IL138051A0 - Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin - Google Patents
Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial originInfo
- Publication number
- IL138051A0 IL138051A0 IL13805199A IL13805199A IL138051A0 IL 138051 A0 IL138051 A0 IL 138051A0 IL 13805199 A IL13805199 A IL 13805199A IL 13805199 A IL13805199 A IL 13805199A IL 138051 A0 IL138051 A0 IL 138051A0
- Authority
- IL
- Israel
- Prior art keywords
- hyaluronic acid
- pharmaceutical formulation
- formulation containing
- microbial origin
- splitting enzyme
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02001—Hyaluronate lyase (4.2.2.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1998160541 DE19860541A1 (en) | 1998-12-23 | 1998-12-23 | Composition for the treatment of vascular disease comprises holozyme with hyaluronate lyase activity from microbial origin |
DE1998160542 DE19860542A1 (en) | 1998-12-23 | 1998-12-23 | An enzyme fragment with hyaluronate lyase activity is derived from streptococci and used for medical applications |
PCT/DE1999/004108 WO2000039290A2 (en) | 1998-12-23 | 1999-12-22 | Pharmaceutical formulation containing a microbial enzyme which digests hyaluronic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
IL138051A0 true IL138051A0 (en) | 2001-10-31 |
Family
ID=26051101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13805199A IL138051A0 (en) | 1998-12-23 | 1999-12-22 | Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1056839A1 (en) |
JP (1) | JP2002533473A (en) |
KR (1) | KR20010041235A (en) |
AU (1) | AU3032400A (en) |
CA (1) | CA2318356A1 (en) |
DE (1) | DE19982882D2 (en) |
HU (1) | HUP0103660A2 (en) |
IL (1) | IL138051A0 (en) |
PL (1) | PL344745A1 (en) |
WO (1) | WO2000039290A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19963538A1 (en) * | 1999-12-22 | 2001-07-05 | Univ Schiller Jena | Use of an enzyme to improve tissue absorption of drugs |
DE10103271A1 (en) * | 2001-01-23 | 2002-07-25 | Knoell Hans Forschung Ev | Pharmaceutical formulation containing hyaluronatlyase, useful for softening of connective tissue in medical and cosmetic treatment, especially in shape correction |
US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
WO2004078140A2 (en) | 2003-03-05 | 2004-09-16 | Halozyme, Inc. | SOLUBLE HYALURONIDASE GLYCOPROTEIN (sHASEGP), PROCESS FOR PREPARING THE SAME, USES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF |
WO2004110479A1 (en) * | 2003-05-27 | 2004-12-23 | Hans-Knöll-Institut für Naturstoff-Forschung e.V. | Hyaluronate lyase-containing agent for treating acute myocardial infarction or symptoms thereof and for the treatment of postinfarction myocarditis and myocardial ischaemia |
DE102007031417A1 (en) | 2007-07-04 | 2009-01-08 | Friedrich-Schiller-Universität Jena | Hyaluronate lyase with a histidine tag e.g. useful in pharmaceutical formulations and medical products |
US20110130473A1 (en) | 2007-11-13 | 2011-06-02 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
SG172064A1 (en) | 2008-12-09 | 2011-07-28 | Halozyme Inc | Extended soluble ph20 polypeptides and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1120298A (en) * | 1966-07-11 | 1968-07-17 | Biorex Laboratories Ltd | Stabilised enzymes |
US3708575A (en) * | 1970-05-13 | 1973-01-02 | Biorex Laboratories Ltd | Method for the treatment of atherosclerosis employing glucuronoglycos-aminoglycan-hyaluronate-lyase |
US3728223A (en) * | 1971-10-08 | 1973-04-17 | Amano Pharma Co Ltd | Production of hyaluronidase from a strain of streptomyces |
ATE245452T1 (en) * | 1998-12-23 | 2003-08-15 | Esparma Gmbh | HYALURONATE LYASE AS A PENETRATION PROMOTER IN TOPICAL AGENTS |
-
1999
- 1999-12-22 HU HU0103660A patent/HUP0103660A2/en unknown
- 1999-12-22 WO PCT/DE1999/004108 patent/WO2000039290A2/en not_active Application Discontinuation
- 1999-12-22 PL PL99344745A patent/PL344745A1/en not_active Application Discontinuation
- 1999-12-22 DE DE19982882T patent/DE19982882D2/en not_active Expired - Lifetime
- 1999-12-22 JP JP2000591182A patent/JP2002533473A/en active Pending
- 1999-12-22 CA CA002318356A patent/CA2318356A1/en not_active Abandoned
- 1999-12-22 KR KR1020007009327A patent/KR20010041235A/en not_active Application Discontinuation
- 1999-12-22 IL IL13805199A patent/IL138051A0/en unknown
- 1999-12-22 AU AU30324/00A patent/AU3032400A/en not_active Abandoned
- 1999-12-22 EP EP99964464A patent/EP1056839A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20010041235A (en) | 2001-05-15 |
WO2000039290A8 (en) | 2000-10-19 |
AU3032400A (en) | 2000-07-31 |
WO2000039290A3 (en) | 2001-03-08 |
EP1056839A1 (en) | 2000-12-06 |
JP2002533473A (en) | 2002-10-08 |
PL344745A1 (en) | 2001-11-19 |
CA2318356A1 (en) | 2000-07-06 |
DE19982882D2 (en) | 2001-10-04 |
WO2000039290A2 (en) | 2000-07-06 |
HUP0103660A2 (en) | 2002-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA987800B (en) | Pharmaceutical composition of meloxicam | |
AU1875501A (en) | System and method of distributing and returning products | |
AU9173698A (en) | Microbial decontamination of food | |
AU6740298A (en) | Pharmaceutical composition | |
AU5387898A (en) | Pharmaceutical agents | |
AU5419500A (en) | Bacteriophage rm 378 of a thermophilic host organism | |
AU1574900A (en) | Pharmaceutical compositions containing insulin | |
AU5619400A (en) | Statine-derived tetrapeptide inhibitors of beta-secretase | |
AU4328800A (en) | Pharmaceutical formulation | |
AU8107998A (en) | Pharmaceutical compositions | |
IL138051A0 (en) | Pharmaceutical formulation containing a hyaluronic acid-splitting enzyme of microbial origin | |
AU7904998A (en) | Pharmaceutical composition containing peptichemio | |
AU6949200A (en) | Human hydrolytic enzymes | |
AU9343098A (en) | Pharmaceutical composition | |
HU9802716D0 (en) | Pharmaceutical composition of analgesic activity | |
AU1930097A (en) | Slow-release pharmaceutical formulations containing mizolastin | |
IL146408A0 (en) | Diphosphate salt of a 4-substituted-9-deoxo-9a-homoerythromycin derivative and its pharmaceutical composition | |
HUP0201880A3 (en) | Pharmaceutical composition containing sibutramine and a lipase inhibitor | |
AU4543500A (en) | Pharmaceutical compositions and uses | |
AU3839900A (en) | Pharmaceutical formulation | |
AU1677100A (en) | Localization of software products | |
AU1567301A (en) | Tablets comprising micro-organisms and method for preparation of the tablets | |
AU5182099A (en) | Pharmaceutical formulation | |
AU1388501A (en) | Pharmaceutical formulation | |
AU3989100A (en) | Pharmaceutical gel formulation |