229940005529 antipsychotics Drugs 0.000 abstract 1
- 230000006399 behavior Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 229960004170 clozapine Drugs 0.000 abstract 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 abstract 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 abstract 1
- 229960001252 methamphetamine Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"PROCESSO PARA TRATAR DA ESQUIZOFRENIA EM UM INDIVìDUO, E, CONJUNTO" Esta invenção diz respeito ao tratamento da esquizofrenia e distúrbios psicóticos relacionados, incluindo a intensificação do funcionamento receptor nas sinapses nas redes cerebrais responsáveis por comportamentos de ordem mais elevada. Em um aspecto particular, a invenção diz respeito a processos para o uso de supra-moduladores do receptor AMPA em conjunção com antipsicóticos para o tratamento da esquizofrenia. Conjuntos contendo as composições na forma apropriada para administração também são fornecidos. A figura mostra que uma Ampacina (CX516) representativa intensifica sinergisticamente o antagonismo da clozapina de atividade de estímulo induzida pela metanfetamina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6362797P | 1997-10-27 | 1997-10-27 | |
PCT/US1998/022707 WO1999021422A1 (en) | 1997-10-27 | 1998-10-26 | Treatment of schizophrenia with ampakines and neuroleptics |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9814106A true BR9814106A (pt) | 2000-10-03 |
Family
ID=22050462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9814106-6A BR9814106A (pt) | 1997-10-27 | 1998-10-26 | Processo para tratar da esquizofrenia em um indivìduo, e, conjunto |
Country Status (15)
Country | Link |
---|---|
US (1) | US6166008A (pt) |
EP (1) | EP1026950B1 (pt) |
JP (1) | JP2001520978A (pt) |
CN (1) | CN1281335A (pt) |
AT (1) | ATE317226T1 (pt) |
AU (1) | AU745641B2 (pt) |
BR (1) | BR9814106A (pt) |
CA (1) | CA2306817A1 (pt) |
CY (1) | CY1105557T1 (pt) |
DE (1) | DE69833451T2 (pt) |
DK (1) | DK1026950T3 (pt) |
ES (1) | ES2258825T3 (pt) |
HK (1) | HK1030338A1 (pt) |
PT (1) | PT1026950E (pt) |
WO (1) | WO1999021422A1 (pt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT651746E (pt) | 1992-07-24 | 2002-09-30 | Univ California | Drogas que intensificam as respostas sinapticas mediadas por receptores de ampa |
US20040229898A1 (en) * | 2001-05-25 | 2004-11-18 | The Regents Of The University Of California | Cyclic bis-compounds clearing malformed proteins |
US20050020582A1 (en) * | 2001-05-25 | 2005-01-27 | Prusiner Stanley B | Optically active compounds clearing malformed proteins |
JP2004538323A (ja) * | 2001-08-10 | 2004-12-24 | ザ ロックフェラー ユニバーシティー | Darpp−32リン酸化のモジュレーションのための組成物及び方法 |
CA2509251A1 (en) * | 2003-01-13 | 2004-07-29 | Cortex Pharmaceuticals, Inc. | Method of treating cognitive decline due to sleep deprivation and stress |
WO2005013961A1 (en) * | 2003-07-17 | 2005-02-17 | Eli Lilly And Company | Combination therapy for treatment of cognitive disorders or psychoses |
NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
AU2004270162B2 (en) | 2003-08-28 | 2010-05-13 | Nicox S.A. | Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use |
GB0325175D0 (en) * | 2003-10-28 | 2003-12-03 | Novartis Ag | Organic compounds |
EP1715863B1 (en) * | 2004-01-26 | 2012-05-09 | Cortex Pharmaceuticals, Inc. | Enhancement of ampakine-induced facilitation of synaptic responses by cholinesterase inhibitors |
ATE551432T1 (de) | 2004-06-21 | 2012-04-15 | Univ Leland Stanford Junior | Bei manisch-depressiver erkrankung und/oder schwerer depressiver erkrankung unterschiedlich exprimierte gene und wege |
WO2006034196A1 (en) * | 2004-09-17 | 2006-03-30 | Lifelike Biomatic Inc. | Compositions for enhancing memory and methods therefor |
AU2005286733B2 (en) * | 2004-09-23 | 2009-11-05 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
WO2006091716A2 (en) * | 2005-02-24 | 2006-08-31 | Nitromed, Inc. | Nitric oxide enhancing diuretic compounds, compositions and methods of use |
ME01541B (me) | 2005-04-13 | 2014-04-20 | Astex Therapeutics Ltd | DERIVATI HIDROKSIBENZAMIDA l NJIHOVA PRIMJENA KAO INHIBITORA HSP90 |
KR20060119373A (ko) * | 2005-05-20 | 2006-11-24 | 엘지전자 주식회사 | 컴퓨터 시스템과 시스템 소프트웨어 설치방법 및 휴대용컴퓨터의 소프트웨어 설치방법 |
JP5366554B2 (ja) | 2005-11-12 | 2013-12-11 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | うつを診断および処置するためのfgf2関連方法 |
EP1960373A2 (en) * | 2005-11-22 | 2008-08-27 | NeuroSearch A/S | Novel quinoxaline derivatives and their medical use |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
WO2008036282A1 (en) * | 2006-09-18 | 2008-03-27 | The Regents Of The University Of Californina | Upregulating activity or expression of bdnf to mitigate cognitive impairment in asymptomatic huntington's subjects |
WO2008044029A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
JP5410285B2 (ja) | 2006-10-12 | 2014-02-05 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
US8198305B2 (en) * | 2007-04-13 | 2012-06-12 | Concert Pharmaceuticals Inc. | 1,2-benzisoxazol-3-yl compounds |
US20090006902A1 (en) * | 2007-06-29 | 2009-01-01 | International Business Machines Corporation | Methods, systems, and computer program products for reporting fru failures in storage device enclosures |
CN101896183B (zh) | 2007-08-10 | 2013-11-27 | 科泰克斯药品公司 | 用于增强谷氨酸能突触反应的二环酰胺 |
US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
US8071914B2 (en) * | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
MX2011008060A (es) * | 2009-02-02 | 2011-09-09 | Cortex Pharma Inc | Derivados de amida biciclica para mejorar las respuestas sinapticas glutamatergicas. |
PT105083A (pt) | 2009-04-28 | 2011-07-25 | Univ De Coimbra | Processo para cultura de células estaminais neurais baseado nas ampacinas e/ou outros moduladores de receptores glutamatérgicos ionotrópicos, composições e seu uso em condições do sistema nervoso central |
WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
EP2801377B1 (en) | 2011-03-04 | 2019-08-07 | The Regents of The University of California | Hydrogel comprising cells for local release of growth factors to mediate motor recovery after stroke |
US8822464B2 (en) | 2011-11-28 | 2014-09-02 | Boehringer Ingelheim International Gmbh | N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
US8741892B2 (en) * | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
US8716277B2 (en) | 2011-12-14 | 2014-05-06 | Boehringer Ingelheim International Gmbh | Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity |
US8883789B2 (en) | 2011-12-14 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
AU2013271609A1 (en) | 2012-06-05 | 2014-12-18 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating psychiatric disorders or symptoms thereof using NCAM peptide mimetics |
CA3098428A1 (en) | 2018-04-18 | 2019-10-24 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8908085D0 (en) * | 1989-04-11 | 1989-05-24 | Lundbeck & Co As H | New therapeutic use |
US5312819A (en) * | 1990-08-20 | 1994-05-17 | Sandoz Ltd. | Pharmaceutical compositions comprising clozapine and a radical scavenger |
US5447948A (en) * | 1992-05-07 | 1995-09-05 | Yale University | Dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia |
GB9507230D0 (en) * | 1995-04-07 | 1995-05-31 | Inst Of Psychiatry | Novel method |
US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
US5773434A (en) * | 1995-08-30 | 1998-06-30 | Gary A. Rogers | Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia |
US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
-
1998
- 1998-10-26 US US09/179,341 patent/US6166008A/en not_active Expired - Lifetime
- 1998-10-26 DK DK98957382T patent/DK1026950T3/da active
- 1998-10-26 CA CA002306817A patent/CA2306817A1/en not_active Abandoned
- 1998-10-26 ES ES98957382T patent/ES2258825T3/es not_active Expired - Lifetime
- 1998-10-26 DE DE69833451T patent/DE69833451T2/de not_active Expired - Lifetime
- 1998-10-26 PT PT98957382T patent/PT1026950E/pt unknown
- 1998-10-26 AU AU13658/99A patent/AU745641B2/en not_active Ceased
- 1998-10-26 JP JP2000517599A patent/JP2001520978A/ja active Pending
- 1998-10-26 CN CN98812086A patent/CN1281335A/zh active Pending
- 1998-10-26 WO PCT/US1998/022707 patent/WO1999021422A1/en active IP Right Grant
- 1998-10-26 BR BR9814106-6A patent/BR9814106A/pt not_active Application Discontinuation
- 1998-10-26 AT AT98957382T patent/ATE317226T1/de active
- 1998-10-26 EP EP98957382A patent/EP1026950B1/en not_active Revoked
-
2001
- 2001-02-15 HK HK01101109A patent/HK1030338A1/xx not_active IP Right Cessation
-
2006
- 2006-05-04 CY CY20061100571T patent/CY1105557T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU745641B2 (en) | 2002-03-28 |
DK1026950T3 (da) | 2006-06-26 |
US6166008A (en) | 2000-12-26 |
WO1999021422A1 (en) | 1999-05-06 |
AU1365899A (en) | 1999-05-17 |
CY1105557T1 (el) | 2010-07-28 |
HK1030338A1 (en) | 2001-05-04 |
JP2001520978A (ja) | 2001-11-06 |
CN1281335A (zh) | 2001-01-24 |
ATE317226T1 (de) | 2006-02-15 |
EP1026950B1 (en) | 2006-02-08 |
DE69833451D1 (de) | 2006-04-20 |
EP1026950A4 (en) | 2004-07-07 |
CA2306817A1 (en) | 1999-05-06 |
DE69833451T2 (de) | 2006-09-28 |
PT1026950E (pt) | 2006-06-30 |
EP1026950A1 (en) | 2000-08-16 |
ES2258825T3 (es) | 2006-09-01 |
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Legal Events
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI. |
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B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |