AU3032400A - Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid - Google Patents

Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid

Info

Publication number
AU3032400A
AU3032400A AU30324/00A AU3032400A AU3032400A AU 3032400 A AU3032400 A AU 3032400A AU 30324/00 A AU30324/00 A AU 30324/00A AU 3032400 A AU3032400 A AU 3032400A AU 3032400 A AU3032400 A AU 3032400A
Authority
AU
Australia
Prior art keywords
hyaluronic acid
pharmaceutical formulation
formulation containing
microbial enzyme
digests
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU30324/00A
Inventor
Albert Hartl
Peter-Jurgen Muller
Jorg-Hermann Ozegowski
Gundela Peschel
Norbert Presselt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Friedrich Schiller Universtaet Jena FSU
id pharma GmbH
Original Assignee
Friedrich Schiller Universtaet Jena FSU
id pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998160542 external-priority patent/DE19860542A1/en
Priority claimed from DE1998160541 external-priority patent/DE19860541A1/en
Application filed by Friedrich Schiller Universtaet Jena FSU, id pharma GmbH filed Critical Friedrich Schiller Universtaet Jena FSU
Publication of AU3032400A publication Critical patent/AU3032400A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02001—Hyaluronate lyase (4.2.2.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU30324/00A 1998-12-23 1999-12-22 Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid Abandoned AU3032400A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE1998160542 DE19860542A1 (en) 1998-12-23 1998-12-23 An enzyme fragment with hyaluronate lyase activity is derived from streptococci and used for medical applications
DE1998160541 DE19860541A1 (en) 1998-12-23 1998-12-23 Composition for the treatment of vascular disease comprises holozyme with hyaluronate lyase activity from microbial origin
DE19860541 1998-12-23
DE19860542 1998-12-23
PCT/DE1999/004108 WO2000039290A2 (en) 1998-12-23 1999-12-22 Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid

Publications (1)

Publication Number Publication Date
AU3032400A true AU3032400A (en) 2000-07-31

Family

ID=26051101

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30324/00A Abandoned AU3032400A (en) 1998-12-23 1999-12-22 Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid

Country Status (10)

Country Link
EP (1) EP1056839A1 (en)
JP (1) JP2002533473A (en)
KR (1) KR20010041235A (en)
AU (1) AU3032400A (en)
CA (1) CA2318356A1 (en)
DE (1) DE19982882D2 (en)
HU (1) HUP0103660A2 (en)
IL (1) IL138051A0 (en)
PL (1) PL344745A1 (en)
WO (1) WO2000039290A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19963538A1 (en) * 1999-12-22 2001-07-05 Univ Schiller Jena Use of an enzyme to improve tissue absorption of drugs
DE10103271A1 (en) * 2001-01-23 2002-07-25 Knoell Hans Forschung Ev Pharmaceutical formulation containing hyaluronatlyase, useful for softening of connective tissue in medical and cosmetic treatment, especially in shape correction
CN1942588B (en) 2003-03-05 2013-06-12 海洋酶公司 Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) * 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
WO2004110479A1 (en) * 2003-05-27 2004-12-23 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Hyaluronate lyase-containing agent for treating acute myocardial infarction or symptoms thereof and for the treatment of postinfarction myocarditis and myocardial ischaemia
DE102007031417A1 (en) 2007-07-04 2009-01-08 Friedrich-Schiller-Universität Jena Hyaluronate lyase with a histidine tag e.g. useful in pharmaceutical formulations and medical products
ES2622834T3 (en) 2007-11-13 2017-07-07 Bio-Technology General (Israel) Ltd. Sterilization procedure by dilution filtration for viscoelastic biopolymers
NZ593641A (en) 2008-12-09 2013-01-25 Halozyme Inc Extended soluble ph20 polypeptides and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1120298A (en) * 1966-07-11 1968-07-17 Biorex Laboratories Ltd Stabilised enzymes
US3708575A (en) * 1970-05-13 1973-01-02 Biorex Laboratories Ltd Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase
US3728223A (en) * 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
AU1865100A (en) * 1998-12-23 2000-07-31 Esparma Gmbh Hyaluronate lyase used for promoting penetration in topical agents

Also Published As

Publication number Publication date
CA2318356A1 (en) 2000-07-06
KR20010041235A (en) 2001-05-15
WO2000039290A3 (en) 2001-03-08
EP1056839A1 (en) 2000-12-06
PL344745A1 (en) 2001-11-19
JP2002533473A (en) 2002-10-08
WO2000039290A2 (en) 2000-07-06
HUP0103660A2 (en) 2002-01-28
IL138051A0 (en) 2001-10-31
WO2000039290A8 (en) 2000-10-19
DE19982882D2 (en) 2001-10-04

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase