HUE028351T2 - Oldható glükózaminoglikanázok és eljárások oldható glükózaminoglikanázok elõállítására és alkalmazására - Google Patents
Oldható glükózaminoglikanázok és eljárások oldható glükózaminoglikanázok elõállítására és alkalmazására Download PDFInfo
- Publication number
- HUE028351T2 HUE028351T2 HUE06736105A HUE06736105A HUE028351T2 HU E028351 T2 HUE028351 T2 HU E028351T2 HU E06736105 A HUE06736105 A HU E06736105A HU E06736105 A HUE06736105 A HU E06736105A HU E028351 T2 HUE028351 T2 HU E028351T2
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- HU
- Hungary
- Prior art keywords
- shasegp
- agent
- hyaluronidase
- polypeptide
- cells
- Prior art date
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Claims (12)
- Oldható tlákéMmtiögMkánázölk és· felJÉrások oldható glüközamlnoglíkanázok aliáijtására és alkalmazására Szahaáalmt Igénypontok Is Gyógyászati készimény, moly PiGiiezett oldható humán hlaluronldáz gllteproteint tartalmaz gyógyszerészefíleg elfogadható hordozóban, ahol; a gyógyászati készítmény Intravénás adagolásra formált; a hiSÍuröfíldáz polipeptidekként 3-6 PEG gyököt tartalmaz; a hlslafonldáz semlegesen aktív; a hialu rooldáz old ható ; és a hialuronldáz egy gllkoproteln, mely legalább egy M-kapcsolt cukorgyököt tartalmaz; ahol az hl-kapcsolt cukorgyók kovalensen kapcsolódik a pollpegtld egy aszparagín gyökéhez, '2. Az Igénypont szerinti gyógyászai készítmény, ahol á hialyronidáz az 2> számú szekvenciával vagy 3, szárny szekvenciával legalább fi- % azonosságot mutató aminosavszekvenpíát tartalmaz, azzal a feltételiéi, hogy a poüpepid nem az 3, számú szekvencia szerinti aminosav szekvenciából áll,
- 3. Az 1, vagy 2, igénypont szérlntl gyógyászati készítmény, ahol a hlaíuronldáz olyan aminosavszekvenclát tartalmaz, mely legalább az t, számú szekvencia 36-464, eminosavszekvencláját tartalmazza, azzal a feltétellel, hogy a polipeptid nem az 1, számú szekvencia szerinti aminosav szekvenciából áll,
- 4. Az 1-3, igénypontok bármelyike Szerinti gyógyászati készítmény,, ahol a hlaíuronldáz p}^i.émi^iavszekvdndiál^rta|pis% mely legalább az 1, számú szekvencia 36-483, amlnosayszekvendéját, vagy ez 1, számú szekvencia 36-483, aminosavszekvencláiávai legalább 9S% azonosságot matató smirmsayszekyendat tartalmazza,
- 5. Az 1-4, Igénypontok bármelyike szerinti gyógyászati készitmény, ahol a hielurónidáz az 1, számú szekvenciában megadott 477, 478, 479, 480, 481 és 482, aminöSávak közül választott Céermlnális aminosav gyököt tartalmaz,
- 6. Az l-S, Igénypontok bármelyike szerinti gyógyászati készítmény,· aboi a hialuronldázt a 6, számú szekvencia i06-|446, hukfeptidoknal megfelelő nuklsotidszekvehciával rendelkező nuklelnsav moiékúla vagy annak agy katalitikusán aktív pöllpeptldét kődoí# része kódolja. 7> A i, Igénypont szerint! gyógyászati készítmény, ahol a hiaiuronídáz CHO sejMÄJ kifejézvtt és kivâiaiisÂt rpfeombmáns hámin PH70 (rHUPH2G), 8< Az 1-7, Igénypontok bármelyike szerinti gyógyászati készítmény, ahol o PiG gyökök elagazoák.
- 9. Az 1-8. igénypontok bármelyike szerinti gyógyászati készítmény, ahol a peg gyökök roPEG~S8A (SkDa), mPEG~58A PÄ), roPEG~SBA 30kDa), mPEG-SMB (20kDa) mPEG-SMB (3ŰkOa|, mPIG-butirainePM (30kDa), mPEG-SPA (20kDa), mPEG-SPA (30kDa)t mPEG2~NHS (lÖkDa elágazó), mPEG2~NNS (20kDa digazéjy mPOG-lkHS (40kDa elágazó}, m PEG2 - N H S pGkPa elágazó},· PEG-NBS-b!otin (SkDa biotinüezett). PEG-p-niirofemókarbonái (30kDa) és PEG-propionaidebid (SGkDa} kézéi választott PEG reagenssel történő reakcióból származik.
- 10. Az 1-9, igénypontok bármelyike szerinti gyógyászati készítmény egy gyógyszernek alanyhoz történő adagolásának vagy diffóitóJÉoak fóteásáfean; tiÄoi..«lkalm8^s}58.
- 11. A löi Igénypont szerini; gyógyiézatl készlmény, ahol a gyógyszer egy kemoterápiás szer, egy fájdalomcsillapító szer, egy gyufladásgáio szög ®i7 antimikfóhiális szer, egy smöfeídé szer, egy tnchomöna-eilenes szer, egy PárkiOson-ellanOs szer, egy malábaelíenes szer, egy antiepiieptlkys szei> egy antidepresszáns szer, egy arthritis-ellenes szer, egy antlfungalis szer, egy yérnyomásgátló szer, egy antigiretlkus szer, egy parazitaeiienes szer, egy antihisztamin szer, egy aiía-adrenerg agoniste szer, egy alfa·· blokkoló szer, egy érzésteleoítöszer, egy hörgőtágítő szer, egy blocló szer, egy haktericid szer, egy bakteriosztatlkus szer, egy béta~adreoerg blokkoló szer, egy kaielumesatoroa blokkoló szer, egy eardlovasenlaris gyógyszer, egy fogamzásgátló szer, egy orresepp, egy dioretikum, egy depresszáns szer, egy diagnosztikám, egy elektrolit, egy hipnotikus szer, egy hormoné, egy hipergkkémlás szer, egy izomlazító szer, egy IzomősMehözo szer, egy szemészeti szer, egy parasympatbomímetikum, egy pszichikai energizáló szer, egy szedálószer, egy altató, egy Sympathomimetikum, egy nyugtatószer, egy húgyúti szer, egy vaginalis szer, égy Vincid szer, egy vitamin, egy nem-szterold gyoiladásgátló szer, egy anglotenzín konvertáló inhibitor szer, egy polipeptití, egy protein, egy nukleinsav, egy drog, es egy szerves molekula közéi választott. 12. A 10. Igénypont szerinti gyógyászati készítmény, ahol a szer egy detektálható molekula vagy más diagnosztikai szer, vagy egy fármakológlallag vagy gyógyászatiiag hatásos szer közül választott. O, A 10. Igénypont szerinti gyógyászatirkésxitmépy, ahotia szer agy rákellenes szar vagy egy lartozés~|étié szer, 14, ijfjO. tsl^p^t^ini.f^gyás^atMszítaíis^: allais a: szer egy vémmoboslio farmakológiái szer, II, A Iá Igeayfoat azenatr gyógyászati készítmény, allai a szer agy 20 nm és 200 nm közötti átmérőjű molekula vagy makromoieküláris komplex, 16.. A 10. Igénypont, szerinti gyógyászati készítmény, ahol a izek Adalimumab, Agafstdase Beta, Aldesleukin, Aiefacept, Ampicillin,. Ana kin ra,Anttpai|onBéll tikos vakcina, Anti-Ttiymoaytaf Azlthmmyoln, Becaplermin, CaspoflinglOÿ SalaMín, ^elepmé, Cefotetao, £eftazldlm% Ceftriaxone, Cetuxlmab, Cilastaiin, klavufinsay, Clindamycin, Darhspoetln Alfa, Deeclizumab, dlftérla toxoid, Efallzumab, Epinephrine, Erythropoietin Alpha, Btanercept, Filgrastim, fluconazole, mirigy-simöiáló hormonok, például FPItrppn Alpha és Follitropin Beta, Fosphenytoin, Fluconazole, Gadodiamlde, Gadopentetate, Gatifloxacin, Glaiiramen fc~ CSF, Goserelm, Granisetron, Haemophilus Influenza B, Haloperidol, Hepatitis A vakcina, Hepatitis δ vakolna, îbrltumomab Tiyxetsn, .immunoglobulin.. Influenza Virus vakcina, InflixIrnaP,: Insulin, Insulin Giargine, Interferon Aifa-2a, Interferon Alfa-2b, Interferon Aifacph-I, Interferon Alfa~n3, Interferon Beta, Interferon Beta- id, Intarfamn Gamma, lodixanoi, lohexel, Idpamldóí, îoversol, Ketorolac, Laronidase, Levofloxacin, bldoeaihe, Unazpild, Lorazépam, Measles vakcina, Measfes-Mumpa^Eubaifa Vírus vakcina, HadröXypro|esterbne, Mezopenem, Méthylprednisolone, Midazolam, Morphine, Gctfeotida, Omaiizumah, Ondansetron, Pallvlzumab, Fantoprazole, Fegaspargase, Fegiigrastim, Feg-Interferon Alfa-2a, Feg-Infarfaroh AffévEb, Üegvisomant, Fetfussis vakcina, Piperacliln, Fneumococcal vakcina es Pneumococcal Conjugate vakcina, Promethazine, Reteplase, Somatropin, Sulbactam, Sumatriptan, Tazobacfam, Tenecteplase, Tetanus furif led toxoid, Tlcarclfiln, Tosltumömeb, frlamcinoiohe Acatbnlde, Vancomycin, és Varicella vakcina közül választott.
- 17- A Xö. igénypont szerinti gyógyászati készítmény, ahol a szer amioogikozldokj amíenikoiok; ansamyclnek; karbacefemek; karbapenemek; cefaiosporinok vagy cefémek; cefémieinek; ciavamok; gyiris tlpopeptidek; dlamínopirlmldlnek; keloIldofG linkozamidok; makrolidok; monohactamok; nitrofuránok; oxacefemek; oxazolfdinonok; penemek, tienamidnek és különböző betalaktámok; penicillinek; polipeptld antibiotikumok;: kínoicnok; szulfonamidok; szuilönok: teiracikiinek; és mm antibiotikumok |pé!déul cloetolok, fuzldinsavak, hexed I nek, m ete na m id ok, nitrofurantoinok, nltroxollnok, rftlpenamak, tanrendinek, xibomoiok) közül választott antibiotikum vagy kombinációs szer. iS, A 10. igénypont szerinti gyógyászati készítmény, ahol a szar aciaeinomyclnek.. actinomycmak,. adríamydnek, ancitabinek,. anthramycinek, azadtidinek, azaserinek, e-ázanrldlnak, bísantrenek, bíeomycinek, cactlnomygnek, Carmennak# carmustinek* carubloíoek, garzíngpbllinek# #romomycírtek# ^s|gii«ok, císöríbinék, cytaraölnek, denopterinek, i-dlaao^S-oxo-k-narlauclaak, doviluddioek, doxarabldnak, edafcrexatátök, emiteforok, enocítabinek, fepíruhicinek, MvúmmMmk-t duorouracílek, gemdtabinek, Idamblopak, loxuÉÉnek, menogariiok:, 6~ merkaptopurínok, methótrexátok, mlthramydnek, miornycíneíg mlÂeéèlsâvafc,. noggiamycinek, oíívoroyclnek, pepiomycinek, plidœbidaeki pmtrexímek, plíeamycínek# partímmydnek,. pteropterinek, pufomyeínek, retininsavak, streptonlgrinek, stmptozoeínok, afyrpk, MmoÄnek, tlamipnnek, tioguaranek, tfiamoinoioaok, tflmetrexátok# tubarcidlnek, vlnbiasztinak, vlnkrisztinek, zínostatinok, és zorubidnak közül választott rákellenes szer vagy kombinációs szer, m. Az .IM, Igénypontok bármelyike szerinti gyógyászati készítmény rak kezelésében történd alkalmazásra.
- 20. Ä gyógyászati készítmény a 19, igénypont szerint! alkalmazásra, aboi a rák egy invazív tumor.
- 21. Az :l-9, igénypontok bármelyike szerinti gyógyászati készítmény erdősök szembetegségének az üvegtest ^folyósításával történi kezelésében történd: alkalmazásra? gíüközamínogíikán felesleggel összefüggd mndéíienességeknek a glü kóza mi nogiikén elti volstásá vél történd kezelésében történő él kai mazásra ; vagy korábban agyvérzésben vagy más központi: idegrendszeri sérilésben szenvedi emiisnik az agyvérzés vagy más központi idegrendszeri sérülés következményeinek javítására irányuló kezelMéban történd alkalmazására. M. A 10. Igénypont szerinti gyógyászat! készítmény# ahol A szer egy antitest.
- 23. A M>, igénypont szerinti gyógyászati készítmény., ahol a szer is egy monokíonáiís antitest.
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