DE69930308D1 - Selektive 5-ht 6-rezeptor-liganden - Google Patents

Selektive 5-ht 6-rezeptor-liganden

Info

Publication number
DE69930308D1
DE69930308D1 DE69930308T DE69930308T DE69930308D1 DE 69930308 D1 DE69930308 D1 DE 69930308D1 DE 69930308 T DE69930308 T DE 69930308T DE 69930308 T DE69930308 T DE 69930308T DE 69930308 D1 DE69930308 D1 DE 69930308D1
Authority
DE
Germany
Prior art keywords
selective
receptor ligands
receptors
compounds
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69930308T
Other languages
English (en)
Other versions
DE69930308T2 (de
Inventor
A Glennon
L Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Commonwealth University
Original Assignee
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Commonwealth University filed Critical Virginia Commonwealth University
Application granted granted Critical
Publication of DE69930308D1 publication Critical patent/DE69930308D1/de
Publication of DE69930308T2 publication Critical patent/DE69930308T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Escalators And Moving Walkways (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Conductive Materials (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
DE69930308T 1998-12-11 1999-12-10 Selektive 5-ht 6-rezeptor-liganden Expired - Fee Related DE69930308T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11178798P 1998-12-11 1998-12-11
US111787P 1998-12-11
PCT/US1999/029219 WO2000034242A1 (en) 1998-12-11 1999-12-10 Selective 5-ht6 receptor ligands

Publications (2)

Publication Number Publication Date
DE69930308D1 true DE69930308D1 (de) 2006-05-04
DE69930308T2 DE69930308T2 (de) 2006-11-30

Family

ID=22340454

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930308T Expired - Fee Related DE69930308T2 (de) 1998-12-11 1999-12-10 Selektive 5-ht 6-rezeptor-liganden

Country Status (10)

Country Link
EP (1) EP1149078B1 (de)
AT (1) ATE319683T1 (de)
AU (1) AU767009B2 (de)
CA (1) CA2353962C (de)
DE (1) DE69930308T2 (de)
DK (1) DK1149078T3 (de)
ES (1) ES2260958T3 (de)
MX (1) MXPA01005905A (de)
PT (1) PT1149078E (de)
WO (1) WO2000034242A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001296193B2 (en) 2000-10-20 2006-04-27 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-N1-(benzensulfonyl)indoles and their use in therapy
ES2566056T3 (es) * 2001-03-29 2016-04-08 Eli Lilly And Company N-(2-ariletil)bencilaminas como antagonistas del receptor 5-HT6
SI1379239T1 (sl) * 2001-03-29 2008-02-29 Lilly Co Eli N-(2-ariletil)benzilamini, uporabljeni kot antagonisti receptorja 5-ht6
US7144883B2 (en) 2001-06-11 2006-12-05 Biovitrum Ab Bicyclic sulfonamide compounds
ITRM20010356A1 (it) * 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
EP1897881A3 (de) 2002-06-20 2009-03-18 Biovitrum AB (publ) Zur Behandlung von Obesitas, Typ II-Diabetes und ZNS-Erkrankungen geeignete Verbindungen
AU2003249582B2 (en) 2002-06-21 2006-08-03 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
JP4571507B2 (ja) * 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
PT1637527E (pt) 2003-06-26 2013-06-28 Takeda Pharmaceutical Modulador do receptor de canabinóides
JP2007500701A (ja) * 2003-07-31 2007-01-18 ワイス ５−ヒドロキシトリプタミン−６リガンドとしてのｎ−スルホニルヘテロシクロピロリルアルキルアミン化合物
SE0303480D0 (sv) 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
AU2005302559A1 (en) 2004-11-01 2006-05-11 Wyeth Substituted indolizines and derivatives as CNS agents
US7582767B2 (en) 2005-06-17 2009-09-01 Biovitrum Ab (Publ.) Substituted sulphonamide compound and uses thereof
BRPI0619308A2 (pt) * 2005-10-19 2013-03-05 Suven Life Sciences Ltd composto, processo para a preparaÇço do composto, mÉtodo para o tratamento de uma desordem do sistema nervoso central relacionadas a ou afetada pelo receptor 5-ht6, composiÇço farmacÊutica, uso do composto e mÉtodo para testar antagonistas e antagonistas com seletividade para o receptor 5-ht6
EP2134714A1 (de) 2007-03-13 2009-12-23 Biovitrum AB (publ) Tricyclische isochinolinderivate zur behandlung von obesitas
EP2231160B1 (de) 2007-12-04 2013-08-14 Merck Sharp & Dohme Corp. Tryptamin-sulfonamide als 5-ht6-antagonisten
EP2103596A1 (de) 2008-03-18 2009-09-23 Laboratorios Del. Dr. Esteve, S.A. Verfahren zur Herstellung von N-(Phenylethyl)-Anilinsalzen und deren Solvate zur nützlichen Verwendung als Serotonin-5-HT6-Antagonisten
GB0905328D0 (en) * 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
FR2961095B1 (fr) * 2010-06-09 2012-06-15 Oreal Composition cosmetique et/ou dermatologique comprenant au moins un compose 6-alcoxy tryptamine
FR2961097B1 (fr) * 2010-06-09 2012-07-13 Oreal Procede cosmetique de traitement des odeurs corporelles humaines utilisant un compose 6-alkoxy tryptamine
CA2853729A1 (en) 2011-10-28 2013-05-02 Board Of Regents, The University Of Texas System Novel compositions and methods for treating cancer
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
KR20240096817A (ko) 2020-05-19 2024-06-26 사이빈 아이알엘 리미티드 중수소화된 트립타민 유도체 및 사용 방법
US20240025850A1 (en) * 2020-12-09 2024-01-25 Caamtech, Inc. Dialkyl tryptamines and their therapeutic uses
WO2023115166A1 (en) * 2021-12-24 2023-06-29 Psylo Pty Ltd Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
GB8416724D0 (en) * 1984-06-30 1984-08-01 Sorbio Sa Lab Active compounds

Also Published As

Publication number Publication date
AU2356200A (en) 2000-06-26
CA2353962A1 (en) 2000-06-15
EP1149078A4 (de) 2003-01-29
DE69930308T2 (de) 2006-11-30
ATE319683T1 (de) 2006-03-15
PT1149078E (pt) 2006-07-31
MXPA01005905A (es) 2002-09-18
EP1149078B1 (de) 2006-03-08
EP1149078A1 (de) 2001-10-31
ES2260958T3 (es) 2006-11-01
WO2000034242A1 (en) 2000-06-15
DK1149078T3 (da) 2006-07-10
CA2353962C (en) 2009-09-29
AU767009B2 (en) 2003-10-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee