ATE160779T1 - Antipsychotische indazolderivate - Google Patents
Antipsychotische indazolderivateInfo
- Publication number
- ATE160779T1 ATE160779T1 AT94909210T AT94909210T ATE160779T1 AT E160779 T1 ATE160779 T1 AT E160779T1 AT 94909210 T AT94909210 T AT 94909210T AT 94909210 T AT94909210 T AT 94909210T AT E160779 T1 ATE160779 T1 AT E160779T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- indazole derivatives
- sec
- dopamine
- antipsychotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939305623A GB9305623D0 (en) | 1993-03-18 | 1993-03-18 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE160779T1 true ATE160779T1 (de) | 1997-12-15 |
Family
ID=10732311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94909210T ATE160779T1 (de) | 1993-03-18 | 1994-03-14 | Antipsychotische indazolderivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5780475A (de) |
| EP (1) | EP0689539B1 (de) |
| JP (1) | JPH08512284A (de) |
| AT (1) | ATE160779T1 (de) |
| AU (1) | AU685090B2 (de) |
| CA (1) | CA2156838A1 (de) |
| DE (1) | DE69407174T2 (de) |
| ES (1) | ES2110225T3 (de) |
| GB (1) | GB9305623D0 (de) |
| WO (1) | WO1994021630A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9324244D0 (en) * | 1993-11-25 | 1994-01-12 | Merck Sharp & Dohme | Therapeutic agents |
| JPH09124643A (ja) * | 1995-08-14 | 1997-05-13 | Bristol Myers Squibb Co | 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体 |
| AU7319096A (en) * | 1995-11-02 | 1997-05-22 | Merck Sharp & Dohme Limited | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation and their use as selective agonists of 5-ht1-like receptors |
| GB9524356D0 (en) * | 1995-11-29 | 1996-01-31 | Merck Sharp & Dohme | Therapeutic agents |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| DE19637237A1 (de) | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazin-Derivate |
| WO1998035942A1 (en) * | 1997-02-18 | 1998-08-20 | American Home Products Corporation | 4-aminoethoxyindazole derivatives |
| US5872144A (en) * | 1997-02-18 | 1999-02-16 | American Home Products Corporation | 4-aminoethoxyindazole derivatives |
| IL126745A (en) * | 1997-11-04 | 2003-09-17 | Pfizer Prod Inc | Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors |
| WO2000012500A2 (en) * | 1998-09-02 | 2000-03-09 | Neurogen Corporation | 2-aryl-4-(1-[4-heteroaryl]piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands |
| US6355801B1 (en) | 1999-11-08 | 2002-03-12 | Schering Corporation | Process for preparing N-(4-hydroxyphenyl)-N′-(4′-aminophenyl)-piperazine |
| HUP0203645A3 (en) * | 1999-12-30 | 2004-01-28 | Lundbeck & Co As H | Phenylpiperazinyl derivatives, pharmaceutical compositions containing them and their use |
| AR035521A1 (es) * | 2000-12-22 | 2004-06-02 | Lundbeck & Co As H | Derivados de 3-indolina y composicion farmaceutica que los comprende |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| KR101255356B1 (ko) | 2002-06-12 | 2013-04-17 | 케모센트릭스, 인크. | 염증 및 면역 질병의 치료를 위한 ｃｃｒ１ 길항물질로서사용하기 위한 1-아릴-4-치환된 피페라진 유도체 |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| JP4845873B2 (ja) * | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
| ATE460415T1 (de) * | 2004-11-29 | 2010-03-15 | Warner Lambert Co | Therapeutische pyrazoloä3,4-büpyridine und - indazole |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| AR065804A1 (es) | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
| US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
| US9238643B2 (en) | 2010-09-06 | 2016-01-19 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Amide compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| US3678059A (en) * | 1969-10-07 | 1972-07-18 | Ciba Geigy Corp | 3-aminoalkylidene-indazoles |
| MX173362B (es) * | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| GB8900382D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
| DE69232907T2 (de) * | 1991-03-28 | 2003-05-15 | Eisai Co Ltd | Neue heterocyclische/cyclische amine |
| PL310443A1 (en) * | 1993-03-01 | 1995-12-11 | Merck Sharp & Dohme | Derivatives of pyrolo-pyridine |
| GB9305641D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
-
1993
- 1993-03-18 GB GB939305623A patent/GB9305623D0/en active Pending
-
1994
- 1994-03-14 EP EP94909210A patent/EP0689539B1/de not_active Expired - Lifetime
- 1994-03-14 DE DE69407174T patent/DE69407174T2/de not_active Expired - Fee Related
- 1994-03-14 WO PCT/GB1994/000504 patent/WO1994021630A1/en active IP Right Grant
- 1994-03-14 ES ES94909210T patent/ES2110225T3/es not_active Expired - Lifetime
- 1994-03-14 AU AU62140/94A patent/AU685090B2/en not_active Ceased
- 1994-03-14 CA CA002156838A patent/CA2156838A1/en not_active Abandoned
- 1994-03-14 AT AT94909210T patent/ATE160779T1/de active
- 1994-03-14 US US08/525,629 patent/US5780475A/en not_active Expired - Fee Related
- 1994-03-14 JP JP6520766A patent/JPH08512284A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69407174T2 (de) | 1998-07-02 |
| CA2156838A1 (en) | 1994-09-29 |
| EP0689539A1 (de) | 1996-01-03 |
| EP0689539B1 (de) | 1997-12-03 |
| DE69407174D1 (de) | 1998-01-15 |
| WO1994021630A1 (en) | 1994-09-29 |
| US5780475A (en) | 1998-07-14 |
| GB9305623D0 (en) | 1993-05-05 |
| JPH08512284A (ja) | 1996-12-24 |
| AU685090B2 (en) | 1998-01-15 |
| ES2110225T3 (es) | 1998-02-01 |
| AU6214094A (en) | 1994-10-11 |
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