DK1149078T3 - Selektive 5-HT6-receptorligander - Google Patents

Selektive 5-HT6-receptorligander

Info

Publication number
DK1149078T3
DK1149078T3 DK99967248T DK99967248T DK1149078T3 DK 1149078 T3 DK1149078 T3 DK 1149078T3 DK 99967248 T DK99967248 T DK 99967248T DK 99967248 T DK99967248 T DK 99967248T DK 1149078 T3 DK1149078 T3 DK 1149078T3
Authority
DK
Denmark
Prior art keywords
selective
receptor ligands
receptors
compounds
treatment
Prior art date
Application number
DK99967248T
Other languages
English (en)
Inventor
Bryan L Roth
Richard A Glennon
Original Assignee
Univ Virginia Commonwealth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia Commonwealth filed Critical Univ Virginia Commonwealth
Application granted granted Critical
Publication of DK1149078T3 publication Critical patent/DK1149078T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Escalators And Moving Walkways (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Conductive Materials (AREA)
DK99967248T 1998-12-11 1999-12-10 Selektive 5-HT6-receptorligander DK1149078T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11178798P 1998-12-11 1998-12-11

Publications (1)

Publication Number Publication Date
DK1149078T3 true DK1149078T3 (da) 2006-07-10

Family

ID=22340454

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99967248T DK1149078T3 (da) 1998-12-11 1999-12-10 Selektive 5-HT6-receptorligander

Country Status (10)

Country Link
EP (1) EP1149078B1 (da)
AT (1) ATE319683T1 (da)
AU (1) AU767009B2 (da)
CA (1) CA2353962C (da)
DE (1) DE69930308T2 (da)
DK (1) DK1149078T3 (da)
ES (1) ES2260958T3 (da)
MX (1) MXPA01005905A (da)
PT (1) PT1149078E (da)
WO (1) WO2000034242A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL361887A1 (en) 2000-10-20 2004-10-04 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy
SI1379239T1 (sl) * 2001-03-29 2008-02-29 Lilly Co Eli N-(2-ariletil)benzilamini, uporabljeni kot antagonisti receptorja 5-ht6
EP1379239B1 (en) * 2001-03-29 2007-09-12 Eli Lilly And Company N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor
AU2002309435B2 (en) 2001-06-11 2008-08-14 Biovitrum Ab (Publ) Substituted sulfonamide compounds, process for their use as medicament for the treatment of CNS disorders, obesity and type II diabetes
ITRM20010356A1 (it) * 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
EP1897876A3 (en) 2002-06-20 2009-03-18 Biovitrum AB (publ) Compounds useful for the treatment of obesity, type II diabetes and CNS disorders
DE60317333T2 (de) * 2002-06-21 2008-08-28 Suven Life Sciences Ltd. Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor
CN100378109C (zh) * 2002-12-18 2008-04-02 苏文生命科学有限公司 具有5-羟色胺受体亲和性的四环3-取代的吲哚类化合物
BRPI0411740A (pt) 2003-06-26 2006-05-23 Takeda Pharmaceutical modulador do receptor de canabinóide, composto, pró-droga, droga, método para prevenir ou tratar uma doença ou condição, uso de um composto, e, método para preparar um composto
ATE370955T1 (de) * 2003-07-31 2007-09-15 Wyeth Corp N-sulfonylheterocyclopyrrolylalkylamin verbindungen als 5-hydroxytryptamin-6 liganden.
SE0303480D0 (sv) 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
CN101094852A (zh) 2004-11-01 2007-12-26 惠氏公司 作为cns活性剂的取代的吲嗪以及衍生物
US7582767B2 (en) 2005-06-17 2009-09-01 Biovitrum Ab (Publ.) Substituted sulphonamide compound and uses thereof
US8143303B2 (en) * 2005-10-19 2012-03-27 Suven Life Sciences Limited Carbazole derivatives as functional 5-HT6 ligands
CN101631787A (zh) 2007-03-13 2010-01-20 比奥维特罗姆上市公司 用于肥胖症治疗的三环异喹啉衍生物
JP2011505418A (ja) * 2007-12-04 2011-02-24 メルク・シャープ・エンド・ドーム・コーポレイション ５−ｈｔ６アンタゴニストとしてのトリプタミンスルホンアミド
EP2103596A1 (en) 2008-03-18 2009-09-23 Laboratorios Del. Dr. Esteve, S.A. Process for the preparation of N-(phenylethyl) anilines salts and solvates thereof useful as serotonin 5-HT6 antagonists
GB0905328D0 (en) * 2009-03-27 2009-05-13 Ge Healthcare Ltd Indole derivatives
FR2961095B1 (fr) * 2010-06-09 2012-06-15 Oreal Composition cosmetique et/ou dermatologique comprenant au moins un compose 6-alcoxy tryptamine
FR2961097B1 (fr) * 2010-06-09 2012-07-13 Oreal Procede cosmetique de traitement des odeurs corporelles humaines utilisant un compose 6-alkoxy tryptamine
WO2013063492A1 (en) * 2011-10-28 2013-05-02 Board Of Regents, The University Of Texas System Novel compositions and methods for treating cancer
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
AU2021276656A1 (en) 2020-05-19 2022-11-24 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
WO2023115167A1 (en) * 2021-12-24 2023-06-29 Psylo Pty Ltd Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
GB8416724D0 (en) * 1984-06-30 1984-08-01 Sorbio Sa Lab Active compounds

Also Published As

Publication number Publication date
ES2260958T3 (es) 2006-11-01
DE69930308T2 (de) 2006-11-30
AU2356200A (en) 2000-06-26
DE69930308D1 (de) 2006-05-04
EP1149078B1 (en) 2006-03-08
PT1149078E (pt) 2006-07-31
MXPA01005905A (es) 2002-09-18
EP1149078A1 (en) 2001-10-31
WO2000034242A1 (en) 2000-06-15
ATE319683T1 (de) 2006-03-15
AU767009B2 (en) 2003-10-30
CA2353962C (en) 2009-09-29
CA2353962A1 (en) 2000-06-15
EP1149078A4 (en) 2003-01-29

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