JP2011252024A5 - - Google Patents

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Publication number

JP2011252024A5

JP2011252024A5 JP2011192962A JP2011192962A JP2011252024A5 JP 2011252024 A5 JP2011252024 A5 JP 2011252024A5 JP 2011192962 A JP2011192962 A JP 2011192962A JP 2011192962 A JP2011192962 A JP 2011192962A JP 2011252024 A5 JP2011252024 A5 JP 2011252024A5

Authority

JP

Japan

Prior art keywords

pyrrolo

pyrazol

pyrimidin

propanenitrile

phenyl

Prior art date

2011-09-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• -1 1H-pyrrolo [2,3-b] pyridin-4-yl Chemical group 0.000 claims description 42
• FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 claims description 4
• HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical compound C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 60
• 125000000217 alkyl group Chemical group 0.000 claims 27
• 201000010099 disease Diseases 0.000 claims 27
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 27
• 125000003118 aryl group Chemical group 0.000 claims 22
• 206010028980 Neoplasm Diseases 0.000 claims 21
• 201000011510 cancer Diseases 0.000 claims 21
• 125000000753 cycloalkyl group Chemical group 0.000 claims 21
• 125000001072 heteroaryl group Chemical group 0.000 claims 20
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 19
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 17
• 125000003710 aryl alkyl group Chemical group 0.000 claims 17
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 16
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 14
• 125000005843 halogen group Chemical group 0.000 claims 14
• 208000027866 inflammatory disease Diseases 0.000 claims 14
• 208000014767 Myeloproliferative disease Diseases 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 13
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 11
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 11
• 229910052799 carbon Inorganic materials 0.000 claims 11
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 11
• 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 11
• 125000001424 substituent group Chemical group 0.000 claims 11
• 150000003839 salts Chemical class 0.000 claims 10
• 208000017520 skin disease Diseases 0.000 claims 9
• 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 8
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 7
• 208000023275 Autoimmune disease Diseases 0.000 claims 7
• 125000003342 alkenyl group Chemical group 0.000 claims 7
• 125000000304 alkynyl group Chemical group 0.000 claims 7
• 201000004681 Psoriasis Diseases 0.000 claims 6
• 230000003612 virological effect Effects 0.000 claims 6
• 206010006895 Cachexia Diseases 0.000 claims 5
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 5
• 208000022531 anorexia Diseases 0.000 claims 5
• 206010061428 decreased appetite Diseases 0.000 claims 5
• 208000024908 graft versus host disease Diseases 0.000 claims 5
• 208000005024 Castleman disease Diseases 0.000 claims 4
• 208000032027 Essential Thrombocythemia Diseases 0.000 claims 4
• 201000011152 Pemphigus Diseases 0.000 claims 4
• WEVYAHXRMPXWCK-UHFFFAOYSA-N acetonitrile Substances CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 4
• KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 4
• 125000004966 cyanoalkyl group Chemical group 0.000 claims 4
• 208000028867 ischemia Diseases 0.000 claims 4
• 230000000302 ischemic effect Effects 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
• 201000001976 pemphigus vulgaris Diseases 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 230000010410 reperfusion Effects 0.000 claims 4
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
• 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 3
• 125000002947 alkylene group Chemical group 0.000 claims 3
• 150000001408 amides Chemical class 0.000 claims 3
• 230000000241 respiratory effect Effects 0.000 claims 3
• TVGMVLZIRSLGAH-UHFFFAOYSA-N 3-(3-methylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CS(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 TVGMVLZIRSLGAH-UHFFFAOYSA-N 0.000 claims 2
• QCEZQKJRYJUQDQ-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-phenylbenzamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1C(=O)NC1=CC=CC=C1 QCEZQKJRYJUQDQ-UHFFFAOYSA-N 0.000 claims 2
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
• 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 2
• 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
• 241000701806 Human papillomavirus Species 0.000 claims 2
• 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 2
• 208000034578 Multiple myelomas Diseases 0.000 claims 2
• 208000009525 Myocarditis Diseases 0.000 claims 2
• 206010034277 Pemphigoid Diseases 0.000 claims 2
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
• 206010060862 Prostate cancer Diseases 0.000 claims 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
• 208000000453 Skin Neoplasms Diseases 0.000 claims 2
• 201000008736 Systemic mastocytosis Diseases 0.000 claims 2
• 208000017733 acquired polycythemia vera Diseases 0.000 claims 2
• 125000004450 alkenylene group Chemical group 0.000 claims 2
• 125000003282 alkyl amino group Chemical group 0.000 claims 2
• 208000000594 bullous pemphigoid Diseases 0.000 claims 2
• 125000004663 dialkyl amino group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 208000032839 leukemia Diseases 0.000 claims 2
• 206010028537 myelofibrosis Diseases 0.000 claims 2
• 208000037244 polycythemia vera Diseases 0.000 claims 2
• 210000002345 respiratory system Anatomy 0.000 claims 2
• 201000000849 skin cancer Diseases 0.000 claims 2
• 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
• PEUPUKDBCPLDIH-UHFFFAOYSA-N 1,2,4-triazole Chemical class C1=NC=N[N]1 PEUPUKDBCPLDIH-UHFFFAOYSA-N 0.000 claims 1
• CGAYFEFKISEIQR-UHFFFAOYSA-N 1-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]cyclopropane-1-carbonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1(C#N)CC1 CGAYFEFKISEIQR-UHFFFAOYSA-N 0.000 claims 1
• GIGYWKFQEDAKGV-UHFFFAOYSA-N 1-[3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]phenyl]-3-phenylurea Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1NC(=O)NC1=CC=CC=C1 GIGYWKFQEDAKGV-UHFFFAOYSA-N 0.000 claims 1
• CJVMUHAGCRAOIH-UHFFFAOYSA-N 1-[3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]phenyl]-3-propan-2-ylurea Chemical compound CC(C)NC(=O)NC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 CJVMUHAGCRAOIH-UHFFFAOYSA-N 0.000 claims 1
• XTPGFCMNNRGNLX-UHFFFAOYSA-N 1-[[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]methyl]cyclopropane-1-carbonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1(C#N)CC1 XTPGFCMNNRGNLX-UHFFFAOYSA-N 0.000 claims 1
• HKTMUSRKGJOFQT-UHFFFAOYSA-N 1-phenyl-2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]ethanone Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC(=O)C1=CC=CC=C1 HKTMUSRKGJOFQT-UHFFFAOYSA-N 0.000 claims 1
• INGUHLZZQKDACC-UHFFFAOYSA-N 1-phenyl-2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]propan-1-one Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C(=O)C1=CC=CC=C1 INGUHLZZQKDACC-UHFFFAOYSA-N 0.000 claims 1
• GDTGNZSOHXXADB-UHFFFAOYSA-N 1-phenyl-2-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propan-1-ol Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)C(O)C1=CC=CC=C1 GDTGNZSOHXXADB-UHFFFAOYSA-N 0.000 claims 1
• NTYBSPKWKAEMKG-UHFFFAOYSA-N 1-phenyl-2-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propan-1-one Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)C(=O)C1=CC=CC=C1 NTYBSPKWKAEMKG-UHFFFAOYSA-N 0.000 claims 1
• BOLDWUBNHGCOKD-UHFFFAOYSA-N 2-[1-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]cyclopentyl]acetonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C1(CC#N)CCCC1 BOLDWUBNHGCOKD-UHFFFAOYSA-N 0.000 claims 1
• IDFICYBUDIOWHA-UHFFFAOYSA-N 2-[1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]cyclohexyl]acetonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C1(CC#N)CCCCC1 IDFICYBUDIOWHA-UHFFFAOYSA-N 0.000 claims 1
• WLWKNCAZCPIQKN-UHFFFAOYSA-N 2-[1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]cyclopentyl]acetonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C1(CC#N)CCCC1 WLWKNCAZCPIQKN-UHFFFAOYSA-N 0.000 claims 1
• DZOWVAFBINXFOB-UHFFFAOYSA-N 2-[1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]cyclopropyl]acetonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C1(CC#N)CC1 DZOWVAFBINXFOB-UHFFFAOYSA-N 0.000 claims 1
• PAWUPHYEOOFEER-UHFFFAOYSA-N 2-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyridine-4-carbonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CC(C#N)=CC=N1 PAWUPHYEOOFEER-UHFFFAOYSA-N 0.000 claims 1
• WBTHKLYGCKGFPM-UHFFFAOYSA-N 2-[3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]cyclohexyl]acetonitrile Chemical compound C1C(CC#N)CCCC1N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 WBTHKLYGCKGFPM-UHFFFAOYSA-N 0.000 claims 1
• BIPPXMZRIQZSKE-UHFFFAOYSA-N 2-[3-chloro-2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-5-(trifluoromethyl)phenyl]acetonitrile Chemical compound N#CCC1=CC(C(F)(F)F)=CC(Cl)=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 BIPPXMZRIQZSKE-UHFFFAOYSA-N 0.000 claims 1
• VYIIVQPPRDOYNI-UHFFFAOYSA-N 2-[3-methyl-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]phenyl]acetonitrile Chemical compound CC1=CC(CC#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 VYIIVQPPRDOYNI-UHFFFAOYSA-N 0.000 claims 1
• KHVBCXARHGPTLW-UHFFFAOYSA-N 2-[3-methyl-4-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]phenyl]acetonitrile Chemical compound CC1=CC(CC#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 KHVBCXARHGPTLW-UHFFFAOYSA-N 0.000 claims 1
• PSWCXILVFVGISQ-UHFFFAOYSA-N 2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-3-(trifluoromethyl)benzonitrile Chemical compound FC(F)(F)C1=CC=CC(C#N)=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 PSWCXILVFVGISQ-UHFFFAOYSA-N 0.000 claims 1
• YKKSCJLAOCFSQC-UHFFFAOYSA-N 2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-5-(trifluoromethyl)benzonitrile Chemical compound N#CC1=CC(C(F)(F)F)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 YKKSCJLAOCFSQC-UHFFFAOYSA-N 0.000 claims 1
• UXKVRHSAYBHZJH-UHFFFAOYSA-N 2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound N#CC1=CC=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 UXKVRHSAYBHZJH-UHFFFAOYSA-N 0.000 claims 1
• JYLQHLUANOQCSK-UHFFFAOYSA-N 2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]cyclohexan-1-ol Chemical compound OC1CCCCC1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 JYLQHLUANOQCSK-UHFFFAOYSA-N 0.000 claims 1
• QAUAPRNFAWLMAD-UHFFFAOYSA-N 2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]cyclohexane-1-carbonitrile Chemical compound N#CC1CCCCC1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 QAUAPRNFAWLMAD-UHFFFAOYSA-N 0.000 claims 1
• GMENCIXDAWPZEP-UHFFFAOYSA-N 2-[4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]phenyl]acetonitrile Chemical compound C1=CC(CC#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 GMENCIXDAWPZEP-UHFFFAOYSA-N 0.000 claims 1
• YJZQNPDRMXNAQI-UHFFFAOYSA-N 2-[4-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]cyclohexyl]acetonitrile Chemical compound C1CC(CC#N)CCC1N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 YJZQNPDRMXNAQI-UHFFFAOYSA-N 0.000 claims 1
• BORJGIRWWXWVED-UHFFFAOYSA-N 2-[4-[[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]methyl]phenyl]benzonitrile Chemical compound N#CC1=CC=CC=C1C(C=C1)=CC=C1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 BORJGIRWWXWVED-UHFFFAOYSA-N 0.000 claims 1
• VQUZGUQADNFJDS-UHFFFAOYSA-N 2-[5-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-2-(trifluoromethyl)phenyl]acetonitrile Chemical compound C1=C(CC#N)C(C(F)(F)F)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 VQUZGUQADNFJDS-UHFFFAOYSA-N 0.000 claims 1
• VLJQJXSQIHYYFI-UHFFFAOYSA-N 2-[[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]methyl]benzonitrile Chemical compound N#CC1=CC=CC=C1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 VLJQJXSQIHYYFI-UHFFFAOYSA-N 0.000 claims 1
• 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
• GQWKHZGBVWSNHU-UHFFFAOYSA-N 2-chloro-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound ClC1=C(C#N)C=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 GQWKHZGBVWSNHU-UHFFFAOYSA-N 0.000 claims 1
• MYDROCLKHWOEDX-UHFFFAOYSA-N 2-fluoro-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound C1=C(C#N)C(F)=CC(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 MYDROCLKHWOEDX-UHFFFAOYSA-N 0.000 claims 1
• 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims 1
• ADCNYQBUDBUNTF-UHFFFAOYSA-N 3-(1-methylcyclopentyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1(C)CCCC1 ADCNYQBUDBUNTF-UHFFFAOYSA-N 0.000 claims 1
• TXRBKHPRGSORKD-UHFFFAOYSA-N 3-(1-methylpyrazol-4-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=NN(C)C=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 TXRBKHPRGSORKD-UHFFFAOYSA-N 0.000 claims 1
• BZZHLZDNLLVCJY-UHFFFAOYSA-N 3-(1-methylsulfonylpyrrolidin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1N(S(=O)(=O)C)CCC1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 BZZHLZDNLLVCJY-UHFFFAOYSA-N 0.000 claims 1
• QIOPTSMJYWGZQX-UHFFFAOYSA-N 3-(2-bromo-1,3-thiazol-5-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound S1C(Br)=NC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 QIOPTSMJYWGZQX-UHFFFAOYSA-N 0.000 claims 1
• BFFDLHXFOKTJJO-UHFFFAOYSA-N 3-(2-bromopyridin-4-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=NC(Br)=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 BFFDLHXFOKTJJO-UHFFFAOYSA-N 0.000 claims 1
• VJOPGWDAQQVHHK-UHFFFAOYSA-N 3-(2-methoxypyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound COC1=NC=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 VJOPGWDAQQVHHK-UHFFFAOYSA-N 0.000 claims 1
• KTQQQXLFJWUKOM-UHFFFAOYSA-N 3-(3,5-dibromophenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CC(Br)=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 KTQQQXLFJWUKOM-UHFFFAOYSA-N 0.000 claims 1
• MBADRWYPVDLHQC-UHFFFAOYSA-N 3-(3,5-dimethyl-1,2-oxazol-4-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CC1=NOC(C)=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 MBADRWYPVDLHQC-UHFFFAOYSA-N 0.000 claims 1
• ZKWJALOZNSEXDT-UHFFFAOYSA-N 3-(3-aminophenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound NC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 ZKWJALOZNSEXDT-UHFFFAOYSA-N 0.000 claims 1
• TVOOWGXRWCNBPV-UHFFFAOYSA-N 3-(3-benzylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CC1=CC=CC=C1 TVOOWGXRWCNBPV-UHFFFAOYSA-N 0.000 claims 1
• FWUMPVDWWFNKEW-UHFFFAOYSA-N 3-(3-bromophenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 FWUMPVDWWFNKEW-UHFFFAOYSA-N 0.000 claims 1
• YBVTVMVSICZEJE-UHFFFAOYSA-N 3-(3-chlorophenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound ClC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 YBVTVMVSICZEJE-UHFFFAOYSA-N 0.000 claims 1
• WCEMDJMNQNQPFW-UHFFFAOYSA-N 3-(3-ethylsulfanylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CCSC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 WCEMDJMNQNQPFW-UHFFFAOYSA-N 0.000 claims 1
• ZVSGNVMLGDTCMY-UHFFFAOYSA-N 3-(3-ethylsulfinylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CCS(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 ZVSGNVMLGDTCMY-UHFFFAOYSA-N 0.000 claims 1
• NDFZUCJGYPZUBI-UHFFFAOYSA-N 3-(3-ethylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CCS(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 NDFZUCJGYPZUBI-UHFFFAOYSA-N 0.000 claims 1
• RTSDRORMCIEHBS-UHFFFAOYSA-N 3-(3-methoxyphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound COC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 RTSDRORMCIEHBS-UHFFFAOYSA-N 0.000 claims 1
• OKARDSIHOMFMDX-UHFFFAOYSA-N 3-(3-methylimidazol-4-yl)-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CN1C=NC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 OKARDSIHOMFMDX-UHFFFAOYSA-N 0.000 claims 1
• CBKOEBGYVBPPLI-UHFFFAOYSA-N 3-(3-morpholin-4-ylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)N1CCOCC1 CBKOEBGYVBPPLI-UHFFFAOYSA-N 0.000 claims 1
• CETUSXLETHLLDA-UHFFFAOYSA-N 3-(3-nitrophenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound [O-][N+](=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 CETUSXLETHLLDA-UHFFFAOYSA-N 0.000 claims 1
• IOUXTQRLYQBBGB-UHFFFAOYSA-N 3-(3-phenoxyphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 IOUXTQRLYQBBGB-UHFFFAOYSA-N 0.000 claims 1
• GMBBHAHHJHZWHJ-UHFFFAOYSA-N 3-(3-phenylmethoxyphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CC=CC=1OCC1=CC=CC=C1 GMBBHAHHJHZWHJ-UHFFFAOYSA-N 0.000 claims 1
• QFUYHBVICXPEKX-UHFFFAOYSA-N 3-(3-piperazin-1-ylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)N1CCNCC1 QFUYHBVICXPEKX-UHFFFAOYSA-N 0.000 claims 1
• NDHPXYGYOUSVNH-UHFFFAOYSA-N 3-(3-piperidin-1-ylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)N1CCCCC1 NDHPXYGYOUSVNH-UHFFFAOYSA-N 0.000 claims 1
• RKUSHUDYOQBDRE-UHFFFAOYSA-N 3-(3-propan-2-ylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CC(C)S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 RKUSHUDYOQBDRE-UHFFFAOYSA-N 0.000 claims 1
• MNQTZPUKIKBGQQ-UHFFFAOYSA-N 3-(3-pyridin-3-ylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CC=CC=1C1=CC=CN=C1 MNQTZPUKIKBGQQ-UHFFFAOYSA-N 0.000 claims 1
• OSCQVFWTKPUFPB-UHFFFAOYSA-N 3-(3-pyridin-4-ylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CC=CC=1C1=CC=NC=C1 OSCQVFWTKPUFPB-UHFFFAOYSA-N 0.000 claims 1
• UPTICASDQRGBOD-UHFFFAOYSA-N 3-(3-pyrrolidin-1-ylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)N1CCCC1 UPTICASDQRGBOD-UHFFFAOYSA-N 0.000 claims 1
• ZZVBYTXBDQSDEO-UHFFFAOYSA-N 3-(4-bromofuran-2-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=COC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 ZZVBYTXBDQSDEO-UHFFFAOYSA-N 0.000 claims 1
• TUWDLPZKZZWETP-UHFFFAOYSA-N 3-(4-bromopyridin-2-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CC=NC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 TUWDLPZKZZWETP-UHFFFAOYSA-N 0.000 claims 1
• UCCNYUVJUXIHNU-UHFFFAOYSA-N 3-(4-bromothiophen-2-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CSC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 UCCNYUVJUXIHNU-UHFFFAOYSA-N 0.000 claims 1
• KPRKIQRSNRKDLZ-UHFFFAOYSA-N 3-(4-methoxyphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=CC(OC)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 KPRKIQRSNRKDLZ-UHFFFAOYSA-N 0.000 claims 1
• QQFUXXKQJAYBQS-UHFFFAOYSA-N 3-(4-methylsulfanylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=CC(SC)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 QQFUXXKQJAYBQS-UHFFFAOYSA-N 0.000 claims 1
• LDVFGVGSGXCINC-UHFFFAOYSA-N 3-(4-methylsulfinylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=CC(S(=O)C)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 LDVFGVGSGXCINC-UHFFFAOYSA-N 0.000 claims 1
• ILRDJUQACMZKCE-UHFFFAOYSA-N 3-(4-methylsulfonylphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 ILRDJUQACMZKCE-UHFFFAOYSA-N 0.000 claims 1
• ZJLCHGSAJYTECE-UHFFFAOYSA-N 3-(5-bromo-2-fluorophenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound FC1=CC=C(Br)C=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 ZJLCHGSAJYTECE-UHFFFAOYSA-N 0.000 claims 1
• INARHFWDLBEPIB-UHFFFAOYSA-N 3-(5-bromo-2-methoxyphenyl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound COC1=CC=C(Br)C=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 INARHFWDLBEPIB-UHFFFAOYSA-N 0.000 claims 1
• OWZQRLUHNBYDBD-UHFFFAOYSA-N 3-(5-bromopyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 OWZQRLUHNBYDBD-UHFFFAOYSA-N 0.000 claims 1
• QIUUNPJERHCTRI-UHFFFAOYSA-N 3-(5-cyclohexylsulfanylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CN=CC=1SC1CCCCC1 QIUUNPJERHCTRI-UHFFFAOYSA-N 0.000 claims 1
• GWFVWTNKERDISB-UHFFFAOYSA-N 3-(5-cyclohexylsulfinylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1N=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)C1CCCCC1 GWFVWTNKERDISB-UHFFFAOYSA-N 0.000 claims 1
• YOOBQEXFWQQOPL-UHFFFAOYSA-N 3-(5-cyclohexylsulfonylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1N=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)C1CCCCC1 YOOBQEXFWQQOPL-UHFFFAOYSA-N 0.000 claims 1
• LWJWGUUTNLAKQG-UHFFFAOYSA-N 3-(5-ethylsulfanylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CCSC1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 LWJWGUUTNLAKQG-UHFFFAOYSA-N 0.000 claims 1
• JXLJWUBYEHEJRB-UHFFFAOYSA-N 3-(5-ethylsulfinylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CCS(=O)C1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 JXLJWUBYEHEJRB-UHFFFAOYSA-N 0.000 claims 1
• UIQXHRAQESDSNP-UHFFFAOYSA-N 3-(5-ethylsulfonylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CCS(=O)(=O)C1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 UIQXHRAQESDSNP-UHFFFAOYSA-N 0.000 claims 1
• HAMDNSCESBAUIU-UHFFFAOYSA-N 3-(5-ethynylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C#CC1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 HAMDNSCESBAUIU-UHFFFAOYSA-N 0.000 claims 1
• ABPKTQVYTSFZQN-UHFFFAOYSA-N 3-(5-formylthiophen-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound S1C(C=O)=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 ABPKTQVYTSFZQN-UHFFFAOYSA-N 0.000 claims 1
• ARTUSOXONCFJSQ-UHFFFAOYSA-N 3-(5-methoxypyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound COC1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 ARTUSOXONCFJSQ-UHFFFAOYSA-N 0.000 claims 1
• TZNUFUUVSLCYTD-UHFFFAOYSA-N 3-(5-morpholin-4-ylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CN=CC=1N1CCOCC1 TZNUFUUVSLCYTD-UHFFFAOYSA-N 0.000 claims 1
• CWPDWRNLICNHPU-UHFFFAOYSA-N 3-(5-phenylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CN=CC=1C1=CC=CC=C1 CWPDWRNLICNHPU-UHFFFAOYSA-N 0.000 claims 1
• GGYPBLHKXGXDIP-UHFFFAOYSA-N 3-(5-phenylsulfanylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CN=CC=1SC1=CC=CC=C1 GGYPBLHKXGXDIP-UHFFFAOYSA-N 0.000 claims 1
• KTXHYLGUVWAFRU-UHFFFAOYSA-N 3-(5-propan-2-ylsulfanylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CC(C)SC1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 KTXHYLGUVWAFRU-UHFFFAOYSA-N 0.000 claims 1
• XEVUCQWBQWHHBF-UHFFFAOYSA-N 3-(5-propan-2-ylsulfinylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CC(C)S(=O)C1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 XEVUCQWBQWHHBF-UHFFFAOYSA-N 0.000 claims 1
• FAVPKMFQHQYNSB-UHFFFAOYSA-N 3-(5-propan-2-ylsulfonylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CC(C)S(=O)(=O)C1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 FAVPKMFQHQYNSB-UHFFFAOYSA-N 0.000 claims 1
• CLLLIYAKXYKLSF-UHFFFAOYSA-N 3-(5-pyridin-3-ylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CN=CC=1C1=CC=CN=C1 CLLLIYAKXYKLSF-UHFFFAOYSA-N 0.000 claims 1
• KGXATMGGZZNBMA-UHFFFAOYSA-N 3-(5-pyrimidin-5-ylpyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CN=CC=1C1=CN=CN=C1 KGXATMGGZZNBMA-UHFFFAOYSA-N 0.000 claims 1
• WBJRCQRCLKJHOM-UHFFFAOYSA-N 3-(6-bromopyridin-2-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 WBJRCQRCLKJHOM-UHFFFAOYSA-N 0.000 claims 1
• RWQABNUWBXVZBE-UHFFFAOYSA-N 3-(6-chloropyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=NC(Cl)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 RWQABNUWBXVZBE-UHFFFAOYSA-N 0.000 claims 1
• NNDMVWHOMAYHCB-UHFFFAOYSA-N 3-(6-methoxypyridin-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=NC(OC)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 NNDMVWHOMAYHCB-UHFFFAOYSA-N 0.000 claims 1
• HMDWMUZBJSLHCU-UHFFFAOYSA-N 3-(furan-3-yl)-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC#N)C=1C=COC=1 HMDWMUZBJSLHCU-UHFFFAOYSA-N 0.000 claims 1
• XFYCGSYZXBNSBF-UHFFFAOYSA-N 3-(furan-3-yl)-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C=1C=COC=1 XFYCGSYZXBNSBF-UHFFFAOYSA-N 0.000 claims 1
• ZXKVHNWMEUMMCE-UHFFFAOYSA-N 3-[1-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]ethyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC=CC(C#N)=C1 ZXKVHNWMEUMMCE-UHFFFAOYSA-N 0.000 claims 1
• VMVGUHXAKOPIET-UHFFFAOYSA-N 3-[1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]but-3-enyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C)C1=CC=CC(C#N)=C1 VMVGUHXAKOPIET-UHFFFAOYSA-N 0.000 claims 1
• LSMKUUVNRFCGEA-UHFFFAOYSA-N 3-[1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]butyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CCC)C1=CC=CC(C#N)=C1 LSMKUUVNRFCGEA-UHFFFAOYSA-N 0.000 claims 1
• PUSFXZKLOYUYBG-UHFFFAOYSA-N 3-[1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]cyclopentyl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C1(CCC#N)CCCC1 PUSFXZKLOYUYBG-UHFFFAOYSA-N 0.000 claims 1
• ZFAXWTITSSKZDD-UHFFFAOYSA-N 3-[1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)C1=CC=CC(C#N)=C1 ZFAXWTITSSKZDD-UHFFFAOYSA-N 0.000 claims 1
• DPOFWPNZBVRHRG-UHFFFAOYSA-N 3-[2-(cyanomethoxy)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound N#CCOC1=CC=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 DPOFWPNZBVRHRG-UHFFFAOYSA-N 0.000 claims 1
• RYVAIFSJRFTOGK-UHFFFAOYSA-N 3-[2-bromo-5-(cyanomethoxy)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CC=C(OCC#N)C=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 RYVAIFSJRFTOGK-UHFFFAOYSA-N 0.000 claims 1
• RQWGVIYKPBHBCN-UHFFFAOYSA-N 3-[2-cyano-1-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]ethyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC#N)C1=CC=CC(C#N)=C1 RQWGVIYKPBHBCN-UHFFFAOYSA-N 0.000 claims 1
• PCRBNQYYGDYYLR-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-4-methoxybenzonitrile Chemical compound COC1=CC=C(C#N)C=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 PCRBNQYYGDYYLR-UHFFFAOYSA-N 0.000 claims 1
• CWSYTCLDKGSWKK-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n,n-diethylbenzenesulfonamide Chemical compound CCN(CC)S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 CWSYTCLDKGSWKK-UHFFFAOYSA-N 0.000 claims 1
• AKEPTFHJTWMGRD-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n,n-dimethylbenzamide Chemical compound CN(C)C(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 AKEPTFHJTWMGRD-UHFFFAOYSA-N 0.000 claims 1
• UCSUSZMJIDLGAR-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n,n-dimethylbenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 UCSUSZMJIDLGAR-UHFFFAOYSA-N 0.000 claims 1
• YQVJBIVNGFPCNO-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-(1,2-oxazol-3-yl)benzamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1C(=O)NC=1C=CON=1 YQVJBIVNGFPCNO-UHFFFAOYSA-N 0.000 claims 1
• SIBSLZRMSDBFER-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-cyclohexylbenzamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1C(=O)NC1CCCCC1 SIBSLZRMSDBFER-UHFFFAOYSA-N 0.000 claims 1
• USMYXBLIFNYKHZ-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-cyclohexylbenzenesulfonamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)NC1CCCCC1 USMYXBLIFNYKHZ-UHFFFAOYSA-N 0.000 claims 1
• ZIAUVAHFFDVBBI-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-cyclopropylbenzenesulfonamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)NC1CC1 ZIAUVAHFFDVBBI-UHFFFAOYSA-N 0.000 claims 1
• OMCISIQSBDRXDH-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-methyl-n-phenylbenzamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1C(=O)N(C)C1=CC=CC=C1 OMCISIQSBDRXDH-UHFFFAOYSA-N 0.000 claims 1
• APSABSADNDECFJ-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-methylbenzamide Chemical compound CNC(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 APSABSADNDECFJ-UHFFFAOYSA-N 0.000 claims 1
• JYMIQPXVZJKKRJ-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-methylbenzenesulfonamide Chemical compound CNS(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 JYMIQPXVZJKKRJ-UHFFFAOYSA-N 0.000 claims 1
• KLQSYAUTHNOZTO-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-naphthalen-1-ylbenzamide Chemical compound C=1C=CC2=CC=CC=C2C=1NC(=O)C(C=1)=CC=CC=1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 KLQSYAUTHNOZTO-UHFFFAOYSA-N 0.000 claims 1
• GUXOOFRIPPWNOW-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-naphthalen-1-ylbenzenesulfonamide Chemical compound C=1C=CC2=CC=CC=C2C=1NS(=O)(=O)C(C=1)=CC=CC=1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 GUXOOFRIPPWNOW-UHFFFAOYSA-N 0.000 claims 1
• REKWPBLPZLMJNM-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-naphthalen-2-ylbenzamide Chemical compound C=1C=C2C=CC=CC2=CC=1NC(=O)C(C=1)=CC=CC=1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 REKWPBLPZLMJNM-UHFFFAOYSA-N 0.000 claims 1
• SDGKWCXUOCTQDQ-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-naphthalen-2-ylbenzenesulfonamide Chemical compound C=1C=C2C=CC=CC2=CC=1NS(=O)(=O)C(C=1)=CC=CC=1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 SDGKWCXUOCTQDQ-UHFFFAOYSA-N 0.000 claims 1
• KJSGVEYMDDCOBV-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-phenylbenzenesulfonamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)NC1=CC=CC=C1 KJSGVEYMDDCOBV-UHFFFAOYSA-N 0.000 claims 1
• ZTIVRMIUUDSCFU-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-propylbenzenesulfonamide Chemical compound CCCNS(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 ZTIVRMIUUDSCFU-UHFFFAOYSA-N 0.000 claims 1
• WASZAAKKBBLVGZ-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]-n-pyridin-3-ylbenzamide Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1C(=O)NC1=CC=CN=C1 WASZAAKKBBLVGZ-UHFFFAOYSA-N 0.000 claims 1
• ZRQHCCCEXVOUJN-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]benzoic acid Chemical compound OC(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 ZRQHCCCEXVOUJN-UHFFFAOYSA-N 0.000 claims 1
• NSGDMTBTXTVZHW-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CC=CC(C#N)=C1 NSGDMTBTXTVZHW-UHFFFAOYSA-N 0.000 claims 1
• DNEQCGDNZFTTAJ-UHFFFAOYSA-N 3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]cyclopentane-1-carbonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1CCC(C#N)C1 DNEQCGDNZFTTAJ-UHFFFAOYSA-N 0.000 claims 1
• QHSMILYAMJWNGM-UHFFFAOYSA-N 3-[3-(1-phenylethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)C(C)C1=CC=CC=C1 QHSMILYAMJWNGM-UHFFFAOYSA-N 0.000 claims 1
• RPNXFYKFEMLUBK-UHFFFAOYSA-N 3-[3-(1h-pyrazol-4-yl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CC=CC=1C=1C=NNC=1 RPNXFYKFEMLUBK-UHFFFAOYSA-N 0.000 claims 1
• PPFUCRICNHNATE-UHFFFAOYSA-N 3-[3-(2,6-dimethylmorpholin-4-yl)sulfonylphenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1C(C)OC(C)CN1S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 PPFUCRICNHNATE-UHFFFAOYSA-N 0.000 claims 1
• HUNKABQMOYQPJN-UHFFFAOYSA-N 3-[3-(2-methylpropylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CC(C)CS(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 HUNKABQMOYQPJN-UHFFFAOYSA-N 0.000 claims 1
• YJLPMITWAXUVTR-UHFFFAOYSA-N 3-[3-(2-phenylethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CCC1=CC=CC=C1 YJLPMITWAXUVTR-UHFFFAOYSA-N 0.000 claims 1
• PWBIZOCHRWGZRT-UHFFFAOYSA-N 3-[3-(3,4,4a,5,6,7,8,8a-octahydro-1h-isoquinolin-2-ylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1CC2CCCCC2CN1S(=O)(=O)C(C=1)=CC=CC=1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 PWBIZOCHRWGZRT-UHFFFAOYSA-N 0.000 claims 1
• OHQQFUHNXRCIOC-UHFFFAOYSA-N 3-[3-(3,4-dihydro-1h-isoquinolin-2-ylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1CC2=CC=CC=C2CN1S(=O)(=O)C(C=1)=CC=CC=1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 OHQQFUHNXRCIOC-UHFFFAOYSA-N 0.000 claims 1
• CRCIGEXBCQQFNX-UHFFFAOYSA-N 3-[3-(4-ethylpiperazin-1-yl)sulfonylphenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1CN(CC)CCN1S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 CRCIGEXBCQQFNX-UHFFFAOYSA-N 0.000 claims 1
• GWJYOFPTLJITLB-UHFFFAOYSA-N 3-[3-(4-hydroxypiperidin-1-yl)sulfonylphenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1CC(O)CCN1S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 GWJYOFPTLJITLB-UHFFFAOYSA-N 0.000 claims 1
• UYNKGROTZHOOHG-UHFFFAOYSA-N 3-[3-(4-methylpiperazin-1-yl)sulfonylphenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1CN(C)CCN1S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 UYNKGROTZHOOHG-UHFFFAOYSA-N 0.000 claims 1
• GYKNHLCPEPNDLQ-UHFFFAOYSA-N 3-[3-(4-oxopiperidin-1-yl)sulfonylphenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1CC(=O)CCN1S(=O)(=O)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 GYKNHLCPEPNDLQ-UHFFFAOYSA-N 0.000 claims 1
• XGQUSDPRLSCVEZ-UHFFFAOYSA-N 3-[3-(cyanomethoxy)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound N#CCOC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 XGQUSDPRLSCVEZ-UHFFFAOYSA-N 0.000 claims 1
• HQNZCVLBJIKVTE-UHFFFAOYSA-N 3-[3-(cyclohexylmethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CC1CCCCC1 HQNZCVLBJIKVTE-UHFFFAOYSA-N 0.000 claims 1
• FDKDOHYSCOHTIL-UHFFFAOYSA-N 3-[3-(cyclopropylmethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CC1CC1 FDKDOHYSCOHTIL-UHFFFAOYSA-N 0.000 claims 1
• KFMMWDYHFNAZOQ-UHFFFAOYSA-N 3-[3-(furan-3-ylmethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CC=1C=COC=1 KFMMWDYHFNAZOQ-UHFFFAOYSA-N 0.000 claims 1
• NXRSOXHKCMTJCK-UHFFFAOYSA-N 3-[3-(hydroxymethyl)cyclopentyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1C(CO)CCC1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 NXRSOXHKCMTJCK-UHFFFAOYSA-N 0.000 claims 1
• GSWJUWXFLAFQGO-UHFFFAOYSA-N 3-[3-(morpholine-4-carbonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1C(=O)N1CCOCC1 GSWJUWXFLAFQGO-UHFFFAOYSA-N 0.000 claims 1
• DBBFIVASUVLZRF-UHFFFAOYSA-N 3-[3-(naphthalen-2-ylmethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=C2C=CC=CC2=CC=1CS(=O)(=O)C(C=1)=CC=CC=1C(CC#N)N(N=C1)C=C1C1=NC=NC2=C1C=CN2 DBBFIVASUVLZRF-UHFFFAOYSA-N 0.000 claims 1
• QIQGWSBEXVIJSF-UHFFFAOYSA-N 3-[3-(oxan-4-ylmethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CC1CCOCC1 QIQGWSBEXVIJSF-UHFFFAOYSA-N 0.000 claims 1
• NUSSHOZXQNCGGW-UHFFFAOYSA-N 3-[3-(pyridin-4-ylmethylsulfonyl)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CC1=CC=NC=C1 NUSSHOZXQNCGGW-UHFFFAOYSA-N 0.000 claims 1
• RKLCZCHFEPGTIU-UHFFFAOYSA-N 3-[3-hydroxy-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propyl]-n,n-dimethylbenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=CC(C(CCO)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 RKLCZCHFEPGTIU-UHFFFAOYSA-N 0.000 claims 1
• RNHGIBLHNAYYDJ-UHFFFAOYSA-N 3-[4,4-difluoro-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]but-3-enyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C(F)F)C1=CC=CC(C#N)=C1 RNHGIBLHNAYYDJ-UHFFFAOYSA-N 0.000 claims 1
• OGPVINHNJYCGAP-UHFFFAOYSA-N 3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-3-(1,3-thiazol-5-yl)propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC#N)C1=CN=CS1 OGPVINHNJYCGAP-UHFFFAOYSA-N 0.000 claims 1
• GXDVHYZUQLHOFR-UHFFFAOYSA-N 3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-3-thiophen-3-ylpropanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC#N)C=1C=CSC=1 GXDVHYZUQLHOFR-UHFFFAOYSA-N 0.000 claims 1
• FQGBLDAAPRYGEX-UHFFFAOYSA-N 3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-4-(trifluoromethyl)benzonitrile Chemical compound FC(F)(F)C1=CC=C(C#N)C=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 FQGBLDAAPRYGEX-UHFFFAOYSA-N 0.000 claims 1
• OZTFAGZGHQSMIX-UHFFFAOYSA-N 3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound N#CC1=CC=CC(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 OZTFAGZGHQSMIX-UHFFFAOYSA-N 0.000 claims 1
• JKKLRUPIJUAHCR-UHFFFAOYSA-N 3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]cyclohexan-1-one Chemical compound C1C(=O)CCCC1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 JKKLRUPIJUAHCR-UHFFFAOYSA-N 0.000 claims 1
• XZJYVKOKNMMFGB-UHFFFAOYSA-N 3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]cyclopentan-1-one Chemical compound C1C(=O)CCC1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 XZJYVKOKNMMFGB-UHFFFAOYSA-N 0.000 claims 1
• VPZWKGSIANBDNX-UHFFFAOYSA-N 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-3-(3-thiomorpholin-4-ylsulfonylphenyl)propanenitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)N1CCSCC1 VPZWKGSIANBDNX-UHFFFAOYSA-N 0.000 claims 1
• UMADGGRVTOQZBW-UHFFFAOYSA-N 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-3-[3-(trifluoromethoxy)phenyl]propanenitrile Chemical compound FC(F)(F)OC1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 UMADGGRVTOQZBW-UHFFFAOYSA-N 0.000 claims 1
• WXQMRSJIJGUBLC-UHFFFAOYSA-N 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-3-[3-(trifluoromethyl)phenyl]propanenitrile Chemical compound FC(F)(F)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 WXQMRSJIJGUBLC-UHFFFAOYSA-N 0.000 claims 1
• SMGWYTKHPZOMFF-UHFFFAOYSA-N 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-3-[5-(1,3-thiazol-2-ylsulfanyl)pyridin-3-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C(C=1)=CN=CC=1SC1=NC=CS1 SMGWYTKHPZOMFF-UHFFFAOYSA-N 0.000 claims 1
• YXGWGLDSROQSIY-UHFFFAOYSA-N 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-3-[6-(trifluoromethyl)pyridin-3-yl]propanenitrile Chemical compound C1=NC(C(F)(F)F)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 YXGWGLDSROQSIY-UHFFFAOYSA-N 0.000 claims 1
• HPFNKZJTZQFOEN-UHFFFAOYSA-N 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]-3-thiophen-3-ylpropanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C=1C=CSC=1 HPFNKZJTZQFOEN-UHFFFAOYSA-N 0.000 claims 1
• KJAFOBQBTYIBSM-UHFFFAOYSA-N 3-[4-(cyanomethoxy)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=CC(OCC#N)=CC=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 KJAFOBQBTYIBSM-UHFFFAOYSA-N 0.000 claims 1
• RSTJBADBYDTUPD-UHFFFAOYSA-N 3-[5-(1-methylpyrazol-4-yl)pyridin-3-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=NN(C)C=C1C1=CN=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 RSTJBADBYDTUPD-UHFFFAOYSA-N 0.000 claims 1
• VYVHOEXPBGOCDZ-UHFFFAOYSA-N 3-[5-(benzenesulfinyl)pyridin-3-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1N=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)C1=CC=CC=C1 VYVHOEXPBGOCDZ-UHFFFAOYSA-N 0.000 claims 1
• IBZKCYJQNLWBIM-UHFFFAOYSA-N 3-[5-(benzenesulfonyl)pyridin-3-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C=1N=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)C1=CC=CC=C1 IBZKCYJQNLWBIM-UHFFFAOYSA-N 0.000 claims 1
• PFAQEHJFJGTYGW-UHFFFAOYSA-N 3-[5-bromo-2-(cyanomethoxy)phenyl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound BrC1=CC=C(OCC#N)C(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 PFAQEHJFJGTYGW-UHFFFAOYSA-N 0.000 claims 1
• CAGSCFQUKPDLOU-UHFFFAOYSA-N 3-[6-(dimethylamino)pyridin-2-yl]-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound CN(C)C1=CC=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=N1 CAGSCFQUKPDLOU-UHFFFAOYSA-N 0.000 claims 1
• IYNVYKIVRVKCTJ-UHFFFAOYSA-N 3-[[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]methyl]benzonitrile Chemical compound N#CC1=CC=CC(CN2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 IYNVYKIVRVKCTJ-UHFFFAOYSA-N 0.000 claims 1
• VRYSVXJBUYKTLO-UHFFFAOYSA-N 3-[[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]methyl]benzonitrile Chemical compound N#CC1=CC=CC(CN2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 VRYSVXJBUYKTLO-UHFFFAOYSA-N 0.000 claims 1
• DDAKGHLNTCKIFL-UHFFFAOYSA-N 3-bromo-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound BrC1=CC(C#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 DDAKGHLNTCKIFL-UHFFFAOYSA-N 0.000 claims 1
• NZJRQYKNACJTEU-UHFFFAOYSA-N 3-chloro-2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound ClC1=CC=CC(C#N)=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 NZJRQYKNACJTEU-UHFFFAOYSA-N 0.000 claims 1
• BWEQVAMKNQHFJS-UHFFFAOYSA-N 3-chloro-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound ClC1=CC(C#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 BWEQVAMKNQHFJS-UHFFFAOYSA-N 0.000 claims 1
• PXBJXXMRMDCVMF-UHFFFAOYSA-N 3-cyclohexyl-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC#N)C1CCCCC1 PXBJXXMRMDCVMF-UHFFFAOYSA-N 0.000 claims 1
• MNCJHFDDDSITIO-UHFFFAOYSA-N 3-cyclohexyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1CCCCC1 MNCJHFDDDSITIO-UHFFFAOYSA-N 0.000 claims 1
• OXUJAONXYLDHIK-UHFFFAOYSA-N 3-cyclopentyl-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC#N)C1CCCC1 OXUJAONXYLDHIK-UHFFFAOYSA-N 0.000 claims 1
• HFNKQEVNSGCOJV-UHFFFAOYSA-N 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1CCCC1 HFNKQEVNSGCOJV-UHFFFAOYSA-N 0.000 claims 1
• MKZZWHGNUHUYCM-UHFFFAOYSA-N 3-cyclopropyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1CC1 MKZZWHGNUHUYCM-UHFFFAOYSA-N 0.000 claims 1
• LZPZFBYRPMORMS-UHFFFAOYSA-N 3-fluoro-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound FC1=CC(C#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 LZPZFBYRPMORMS-UHFFFAOYSA-N 0.000 claims 1
• YQCNERDTJVEHBB-UHFFFAOYSA-N 3-methyl-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzaldehyde Chemical compound CC1=CC(C=O)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 YQCNERDTJVEHBB-UHFFFAOYSA-N 0.000 claims 1
• RXPMDAQIPZWBRY-UHFFFAOYSA-N 3-methyl-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound CC1=CC(C#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 RXPMDAQIPZWBRY-UHFFFAOYSA-N 0.000 claims 1
• AKUNHDMTESOUJE-UHFFFAOYSA-N 3-methyl-5-[2-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propyl]-1,2,4-oxadiazole Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)CC1=NC(C)=NO1 AKUNHDMTESOUJE-UHFFFAOYSA-N 0.000 claims 1
• FSWCHUZTZVAVHQ-UHFFFAOYSA-N 3-pyridin-2-yl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CC=CC=N1 FSWCHUZTZVAVHQ-UHFFFAOYSA-N 0.000 claims 1
• UYFXFMAEIPPFAG-UHFFFAOYSA-N 3-pyridin-3-yl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CC=CN=C1 UYFXFMAEIPPFAG-UHFFFAOYSA-N 0.000 claims 1
• IPRAABXWTRGWDG-UHFFFAOYSA-N 3-pyridin-4-yl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CC=NC=C1 IPRAABXWTRGWDG-UHFFFAOYSA-N 0.000 claims 1
• WJOVXYZBOIIIIM-UHFFFAOYSA-N 3-pyrimidin-5-yl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CN=CN=C1 WJOVXYZBOIIIIM-UHFFFAOYSA-N 0.000 claims 1
• IGOCJDKGMYDZSD-UHFFFAOYSA-N 4-(1-benzylpyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1=CC=CC=C1 IGOCJDKGMYDZSD-UHFFFAOYSA-N 0.000 claims 1
• RWJKKNBOVOMPSI-UHFFFAOYSA-N 4-(1-cyclohex-2-en-1-ylpyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine Chemical compound C1CCC=CC1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 RWJKKNBOVOMPSI-UHFFFAOYSA-N 0.000 claims 1
• AVEMYBWNWUNQFS-UHFFFAOYSA-N 4-(1-cyclohexylpyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine Chemical compound C1CCCCC1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 AVEMYBWNWUNQFS-UHFFFAOYSA-N 0.000 claims 1
• QOUXMGUQHNIMDL-UHFFFAOYSA-N 4-(1-phenylpyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=CN=C2NC=CC2=C1C(=C1)C=NN1C1=CC=CC=C1 QOUXMGUQHNIMDL-UHFFFAOYSA-N 0.000 claims 1
• UVWPYXOOEMDENN-UHFFFAOYSA-N 4-(cyanomethoxy)-2-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]benzonitrile Chemical compound N#CCOC1=CC=C(C#N)C(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 UVWPYXOOEMDENN-UHFFFAOYSA-N 0.000 claims 1
• XPKQBAHJYSCQJF-UHFFFAOYSA-N 4-(cyanomethoxy)-3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]benzonitrile Chemical compound N#CCOC1=CC=C(C#N)C=C1C(CC#N)N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 XPKQBAHJYSCQJF-UHFFFAOYSA-N 0.000 claims 1
• SISSFPZQFDPIFT-UHFFFAOYSA-N 4-[1-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C12=CC=CC=C2CCCC1N(N=C1)C=C1C1=CC=NC2=C1C=CN2 SISSFPZQFDPIFT-UHFFFAOYSA-N 0.000 claims 1
• OPSJJAHKIDSFFB-UHFFFAOYSA-N 4-[1-(1-cyclobutylethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1CCC1 OPSJJAHKIDSFFB-UHFFFAOYSA-N 0.000 claims 1
• XHDIGOMAQUEQBO-UHFFFAOYSA-N 4-[1-(1-cyclohexylethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1CCCCC1 XHDIGOMAQUEQBO-UHFFFAOYSA-N 0.000 claims 1
• WBMFDJFNNHCCHP-UHFFFAOYSA-N 4-[1-(1-cyclopentyl-4,4-difluorobut-3-enyl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C(F)F)C1CCCC1 WBMFDJFNNHCCHP-UHFFFAOYSA-N 0.000 claims 1
• AVBDWSJSKJEDSI-UHFFFAOYSA-N 4-[1-(1-cyclopentyl-4,4-difluorobutyl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CCC(F)F)C1CCCC1 AVBDWSJSKJEDSI-UHFFFAOYSA-N 0.000 claims 1
• ZPQGCBHCCIVGSL-UHFFFAOYSA-N 4-[1-(1-cyclopentylbut-3-enyl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C)C1CCCC1 ZPQGCBHCCIVGSL-UHFFFAOYSA-N 0.000 claims 1
• BQJJZWYBIPVMSQ-UHFFFAOYSA-N 4-[1-(1-cyclopentylbutyl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CCC)C1CCCC1 BQJJZWYBIPVMSQ-UHFFFAOYSA-N 0.000 claims 1
• MSXWLBALCWWYNX-UHFFFAOYSA-N 4-[1-(1-cyclopentylethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1CCCC1 MSXWLBALCWWYNX-UHFFFAOYSA-N 0.000 claims 1
• YBXXHVGMAXOQJK-UHFFFAOYSA-N 4-[1-(1-cyclopentylpropyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC)C1CCCC1 YBXXHVGMAXOQJK-UHFFFAOYSA-N 0.000 claims 1
• BLLAEKRDPJDWAJ-UHFFFAOYSA-N 4-[1-(1-cyclopentylpropyl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC)C1CCCC1 BLLAEKRDPJDWAJ-UHFFFAOYSA-N 0.000 claims 1
• XWBOICJTJKYPEC-UHFFFAOYSA-N 4-[1-(1-cyclopropyl-4,4-difluorobut-3-enyl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C(F)F)C1CC1 XWBOICJTJKYPEC-UHFFFAOYSA-N 0.000 claims 1
• KPTZIFDWCMSAAN-UHFFFAOYSA-N 4-[1-(1-imidazol-1-ylpropan-2-yl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)CN1C=CN=C1 KPTZIFDWCMSAAN-UHFFFAOYSA-N 0.000 claims 1
• XXFCTCGGKZDPCK-UHFFFAOYSA-N 4-[1-(1-phenylethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC=CC=C1 XXFCTCGGKZDPCK-UHFFFAOYSA-N 0.000 claims 1
• RUHRCYUKTRUIOG-UHFFFAOYSA-N 4-[1-(1-phenylpropan-2-yl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)CC1=CC=CC=C1 RUHRCYUKTRUIOG-UHFFFAOYSA-N 0.000 claims 1
• RJFWZTCSGRHOKR-UHFFFAOYSA-N 4-[1-(1-phenylpropyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CC)C1=CC=CC=C1 RJFWZTCSGRHOKR-UHFFFAOYSA-N 0.000 claims 1
• NUIRKABRGZSRAQ-UHFFFAOYSA-N 4-[1-(1-thiophen-3-ylpropan-2-yl)pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)CC=1C=CSC=1 NUIRKABRGZSRAQ-UHFFFAOYSA-N 0.000 claims 1
• QWCJFEMSUKWZSE-UHFFFAOYSA-N 4-[1-(2,3-dihydro-1h-inden-1-yl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1CC2=CC=CC=C2C1N(N=C1)C=C1C1=CC=NC2=C1C=CN2 QWCJFEMSUKWZSE-UHFFFAOYSA-N 0.000 claims 1
• PCKUVKTWZIOGRU-UHFFFAOYSA-N 4-[1-(2,5-dimethylphenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound CC1=CC=C(C)C(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 PCKUVKTWZIOGRU-UHFFFAOYSA-N 0.000 claims 1
• ZNLPONYTZLZNAR-UHFFFAOYSA-N 4-[1-(2,6-dichlorophenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound ClC1=CC=CC(Cl)=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 ZNLPONYTZLZNAR-UHFFFAOYSA-N 0.000 claims 1
• XRRASNMDADUWRT-UHFFFAOYSA-N 4-[1-(2,6-dimethylphenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound CC1=CC=CC(C)=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 XRRASNMDADUWRT-UHFFFAOYSA-N 0.000 claims 1
• NDWMZOXGMJDCFE-UHFFFAOYSA-N 4-[1-(2-chlorophenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound ClC1=CC=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 NDWMZOXGMJDCFE-UHFFFAOYSA-N 0.000 claims 1
• JRYUBBQUAYYARA-UHFFFAOYSA-N 4-[1-(2-methoxyphenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound COC1=CC=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 JRYUBBQUAYYARA-UHFFFAOYSA-N 0.000 claims 1
• KNNMPVOODNBOPR-UHFFFAOYSA-N 4-[1-(2-methyl-4-nitrophenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound CC1=CC([N+]([O-])=O)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 KNNMPVOODNBOPR-UHFFFAOYSA-N 0.000 claims 1
• YVIBKPAPEOCFGP-UHFFFAOYSA-N 4-[1-(2-methylphenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound CC1=CC=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 YVIBKPAPEOCFGP-UHFFFAOYSA-N 0.000 claims 1
• AUSYSAVTHOHINA-UHFFFAOYSA-N 4-[1-(3,5-dimethylphenyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound CC1=CC(C)=CC(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 AUSYSAVTHOHINA-UHFFFAOYSA-N 0.000 claims 1
• WHJRSHMXXSNWBP-UHFFFAOYSA-N 4-[1-(4-bromo-3,5,6-trifluoropyridin-2-yl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound BrC1=C(F)C(F)=NC(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1F WHJRSHMXXSNWBP-UHFFFAOYSA-N 0.000 claims 1
• SMGOMFJCXSIUNI-UHFFFAOYSA-N 4-[1-(4-imidazol-1-ylbutan-2-yl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)CCN1C=CN=C1 SMGOMFJCXSIUNI-UHFFFAOYSA-N 0.000 claims 1
• JBYYIAPFFJVTHM-UHFFFAOYSA-N 4-[1-(4-phenylbut-3-enyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CCC=CC1=CC=CC=C1 JBYYIAPFFJVTHM-UHFFFAOYSA-N 0.000 claims 1
• CYGZDVWGPDUEPZ-UHFFFAOYSA-N 4-[1-(4-phenylbutan-2-yl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)CCC1=CC=CC=C1 CYGZDVWGPDUEPZ-UHFFFAOYSA-N 0.000 claims 1
• NPBMGHYDURUBAZ-UHFFFAOYSA-N 4-[1-(4-pyrazol-1-ylbutan-2-yl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)CCN1C=CC=N1 NPBMGHYDURUBAZ-UHFFFAOYSA-N 0.000 claims 1
• UCBDAVYDYCPYGI-UHFFFAOYSA-N 4-[1-(cyclohexylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1CCCCC1 UCBDAVYDYCPYGI-UHFFFAOYSA-N 0.000 claims 1
• IUMPZECXORUGLN-UHFFFAOYSA-N 4-[1-(cyclopropylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1CC1 IUMPZECXORUGLN-UHFFFAOYSA-N 0.000 claims 1
• HYLUMDMBMDXZGW-UHFFFAOYSA-N 4-[1-(furan-2-ylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1=CC=CO1 HYLUMDMBMDXZGW-UHFFFAOYSA-N 0.000 claims 1
• ZLVIVDMETWXEMH-UHFFFAOYSA-N 4-[1-(furan-3-ylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC=1C=COC=1 ZLVIVDMETWXEMH-UHFFFAOYSA-N 0.000 claims 1
• UJVCRJUQYRPVBQ-UHFFFAOYSA-N 4-[1-(naphthalen-2-ylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C=1C=C2C=CC=CC2=CC=1CN(N=C1)C=C1C1=CC=NC2=C1C=CN2 UJVCRJUQYRPVBQ-UHFFFAOYSA-N 0.000 claims 1
• YWYZNMFJXKODNM-UHFFFAOYSA-N 4-[1-(oxan-2-ylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1CCCCO1 YWYZNMFJXKODNM-UHFFFAOYSA-N 0.000 claims 1
• FWDUYQSOHIPKHM-UHFFFAOYSA-N 4-[1-(oxolan-2-ylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1CCCO1 FWDUYQSOHIPKHM-UHFFFAOYSA-N 0.000 claims 1
• YUPGEFVFGQTEEX-UHFFFAOYSA-N 4-[1-(oxolan-3-ylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1CCOC1 YUPGEFVFGQTEEX-UHFFFAOYSA-N 0.000 claims 1
• FINCFYNGKVBECW-UHFFFAOYSA-N 4-[1-(pyridin-3-ylmethyl)pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1CC1=CC=CN=C1 FINCFYNGKVBECW-UHFFFAOYSA-N 0.000 claims 1
• AEXHOUJPVURVGG-UHFFFAOYSA-N 4-[1-[(1-methylsulfonylpiperidin-4-yl)methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1CN(S(=O)(=O)C)CCC1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 AEXHOUJPVURVGG-UHFFFAOYSA-N 0.000 claims 1
• AEIMUOSUUCBSDK-UHFFFAOYSA-N 4-[1-[(1-methylsulfonylpyrrolidin-2-yl)methyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound CS(=O)(=O)N1CCCC1CN1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 AEIMUOSUUCBSDK-UHFFFAOYSA-N 0.000 claims 1
• ADGOXQSPBJHMAB-UHFFFAOYSA-N 4-[1-[(2,6-dichlorophenyl)methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound ClC1=CC=CC(Cl)=C1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 ADGOXQSPBJHMAB-UHFFFAOYSA-N 0.000 claims 1
• BRCUDYIFYGGXOL-UHFFFAOYSA-N 4-[1-[(2-bromophenyl)methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound BrC1=CC=CC=C1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 BRCUDYIFYGGXOL-UHFFFAOYSA-N 0.000 claims 1
• VFVPXSBJCKFCCC-UHFFFAOYSA-N 4-[1-[(2-nitrophenyl)methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound [O-][N+](=O)C1=CC=CC=C1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 VFVPXSBJCKFCCC-UHFFFAOYSA-N 0.000 claims 1
• BIALYXKEVRSRRM-UHFFFAOYSA-N 4-[1-[(3,5-dimethoxyphenyl)methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound COC1=CC(OC)=CC(CN2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 BIALYXKEVRSRRM-UHFFFAOYSA-N 0.000 claims 1
• VEMASNDJNTVFCT-UHFFFAOYSA-N 4-[1-[(3-nitrophenyl)methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound [O-][N+](=O)C1=CC=CC(CN2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 VEMASNDJNTVFCT-UHFFFAOYSA-N 0.000 claims 1
• LPHKPQYSTVLQKS-UHFFFAOYSA-N 4-[1-[1,1,1-trifluoro-3-(1h-imidazol-2-yl)propan-2-yl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C(F)(F)F)CC1=NC=CN1 LPHKPQYSTVLQKS-UHFFFAOYSA-N 0.000 claims 1
• MGHXICVWGTWYOU-UHFFFAOYSA-N 4-[1-[1-(1,2,4-triazol-1-yl)propan-2-yl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(C)CN1C=NC=N1 MGHXICVWGTWYOU-UHFFFAOYSA-N 0.000 claims 1
• YWHFXRJONXQDRD-UHFFFAOYSA-N 4-[1-[1-(2,4-dichloro-5-fluorophenyl)ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC(F)=C(Cl)C=C1Cl YWHFXRJONXQDRD-UHFFFAOYSA-N 0.000 claims 1
• GFNXLXQKWPJYJT-UHFFFAOYSA-N 4-[1-[1-(3-bromophenyl)but-3-enyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound BrC1=CC=CC(C(CC=C)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 GFNXLXQKWPJYJT-UHFFFAOYSA-N 0.000 claims 1
• PFDAHEMTXMXNCU-UHFFFAOYSA-N 4-[1-[1-(3-ethylsulfonylphenyl)-4,4-difluorobut-3-enyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound CCS(=O)(=O)C1=CC=CC(C(CC=C(F)F)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 PFDAHEMTXMXNCU-UHFFFAOYSA-N 0.000 claims 1
• XDOHYPHRAPUZMC-UHFFFAOYSA-N 4-[1-[1-(3-ethylsulfonylphenyl)-4,4-difluorobutyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound CCS(=O)(=O)C1=CC=CC(C(CCC(F)F)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 XDOHYPHRAPUZMC-UHFFFAOYSA-N 0.000 claims 1
• AZINIKIRVOBDRS-UHFFFAOYSA-N 4-[1-[1-(3-fluoro-4-methoxyphenyl)ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(F)C(OC)=CC=C1C(C)N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 AZINIKIRVOBDRS-UHFFFAOYSA-N 0.000 claims 1
• IMPSDXDGDRSILN-UHFFFAOYSA-N 4-[1-[1-(4-methylsulfonylphenyl)ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC=C(S(C)(=O)=O)C=C1 IMPSDXDGDRSILN-UHFFFAOYSA-N 0.000 claims 1
• GACGWODHSXJIJI-UHFFFAOYSA-N 4-[1-[1-(5-bromopyridin-3-yl)-4,4-difluorobut-3-enyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C(F)F)C1=CN=CC(Br)=C1 GACGWODHSXJIJI-UHFFFAOYSA-N 0.000 claims 1
• YNDGQIXYUOBYCP-UHFFFAOYSA-N 4-[1-[1-[2-(trifluoromethyl)phenyl]ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC=CC=C1C(F)(F)F YNDGQIXYUOBYCP-UHFFFAOYSA-N 0.000 claims 1
• LTETXRJDTSYEOZ-UHFFFAOYSA-N 4-[1-[1-[2-chloro-5-(trifluoromethyl)phenyl]ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC(C(F)(F)F)=CC=C1Cl LTETXRJDTSYEOZ-UHFFFAOYSA-N 0.000 claims 1
• FBBFJGCTDBJIAC-UHFFFAOYSA-N 4-[1-[1-[3,5-bis(trifluoromethyl)phenyl]ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 FBBFJGCTDBJIAC-UHFFFAOYSA-N 0.000 claims 1
• MVUGIUIISFQQFR-UHFFFAOYSA-N 4-[1-[1-[3-(trifluoromethyl)phenyl]ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC=CC(C(F)(F)F)=C1 MVUGIUIISFQQFR-UHFFFAOYSA-N 0.000 claims 1
• IXJQUTNCJXCUOR-UHFFFAOYSA-N 4-[1-[1-[4-(trifluoromethyl)phenyl]ethyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC=C(C(F)(F)F)C=C1 IXJQUTNCJXCUOR-UHFFFAOYSA-N 0.000 claims 1
• NNAAJLCAIRDSID-UHFFFAOYSA-N 4-[1-[2,6-dichloro-4-(trifluoromethyl)phenyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound ClC1=CC(C(F)(F)F)=CC(Cl)=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 NNAAJLCAIRDSID-UHFFFAOYSA-N 0.000 claims 1
• ITOSTXSZFJJCJG-UHFFFAOYSA-N 4-[1-[2-(trifluoromethyl)phenyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound FC(F)(F)C1=CC=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 ITOSTXSZFJJCJG-UHFFFAOYSA-N 0.000 claims 1
• UPCFPKCSOKBCMR-UHFFFAOYSA-N 4-[1-[2-chloro-4-(trifluoromethyl)phenyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound ClC1=CC(C(F)(F)F)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 UPCFPKCSOKBCMR-UHFFFAOYSA-N 0.000 claims 1
• YYJQZKWSTLADRL-UHFFFAOYSA-N 4-[1-[2-chloro-6-nitro-4-(trifluoromethyl)phenyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC(Cl)=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 YYJQZKWSTLADRL-UHFFFAOYSA-N 0.000 claims 1
• HXUJIMFEBWNYLW-UHFFFAOYSA-N 4-[1-[4,4-difluoro-1-(3-methylsulfonylphenyl)but-3-enyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound CS(=O)(=O)C1=CC=CC(C(CC=C(F)F)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=C1 HXUJIMFEBWNYLW-UHFFFAOYSA-N 0.000 claims 1
• NKWYOPSPILCIMC-UHFFFAOYSA-N 4-[1-[4,4-difluoro-1-(3-phenylmethoxyphenyl)but-3-enyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C(F)F)C(C=1)=CC=CC=1OCC1=CC=CC=C1 NKWYOPSPILCIMC-UHFFFAOYSA-N 0.000 claims 1
• MZRURNDZJKOUFU-UHFFFAOYSA-N 4-[1-[4,4-difluoro-1-(oxolan-3-yl)but-3-enyl]pyrazol-4-yl]-7h-pyrrolo[2,3-d]pyrimidine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C(F)F)C1CCOC1 MZRURNDZJKOUFU-UHFFFAOYSA-N 0.000 claims 1
• ADCQVHRWDHLMKN-UHFFFAOYSA-N 4-[1-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]ethyl]benzonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(C)C1=CC=C(C#N)C=C1 ADCQVHRWDHLMKN-UHFFFAOYSA-N 0.000 claims 1
• MSKZMZQLQNEZFK-UHFFFAOYSA-N 4-[1-[4-nitro-2-(trifluoromethyl)phenyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound FC(F)(F)C1=CC([N+](=O)[O-])=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 MSKZMZQLQNEZFK-UHFFFAOYSA-N 0.000 claims 1
• FIKVXGUGMRQNIV-UHFFFAOYSA-N 4-[1-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound FC1=CC=C(C(F)(F)F)C=C1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 FIKVXGUGMRQNIV-UHFFFAOYSA-N 0.000 claims 1
• ZHYMXRKXONMONQ-UHFFFAOYSA-N 4-[1-[[3-(trifluoromethoxy)phenyl]methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound FC(F)(F)OC1=CC=CC(CN2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 ZHYMXRKXONMONQ-UHFFFAOYSA-N 0.000 claims 1
• ODWWNKGROJEMAL-UHFFFAOYSA-N 4-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound FC(F)(F)C1=CC=CC(CN2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 ODWWNKGROJEMAL-UHFFFAOYSA-N 0.000 claims 1
• MFJXFAIWGALONE-UHFFFAOYSA-N 4-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyridine-2-carbonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CC=NC(C#N)=C1 MFJXFAIWGALONE-UHFFFAOYSA-N 0.000 claims 1
• IBUPISPSRGZYSY-UHFFFAOYSA-N 4-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]thiophene-2-carbonitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)C1=CSC(C#N)=C1 IBUPISPSRGZYSY-UHFFFAOYSA-N 0.000 claims 1
• WFEUJGXMERLUJW-UHFFFAOYSA-N 4-[3-[4,4-difluoro-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]but-3-enyl]phenyl]sulfonylmorpholine Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC=C(F)F)C(C=1)=CC=CC=1S(=O)(=O)N1CCOCC1 WFEUJGXMERLUJW-UHFFFAOYSA-N 0.000 claims 1
• VUJDQNCNIGUIGZ-UHFFFAOYSA-N 4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]-2-(trifluoromethyl)benzonitrile Chemical compound C1=C(C#N)C(C(F)(F)F)=CC(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 VUJDQNCNIGUIGZ-UHFFFAOYSA-N 0.000 claims 1
• CAFLLVDAMSUHFY-UHFFFAOYSA-N 4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzene-1,2-dicarbonitrile Chemical compound C1=C(C#N)C(C#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 CAFLLVDAMSUHFY-UHFFFAOYSA-N 0.000 claims 1
• JXWWUJDWTJYYCS-UHFFFAOYSA-N 4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound C1=CC(C#N)=CC=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 JXWWUJDWTJYYCS-UHFFFAOYSA-N 0.000 claims 1
• SHAULNTZBPRZJR-UHFFFAOYSA-N 4-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]cyclohexane-1-carbonitrile Chemical compound C1CC(C#N)CCC1N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 SHAULNTZBPRZJR-UHFFFAOYSA-N 0.000 claims 1
• OYKOFGIGGKUSAT-UHFFFAOYSA-N 4-[[3-[2-cyano-1-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]phenyl]sulfonylmethyl]benzonitrile Chemical compound C=1C=CC(C(CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)=CC=1S(=O)(=O)CC1=CC=C(C#N)C=C1 OYKOFGIGGKUSAT-UHFFFAOYSA-N 0.000 claims 1
• XJGSJZDKTYSYQY-UHFFFAOYSA-N 4-[[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]methyl]benzonitrile Chemical compound C1=CC(C#N)=CC=C1CN1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 XJGSJZDKTYSYQY-UHFFFAOYSA-N 0.000 claims 1
• NCRFMZFMXPJTLM-UHFFFAOYSA-N 4-amino-5,6-difluoro-2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzene-1,3-dicarbonitrile Chemical compound NC1=C(F)C(F)=C(C#N)C(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1C#N NCRFMZFMXPJTLM-UHFFFAOYSA-N 0.000 claims 1
• CEODRDFAPCUYEV-UHFFFAOYSA-N 4-chloro-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound ClC1=CC=C(C#N)C=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 CEODRDFAPCUYEV-UHFFFAOYSA-N 0.000 claims 1
• MKBICQOOEBQMNQ-UHFFFAOYSA-N 4-chloro-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound ClC1=CC=C(C#N)C=C1N1N=CC(C=2C=3C=CNC=3N=CN=2)=C1 MKBICQOOEBQMNQ-UHFFFAOYSA-N 0.000 claims 1
• BYPCYQPASFKGOL-UHFFFAOYSA-N 4-cyclopentyl-4-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]butanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CC=2)C=NN1C(CCC#N)C1CCCC1 BYPCYQPASFKGOL-UHFFFAOYSA-N 0.000 claims 1
• QQKLULYCCPELLE-UHFFFAOYSA-N 4-cyclopropyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]butanenitrile Chemical compound C1=C(C=2C=3C=CNC=3N=CN=2)C=NN1C(CC#N)CC1CC1 QQKLULYCCPELLE-UHFFFAOYSA-N 0.000 claims 1
• GRUWCEQHXOCEHR-UHFFFAOYSA-N 4-fluoro-2-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound FC1=CC=C(C#N)C(N2N=CC(=C2)C=2C=3C=CNC=3N=CC=2)=C1 GRUWCEQHXOCEHR-UHFFFAOYSA-N 0.000 claims 1
• FXPVFIGMSPCKHM-UHFFFAOYSA-N 4-methyl-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]benzonitrile Chemical compound CC1=CC=C(C#N)C=C1N1N=CC(C=2C=3C=CNC=3N=CC=2)=C1 FXPVFIGMSPCKHM-UHFFFAOYSA-N 0.000 claims 1
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