DE69407607T2 - Imidanolon- und oxanolonderivate als dopaminantagonisten - Google Patents
Imidanolon- und oxanolonderivate als dopaminantagonistenInfo
- Publication number
- DE69407607T2 DE69407607T2 DE69407607T DE69407607T DE69407607T2 DE 69407607 T2 DE69407607 T2 DE 69407607T2 DE 69407607 T DE69407607 T DE 69407607T DE 69407607 T DE69407607 T DE 69407607T DE 69407607 T2 DE69407607 T2 DE 69407607T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- image
- date mar
- derivatives
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003210 dopamine receptor blocking agent Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- SJHPCNCNNSSLPL-CSKARUKUSA-N (4e)-4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one Chemical class O1C(=O)C(=C/OCC)\N=C1C1=CC=CC=C1 SJHPCNCNNSSLPL-CSKARUKUSA-N 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical compound O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- WZELXJBMMZFDDU-UHFFFAOYSA-N Imidazol-2-one Chemical class O=C1N=CC=N1 WZELXJBMMZFDDU-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939319126A GB9319126D0 (en) | 1993-09-15 | 1993-09-15 | Therapeutic agents |
GB9407032A GB9407032D0 (en) | 1994-04-08 | 1994-04-08 | Therapeutic agents |
PCT/GB1994/001934 WO1995007904A1 (en) | 1993-09-15 | 1994-09-06 | Imidazolone and oxazolone derivatives as dopamine antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69407607D1 DE69407607D1 (de) | 1998-02-05 |
DE69407607T2 true DE69407607T2 (de) | 1998-08-06 |
Family
ID=26303524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69407607T Expired - Fee Related DE69407607T2 (de) | 1993-09-15 | 1994-09-06 | Imidanolon- und oxanolonderivate als dopaminantagonisten |
Country Status (9)
Country | Link |
---|---|
US (1) | US5698573A (de) |
EP (1) | EP0719264B1 (de) |
JP (1) | JPH09504272A (de) |
AT (1) | ATE161533T1 (de) |
AU (1) | AU682889B2 (de) |
CA (1) | CA2168740A1 (de) |
DE (1) | DE69407607T2 (de) |
ES (1) | ES2111326T3 (de) |
WO (1) | WO1995007904A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3916093B2 (ja) * | 1993-09-17 | 2007-05-16 | 杏林製薬株式会社 | 光学活性イミダゾリジノン誘導体とその製造方法 |
IL114027A (en) * | 1994-06-08 | 1999-11-30 | Lundbeck & Co As H | 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them |
GB9500580D0 (en) * | 1995-01-12 | 1995-03-01 | Merck Sharp & Dohme | Therapeutic agents |
AU740064B2 (en) * | 1997-06-18 | 2001-10-25 | H. Lundbeck A/S | Heterocyclic substituted piperidines and uses thereof |
US6159990A (en) | 1997-06-18 | 2000-12-12 | Synaptic Pharmaceutical Corporation | Oxazolidinones as α1A receptor antagonists |
US6228870B1 (en) | 1998-11-10 | 2001-05-08 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1a adrenoceptor antagonists |
US6319932B1 (en) | 1998-11-10 | 2001-11-20 | Merck & Co., Inc. | Oxazolidinones useful as alpha 1A adrenoceptor antagonists |
EP3929192A1 (de) | 2020-06-23 | 2021-12-29 | Université de Franche-Comté | Verbindungen zur behandlung von neurodegenerativen erkrankungen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3355457A (en) * | 1965-05-21 | 1967-11-28 | American Cyanamid Co | Substituted 2-imidazolinones |
NL130094C (de) * | 1966-06-13 | 1900-01-01 | ||
JPS6183170A (ja) * | 1984-09-28 | 1986-04-26 | Nippon Chemiphar Co Ltd | 新規な1,3−オキサゾリジン−2−オン誘導体およびその製造法 |
IT1230703B (it) * | 1989-01-26 | 1991-10-29 | Luso Farmaco Inst | Derivati imidazolonici ad attivita' antiipertensiva, loro metodi di preparazione e composizioni farmaceutiche che li contengono. |
JP3916093B2 (ja) * | 1993-09-17 | 2007-05-16 | 杏林製薬株式会社 | 光学活性イミダゾリジノン誘導体とその製造方法 |
-
1994
- 1994-09-06 CA CA002168740A patent/CA2168740A1/en not_active Abandoned
- 1994-09-06 ES ES94925559T patent/ES2111326T3/es not_active Expired - Lifetime
- 1994-09-06 AT AT94925559T patent/ATE161533T1/de not_active IP Right Cessation
- 1994-09-06 DE DE69407607T patent/DE69407607T2/de not_active Expired - Fee Related
- 1994-09-06 AU AU75424/94A patent/AU682889B2/en not_active Ceased
- 1994-09-06 WO PCT/GB1994/001934 patent/WO1995007904A1/en active IP Right Grant
- 1994-09-06 US US08/615,238 patent/US5698573A/en not_active Expired - Fee Related
- 1994-09-06 EP EP94925559A patent/EP0719264B1/de not_active Expired - Lifetime
- 1994-09-06 JP JP7509035A patent/JPH09504272A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2168740A1 (en) | 1995-03-23 |
DE69407607D1 (de) | 1998-02-05 |
AU682889B2 (en) | 1997-10-23 |
US5698573A (en) | 1997-12-16 |
JPH09504272A (ja) | 1997-04-28 |
AU7542494A (en) | 1995-04-03 |
EP0719264A1 (de) | 1996-07-03 |
EP0719264B1 (de) | 1997-12-29 |
WO1995007904A1 (en) | 1995-03-23 |
ES2111326T3 (es) | 1998-03-01 |
ATE161533T1 (de) | 1998-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE182139T1 (de) | Dopamin rezeptor subtyp liganden | |
DE69223989D1 (en) | Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten | |
ES2141174T3 (es) | 4-arilmetiloximetil piperidinas como antagonistas de taquiquinina. | |
DE69032020D1 (de) | N-Substituierte 4-Pyrimidinamine und -Pyrimidindiamine, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel | |
NZ504336A (en) | Tetrahydrofuran substituted adenosine A1 receptor agonists, pharmaceuticals thereof, and their use as medicaments | |
GR3026231T3 (en) | 3-aminopiperidine derivatives and related nitrogen containing heterocycles. | |
YU41100A (sh) | N-acil derivati cikličnih amina | |
DE69407607D1 (de) | Imidanolon- und oxanolonderivate als dopaminantagonisten | |
DK0572635T3 (da) | Hidtil ukendte forbindelser med guanidinstruktur og farmaceutisk komposition indeholdende forbindelserne | |
GB9305641D0 (en) | Therapeutic agents | |
ES2094840T3 (es) | 1-(pirido(3,4-b)-1,4-oxazinil-4-il)-1h-indoles, compuestos intermedios y un procedimiento para su preparacion, y su uso como medicamentos. | |
WO1996005166A1 (fr) | Derive d'amine substitue et composition medicamenteuse le contenant | |
DE69415341D1 (de) | Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtyps | |
DE69407191D1 (de) | Kondensierte tricyclische heteroaromatische verbindungen als dopamin-rezeptor-subtyp-liganden | |
DE69016531T2 (de) | 2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel. | |
DE69431471D1 (de) | Amide derivate als 5-ht1a liganden | |
ATE159943T1 (de) | Heterozyclische amine mit zns-wirksamkeit | |
ES2173167T3 (es) | Derivados de benzodiazepina. | |
MX9703671A (es) | Compuesto de aminometil arilo y ligandos selectivos del subtipo de receptor de la dopamina. | |
DE3161640D1 (en) | Propanol amine, derivatives, process for their preparation and medicines containing these compounds | |
ES2135383T3 (es) | Pirido(3,4-b)pirrolo(1,2-e)(1,4,5)oxadiazepinas y compuestos analogos relacionados, un procedimiento para su preparacion y su uso como medicamentos. | |
ATE167873T1 (de) | Neue heterocyclische acyldipeptide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung | |
TH11174EX (th) | อนุพันธ์ของพิเพอดิลอกซิ-ไอซอกซาโซล,การเตรียมสารเหล่านั้นและการใช้ในการรักษา | |
TH35872A (th) | อนุพันธ์ 1,4-ไดซับสทิทิวเทด พิเพอริดีนที่มีฟลูออรีน |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |