BR9809071A - Agentes farmacológicos - Google Patents
Agentes farmacológicosInfo
- Publication number
- BR9809071A BR9809071A BR9809071-2A BR9809071A BR9809071A BR 9809071 A BR9809071 A BR 9809071A BR 9809071 A BR9809071 A BR 9809071A BR 9809071 A BR9809071 A BR 9809071A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmacological agents
- selective
- antagonists
- glur5 receptor
- pain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"AGENTES FARMACOLóGICOS"<D>. Antagonistas seletivos para o receptor de GluR5 são úteis no tratamento de dor. Também são apresentados novos derivados de decaidroisoquinolina que são antagonistas seletivos do receptor de GluR5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4279597P | 1997-04-07 | 1997-04-07 | |
PCT/US1998/006905 WO1998045270A1 (en) | 1997-04-07 | 1998-04-06 | Pharmacological agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9809071A true BR9809071A (pt) | 2000-08-01 |
Family
ID=21923795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9809071-2A BR9809071A (pt) | 1997-04-07 | 1998-04-06 | Agentes farmacológicos |
Country Status (17)
Country | Link |
---|---|
US (1) | US6242462B1 (pt) |
EP (1) | EP0980358A4 (pt) |
JP (1) | JP2001521505A (pt) |
KR (1) | KR20010006075A (pt) |
CN (1) | CN1259126A (pt) |
AU (1) | AU734657B2 (pt) |
BR (1) | BR9809071A (pt) |
CA (1) | CA2285192A1 (pt) |
EA (1) | EA199900912A1 (pt) |
HU (1) | HUP0002030A3 (pt) |
ID (1) | ID23013A (pt) |
IL (1) | IL132086A0 (pt) |
NO (1) | NO994850L (pt) |
NZ (1) | NZ337827A (pt) |
PL (1) | PL336068A1 (pt) |
TR (1) | TR199902449T2 (pt) |
WO (1) | WO1998045270A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60002733T2 (de) * | 1999-07-06 | 2004-03-18 | Eli Lilly And Co., Indianapolis | Diester prodrugs von decahydroischinoline-3-carbonsäure |
BR0012175A (pt) | 1999-07-06 | 2002-03-05 | Lilly Co Eli | Antagonistas de receptor de igiur5, seletivos para o tratamento de enxaqueca |
AU2574801A (en) | 1999-12-22 | 2001-07-03 | Eli Lilly And Company | Selective iGLUR5 receptor antagonists |
US7205313B2 (en) | 2001-01-05 | 2007-04-17 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
US6924294B2 (en) | 2001-01-05 | 2005-08-02 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
AU2002241565A1 (en) * | 2001-01-05 | 2002-07-16 | Eli Lilly And Company | Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders |
US6953805B2 (en) | 2001-01-05 | 2005-10-11 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
JP4132049B2 (ja) * | 2001-01-05 | 2008-08-13 | イーライ リリー アンド カンパニー | 興奮性アミノ酸レセプターアンタゴニスト |
AU2002228736A1 (en) | 2001-01-05 | 2002-07-16 | Eli Lilly And Company | Pyrrolidinylmethyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists |
EP1355640A1 (en) | 2001-01-23 | 2003-10-29 | Neurosearch A/S | Use of non-competitive and selective glur5 antagonists as glutamate receptor modulating compounds |
DK1511741T3 (da) | 2002-04-26 | 2013-01-21 | Lilly Co Eli | Esterderivater af en decahydroisoquinolin-3-carboxylsyre som analgetika |
US20050101597A1 (en) * | 2003-07-10 | 2005-05-12 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitior and a non-NMDA glutamate modulator for the treatment of central nervous system damage |
US7795266B2 (en) * | 2003-09-25 | 2010-09-14 | Helton David R | Tetrahydroindolone derivatives for treament of neurological conditions |
US20050107439A1 (en) * | 2003-11-10 | 2005-05-19 | Helton David R. | Composition and method for treating emesis |
JP2010510314A (ja) | 2006-11-22 | 2010-04-02 | シーサイド セラピューティクス,エルエルシー | 精神遅滞、ダウン症候群、脆弱x症候群および自閉症の治療方法 |
US8603980B2 (en) | 2007-01-16 | 2013-12-10 | The Johns Hopkins University | Glutamate receptor antagonists and methods of use |
WO2009062134A1 (en) * | 2007-11-09 | 2009-05-14 | Cenomed Biosciences, Llc | Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds |
US20090264443A1 (en) * | 2008-04-18 | 2009-10-22 | David Helton | Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds |
US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
US20110294879A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
US20120016021A1 (en) | 2010-07-15 | 2012-01-19 | Xenoport, Inc. | Methods of treating fragile x syndrome, down's syndrome, autism and related disorders |
KR101746944B1 (ko) * | 2015-09-23 | 2017-06-14 | 주식회사 포스코 | 도장 선영성이 우수한 도금강판의 제조방법 및 이에 의해 제조된 도금강판 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284957A (en) | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
US5446051A (en) | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
CA2216648A1 (en) * | 1995-02-15 | 1996-08-22 | Bearsden Bio, Inc. | Alkylcarboxy amino acids-modulators of the kainate receptor |
-
1998
- 1998-04-06 IL IL13208698A patent/IL132086A0/xx unknown
- 1998-04-06 KR KR1019997009153A patent/KR20010006075A/ko not_active Application Discontinuation
- 1998-04-06 CA CA002285192A patent/CA2285192A1/en not_active Abandoned
- 1998-04-06 ID IDW991132A patent/ID23013A/id unknown
- 1998-04-06 NZ NZ337827A patent/NZ337827A/xx unknown
- 1998-04-06 CN CN98805687A patent/CN1259126A/zh active Pending
- 1998-04-06 TR TR1999/02449T patent/TR199902449T2/xx unknown
- 1998-04-06 AU AU69555/98A patent/AU734657B2/en not_active Ceased
- 1998-04-06 WO PCT/US1998/006905 patent/WO1998045270A1/en not_active Application Discontinuation
- 1998-04-06 JP JP54212798A patent/JP2001521505A/ja active Pending
- 1998-04-06 EA EA199900912A patent/EA199900912A1/ru unknown
- 1998-04-06 PL PL98336068A patent/PL336068A1/xx unknown
- 1998-04-06 US US09/402,174 patent/US6242462B1/en not_active Expired - Fee Related
- 1998-04-06 HU HU0002030A patent/HUP0002030A3/hu unknown
- 1998-04-06 BR BR9809071-2A patent/BR9809071A/pt not_active IP Right Cessation
- 1998-04-06 EP EP98915346A patent/EP0980358A4/en not_active Withdrawn
-
1999
- 1999-10-05 NO NO994850A patent/NO994850L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO994850D0 (no) | 1999-10-05 |
EA199900912A1 (ru) | 2000-04-24 |
ID23013A (id) | 1999-12-30 |
CN1259126A (zh) | 2000-07-05 |
TR199902449T2 (xx) | 2000-07-21 |
NZ337827A (en) | 2000-12-22 |
KR20010006075A (ko) | 2001-01-15 |
WO1998045270A1 (en) | 1998-10-15 |
US6242462B1 (en) | 2001-06-05 |
IL132086A0 (en) | 2001-03-19 |
AU6955598A (en) | 1998-10-30 |
PL336068A1 (en) | 2000-06-05 |
AU734657B2 (en) | 2001-06-21 |
CA2285192A1 (en) | 1998-10-15 |
EP0980358A4 (en) | 2001-02-07 |
NO994850L (no) | 1999-10-05 |
HUP0002030A3 (en) | 2002-01-28 |
EP0980358A1 (en) | 2000-02-23 |
HUP0002030A2 (hu) | 2001-04-28 |
JP2001521505A (ja) | 2001-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1891 DE 03/04/2007. |