IL138051A0 - Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin - Google Patents

Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin

Info

Publication number
IL138051A0
IL138051A0 IL13805199A IL13805199A IL138051A0 IL 138051 A0 IL138051 A0 IL 138051A0 IL 13805199 A IL13805199 A IL 13805199A IL 13805199 A IL13805199 A IL 13805199A IL 138051 A0 IL138051 A0 IL 138051A0
Authority
IL
Israel
Prior art keywords
hyaluronic acid
pharmaceutical formulation
formulation containing
microbial origin
splitting enzyme
Prior art date
Application number
IL13805199A
Original Assignee
Id Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998160542 external-priority patent/DE19860542A1/en
Priority claimed from DE1998160541 external-priority patent/DE19860541A1/en
Application filed by Id Pharma Gmbh filed Critical Id Pharma Gmbh
Publication of IL138051A0 publication Critical patent/IL138051A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
    • C12Y402/02001—Hyaluronate lyase (4.2.2.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13805199A 1998-12-23 1999-12-22 Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin IL138051A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998160542 DE19860542A1 (en) 1998-12-23 1998-12-23 An enzyme fragment with hyaluronate lyase activity is derived from streptococci and used for medical applications
DE1998160541 DE19860541A1 (en) 1998-12-23 1998-12-23 Composition for the treatment of vascular disease comprises holozyme with hyaluronate lyase activity from microbial origin
PCT/DE1999/004108 WO2000039290A2 (en) 1998-12-23 1999-12-22 Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid

Publications (1)

Publication Number Publication Date
IL138051A0 true IL138051A0 (en) 2001-10-31

Family

ID=26051101

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13805199A IL138051A0 (en) 1998-12-23 1999-12-22 Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin

Country Status (10)

Country Link
EP (1) EP1056839A1 (en)
JP (1) JP2002533473A (en)
KR (1) KR20010041235A (en)
AU (1) AU3032400A (en)
CA (1) CA2318356A1 (en)
DE (1) DE19982882D2 (en)
HU (1) HUP0103660A2 (en)
IL (1) IL138051A0 (en)
PL (1) PL344745A1 (en)
WO (1) WO2000039290A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19963538A1 (en) * 1999-12-22 2001-07-05 Univ Schiller Jena Use of an enzyme to improve tissue absorption of drugs
DE10103271A1 (en) * 2001-01-23 2002-07-25 Knoell Hans Forschung Ev Pharmaceutical formulation containing hyaluronatlyase, useful for softening of connective tissue in medical and cosmetic treatment, especially in shape correction
CN1942588B (en) 2003-03-05 2013-06-12 海洋酶公司 Soluble hyaluronidase glycoproteins (sHASEGP), methods for their preparation, their use and pharmaceutical compositions comprising them
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) * 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
AU2003239763A1 (en) * 2003-05-27 2005-01-04 Friedrich-Schiller- Universität Jena Hyaluronate lyase-containing agent for treating acute myocardial infarction or symptoms thereof and for the treatment of postinfarction myocarditis and myocardial ischaemia
DE102007031417A1 (en) 2007-07-04 2009-01-08 Friedrich-Schiller-Universität Jena Hyaluronate lyase with a histidine tag e.g. useful in pharmaceutical formulations and medical products
KR20100094982A (en) 2007-11-13 2010-08-27 바이오-테크널러지 제너럴 (이스라엘) 리미티드 Dilute filtration sterilization process for viscoelastic biopolymers
ES2724588T3 (en) 2008-12-09 2019-09-12 Halozyme Inc Extended soluble PH20 polypeptides and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1120298A (en) * 1966-07-11 1968-07-17 Biorex Laboratories Ltd Stabilised enzymes
US3708575A (en) * 1970-05-13 1973-01-02 Biorex Laboratories Ltd Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase
US3728223A (en) * 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
JP2002533417A (en) * 1998-12-23 2002-10-08 エスパルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング Hyaluronate lyase used to enhance penetration of topically applied drugs

Also Published As

Publication number Publication date
CA2318356A1 (en) 2000-07-06
AU3032400A (en) 2000-07-31
DE19982882D2 (en) 2001-10-04
HUP0103660A2 (en) 2002-01-28
PL344745A1 (en) 2001-11-19
WO2000039290A2 (en) 2000-07-06
WO2000039290A3 (en) 2001-03-08
EP1056839A1 (en) 2000-12-06
WO2000039290A8 (en) 2000-10-19
KR20010041235A (en) 2001-05-15
JP2002533473A (en) 2002-10-08

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