DE69838062T2 - Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor - Google Patents

Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor Download PDF

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Publication number
DE69838062T2
DE69838062T2 DE69838062T DE69838062T DE69838062T2 DE 69838062 T2 DE69838062 T2 DE 69838062T2 DE 69838062 T DE69838062 T DE 69838062T DE 69838062 T DE69838062 T DE 69838062T DE 69838062 T2 DE69838062 T2 DE 69838062T2
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Germany
Prior art keywords
antibody
sequence
human
antibodies
egf
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69838062T
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German (de)
English (en)
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DE69838062D1 (de
Inventor
Aya Menlo Park JAKOBOVITS
Xiao-Dong Palo Alto YANG
Michael San Jose GALLO
Xiao-Chi San Mateo JIA
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Amgen Fremont Inc
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Amgen Fremont Inc
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Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69838062T 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor Expired - Lifetime DE69838062T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/851,362 US6235883B1 (en) 1997-05-05 1997-05-05 Human monoclonal antibodies to epidermal growth factor receptor
US851362 1997-05-05
PCT/US1998/009160 WO1998050433A2 (en) 1997-05-05 1998-05-05 Human monoclonal antibodies to epidermal growth factor receptor

Publications (2)

Publication Number Publication Date
DE69838062D1 DE69838062D1 (de) 2007-08-23
DE69838062T2 true DE69838062T2 (de) 2008-01-31

Family

ID=25310591

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69838062T Expired - Lifetime DE69838062T2 (de) 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor
DE122008000009C Pending DE122008000009I1 (de) 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE122008000009C Pending DE122008000009I1 (de) 1997-05-05 1998-05-05 Menschliche monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor

Country Status (16)

Country Link
US (1) US6235883B1 (enExample)
EP (3) EP1878746A3 (enExample)
JP (9) JP3757986B2 (enExample)
KR (1) KR100558110B1 (enExample)
AT (1) ATE366747T1 (enExample)
AU (1) AU7287098A (enExample)
CA (1) CA2288962C (enExample)
CY (2) CY1107708T1 (enExample)
DE (2) DE69838062T2 (enExample)
DK (1) DK0979246T3 (enExample)
ES (1) ES2289779T3 (enExample)
FR (1) FR08C0006I2 (enExample)
LU (1) LU91411I2 (enExample)
NL (1) NL300335I2 (enExample)
PT (1) PT979246E (enExample)
WO (1) WO1998050433A2 (enExample)

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CY2008003I1 (el) 2009-11-04
JP5356287B2 (ja) 2013-12-04
FR08C0006I1 (fr) 2008-08-21
NL300335I1 (nl) 2008-04-01
CA2288962A1 (en) 1998-11-12
US6235883B1 (en) 2001-05-22
ES2289779T3 (es) 2008-02-01
HK1027114A1 (en) 2001-01-05
EP1878746A3 (en) 2011-05-25
AU7287098A (en) 1998-11-27
DE122008000009I1 (de) 2008-04-30
JP2014185165A (ja) 2014-10-02
EP2332993A1 (en) 2011-06-15
JP2012158601A (ja) 2012-08-23
WO1998050433A2 (en) 1998-11-12
PT979246E (pt) 2007-08-16
JP3757986B2 (ja) 2006-03-22
DE69838062D1 (de) 2007-08-23
EP1878746A2 (en) 2008-01-16
JP2005225884A (ja) 2005-08-25
WO1998050433A3 (en) 1999-02-04
ATE366747T1 (de) 2007-08-15
CY1107708T1 (el) 2010-07-28
NL300335I2 (nl) 2008-06-02
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JP2018076321A (ja) 2018-05-17
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EP0979246B1 (en) 2007-07-11
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