CN108715615A - 抗pd1抗体及其作为治疗剂与诊断剂的用途 - Google Patents
抗pd1抗体及其作为治疗剂与诊断剂的用途 Download PDFInfo
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- CN108715615A CN108715615A CN201810552595.XA CN201810552595A CN108715615A CN 108715615 A CN108715615 A CN 108715615A CN 201810552595 A CN201810552595 A CN 201810552595A CN 108715615 A CN108715615 A CN 108715615A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810552595.XA CN108715615B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2013/083467 WO2015035606A1 (en) | 2013-09-13 | 2013-09-13 | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
CN201810552595.XA CN108715615B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201380079581.6A CN105531288B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
Related Parent Applications (1)
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CN201380079581.6A Division CN105531288B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
Publications (2)
Publication Number | Publication Date |
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CN108715615A true CN108715615A (zh) | 2018-10-30 |
CN108715615B CN108715615B (zh) | 2020-11-27 |
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Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
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CN202011322092.7A Active CN112552401B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201710207300.0A Active CN107011441B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN202011322081.9A Active CN112457403B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201710208535.1A Active CN107090041B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201380079581.6A Active CN105531288B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201810552595.XA Active CN108715615B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
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CN202011322092.7A Active CN112552401B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201710207300.0A Active CN107011441B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN202011322081.9A Active CN112457403B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201710208535.1A Active CN107090041B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
CN201380079581.6A Active CN105531288B (zh) | 2013-09-13 | 2013-09-13 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
Country Status (30)
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US (9) | US8735553B1 (zh) |
EP (3) | EP3702373B9 (zh) |
JP (1) | JP6623353B2 (zh) |
KR (1) | KR102100419B1 (zh) |
CN (6) | CN112552401B (zh) |
AU (3) | AU2013400609B9 (zh) |
BR (1) | BR112016005408B1 (zh) |
CA (3) | CA2924172C (zh) |
CY (2) | CY1125652T1 (zh) |
DK (2) | DK3702373T3 (zh) |
EA (1) | EA034666B1 (zh) |
ES (2) | ES2927567T3 (zh) |
FR (1) | FR24C1001I1 (zh) |
HK (1) | HK1217501A1 (zh) |
HR (1) | HRP20221262T1 (zh) |
HU (3) | HUE049281T2 (zh) |
IL (5) | IL296026B1 (zh) |
LT (1) | LT3702373T (zh) |
MX (1) | MX2016003292A (zh) |
NL (1) | NL301252I2 (zh) |
NO (1) | NO2023045I1 (zh) |
NZ (1) | NZ718643A (zh) |
PL (2) | PL3702373T3 (zh) |
PT (2) | PT3044234T (zh) |
RS (1) | RS63571B9 (zh) |
SG (1) | SG11201601844TA (zh) |
SI (1) | SI3702373T1 (zh) |
TW (1) | TWI636995B (zh) |
WO (1) | WO2015035606A1 (zh) |
ZA (1) | ZA201601953B (zh) |
Cited By (2)
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CN109470806A (zh) * | 2018-10-19 | 2019-03-15 | 张骐 | 通过二维液相对单抗类产品细胞株进行高通量筛选的方法 |
CN110297093A (zh) * | 2019-03-18 | 2019-10-01 | 山西瑞豪生物科技有限公司 | 一种检测人免疫球蛋白g4的方法和试剂盒 |
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ES2634098T3 (es) | 2011-01-14 | 2017-09-26 | The Regents Of The University Of California | Anticuerpos terapéuticos contra la proteína ROR-1 y procedimientos para el uso de los mismos. |
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NZ711540A (en) | 2013-04-25 | 2018-08-31 | Beigene Ltd | Fused heterocyclic compounds as protein kinase inhibitors |
WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
PT3041828T (pt) | 2013-09-06 | 2018-10-09 | Aurigene Discovery Tech Ltd | Derivados 1,3,4-0xadiazoles como imonomoduladores |
ES2788848T3 (es) | 2013-09-06 | 2020-10-23 | Aurigene Discovery Tech Ltd | Derivados de 1,2,4-oxadiazol como inmunomoduladores |
SI3041468T1 (sl) | 2013-09-06 | 2018-10-30 | Aurigene Discovery Technologies Limited | Ciklične peptidomimetične spojine kot imunomodulatorji |
BR112016005408B1 (pt) | 2013-09-13 | 2023-03-21 | Beigene Switzerland Gmbh | Anticorpos anti-pd1, f(ab) ou f(ab)2 e uso referido anticorpo para tratamento de cancer ou infecção viral |
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KR20230097209A (ko) | 2014-03-12 | 2023-06-30 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소 |
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